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公开(公告)号：US06482509B2
公开(公告)日：2002-11-19
申请号：US09260757
申请日：1999-03-02
申请人： Thomas Buch-Rasmussen , Patric Jannasch , Erling Bonne Jørgensen , Ib Johannesen , Sokol Ndoni , Nils Berg Madsen
发明人： Thomas Buch-Rasmussen , Patric Jannasch , Erling Bonne Jørgensen , Ib Johannesen , Sokol Ndoni , Nils Berg Madsen
IPC分类号： B32B1706
CPC分类号： C08J7/047 , A61J1/062 , A61M5/3129 , A61M5/31513 , A61M2005/3131 , C08J2483/00 , Y10T428/265 , Y10T428/31612 , Y10T428/31663 , Y10T428/31667
摘要： The present invention relates to a coating system, in particular to a coating system for articles where plastic materials slide against flexible rubber materials. The coating system is a silicone oil based coating having a viscosity of at least 200,000 centistokes, i.e. a high viscosity coating. The coating comprises in a preferred embodiment a silicone oil based block or graft copolymer, or segmented copolymer. Further the invention relates to a process of producing a component of an article coated as described above, comprising adding the coating material to the component material prior to molding and subsequently molding the component from the mixture, or molding the component from the component material and subsequently applying the coating material to the at least one surface of the component, as well as an article coated with a silicone oil based coating as defined above. Such an article is preferably a medical article, such as a container or an injection cylinder and a stopper. The coatings according to the present invention are especially suited to use for permanently coating internal surfaces of containers equipped with stoppers for storage and administration of liquid protein preparations. The coatings providing low friction between the two components, such as a container wall and a rubber stopper, result in high-precision dosing. The described coatings are particularly useful for coating containers for storage and administration of liquid protein solutions, such as insulin formulations.
摘要翻译： 本发明涉及一种涂覆系统，特别涉及一种用于制品的涂层系统，其中塑料材料滑动抵靠柔性橡胶材料。 该涂层系统是一种硅油基涂层，其粘度至少为20万厘沲，即高粘度涂层。 该涂层在优选的实施方案中包括基于硅油的嵌段或接枝共聚物或分段的共聚物。 此外，本发明涉及一种制造如上所述涂覆的制品的组分的方法，包括在模制之前将涂料添加到组分材料中，随后从混合物中模制组分，或者将组分从组分材料中模制，随后 将涂层材料施加到部件的至少一个表面上，以及涂覆有如上所述的硅油基涂层的制品。 这样的制品优选为医疗用品，例如容器，注射筒和塞子。 根据本发明的涂层特别适用于永久地涂覆装有用于储存和施用液体蛋白制剂的塞子的容器的内表面。 在两个部件之间提供低摩擦的涂层，例如容器壁和橡胶塞，导致高精度计量。 所描述的涂层对于包衣容器特别有用，用于储存和施用液体蛋白质溶液，例如胰岛素制剂。
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2.发明授权Medical article with coated surfaces exhibiting low friction and protein adsorption 失效具有低摩擦和蛋白质吸附的涂层表面的医疗制品公开(公告)号：US06461334B1
公开(公告)日：2002-10-08
申请号：US09260758
申请日：1999-03-02
IPC分类号： A61M5315
CPC分类号： A61M5/31513 , A61J1/062 , A61M5/2448 , A61M2005/3131
摘要： The present invention relates to a medical article for containing a pharmaceutical protein preparation comprising at least a first component and a second component, having at least one surface coated with a coating to reduce the friction between the two components and to reduce the protein adsorption to the coating. The coating is a hydrophilic coating whereby the hydrophilicity of the surface of the coating as measured by the water contact angle is below 90°, and the long term static friction forces between the first and the second component are below 14 N. The coatings according to the present invention are especially suited for permanently coating in ternal surfaces of containers equipped with stoppers for storage and administration of liquid protein preparations, such as insulin preparations. The coating is preferably a silicon-containing coating, such as a poly(dialkyl siloxane) oil or copolymer. The invention further relates to a process of producing a component of a medical article coated as described above, comprising adding the coating material to the component material prior to molding and subsequently molding the component from the mixture, or molding the component from the component material and subsequently applying the coating material to the at least one surface of the component, and hydrophilizing the coating material prior to the molding or after the molding. Also the invention relates to a coating as defined above for articles having at least a first component and a second component.
