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公开(公告)号：US08431411B2
公开(公告)日：2013-04-30
申请号：US13327650
申请日：2011-12-15
Applicant: Nigel Clarke , Brett Holmquist , Gloria Kwang-Ja Lee , Richard E. Reitz
Inventor： Nigel Clarke , Brett Holmquist , Gloria Kwang-Ja Lee , Richard E. Reitz
IPC: G01N31/00
CPC classification number: G01N33/82 , G01N30/72 , G01N30/7233 , G01N2030/8813 , G01N2030/8822 , G01N2458/15 , G01N2560/00 , H01J49/00 , H01J49/004 , Y10T436/20 , Y10T436/203332 , Y10T436/24
Abstract: Provided are methods of detecting the presence or amount of a vitamin D metabolite in a sample using mass spectrometry. The methods generally comprise ionizing a vitamin D metabolite in a sample and detecting the amount of the ion to determine the presence or amount of the vitamin D metabolite in the sample. Also provided are methods to detect the presence or amount of two or more vitamin D metabolites in a single assay.
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2.发明申请VITAMIN D METABOLITE DETERMINATION UTILIZING MASS SPECTROMETRY FOLLOWING DERIVATIZATION 有权维生素D代谢决定利用衍生物进行质谱分析公开(公告)号：US20120115242A1
公开(公告)日：2012-05-10
申请号：US13287012
申请日：2011-11-01
Applicant: Brett Holmquist , Nigel Clarke , Richard E. Reitz
Inventor： Brett Holmquist , Nigel Clarke , Richard E. Reitz
IPC: G01N27/72
CPC classification number: G01N33/82 , G01N30/7233 , G01N30/88 , G01N2030/8813 , H01J49/0031 , H01J49/0045 , Y10T436/203332 , Y10T436/24
Abstract: The invention relates to the detection of vitamin D metabolites. In a particular aspect, the invention relates to methods for detecting derivatized vitamin D metabolites by mass spectrometry.
Abstract translation: 本发明涉及维生素D代谢物的检测。 在一个特定方面，本发明涉及通过质谱法检测衍生的维生素D代谢物的方法。
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公开(公告)号：US20120088260A1
公开(公告)日：2012-04-12
申请号：US13330537
申请日：2011-12-19
Applicant: Cory E. Bystrom , Richard E. Reitz , Nigel J. Clarke
Inventor： Cory E. Bystrom , Richard E. Reitz , Nigel J. Clarke
CPC classification number: G01N33/6848 , G01N33/74 , Y10T436/10
Abstract: Provided are methods for measuring renin activity in a plasma sample using mass spectrometry. The methods generally involve ionizing purified angiotensin 1 from the sample and detecting the amount of angiotensin 1 ions generated. The amount of detected angiotensin 1 ions are then related to the amount of angiotensin 1 generated in the sample, which in turn is related to renin activity in the sample.
Abstract translation: 提供了使用质谱法测量血浆样品中的肾素活性的方法。 该方法通常涉及从样品离子化纯化的血管紧张素1并检测产生的血管紧张素1离子的量。 然后检测到的血管紧张素1离子的量与样品中产生的血管紧张素1的量相关，其又与样品中的肾素活性相关。
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公开(公告)号：US08101427B2
公开(公告)日：2012-01-24
申请号：US13115916
申请日：2011-05-25
Applicant: Nigel Clarke , Brett Holmquist , Kwang-Ja Lee , Richard E. Reitz
Inventor： Nigel Clarke , Brett Holmquist , Kwang-Ja Lee , Richard E. Reitz
IPC: G01N24/00
CPC classification number: G01N33/82 , G01N30/72 , G01N30/7233 , G01N2030/8813 , G01N2030/8822 , G01N2458/15 , G01N2560/00 , H01J49/00 , H01J49/004 , Y10T436/20 , Y10T436/203332 , Y10T436/24
Abstract: Provided are methods of detecting the presence or amount of a vitamin D metabolite in a sample using mass spectrometry. The methods generally comprise ionizing a vitamin D metabolite in a sample and detecting the amount of the ion to determine the presence or amount of the vitamin D metabolite in the sample. Also provided are methods to detect the presence or amount of two or more vitamin D metabolites in a single assay.
