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公开(公告)号：US07951822B2
公开(公告)日：2011-05-31
申请号：US12413894
申请日：2009-03-30
申请人： Ayumu Okuda , Takayuki Matsuda , Toru Miura , Koichi Yamazaki , Yuki Yamaguchi , Minoru Koura , Sayaka Kurobuchi , Yuichiro Watanabe , Kimiyuki Shibuya
发明人： Ayumu Okuda , Takayuki Matsuda , Toru Miura , Koichi Yamazaki , Yuki Yamaguchi , Minoru Koura , Sayaka Kurobuchi , Yuichiro Watanabe , Kimiyuki Shibuya
IPC分类号： A61K31/4166 , A61K31/427 , A61K31/422 , A61K31/45 , A61K31/4525 , C07D405/12 , C07D417/12 , C07D413/12 , C07D407/12
CPC分类号： C07D405/12 , C07D405/14 , C07D417/12 , C07D417/14
摘要： The object is to provide a novel LXRβ agonist that is useful as a preventative and/or therapeutic agent for atherosclerosis; arteriosclerosis such as those resulting from diabetes; dyslipidemia; hypercholesterolemia; lipid-related diseases; inflammatory diseases that are caused by inflammatory cytokines; skin diseases such as allergic skin diseases; diabetes; or Alzheimer's disease. The solving means is a 1,3-dihydroisobenzofuran derivative represented by the following general formula (1) or salt thereof, or their solvate.
摘要翻译： 目的是提供一种新颖的LXR＆bgr; 可用作动脉粥样硬化的预防和/或治疗剂的激动剂; 动脉硬化，如糖尿病引起的; 血脂异常 高胆固醇血症 脂质相关疾病; 由炎性细胞因子引起的炎性疾病; 皮肤病如过敏性皮肤病; 糖尿病; 或阿尔茨海默病。 解决方法是由以下通式（1）表示的1,3-二氢异苯并呋喃衍生物或其盐或其溶剂合物。
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公开(公告)号：US20090286780A1
公开(公告)日：2009-11-19
申请号：US12394548
申请日：2009-02-27
申请人： Ayumu OKUDA , Takayuki MATSUDA , Toru MIURA , Hidefumi OZAWA , Ayako TOSAKA , Koichi YAMAZAKI , Yuki YAMAGUCHI , Sayaka KUROBUCHI , Yuuichirou WATANABE , Kimiyuki SHIBUYA
发明人： Ayumu OKUDA , Takayuki MATSUDA , Toru MIURA , Hidefumi OZAWA , Ayako TOSAKA , Koichi YAMAZAKI , Yuki YAMAGUCHI , Sayaka KUROBUCHI , Yuuichirou WATANABE , Kimiyuki SHIBUYA
IPC分类号： A61K31/4178 , C07D407/12 , C07D413/14 , A61K31/5377 , A61P3/00 , A61P25/00 , A61P17/00
CPC分类号： C07D405/12 , C07D405/14 , C07D409/14 , C07D413/12 , C07D417/12
摘要： To provide a novel LXRβ agonist that is useful as a preventative and/or therapeutic agent for atherosclerosis; arteriosclerosis such as those resulting from diabetes; dyslipidemia; hypercholesterolemia; lipid-related diseases; inflammatory diseases that are caused by inflammatory cytokines; skin diseases such as allergic skin diseases; diabetes; or Alzheimer's disease.[Solving Means] A 2-oxochromene derivative represented by the following general formula (1) or salt thereof, or their solvate.
