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公开(公告)号：US06482509B2
公开(公告)日：2002-11-19
申请号：US09260757
申请日：1999-03-02
申请人： Thomas Buch-Rasmussen , Patric Jannasch , Erling Bonne Jørgensen , Ib Johannesen , Sokol Ndoni , Nils Berg Madsen
发明人： Thomas Buch-Rasmussen , Patric Jannasch , Erling Bonne Jørgensen , Ib Johannesen , Sokol Ndoni , Nils Berg Madsen
IPC分类号： B32B1706
CPC分类号： C08J7/047 , A61J1/062 , A61M5/3129 , A61M5/31513 , A61M2005/3131 , C08J2483/00 , Y10T428/265 , Y10T428/31612 , Y10T428/31663 , Y10T428/31667
摘要： The present invention relates to a coating system, in particular to a coating system for articles where plastic materials slide against flexible rubber materials. The coating system is a silicone oil based coating having a viscosity of at least 200,000 centistokes, i.e. a high viscosity coating. The coating comprises in a preferred embodiment a silicone oil based block or graft copolymer, or segmented copolymer. Further the invention relates to a process of producing a component of an article coated as described above, comprising adding the coating material to the component material prior to molding and subsequently molding the component from the mixture, or molding the component from the component material and subsequently applying the coating material to the at least one surface of the component, as well as an article coated with a silicone oil based coating as defined above. Such an article is preferably a medical article, such as a container or an injection cylinder and a stopper. The coatings according to the present invention are especially suited to use for permanently coating internal surfaces of containers equipped with stoppers for storage and administration of liquid protein preparations. The coatings providing low friction between the two components, such as a container wall and a rubber stopper, result in high-precision dosing. The described coatings are particularly useful for coating containers for storage and administration of liquid protein solutions, such as insulin formulations.
摘要翻译： 本发明涉及一种涂覆系统，特别涉及一种用于制品的涂层系统，其中塑料材料滑动抵靠柔性橡胶材料。 该涂层系统是一种硅油基涂层，其粘度至少为20万厘沲，即高粘度涂层。 该涂层在优选的实施方案中包括基于硅油的嵌段或接枝共聚物或分段的共聚物。 此外，本发明涉及一种制造如上所述涂覆的制品的组分的方法，包括在模制之前将涂料添加到组分材料中，随后从混合物中模制组分，或者将组分从组分材料中模制，随后 将涂层材料施加到部件的至少一个表面上，以及涂覆有如上所述的硅油基涂层的制品。 这样的制品优选为医疗用品，例如容器，注射筒和塞子。 根据本发明的涂层特别适用于永久地涂覆装有用于储存和施用液体蛋白制剂的塞子的容器的内表面。 在两个部件之间提供低摩擦的涂层，例如容器壁和橡胶塞，导致高精度计量。 所描述的涂层对于包衣容器特别有用，用于储存和施用液体蛋白质溶液，例如胰岛素制剂。
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2.发明授权Medical article with coated surfaces exhibiting low friction and protein adsorption 失效具有低摩擦和蛋白质吸附的涂层表面的医疗制品公开(公告)号：US06461334B1
公开(公告)日：2002-10-08
申请号：US09260758
申请日：1999-03-02
IPC分类号： A61M5315
CPC分类号： A61M5/31513 , A61J1/062 , A61M5/2448 , A61M2005/3131
摘要： The present invention relates to a medical article for containing a pharmaceutical protein preparation comprising at least a first component and a second component, having at least one surface coated with a coating to reduce the friction between the two components and to reduce the protein adsorption to the coating. The coating is a hydrophilic coating whereby the hydrophilicity of the surface of the coating as measured by the water contact angle is below 90°, and the long term static friction forces between the first and the second component are below 14 N. The coatings according to the present invention are especially suited for permanently coating in ternal surfaces of containers equipped with stoppers for storage and administration of liquid protein preparations, such as insulin preparations. The coating is preferably a silicon-containing coating, such as a poly(dialkyl siloxane) oil or copolymer. The invention further relates to a process of producing a component of a medical article coated as described above, comprising adding the coating material to the component material prior to molding and subsequently molding the component from the mixture, or molding the component from the component material and subsequently applying the coating material to the at least one surface of the component, and hydrophilizing the coating material prior to the molding or after the molding. Also the invention relates to a coating as defined above for articles having at least a first component and a second component.