Abstract translation: 提供了使用质谱法检测样品中维生素D代谢物的存在或量的方法。 方法通常包括在样品中电离维生素D代谢物并检测离子的量以确定样品中维生素D代谢物的存在或量。 还提供了在单个测定中检测两种或更多种维生素D代谢物的存在或量的方法。
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5.发明授权公开(公告)号：US07972868B2
公开(公告)日：2011-07-05
申请号：US11946765
申请日：2007-11-28
Applicant: Brett Holmquist , Nigel J. Clarke , Anne Caston-Balderrama , Richard E. Reitz
Inventor： Brett Holmquist , Nigel J. Clarke , Anne Caston-Balderrama , Richard E. Reitz
IPC: G01N24/00
CPC classification number: G01N27/62 , G01N33/82 , Y10T436/10 , Y10T436/20 , Y10T436/203332 , Y10T436/24
Abstract: Provided are methods of detecting the presence or amount of a dihydroxyvitamin in D metabolite in a sample using mass spectrometry. The methods generally comprise ionizing a dihydroxyvitamin D metabolite in a sample and detecting the amount of the ion to determine the presence or amount of the vitamin D metabolite in the sample. In certain preferred embodiments the methods include immunopurifying the dihydroxyvitamin D metabolites prior to mass spectrometry. Also provided are methods to detect the presence or amount of two or more dihydroxyvitamin D metabolites in a single assay.
Abstract translation: 提供了使用质谱法检测样品中二羟基维生素D代谢物的存在或量的方法。 方法通常包括在样品中离子化二羟基维生素D代谢物，并检测离子的量以确定样品中维生素D代谢物的存在或量。 在某些优选的实施方案中，所述方法包括在质谱法之前免疫促进二羟维生素D代谢物。 还提供了在单个测定中检测两种或更多种二羟维生素D代谢物的存在或量的方法。
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Patent Agency Ranking
公开(公告)号：US20110059534A1
公开(公告)日：2011-03-10
申请号：US12946785
申请日：2010-11-15
Applicant: Michael P. Caulfield , Darren A. Carns , Richard E. Reitz
Inventor： Michael P. Caulfield , Darren A. Carns , Richard E. Reitz
IPC: G01N33/92
CPC classification number: G01N33/743 , Y10T436/108331 , Y10T436/200833
Abstract: Provided are methods for determining the presence or amount of testosterone in a test sample, comprising ionizing all or a portion of the testosterone present in the sample to produce one or more testosterone ions that are detectable in a mass spectrometer. All or a portion of the testosterone present in the sample is ionized to produce one or more testosterone ions, which may be isolated and fragmented to produce precursor ions. A separately detectable internal testosterone standard can be provided in the sample. In a preferred embodiment, the reference is 2,2,4,6,6-d5 testosterone.
Abstract translation: 提供了用于确定测试样品中睾丸酮的存在或量的方法，其包括电离样品中存在的全部或部分睾酮以产生在质谱仪中可检测的一种或多种睾酮离子。 存在于样品中的全部或一部分睾酮被离子化以产生一种或多种睾丸酮离子，其可被分离并碎裂以产生前体离子。 可以在样品中提供可单独检测的内部睾酮标准品。 在优选的实施方案中，参考文献是2,2,4,6,6-d5睾酮。
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公开(公告)号：US20100219338A1
公开(公告)日：2010-09-02
申请号：US12715343
申请日：2010-03-01
Applicant: Cory E. Bystrom , Richard E. Reitz , Nigel J. Clarke
Inventor： Cory E. Bystrom , Richard E. Reitz , Nigel J. Clarke
CPC classification number: G01N33/6848 , G01N33/74 , Y10T436/10
Abstract: Provided are methods for measuring renin activity in a plasma sample using mass spectrometry. The methods generally involve ionizing purified angiotensin 1 from the sample and detecting the amount of angiotensin 1 ions generated. The amount of detected angiotensin 1 ions are then related to the amount of angiotensin 1 generated in the sample, which in turn is related to renin activity in the sample.