摘要翻译： 本发明涉及一种用于容纳含有至少第一组分和第二组分的药物蛋白质制剂的医疗制品，其具有至少一个涂覆有涂层的表面以减少两种组分之间的摩擦并减少蛋白质吸附至 涂层。 涂层是一种亲水性涂层，其中通过水接触角测量的涂层表面的亲水性低于90°，第一和第二组分之间的长期静摩擦力低于14N。根据 本发明特别适用于在装有用于贮存和给药液体蛋白制剂例如胰岛素制剂的塞子的容器的三元表面中永久地涂覆。 涂层优选为含硅涂层，例如聚（二烷基硅氧烷）油或共聚物。 本发明还涉及如上所述涂敷的医疗用品的成分的制造方法，其特征在于，在成型前将所述涂料添加到所述成分材料中，从所述混合物中随后成型所述成分，或者从所述成分材料成型所述成分， 随后将涂层材料施加到部件的至少一个表面，并且在模制之前或模制之后使涂层材料亲水化。 本发明还涉及如上所述的具有至少第一组分和第二组分的制品的涂层。
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3.发明授权Medicament container of polymer of cyclic hydrocarbon for storing a liquid medicament 失效用于储存液体药物的环状烃聚合物的药物容器公开(公告)号：US06680091B2
公开(公告)日：2004-01-20
申请号：US08991519
申请日：1997-12-16
IPC分类号： B29D2200
CPC分类号： A61J1/062 , A61J1/10 , C08L23/04 , C08L23/10 , C08L23/12 , Y10T428/1352 , Y10T428/1397
摘要： A medicament container for storing a liquid medicament, such as insulin, comprises a wall with at least two opposite portions made of a polymer material having a light transmission at 400 nm of at least 25%, a glass transition temperature above 50° C., and a density of 0.95 g/cm3 or more. The polymer material comprises at least 70% by weight of a copolymer material composed of aliphatic cyclic or bicyclic hydrocarbons with 5 to 7 membered ring or rings and ethylene or propylene. The container is substantially inert to the medicament and, because it is either transparent or at least includes at least two opposed transparent portions, it is possible visually to inspect the contents of the container to make sure that the medicament has not crystalized or polymerized. The walls of the container provide a good barrier against m-cresol/phenol/benzyl alcohol preservatives and water.
摘要翻译： 用于储存诸如胰岛素的液体药物的药物容器包括具有至少两个相对部分的壁，所述至少两个相对部分由聚合物材料制成，所述聚合物材料在400nm处的透光率至少为25％，玻璃化转变温度高于50℃， 且密度为0.95g / cm 3以上。 聚合物材料包含至少70重量％的由具有5至7元环或环的脂族环或双环烃和乙烯或丙烯组成的共聚物材料。 容器对药物基本上是惰性的，并且由于其是透明的或至少包括至少两个相对的透明部分，所以可以在目视上检查容器的内容物以确保药物未结晶化或聚合。 容器壁提供了对间甲酚/苯酚/苯甲醇防腐剂和水的良好屏障。
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公开(公告)号：US6033377A
公开(公告)日：2000-03-07
申请号：US17963
申请日：1998-02-03
CPC分类号： B01F13/0818 , A61J1/062 , A61M5/2448 , B01F11/0082 , B01F13/002 , B01F13/0052 , B01F15/00512 , B01F2215/0034 , Y10S604/903
摘要： In an ampoule for a medicament the space accommodating the medicament is defined by an ampoule wall (1) a pierceable seal (5) closing one end of the ampoule and a piston (7) closing the other end of the ampoule. A metal containing fixation element (8) is secured to one of the parts defining the medicament accommodating space. A mixing element (9, 10) also containing a metal and having a density larger than 1,0 g/cm.sup.3 is movable in medicament accommodating space. At least one of the elements, the fixation element (8) and the mixing element (9, 10), can be attracted by a magnet, and at least one of these elements is a magnetic element, the magnetic strength being so that the mixing element (9, 10) can during normal handling of the ampoule be fixed relative to this ampoule by the magnetic attraction between the fixation element (8) and the mixing element (9, 10) but may be released from its fixed position by manual operation.