摘要翻译： 本发明涉及一种用于容纳含有至少第一组分和第二组分的药物蛋白质制剂的医疗制品，其具有至少一个涂覆有涂层的表面以减少两种组分之间的摩擦并减少蛋白质吸附至 涂层。 涂层是一种亲水性涂层，其中通过水接触角测量的涂层表面的亲水性低于90°，第一和第二组分之间的长期静摩擦力低于14N。根据 本发明特别适用于在装有用于贮存和给药液体蛋白制剂例如胰岛素制剂的塞子的容器的三元表面中永久地涂覆。 涂层优选为含硅涂层，例如聚（二烷基硅氧烷）油或共聚物。 本发明还涉及如上所述涂敷的医疗用品的成分的制造方法，其特征在于，在成型前将所述涂料添加到所述成分材料中，从所述混合物中随后成型所述成分，或者从所述成分材料成型所述成分， 随后将涂层材料施加到部件的至少一个表面，并且在模制之前或模制之后使涂层材料亲水化。 本发明还涉及如上所述的具有至少第一组分和第二组分的制品的涂层。
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3.发明授权Medicament container of polymer of cyclic hydrocarbon for storing a liquid medicament 失效用于储存液体药物的环状烃聚合物的药物容器公开(公告)号：US06680091B2
公开(公告)日：2004-01-20
申请号：US08991519
申请日：1997-12-16
IPC分类号： B29D2200
CPC分类号： A61J1/062 , A61J1/10 , C08L23/04 , C08L23/10 , C08L23/12 , Y10T428/1352 , Y10T428/1397
摘要： A medicament container for storing a liquid medicament, such as insulin, comprises a wall with at least two opposite portions made of a polymer material having a light transmission at 400 nm of at least 25%, a glass transition temperature above 50° C., and a density of 0.95 g/cm3 or more. The polymer material comprises at least 70% by weight of a copolymer material composed of aliphatic cyclic or bicyclic hydrocarbons with 5 to 7 membered ring or rings and ethylene or propylene. The container is substantially inert to the medicament and, because it is either transparent or at least includes at least two opposed transparent portions, it is possible visually to inspect the contents of the container to make sure that the medicament has not crystalized or polymerized. The walls of the container provide a good barrier against m-cresol/phenol/benzyl alcohol preservatives and water.
摘要翻译： 用于储存诸如胰岛素的液体药物的药物容器包括具有至少两个相对部分的壁，所述至少两个相对部分由聚合物材料制成，所述聚合物材料在400nm处的透光率至少为25％，玻璃化转变温度高于50℃， 且密度为0.95g / cm 3以上。 聚合物材料包含至少70重量％的由具有5至7元环或环的脂族环或双环烃和乙烯或丙烯组成的共聚物材料。 容器对药物基本上是惰性的，并且由于其是透明的或至少包括至少两个相对的透明部分，所以可以在目视上检查容器的内容物以确保药物未结晶化或聚合。 容器壁提供了对间甲酚/苯酚/苯甲醇防腐剂和水的良好屏障。
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4.发明授权Medicament container of polymer of linear olefin for storing a liquid medicament 失效用于储存液体药物的线性烯烃聚合物的药物容器
公开(公告)号：US5945187A
公开(公告)日：1999-08-31
申请号：US991518
申请日：1997-12-16
IPC分类号： A61J1/00 , A61J1/05 , A61J1/06 , C08K3/40 , C08L23/04 , C08L23/10 , C08L23/12 , C08L45/00 , C08L23/00
CPC分类号： A61J1/062 , A61J1/10 , C08L23/04 , C08L23/10 , C08L23/12 , Y10T428/1352 , Y10T428/1397
摘要： A medicaments, container for storing a liquid medicament comprising one or more active medicaments, water and at least one preservative has a preferably cylindrical wall defining an interior space for such liquid medicament. The wall includes at least two opposed portions composed of a polymer material with a thickness of between 0.3 mm and 3 mm, a light transmission at 400 nm of 25% or more measured through the opposed container wall portions when the container is filled with water, using a standard spectrophotometer and air as reference. The polymer wall portions are of a material comprising at least 70% by weight of a linear optionally branched polyolefin material, the olefin monomer being selected from ethylene, propylene, butylene or a mixture thereof The polyolefin material has a crystallinity above 35% by weight, measured by differential scanning calorimetry, by cutting pieces from the container walls and heating them in an aluminum pan from 10.degree. C. to 270.degree. C. at the scanning rate of 10.degree. C./min, recording and integrating the melting endotherms, and using the value of 209 J/g for 100% crystalline polypropylene as a reference.