Abstract translation: 提供了使用质谱法测量血浆样品中的肾素活性的方法。 该方法通常涉及从样品离子化纯化的血管紧张素1并检测产生的血管紧张素1离子的量。 然后检测到的血管紧张素1离子的量与样品中产生的血管紧张素1的量相关，其又与样品中的肾素活性相关。
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公开(公告)号：US07745226B2
公开(公告)日：2010-06-29
申请号：US11101166
申请日：2005-04-06
Applicant: Nigel Clarke , Brett Holmquist , Kwang-Ja Lee , Richard E. Reitz
Inventor： Nigel Clarke , Brett Holmquist , Kwang-Ja Lee , Richard E. Reitz
IPC: G01N24/10
CPC classification number: G01N33/82 , G01N30/72 , G01N30/7233 , G01N2030/8813 , G01N2030/8822 , G01N2458/15 , G01N2560/00 , H01J49/00 , H01J49/004 , Y10T436/20 , Y10T436/203332 , Y10T436/24
Abstract: Provided are methods of detecting the presence or amount of a vitamin D metabolite in a sample using mass spectrometry. The methods generally comprise ionizing a vitamin D metabolite in a sample and detecting the amount of the ion to determine the presence or amount of the vitamin D metabolite in the sample. Also provided are methods to detect the presence or amount of two or more vitamin D metabolites in a single assay.
Abstract translation: 提供了使用质谱法检测样品中维生素D代谢物的存在或量的方法。 方法通常包括在样品中电离维生素D代谢物并检测离子的量以确定样品中维生素D代谢物的存在或量。 还提供了在单个测定中检测两种或更多种维生素D代谢物的存在或量的方法。
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公开(公告)号：US08916385B2
公开(公告)日：2014-12-23
申请号：US12002314
申请日：2007-12-13
Applicant: Mildred M. Goldman , Nigel J. Clarke , Richard E. Reitz
Inventor： Mildred M. Goldman , Nigel J. Clarke , Richard E. Reitz
CPC classification number: G01N33/743 , G01N33/6851 , G01N2560/00 , Y10T436/20 , Y10T436/200833 , Y10T436/203332 , Y10T436/24 , Y10T436/25
Abstract: Provided are methods for determining the amount of estrone in a sample using mass spectrometry. The methods generally involve ionizing estrone in a sample and detecting and quantifying the amount of the ion to determine the amount of estrone in the sample.
Abstract translation: 提供了使用质谱法测定样品中雌酮的量的方法。 方法通常涉及电离样品中的雌酮，并检测和定量离子的量以确定样品中雌酮的量。
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公开(公告)号：US20130165627A1
公开(公告)日：2013-06-27
申请号：US13682304
申请日：2012-11-20
Applicant: Cory E. Bystrom , Richard E. Reitz
Inventor： Cory E. Bystrom , Richard E. Reitz
IPC: H01J49/00
CPC classification number: G01N33/6848 , G01N33/689 , G01N2333/4704 , G01N2333/705 , G01N2800/368 , H01J49/0031 , H01J49/0036 , H01J49/004 , H01J49/0045
Abstract: Methods are described for measuring the amount of a kisspeptin-54-derived peptides in a sample. More specifically, mass spectrometric methods are described for detecting and quantifying a kisspeptin-54 derived peptides in a sample utilizing on-line extraction methods coupled with tandem mass spectrometric techniques.
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