公开(公告)号：US06461334B1

公开(公告)日：2002-10-08

申请号：US09260758

申请日：1999-03-02

申请人： Thomas Buch-Rasmussen ,  Patric Jannasch ,  Erling Bonne Jørgensen ,  Ib Johannesen ,  Sokol Ndoni

发明人： Thomas Buch-Rasmussen ,  Patric Jannasch ,  Erling Bonne Jørgensen ,  Ib Johannesen ,  Sokol Ndoni

IPC分类号： A61M5315

CPC分类号： A61M5/31513 ,  A61J1/062 ,  A61M5/2448 ,  A61M2005/3131

摘要： The present invention relates to a medical article for containing a pharmaceutical protein preparation comprising at least a first component and a second component, having at least one surface coated with a coating to reduce the friction between the two components and to reduce the protein adsorption to the coating. The coating is a hydrophilic coating whereby the hydrophilicity of the surface of the coating as measured by the water contact angle is below 90°, and the long term static friction forces between the first and the second component are below 14 N. The coatings according to the present invention are especially suited for permanently coating in ternal surfaces of containers equipped with stoppers for storage and administration of liquid protein preparations, such as insulin preparations. The coating is preferably a silicon-containing coating, such as a poly(dialkyl siloxane) oil or copolymer. The invention further relates to a process of producing a component of a medical article coated as described above, comprising adding the coating material to the component material prior to molding and subsequently molding the component from the mixture, or molding the component from the component material and subsequently applying the coating material to the at least one surface of the component, and hydrophilizing the coating material prior to the molding or after the molding. Also the invention relates to a coating as defined above for articles having at least a first component and a second component.

摘要翻译： 本发明涉及一种用于容纳含有至少第一组分和第二组分的药物蛋白质制剂的医疗制品，其具有至少一个涂覆有涂层的表面以减少两种组分之间的摩擦并减少蛋白质吸附至 涂层。 涂层是一种亲水性涂层，其中通过水接触角测量的涂层表面的亲水性低于90°，​​第一和第二组分之间的长期静摩擦力低于14N。根据 本发明特别适用于在装有用于贮存和给药液体蛋白制剂例如胰岛素制剂的塞子的容器的三元表面中永久地涂覆。 涂层优选为含硅涂层，例如聚（二烷基硅氧烷）油或共聚物。 本发明还涉及如上所述涂敷的医疗用品的成分的制造方法，其特征在于，在成型前将所述涂料添加到所述成分材料中，从所述混合物中随后成型所述成分，或者从所述成分材料成型所述成分， 随后将涂层材料施加到部件的至少一个表面，并且在模制之前或模制之后使涂层材料亲水化。 本发明还涉及如上所述的具有至少第一组分和第二组分的制品的涂层。

公开(公告)号：US06482509B2

公开(公告)日：2002-11-19

申请号：US09260757

申请日：1999-03-02

申请人： Thomas Buch-Rasmussen ,  Patric Jannasch ,  Erling Bonne Jørgensen ,  Ib Johannesen ,  Sokol Ndoni ,  Nils Berg Madsen

发明人： Thomas Buch-Rasmussen ,  Patric Jannasch ,  Erling Bonne Jørgensen ,  Ib Johannesen ,  Sokol Ndoni ,  Nils Berg Madsen

IPC分类号： B32B1706

CPC分类号： C08J7/047 ,  A61J1/062 ,  A61M5/3129 ,  A61M5/31513 ,  A61M2005/3131 ,  C08J2483/00 ,  Y10T428/265 ,  Y10T428/31612 ,  Y10T428/31663 ,  Y10T428/31667