摘要翻译： 药物，用于储存包含一种或多种活性药物，水和至少一种防腐剂的液体药物的容器具有限定用于这种液体药物的内部空间的优选圆柱形壁。 所述壁包括至少两个相对部分，所述至少两个相对部分由厚度在0.3mm至3mm之间的聚合物材料组成，当容器充满水时通过相对的容器壁部分测量的400nm的透光率为25％或更高， 使用标准分光光度计和空气作为参考。 聚合物壁部分是包含至少70重量％的线性任意支化聚烯烃材料的材料，烯烃单体选自乙烯，丙烯，丁烯或其混合物。聚烯烃材料的结晶度高于35重量％ 通过差示扫描量热法测量，通过从容器壁切割并将其在10℃至270℃的铝盘中以10℃/分钟的扫描速率加热，记录并整合熔融吸热温度， 使用209J / g的值作为100％结晶聚丙烯的参考。
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公开(公告)号：US06562011B1
公开(公告)日：2003-05-13
申请号：US09348536
申请日：1999-07-07
申请人： Thomas Buch-Rasmussen , Benny Munk , Jens Ulrik Poulsen , Henrik Ljungreen , Peter Møller Jensen , Jens Møller Jensen
发明人： Thomas Buch-Rasmussen , Benny Munk , Jens Ulrik Poulsen , Henrik Ljungreen , Peter Møller Jensen , Jens Møller Jensen
IPC分类号： A61M500
CPC分类号： A61M5/24 , A61M5/31525 , A61M5/31535 , A61M5/31566 , A61M5/31578 , A61M2005/2407 , A61M2005/2488 , A61M2005/2492
摘要： The present invention relates to a medication delivery device comprising a cartridge assembly, a dosing assembly and optionally a needle assembly. The cartridge assembly comprises a cartridge having a stopper adapted to receive a plunger means. Furthermore, the cartridge assembly has one end sealed with a pierceable sealing, said end comprising coupling means for engaging a needle assembly, and another end comprising coupling means for engaging the dosing assembly. At least one of the coupling means of the cartridge assembly is unitarily moulded with the cartridge. The dosing assembly comprises a plunger means and has coupling means for engaging the cartridge assembly. The cartridge assembly and the dosing assembly are coupled together for delivering selected doses of medication. The cartridge is preferably moulded from a plastic material, such as a transparent material, and may be housed in a cartridge housing for protection of the cartridge. The coupling means may be selected from threaded locks, snap locks, hinged locks, or bajonet locks. The medication delivery device is especially suitable for delivering insulin, growth hormone or other medicines.
摘要翻译： 本发明涉及药物输送装置，其包括药筒组件，剂量组合件和任选的针组件。 盒组件包括具有适于容纳柱塞装置的止动件的盒。 此外，盒组件具有用可刺破密封件密封的一端，所述端部包括用于接合针组件的联接装置，以及包括用于接合给药组件的联接装置的另一端。 盒组件的联接装置中的至少一个与盒一体地模制。 配料组件包括柱塞装置并具有用于接合盒组件的联接装置。 药筒组件和剂量组合件联接在一起以递送选定剂量的药物。 盒优选地由诸如透明材料的塑料材料成型，并且可以容纳在盒壳体中以保护盒。 联接装置可以选自螺纹锁，卡扣锁，铰链锁或双面胶锁。 药物输送装置特别适用于输送胰岛素，生长激素或其他药物。
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6.发明申请Method of Forming a Sterilized Sensor Package and a Sterilized Sensor Package 审中-公开形成灭菌传感器封装和灭菌传感器封装的方法公开(公告)号：US20080255440A1
公开(公告)日：2008-10-16
申请号：US11660035
申请日：2005-07-13
CPC分类号： A61B5/14865 , A61B5/076 , A61B5/14532 , A61B5/6849 , A61B2560/063 , A61B2562/125 , A61B2562/242 , A61L2/087 , A61N1/05 , A61N1/08 , A61N1/375
摘要： A sensor package is provided comprising an implantable sensor having an electrode area and an electric contact area, the package comprising a shielding packaging enclosing at least the electrode area of the sensor while exposing the electric contact area. The sensor package fascilitates handling of the implantable sensor and provides for the possibility of sterilising the electric contact area leaving the electrode area protected.
