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    Pyrimidine-2, 4-diamine JAK2 Kinase inhibiting anti-inflammation use
    1.
    发明申请
    Pyrimidine-2, 4-diamine JAK2 Kinase inhibiting anti-inflammation use 审中-公开
    嘧啶-2,4-二胺JAK2激酶抑制抗炎使用

    公开(公告)号：US20100029675A1

    公开(公告)日：2010-02-04

    申请号：US12460820

    申请日：2009-07-23

    申请人： Soo-In Hwang

    发明人： Soo-In Hwang

    IPC分类号： A61K31/496 ,  A61P9/10 ,  A61P11/06 ,  A61P11/00 ,  A61P3/00 ,  A61P31/00 ,  A61P29/00 ,  A61P19/02 ,  A61P31/10 ,  A61P31/12 ,  A61P31/04 ,  A61P17/00 ,  A61P27/06

    CPC分类号： A61K31/506

    摘要： A method of treatment or prevention of Castleman's disease, atherosclerosis, coronary artery disease, peripheral edema, peripheral vascular disease, glaucoma, and wet or dry age-related macular degeneration (AMD), asthma; chronic bronchitis; chronic obstructive pulmonary disease; adult respiratory distress syndrome; infant respiratory distress syndrome; cough; chronic obstructive pulmonary disease in animals; adult respiratory distress syndrome; ulcerative colitis; Crohn's disease; hypersecretion of gastric acid; bacterial, fungal, or viral induced sepsis or septic shock; endotoxic shock; laminitis or colic in horses; spinal cord trauma; head injury; neurogenic inflammation; pain; reperfusion injury of the brain; psoriatic arthritis; rheumatoid arthritis; alkylosing spondylitis; osteoarthritis; inflammation; or cytokine-mediated chronic tissue degeneration comprises the step of administering a therapeutically effective amount, or a prophylactically effective amount, of a compound having the following structure (I):

    摘要翻译： 治疗或预防卡尔曼氏病，动脉粥样硬化，冠状动脉疾病，外周水肿，外周血管病，青光眼和湿性或干性年龄相关性黄斑变性（AMD），哮喘的方法; 慢性支气管炎; 慢性阻塞性肺疾病; 成人呼吸窘迫综合征 婴儿呼吸窘迫综合征; 咳嗽; 动物慢性阻塞性肺疾病; 成人呼吸窘迫综合征 溃疡性结肠炎 克罗恩病; 胃酸分泌过多; 细菌，真菌或病毒诱导的败血症或败血性休克; 内毒素休克; 扁桃体炎或马蹄绞痛; 脊髓创伤; 头部受伤; 神经源性炎症; 疼痛; 大脑再灌注损伤; 牛皮癣关节炎 类风湿关节炎; 碱性脊柱炎 骨关节炎 炎; 或细胞因子介导的慢性组织变性包括施用治疗有效量或预防有效量的具有以下结构（I）的化合物的步骤：

    Estrogen receptor beta variants and methods of detection thereof
    9.
    发明授权
    Estrogen receptor beta variants and methods of detection thereof 失效
    雌激素受体β变体及其检测方法

    公开(公告)号：US06818758B2

    公开(公告)日：2004-11-16

    申请号：US09768185

    申请日：2001-01-24

    申请人： Francis Kalush ,  Michael J Cassel ,  Stuart Soo-In Hwang ,  Emily S Winn-Deen

    发明人： Francis Kalush ,  Michael J Cassel ,  Stuart Soo-In Hwang ,  Emily S Winn-Deen

    IPC分类号： C12Q168

    CPC分类号： C12Q1/6883 ,  C07K14/70567 ,  C12Q2600/156

    摘要： The present invention is based on sequencing genomic DNA from human chromosome 6 and cDNAs to define the genomic structure of estrogen receptor beta genes and novel polymorphism in the estrogen receptor gene/protein. Such polymorphism can lead to a variety of disorders that are mediated/modulated by a variant estrogen receptor, such as a susceptibility to cancer, osteoporosis, cardiovascular disorder, etc. Based on this sequencing approach, the present invention provides genomic nucleotide sequences, cDNA sequences, amino acid sequences and sequence polymorphism in the ESR-beta genes, methods of detecting these sequences/polymorphism in a sample, methods of determining a risk of having or developing a disorder mediated by a variant estrogen receptor and methods of screening for compounds used to treat disorders mediated by a variant estrogen receptor.

    摘要翻译： 本发明基于来自人染色体6的基因组DNA和cDNAs来定义雌激素受体基因的基因组结构和雌激素受体基因/蛋白质中的新型多态性。 这种多态性可导致由变体雌激素受体介导/调节的多种疾病，例如对癌症的易感性，骨质疏松症，心血管疾病等。基于该测序方法，本发明提供基因组核苷酸序列，cDNA序列 ，ESR-β基因中的氨基酸序列和序列多态性，检测样品中的这些序列/多态性的方法，确定具有或发展由变体雌激素受体介导的病症的风险的方法以及筛选用于 治疗由变体雌激素受体介导的疾病。