摘要翻译： 提供可用作动脉粥样硬化的预防和/或治疗剂的新型LXRβ激动剂; 动脉硬化，如糖尿病引起的; 血脂异常 高胆固醇血症 脂质相关疾病; 由炎性细胞因子引起的炎性疾病; 皮肤病如过敏性皮肤病; 糖尿病; 或阿尔茨海默病。 [解决方案]由以下通式（1）表示的2-氧代色烯衍生物或其盐或其溶剂合物。
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公开(公告)号：US20100063119A1
公开(公告)日：2010-03-11
申请号：US12516944
申请日：2007-11-29
申请人： Takayuki Matsuda , Ayumu Okuda , Minoru Koura , Yuki Yamaguchi , Sayaka Kurobuchi , Yuuichirou Watanabe , Kimiyuki Shibuya
发明人： Takayuki Matsuda , Ayumu Okuda , Minoru Koura , Yuki Yamaguchi , Sayaka Kurobuchi , Yuuichirou Watanabe , Kimiyuki Shibuya
IPC分类号： A61K31/4164 , C07D233/72 , C07D405/10 , C07D409/04 , A61K31/4178
CPC分类号： C07D233/72 , C07D233/76 , C07D233/78 , C07D235/02 , C07D401/04 , C07D403/04 , C07D405/04 , C07D409/04
摘要： There is provided a novel LXRβ agonist useful as a preventative and/or therapeutic agent for arteriosclerosis; arteriosclerosis such as those resulting from diabetes; hyperlipidemia; hypercholesterolemia; lipid-related diseases; inflammatory diseases caused by inflammatory cytokines, skin diseases such as allergic skin diseases, diabetes or Alzheimer's disease. The agonist is a carbinol derivative represented by the following general formula (1) or salt thereof, or their solvate.
摘要翻译： 提供了一个新颖的LXR＆bgr; 可用作动脉硬化的预防和/或治疗剂的激动剂; 动脉硬化，如糖尿病引起的; 高脂血症 高胆固醇血症 脂质相关疾病; 由炎性细胞因子引起的炎性疾病，皮肤疾病如过敏性皮肤疾病，糖尿病或阿尔茨海默病。 激动剂是由以下通式（1）表示的甲醇衍生物或其盐或其溶剂合物。
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公开(公告)号：US08168666B2
公开(公告)日：2012-05-01
申请号：US12516944
申请日：2007-11-29
申请人： Takayuki Matsuda , Ayumu Okuda , Minoru Koura , Yuki Yamaguchi , Sayaka Kurobuchi , Yuuichirou Watanabe , Kimiyuki Shibuya
发明人： Takayuki Matsuda , Ayumu Okuda , Minoru Koura , Yuki Yamaguchi , Sayaka Kurobuchi , Yuuichirou Watanabe , Kimiyuki Shibuya
IPC分类号： A61K31/4015 , C07D233/32
CPC分类号： C07D233/72 , C07D233/76 , C07D233/78 , C07D235/02 , C07D401/04 , C07D403/04 , C07D405/04 , C07D409/04
摘要： There is provided a novel LXRβ agonist useful as a preventative and/or therapeutic agent for arteriosclerosis; arteriosclerosis such as those resulting from diabetes; hyperlipidemia; hypercholesterolemia; lipid-related diseases; inflammatory diseases caused by inflammatory cytokines, skin diseases such as allergic skin diseases, diabetes or Alzheimer's disease. The agonist is a carbinol derivative represented by the following general formula (1) or salt thereof, or their solvate.
摘要翻译： 提供了一个新颖的LXR＆bgr; 可用作动脉硬化的预防和/或治疗剂的激动剂; 动脉硬化，如糖尿病引起的; 高脂血症 高胆固醇血症 脂质相关疾病; 由炎性细胞因子引起的炎性疾病，皮肤疾病如过敏性皮肤疾病，糖尿病或阿尔茨海默病。 激动剂是由以下通式（1）表示的甲醇衍生物或其盐或其溶剂合物。
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公开(公告)号：US08153634B2
公开(公告)日：2012-04-10
申请号：US12474799
申请日：2009-05-29
申请人： Yuki Yamaguchi , Minoru Koura , Sayaka Kurobuchi , Takayuki Matsuda , Ayumu Okuda , Hisashi Sumida , Yuichiro Watanabe , Takashi Enomoto , Kimiyuki Shibuya
发明人： Yuki Yamaguchi , Minoru Koura , Sayaka Kurobuchi , Takayuki Matsuda , Ayumu Okuda , Hisashi Sumida , Yuichiro Watanabe , Takashi Enomoto , Kimiyuki Shibuya
IPC分类号： A61K31/4166 , A61K31/4178 , A61K31/4355 , A61K31/4439 , A61K31/497 , A61K31/501 , A61K31/506 , C07D401/02 , C07D401/06 , C07D405/14 , C07D405/02 , C07D491/048 , C07D233/72 , C07D403/02 , C07D403/06
CPC分类号： C07D233/72 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D405/04 , C07D405/14 , C07D491/048
摘要： [Object] To provide a novel LXRβ agonist that is useful as a preventative and/or therapeutic agent for atherosclerosis; arteriosclerosis such as those resulting from diabetes; dyslipidemia; hypercholesterolemia; lipid-related diseases; inflammatory diseases that are caused by inflammatory cytokines; skin diseases such as allergic skin diseases; diabetes; or Alzheimer's disease.[Solving Means] A carbinol compound represented by the following general formula (I) or salt thereof, or their solvate.
