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    DENDRITIC POLYMERS AND MAGNETIC RESONANCE IMAGING CONTRAST AGENT EMPLOYING THE SAME
    2.
    发明申请
    DENDRITIC POLYMERS AND MAGNETIC RESONANCE IMAGING CONTRAST AGENT EMPLOYING THE SAME 审中-公开
    透明聚合物和磁共振成像对比剂使用它

    公开(公告)号：US20090169480A1

    公开(公告)日：2009-07-02

    申请号：US12174431

    申请日：2008-07-16

    申请人： Dhakshanamurthy Thirumalai ,  Chin-I Lin ,  Shian-Jy Jassy Wang

    发明人： Dhakshanamurthy Thirumalai ,  Chin-I Lin ,  Shian-Jy Jassy Wang

    IPC分类号： A61K49/06

    CPC分类号： A61K49/124

    摘要： A dendritic polymer and a magnetic resonance imaging contrast agent employing the same. The magnetic resonance contrast agent includes the dendritic polymer according to the structure of wherein, P is CH2CH2O1, and 1 is not less than 1 and j is not less than 2; D is a C3-30 dendritic moiety having n oxygen residue, and n is not less than 3 and i is more than 1; X is C3-30 moiety having bi-functional groups; Z is independent and includes a C3-20 moiety having a plurality of functional group, wherein the functional groups are selected from a group consisting of carbonyl, carboxyl, amine, ester, amide, or chelate group, and Z respectively bonds with X by a group; and L is a metal cation.

    摘要翻译： 树突状聚合物和使用其的磁共振成像造影剂。 磁共振造影剂包括根据其结构的树枝状聚合物，其中P是CH 2 CH 2 O 1，1不小于1，j不小于2; D是具有n个氧残基的C3-30树枝状部分，n不小于3且i大于1; X是具有双官能团的C3-30部分; Z是独立的，并且包括具有多个官能团的C 3-20部分，其中所述官能团选自羰基，羧基，胺，酯，酰胺或螯合基团，Z分别与X键合 组; L是金属阳离子。

    Antifungal formulation and manufacturing method thereof
    9.
    发明申请
    Antifungal formulation and manufacturing method thereof 审中-公开
    抗真菌配方及其制备方法

    公开(公告)号：US20090220599A1

    公开(公告)日：2009-09-03

    申请号：US12382379

    申请日：2009-03-16

    申请人： Jih Dar Tsai ,  Lelinda Chang ,  Shian Jy Jassy Wang ,  Ming Shang Kuo

    发明人： Jih Dar Tsai ,  Lelinda Chang ,  Shian Jy Jassy Wang ,  Ming Shang Kuo

    IPC分类号： A61K9/30 ,  A61K9/00 ,  A61K31/7048

    CPC分类号： A61K9/1075 ,  A61K31/7048 ,  A61K31/785

    摘要： A new antifungal formulation is provided. The present invention uses a sterol modified with polyethylene glycol (PEG) as a drug carrier. The drug carrier encapsulates Amphotericin B (AmB) by self-assembly to form polymeric micelles. The polymeric micelles can reduce toxicity of Amphotericin B and control release of Amphotericin B. The polymeric micelles of Amphotericin B are used as a new antifungal formulation.

    摘要翻译： 提供了一种新的抗真菌剂。 本发明使用用聚乙二醇（PEG）修饰的固醇作为药物载体。 药物载体通过自组装封装两性霉素B（AmB）以形成聚合胶束。 聚合物胶束可以减少两性霉素B的毒性和控制两性霉素B的释放。两性霉素B的聚合物胶束用作新的抗真菌剂型。