摘要翻译： 提供了包括具有电极区域和电接触区域的可植入传感器的传感器封装，所述封装包括在暴露所述电接触区域的同时封闭所述传感器的电极区域的屏蔽封装。 传感器组件可以处理植入式传感器的处理，并提供对电气接触区域进行灭菌的可能性，使电极区域受到保护。
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公开(公告)号：US06755810B1
公开(公告)日：2004-06-29
申请号：US09856258
申请日：2001-09-20
IPC分类号： A61M532
CPC分类号： A61J1/2096 , A61J1/201 , A61M5/1782 , A61M5/31511
摘要： The present invention relates to a transfer device for transferring medicament from a medicament container to a syringe with a needle. The transfer device is arranged for transferring accurate dosages of insulin, growth hormone or other medicaments. The accuracy is ensured by the device comprising means for mounting a syringe to the device, the needle piercing a sealing of the device. Opposite the sealing a piston is arranged, said piston being non-releasable engaged with the piston driver during transfer of the medicament. Thereby the piston is not erroneously drawn from the piston driver, which would otherwise lead to incorrect dosing. Furthermore, the device comprises dosing means including the piston driver.
摘要翻译： 本发明涉及一种用于将药物从药物容器转移到具有针的注射器的转移装置。 转移装置被设置用于转移精确剂量的胰岛素，生长激素或其他药物。 通过装置确保精度，该装置包括用于将注射器安装到装置的装置，针刺穿装置的密封。 在密封件相对的位置布置有活塞，所述活塞在药物转移期间不可释放地与活塞驱动器接合。 因此，活塞不会从活塞驱动器错误地抽出，否则会导致不正确的配量。 此外，该装置包括包括活塞驱动器的计量装置。
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公开(公告)号：US6010485A
公开(公告)日：2000-01-04
申请号：US932354
申请日：1997-09-17
CPC分类号： A61M5/31525 , A61M5/204 , A61M5/31595 , A61M5/31555 , A61M5/31561 , A61M5/3158
摘要： The present invention relates to a drug delivery system, comprising a reservoir from which set doses are apportioned, a dose setting mechanism by which the relative position of two elements is changed by a distance proportional to a set dose, and a push button by activation of which an element is moved a distance corresponding to the distance proportional to the set dose, further comprises a working cylinder having an open end into which a plunger fits, and a closed end at which an inlet and an outlet port connect the space beneath the plunger with an inlet communicating with the reservoir and an outlet communicating with a drug delivery member, respectively. Valves means at the inlet and outlet control the passages from the reservoir to the working cylinder and from the working cylinder to the drug delivery member, respectively. The cylinder with the plunger, and the injection member are independently exchangeable, disposable parts.
摘要翻译： 本发明涉及一种药物递送系统，其包括分配设定剂量的储存器，剂量设定机构，通过该剂量设定机构将两个元件的相对位置改变与设定剂量成比例的距离，以及按钮，通过激活 元件被移动到与设定剂量成比例的距离处的距离，还包括具有开口端的柱塞配合的工作缸和入口和出口连接柱塞下方的空间的封闭端 其中入口与储存器连通并且分别与药物递送构件连通。 阀门在入口和出口处分别控制从储存器到工作缸以及从工作缸到药物传送构件的通道。 具有柱塞的气缸和注射构件可独立地更换，一次性部件。
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公开(公告)号：US08518430B2
公开(公告)日：2013-08-27
申请号：US13285470
申请日：2011-10-31
申请人： Thomas Buch-Rasmussen , James M. Flink , Jens Ulrich Poulsen , Søren Aasmul , Philip Hansen , Claus Juul Mortensen
发明人： Thomas Buch-Rasmussen , James M. Flink , Jens Ulrich Poulsen , Søren Aasmul , Philip Hansen , Claus Juul Mortensen
CPC分类号： A61K9/145 , A61K9/0024
摘要： Solid pharmaceutical compositions for parenteral injection comprising a binder and at least one therapeutic agent. The pharmaceutical composition has the strength to be injected directly with the need of using cannulas or the like.
摘要翻译： 用于肠胃外注射的固体药物组合物，其包含粘合剂和至少一种治疗剂。 药物组合物具有直接注射使用插管等的强度。
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公开(公告)号：US08084053B2
公开(公告)日：2011-12-27
申请号：US12462794
申请日：2009-08-07
申请人： Thomas Buch-Rasmussen , James M. Flink , Jens Ulrich Poulsen , Søren Aasmul , Philip Hansen , Claus Juul Mortensen
发明人： Thomas Buch-Rasmussen , James M. Flink , Jens Ulrich Poulsen , Søren Aasmul , Philip Hansen , Claus Juul Mortensen
CPC分类号： A61K9/145 , A61K9/0024
摘要： Solid pharmaceutical compositions and methods of making and administering for parenteral injection comprising a binder and at least one therapeutic agent. The pharmaceutical composition has the strength to be injected directly with the need of using cannulas or the like.
摘要翻译： 固体药物组合物和用于肠胃外注射的制备和施用的方法，包括粘合剂和至少一种治疗剂。 药物组合物具有直接注射使用插管等的强度。
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