摘要翻译： [目的]提供一种新型的LXR＆bgr; 可用作动脉粥样硬化的预防和/或治疗剂的激动剂; 动脉硬化，如糖尿病引起的; 血脂异常 高胆固醇血症 脂质相关疾病; 由炎性细胞因子引起的炎性疾病; 皮肤病如过敏性皮肤病; 糖尿病; 或阿尔茨海默病。 [解决方案]由以下通式（I）表示的甲醇化合物或其盐或其溶剂化物。
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公开(公告)号：US20090247587A1
公开(公告)日：2009-10-01
申请号：US12413894
申请日：2009-03-30
申请人： Ayumu OKUDA , Takayuki MATSUDA , Toru MIURA , Koichi YAMAZAKI , Yuki YAMAGUCHI , Minoru KOURA , Sayaka KUROBUCHI , Yuuichiro WATANABE , Kimiyuki SHIBUYA
发明人： Ayumu OKUDA , Takayuki MATSUDA , Toru MIURA , Koichi YAMAZAKI , Yuki YAMAGUCHI , Minoru KOURA , Sayaka KUROBUCHI , Yuuichiro WATANABE , Kimiyuki SHIBUYA
IPC分类号： A61K31/4178 , C07D405/12 , C07D405/14 , C07D417/14 , A61K31/4439 , A61K31/427 , A61P3/00 , A61P17/00 , A61P29/00 , A61P25/28
CPC分类号： C07D405/12 , C07D405/14 , C07D417/12 , C07D417/14
摘要： The object is to provide a novel LXRβ agonist that is useful as a preventative and/or therapeutic agent for atherosclerosis; arteriosclerosis such as those resulting from diabetes; dyslipidemia; hypercholesterolemia; lipid-related diseases; inflammatory diseases that are caused by inflammatory cytokines; skin diseases such as allergic skin diseases; diabetes; or Alzheimer's disease. The solving means is a 1,3-dihydroisobenzofuran derivative represented by the following general formula (1) or salt thereof, or their solvate.
摘要翻译： 目的是提供可用作动脉粥样硬化的预防和/或治疗剂的新型LXRβ激动剂; 动脉硬化，如糖尿病引起的; 血脂异常 高胆固醇血症 脂质相关疾病; 由炎性细胞因子引起的炎性疾病; 皮肤病如过敏性皮肤病; 糖尿病; 或阿尔茨海默病。 解决方法是由以下通式（1）表示的1,3-二氢异苯并呋喃衍生物或其盐或其溶剂合物。
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公开(公告)号：US08008306B2
公开(公告)日：2011-08-30
申请号：US12430397
申请日：2009-04-27
申请人： Minoru Koura , Ayumu Okuda , Takayuki Matsuda , Yuki Yamaguchi , Hisashi Sumida , Sayaka Kurobuchi , Yuichiro Watanabe , Takashi Enomoto , Kimiyuki Shibuya
发明人： Minoru Koura , Ayumu Okuda , Takayuki Matsuda , Yuki Yamaguchi , Hisashi Sumida , Sayaka Kurobuchi , Yuichiro Watanabe , Takashi Enomoto , Kimiyuki Shibuya
IPC分类号： C07D215/12 , C07D215/233 , C07D241/40 , A61K31/4709 , A61K31/498
CPC分类号： C07D401/14 , C07D401/12 , C07D405/14
摘要： To provide a novel LXRβ agonist that is useful as a preventative and/or therapeutic agent for atherosclerosis; arteriosclerosis such as those resulting from diabetes; dyslipidemia; hypercholesterolemia; lipid-related diseases; inflammatory diseases that are caused by inflammatory cytokines; skin diseases such as allergic skin diseases; diabetes; or Alzheimer's disease.A quinoline compound represented by the following general formula (1) or salt thereof, or their solvate.