摘要： The present invention relates to a coating system, in particular to a coating system for articles where plastic materials slide against flexible rubber materials. The coating system is a silicone oil based coating having a viscosity of at least 200,000 centistokes, i.e. a high viscosity coating. The coating comprises in a preferred embodiment a silicone oil based block or graft copolymer, or segmented copolymer. Further the invention relates to a process of producing a component of an article coated as described above, comprising adding the coating material to the component material prior to molding and subsequently molding the component from the mixture, or molding the component from the component material and subsequently applying the coating material to the at least one surface of the component, as well as an article coated with a silicone oil based coating as defined above. Such an article is preferably a medical article, such as a container or an injection cylinder and a stopper. The coatings according to the present invention are especially suited to use for permanently coating internal surfaces of containers equipped with stoppers for storage and administration of liquid protein preparations. The coatings providing low friction between the two components, such as a container wall and a rubber stopper, result in high-precision dosing. The described coatings are particularly useful for coating containers for storage and administration of liquid protein solutions, such as insulin formulations.

摘要翻译： 本发明涉及一种涂覆系统，特别涉及一种用于制品的涂层系统，其中塑料材料滑动抵靠柔性橡胶材料。 该涂层系统是一种硅油基涂层，其粘度至少为20万厘沲，即高粘度涂层。 该涂层在优选的实施方案中包括基于硅油的嵌段或接枝共聚物或分段的共聚物。 此外，本发明涉及一种制造如上所述涂覆的制品的组分的方法，包括在模制之前将涂料添加到组分材料中，随后从混合物中模制组分，或者将组分从组分材料中模制，随后 将涂层材料施加到部件的至少一个表面上，以及涂覆有如上所述的硅油基涂层的制品。 这样的制品优选为医疗用品，例如容器，注射筒和塞子。 根据本发明的涂层特别适用于永久地涂覆装有用于储存和施用液体蛋白制剂的塞子的容器的内表面。 在两个部件之间提供低摩擦的涂层，例如容器壁和橡胶塞，导致高精度计量。 所描述的涂层对于包衣容器特别有用，用于储存和施用液体蛋白质溶液，例如胰岛素制剂。

公开(公告)号：US20110305993A1

公开(公告)日：2011-12-15

申请号：US13133701

申请日：2009-12-09

申请人： Li Li ,  Sokol Ndoni ,  Rolf Henrik Berg ,  Lars Schulte ,  Martin E. Vigild

发明人： Li Li ,  Sokol Ndoni ,  Rolf Henrik Berg ,  Lars Schulte ,  Martin E. Vigild

IPC分类号： G03F7/20 ,  B82B3/00

CPC分类号： C08J9/0071 ,  C08J9/26 ,  C08J9/36 ,  C08J2201/046 ,  C08J2300/00 ,  C08J2353/00

摘要： The present application discloses a method for preparing and rendering hydrophilic a nanoporous material of a polymer matrix which has a porosity of 0.1-90% (v/v), such that the ratio between the fmal water absorption (% (w/w)) and the porosity (% (v/v)) is at least 0.05, the method comprising the steps of: (a) preparing a precursor material comprising at least one polymeric component and having a first phase and a second phase; (b) removal of at least a part of the first phase of the precursor material prepared in step (a) so as to leave behind a nanoporous material of the polymer matrix; (c) irradiating at least a part of said nanoporous material with light of a wave length of in the range of 250-400 nm (or 200-700 nm) in the presence of oxygen and/or ozone. Corresponding hydrophilic nanoporous materials are also disclosed.

摘要翻译： 本申请公开了一种制备和使亲水性的聚合物基质的纳米多孔材料的孔隙率为0.1-90％（v / v）的亲水性方法，使得吸水率（％（w / w）） 并且孔隙率（％（v / v））至少为0.05，该方法包括以下步骤：（a）制备包含至少一种聚合物组分并具有第一相和第二相的前体材料; （b）除去在步骤（a）中制备的前体材料的至少一部分第一相，以留下聚合物基体的纳米多孔材料; （c）在存在氧和/或臭氧的情况下用波长为250-400nm（或200-700nm）的波长照射所述纳米多孔材料的至少一部分。 还公开了相应的亲水纳米多孔材料。