摘要翻译： 在用于药物的安瓿中，容纳药物的空间由安瓿壁（1）限定，该安瓿壁（1）封闭安瓿的一端的可刺破密封件（5）和封闭安瓿瓶另一端的活塞（7）。 含有金属的固定元件（8）固定到限定药物容纳空间的部件之一。 还含有金属并且密度大于1.0g / cm 3的混合元件（9,10）可在药物容纳空间中移动。 固定元件（8）和混合元件（9,10）中的至少一个元件可以被磁体吸引，并且这些元件中的至少一个是磁性元件，磁强度使得混合 元件（9,10）可以在通过固定元件（8）和混合元件（9,10）之间的磁吸引力相对于该安瓿来固定安瓿的正常操作期间，但是可以通过手动操作从其固定位置释放 。
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5.发明授权Medicament container of polymer of linear olefin for storing a liquid medicament 失效用于储存液体药物的线性烯烃聚合物的药物容器
公开(公告)号：US5945187A
公开(公告)日：1999-08-31
申请号：US991518
申请日：1997-12-16
IPC分类号： A61J1/00 , A61J1/05 , A61J1/06 , C08K3/40 , C08L23/04 , C08L23/10 , C08L23/12 , C08L45/00 , C08L23/00
CPC分类号： A61J1/062 , A61J1/10 , C08L23/04 , C08L23/10 , C08L23/12 , Y10T428/1352 , Y10T428/1397
摘要： A medicaments, container for storing a liquid medicament comprising one or more active medicaments, water and at least one preservative has a preferably cylindrical wall defining an interior space for such liquid medicament. The wall includes at least two opposed portions composed of a polymer material with a thickness of between 0.3 mm and 3 mm, a light transmission at 400 nm of 25% or more measured through the opposed container wall portions when the container is filled with water, using a standard spectrophotometer and air as reference. The polymer wall portions are of a material comprising at least 70% by weight of a linear optionally branched polyolefin material, the olefin monomer being selected from ethylene, propylene, butylene or a mixture thereof The polyolefin material has a crystallinity above 35% by weight, measured by differential scanning calorimetry, by cutting pieces from the container walls and heating them in an aluminum pan from 10.degree. C. to 270.degree. C. at the scanning rate of 10.degree. C./min, recording and integrating the melting endotherms, and using the value of 209 J/g for 100% crystalline polypropylene as a reference.
摘要翻译： 药物，用于储存包含一种或多种活性药物，水和至少一种防腐剂的液体药物的容器具有限定用于这种液体药物的内部空间的优选圆柱形壁。 所述壁包括至少两个相对部分，所述至少两个相对部分由厚度在0.3mm至3mm之间的聚合物材料组成，当容器充满水时通过相对的容器壁部分测量的400nm的透光率为25％或更高， 使用标准分光光度计和空气作为参考。 聚合物壁部分是包含至少70重量％的线性任意支化聚烯烃材料的材料，烯烃单体选自乙烯，丙烯，丁烯或其混合物。聚烯烃材料的结晶度高于35重量％ 通过差示扫描量热法测量，通过从容器壁切割并将其在10℃至270℃的铝盘中以10℃/分钟的扫描速率加热，记录并整合熔融吸热温度， 使用209J / g的值作为100％结晶聚丙烯的参考。
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6.发明申请Method for Recovery of Stabilized Polyhydroxyalkanoates from Biomass that has been used to Treat Organic Waste 有权从已经用于处理有机废物的生物质中回收稳定的聚羟基链烷酸酯的方法公开(公告)号：US20130203954A1
公开(公告)日：2013-08-08
申请号：US13816985
申请日：2010-08-18
申请人： Alan Gideon Werker , Peter Stig Tomas Johansson , Per Olof Gosta Magnusson , Franciscus Hubertus Jacobus Maurer , Patric Jannasch
发明人： Alan Gideon Werker , Peter Stig Tomas Johansson , Per Olof Gosta Magnusson , Franciscus Hubertus Jacobus Maurer , Patric Jannasch
IPC分类号： C08G63/89
摘要： The invention is directed to a method of increasing the chemical and/or thermal stability of PHA in biomass where the biomass is contained within mixed liquor, and wherein the mixed liquor is treated by a combination of removing water from the mixed liquor and pH adjustment of the mixed liquor or maintenance of the pH of the mixed liquor within a selected pH range, and wherein the method includes reducing the pH of the mixed liquor below 6, or maintaining the pH of the mixed liquor below 6 for a selected period of time, and wherein the pH adjustment of the mixed liquor to below 6 or the maintenance of the pH of the mixed liquor below 6 gives rise to an increase in chemical and/or thermal stability of the PHA in the biomass.