摘要翻译： 提供一种新颖的LXR＆bgr 可用作动脉粥样硬化的预防和/或治疗剂的激动剂; 动脉硬化，如糖尿病引起的; 血脂异常 高胆固醇血症 脂质相关疾病; 由炎性细胞因子引起的炎性疾病; 皮肤病如过敏性皮肤病; 糖尿病; 或阿尔茨海默病。 由以下通式（1）表示的喹啉化合物或其盐或其溶剂化物。
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公开(公告)号：US07919509B2
公开(公告)日：2011-04-05
申请号：US12394548
申请日：2009-02-27
申请人： Ayumu Okuda , Takayuki Matsuda , Toru Miura , Hidefumi Ozawa , Ayako Tosaka , Koichi Yamazaki , Yuki Yamaguchi , Sayaka Kurobuchi , Yuichiro Watanabe , Kimiyuki Shibuya
发明人： Ayumu Okuda , Takayuki Matsuda , Toru Miura , Hidefumi Ozawa , Ayako Tosaka , Koichi Yamazaki , Yuki Yamaguchi , Sayaka Kurobuchi , Yuichiro Watanabe , Kimiyuki Shibuya
IPC分类号： A61K31/4166 , A61K31/427 , A61K31/45 , A61K31/422 , A61K31/4525 , C07D405/12 , C07D417/12 , C07D413/12 , C07D407/12
CPC分类号： C07D405/12 , C07D405/14 , C07D409/14 , C07D413/12 , C07D417/12
摘要： To provide a novel LXRβ agonist that is useful as a preventative and/or therapeutic agent for atherosclerosis; arteriosclerosis such as those resulting from diabetes; dyslipidemia; hypercholesterolemia; lipid-related diseases; inflammatory diseases that are caused by inflammatory cytokines; skin diseases such as allergic skin diseases; diabetes; or Alzheimer's disease.[Solving Means] A 2-oxochromene derivative represented by the following general formula (1) or salt thereof, or their solvate.
摘要翻译： 提供一种新颖的LXR＆bgr 可用作动脉粥样硬化的预防和/或治疗剂的激动剂; 动脉硬化，如糖尿病引起的; 血脂异常 高胆固醇血症 脂质相关疾病; 由炎性细胞因子引起的炎性疾病; 皮肤病如过敏性皮肤病; 糖尿病; 或阿尔茨海默病。 [解决方案]由以下通式（1）表示的2-氧代色烯衍生物或其盐或其溶剂合物。
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公开(公告)号：US20100280013A1
公开(公告)日：2010-11-04
申请号：US12769104
申请日：2010-04-28
申请人： Minoru Koura , Hisashi Sumida , Sayaka Kurobuchi , Takayuki Matsuda , Yuichiro Watanabe , Takashi Enomoto , Kimiyuki Shibuya , Sumiko Kurobuchi
发明人： Minoru Koura , Hisashi Sumida , Sayaka Kurobuchi , Takayuki Matsuda , Yuichiro Watanabe , Takashi Enomoto , Kimiyuki Shibuya , Sumiko Kurobuchi
IPC分类号： A61K31/551 , C07D401/14 , C07D403/06 , C07D407/14 , A61P3/10 , A61P25/28 , A61P3/06 , A61P29/00 , A61K31/496 , A61P7/00 , A61P9/10 , A61P17/00
CPC分类号： C07D233/78 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/06 , C07D405/04 , C07D405/14 , C07D491/04