公开(公告)号：US08785111B2

公开(公告)日：2014-07-22

申请号：US13133701

申请日：2009-12-09

申请人： Li Li ,  Sokol Ndoni ,  Rolf Henrik Berg ,  Lars Schulte ,  Martin E. Vigild

发明人： Li Li ,  Sokol Ndoni ,  Rolf Henrik Berg ,  Lars Schulte ,  Martin E. Vigild

IPC分类号： G03F7/26

CPC分类号： C08J9/0071 ,  C08J9/26 ,  C08J9/36 ,  C08J2201/046 ,  C08J2300/00 ,  C08J2353/00

摘要： The present application discloses a method for preparing and rendering hydrophilic a nanoporous material of a polymer matrix which has a porosity of 0.1-90% (v/v), such that the ratio between the final water absorption (% (w/w)) and the porosity (% (v/v)) is at least 0.05, the method comprising the steps of: (a) preparing a precursor material comprising at least one polymeric component and having a first phase and a second phase; (b) removal of at least a part of the first phase of the precursor material prepared in step (a) so as to leave behind a nanoporous material of the polymer matrix; (c) irradiating at least a part of said nanoporous material with light of a wave length of in the range of 250-400 nm (or 200-700 nm) in the presence of oxygen and/or ozone. Corresponding hydrophilic nanoporous materials are also disclosed.

摘要翻译： 本申请公开了一种制备和使亲水性的聚合物基质的纳米多孔材料的方法，其具有0.1-90％（v / v）的孔隙率，使得最终吸水率（％（w / w）） 并且孔隙率（％（v / v））至少为0.05，该方法包括以下步骤：（a）制备包含至少一种聚合物组分并具有第一相和第二相的前体材料; （b）除去在步骤（a）中制备的前体材料的至少一部分第一相，以留下聚合物基体的纳米多孔材料; （c）在存在氧和/或臭氧的情况下用波长为250-400nm（或200-700nm）的波长照射所述纳米多孔材料的至少一部分。 还公开了相应的亲水纳米多孔材料。

公开(公告)号：US20130057863A1

公开(公告)日：2013-03-07

申请号：US13577736

申请日：2011-02-15

申请人： Mads Bøkner Christiansen ,  Sokol Ndoni ,  Martin Etchells Vigild ,  Anders Kristensen ,  Peter Thomsen

发明人： Mads Bøkner Christiansen ,  Sokol Ndoni ,  Martin Etchells Vigild ,  Anders Kristensen ,  Peter Thomsen

IPC分类号： G02B6/00 ,  G01N21/25 ,  B23P17/04 ,  G01J1/04

CPC分类号： G01N21/0303 ,  G01N2021/0346 ,  G01N2021/495 ,  G01N2201/088 ,  G02B6/02033 ,  Y10T29/49826

摘要： A sensor element is disclosed. The sensor element comprises a first element which is nanoporous, and a second element which is nanoporous, the second element enclosing the first element. The surfaces of the nanopores of the first- and second element differ in hydrophilicity, so that the surfaces of the nanopores of one element is generally more hydrophobic while the other is generally more hydrophilic, and hence the sensor element is capable of selectively having the first element filled with a fluid. The sensor element is capable of guiding light through the fluid-filled first element and can act as a nanoporous waveguide. The sensor element according to the invention is particularly useful for spectroscopy on fluids.

摘要翻译： 公开了一种传感器元件。 传感器元件包括纳米多孔的第一元件和纳米孔的第二元件，第二元件包围第一元件。 第一和第二元件的纳米孔的表面的亲水性不同，使得一个元件的纳米孔的表面通常更疏水，而另一个的纳米孔的表面通常更亲水，因此传感器元件能够选择性地具有第一 元素充满流体。 传感器元件能够引导光通过流体填充的第一元件并且可以充当纳米多孔波导。 根据本发明的传感器元件对于流体上的光谱特别有用。