摘要翻译： 本发明涉及一种提高PHA在生物质中的化学和/或热稳定性的方法，其中生物质包含在混合液中，并且其中混合液通过从混合液中除去水和pH调节 混合液或在选定的pH范围内维持混合液的pH，并且其中所述方法包括将混合液的pH降低至6以下，或将混合液的pH保持在低于6的选定时间段内， 并且其中将混合液的pH调节至低于6或维持低于6的混合液的pH导致PHA在生物质中的化学和/或热稳定性的增加。
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7.发明授权Method for recovery of stabilized polyhydroxyalkanoates from biomass that has been used to treat organic waste 有权从已经用于处理有机废物的生物质中回收稳定的聚羟基链烷酸酯的方法公开(公告)号：US09487624B2
公开(公告)日：2016-11-08
申请号：US13816985
申请日：2010-08-18
申请人： Alan Gideon Werker , Patric Jannasch , Peter Stig Tomas Johansson , Per Olof Gosta Magnusson , Franciscus Hubertus Jacobus Maurer
发明人： Alan Gideon Werker , Patric Jannasch , Peter Stig Tomas Johansson , Per Olof Gosta Magnusson , Franciscus Hubertus Jacobus Maurer
摘要： The invention is directed to a method of increasing the chemical and/or thermal stability of PHA in biomass where the biomass is contained within mixed liquor, and wherein the mixed liquor is treated by a combination of removing water from the mixed liquor and pH adjustment of the mixed liquor or maintenance of the pH of the mixed liquor within a selected pH range, and wherein the method includes reducing the pH of the mixed liquor below 6, or maintaining the pH of the mixed liquor below 6 for a selected period of time, and wherein the pH adjustment of the mixed liquor to below 6 or the maintenance of the pH of the mixed liquor below 6 gives rise to an increase in chemical and/or thermal stability of the PHA in the biomass.
摘要翻译： 本发明涉及一种提高PHA在生物质中的化学和/或热稳定性的方法，其中生物质包含在混合液中，并且其中混合液通过从混合液中除去水和pH调节 混合液或在选定的pH范围内维持混合液的pH，并且其中所述方法包括将混合液的pH降低至6以下，或将混合液的pH保持在低于6的选定时间段内， 并且其中将混合液的pH调节至低于6或维持低于6的混合液的pH导致PHA在生物质中的化学和/或热稳定性的增加。
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公开(公告)号：US06465126B1
公开(公告)日：2002-10-15
申请号：US09593041
申请日：2000-06-13
申请人： Patric Jannasch , Anna-Karin Hjelm
发明人： Patric Jannasch , Anna-Karin Hjelm
IPC分类号： H01M462
CPC分类号： H01M10/0565 , H01M4/62 , H01M4/622 , H01M10/052 , H01M2300/0082
摘要： A binder and/or electrolyte material and method for production thereof, which material is intended to be used in the preparation of a porous electrode (5) for a cell (100), wherein the binder and/or electrolyte material (20) comprises an ion conducting polymer (10).
摘要翻译： 一种粘合剂和/或电解质材料及其制备方法，该材料旨在用于制备用于电池（100）的多孔电极（5），其中粘合剂和/或电解质材料（20）包括 离子导电聚合物（10）。
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