摘要： [Object] It is to provide a novel LXRβ agonist useful as a preventative and/or therapeutic agent for atherosclerosis; arteriosclerosis such as those resulting from diabetes; dyslipidemia; hypercholesterolemia; lipid-related diseases; inflammatory diseases that are caused by inflammatory cytokines; skin diseases such as allergic skin diseases; diabetes; or Alzheimer's disease.[Solving Means] A carbinol compound represented by the following general formula (I) or salt thereof, or their solvate: (wherein, each V and W independently show N or C—R7; each X and Y independently show CH2, C═O, SO2, etc; Z shows CH or N; each R1, R2 and R7 independently show a hydrogen atom, C1-8 alkyl group, etc.; R3 shows C1-8 alkyl group; R4 shows an optionally substituted C6-10 aryl group or an optionally substituted 5- to 11-membered heterocyclic group; R5 and R6 show a hydrogen atom, etc.; L shows a C1-8 alkyl chain optionally substituted with an oxo group, etc.; and n shows any integer of 0 to 2.)
摘要翻译： [对象]提供一个新颖的LXR＆bgr; 可用作动脉粥样硬化的预防和/或治疗剂的激动剂; 动脉硬化，如糖尿病引起的; 血脂异常 高胆固醇血症 脂质相关疾病; 由炎性细胞因子引起的炎性疾病; 皮肤病如过敏性皮肤病; 糖尿病; 或阿尔茨海默病。 [解决方案]由以下通式（I）表示的甲醇化合物或其盐或其溶剂化物：（其中，V和W各自独立地表示N或C-R7; X和Y各自独立地表示CH 2，C = O ，SO2等; Z表示CH或N;每个R1，R2和R7独立地表示氢原子，C1-8烷基等; R3表示C1-8烷基; R4表示任选取代的C6-10芳基 或任选取代的5至11元杂环基; R 5和R 6表示氢原子等; L表示任选被氧代基等取代的C 1-8烷基链; n表示0〜 2.）
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公开(公告)号：US20100048610A1
公开(公告)日：2010-02-25
申请号：US12474799
申请日：2009-05-29
申请人： Yuki Yamaguchi , Minoru Koura , Sayaka Kurobuchi , Takayuki Matsuda , Ayumu Okuda , Hisashi Sumida , Yuuichirou Watanabe , Takashi Enomoto , Kimiyuki Shibuya
发明人： Yuki Yamaguchi , Minoru Koura , Sayaka Kurobuchi , Takayuki Matsuda , Ayumu Okuda , Hisashi Sumida , Yuuichirou Watanabe , Takashi Enomoto , Kimiyuki Shibuya
IPC分类号： A61K31/436 , C07D401/06 , A61K31/4439 , C07D491/056
CPC分类号： C07D233/72 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D405/04 , C07D405/14 , C07D491/048
摘要： [Object] To provide a novel LXRβ agonist that is useful as a preventative and/or therapeutic agent for atherosclerosis; arteriosclerosis such as those resulting from diabetes; dyslipidemia; hypercholesterolemia; lipid-related diseases; inflammatory diseases that are caused by inflammatory cytokines; skin diseases such as allergic skin diseases; diabetes; or Alzheimer's disease.[Solving Means] A carbinol compound represented by the following general formula (I) or salt thereof, or their solvate.
摘要翻译： [目的]提供一种新型的LXR＆bgr; 可用作动脉粥样硬化的预防和/或治疗剂的激动剂; 动脉硬化，如糖尿病引起的; 血脂异常 高胆固醇血症 脂质相关疾病; 由炎性细胞因子引起的炎性疾病; 皮肤病如过敏性皮肤病; 糖尿病; 或阿尔茨海默病。 [解决方案]由以下通式（I）表示的甲醇化合物或其盐或其溶剂化物。
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