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公开(公告)号：US07049424B2
公开(公告)日：2006-05-23
申请号：US08731499
申请日：1996-10-16
申请人： Joe W. Gray , Colin Collins , Soo-in Hwang , Tony Godfrey , David Kowbel , Johanna Rommens
发明人： Joe W. Gray , Colin Collins , Soo-in Hwang , Tony Godfrey , David Kowbel , Johanna Rommens
IPC分类号： C07H21/04
CPC分类号： C12Q1/6886 , C07K14/47 , C07K14/4702 , C07K14/4705 , C07K14/82 , C12N9/1205 , C12N9/90 , C12Q2600/112 , C12Q2600/118 , G01N33/57484
摘要： The present invention relates to cDNA sequences from a region of amplification on chromosome 20 associated with disease. The sequences can be used in hybridization methods for the identification of chromosomal abnormalities associated with various diseases. The sequences can also be used for treatment of diseases.
摘要翻译： 本发明涉及与染色体20相关的扩增区域的cDNA序列。 该序列可以用于鉴定与各种疾病相关的染色体异常的杂交方法中。 序列也可用于治疗疾病。
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公开(公告)号：US20060068433A1
公开(公告)日：2006-03-30
申请号：US11230412
申请日：2005-09-20
申请人： Tony Godfrey , William McMillan
发明人： Tony Godfrey , William McMillan
CPC分类号： C12Q1/6886 , C12Q1/6851 , C12Q1/686 , C12Q2600/16 , C12Q2537/143 , C12Q2527/107 , C12Q2527/113 , C12Q2545/101 , C12Q2561/101
摘要： Methods for balancing multiplexed PCR reactions are provided which exploit differences in primer and amplicon Tms. The methods may be controlled by a computer process. Also provided are articles of manufacture useful in such methods and compositions containing primers and probes useful in such methods.
摘要翻译： 提供平衡多重PCR反应的方法，其利用引物和扩增子Tms中的差异。 这些方法可以由计算机进程控制。 还提供了可用于这种方法的制品，和含有可用于这些方法的引物和探针的组合物。
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公开(公告)号：US08993251B2
公开(公告)日：2015-03-31
申请号：US13328999
申请日：2011-12-16
申请人： Joe W. Gray , Colin Conrad Collins , Soo-In Hwang , Tony Godfrey , David Kowbel , Johanna Rommens
发明人： Joe W. Gray , Colin Conrad Collins , Soo-In Hwang , Tony Godfrey , David Kowbel , Johanna Rommens
CPC分类号： C12Q1/6886 , C07K14/47 , C07K14/4705 , C07K14/82 , C12N9/1205 , C12N9/90 , C12Q2600/112 , C12Q2600/118 , G01N33/6893 , Y10S436/813
摘要： The present invention relates to cDNA sequences from a region of amplification on chromosome 20 associated with disease. The sequences can be used in hybridization methods for the identification of chromosomal abnormalities associated with various diseases. The sequences can also be used for treatment of diseases.
摘要翻译： 本发明涉及与染色体20相关的扩增区域的cDNA序列。 该序列可以用于鉴定与各种疾病相关的染色体异常的杂交方法中。 序列也可用于治疗疾病。
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公开(公告)号：US07811986B2
公开(公告)日：2010-10-12
申请号：US12177608
申请日：2008-07-22
申请人： Joe W. Gray , Colin Conrad Collins , Soo-in Hwang , Tony Godfrey , David Kowbel , Johanna Rommens
发明人： Joe W. Gray , Colin Conrad Collins , Soo-in Hwang , Tony Godfrey , David Kowbel , Johanna Rommens
IPC分类号： A61K38/00
CPC分类号： C12Q1/6886 , C07K14/47 , C07K14/4702 , C07K14/4705 , C07K14/82 , C12N9/1205 , C12N9/90 , C12Q2600/112 , C12Q2600/118 , G01N33/57484
摘要： The present invention relates to cDNA sequences from a region of amplification on chromosome 20 associated with disease. The sequences can be used in hybridization methods for the identification of chromosomal abnormalities associated with various diseases. The sequences can also be used for treatment of diseases.
摘要翻译： 本发明涉及与染色体20相关的扩增区域的cDNA序列。 该序列可以用于鉴定与各种疾病相关的染色体异常的杂交方法中。 序列也可用于治疗疾病。
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公开(公告)号：US20090081672A1
公开(公告)日：2009-03-26
申请号：US12177608
申请日：2008-07-22
申请人： Joe W. Gray , Colin Conrad Collins , Soo-in Hwang , Tony Godfrey , David Kowbel , Johanna Rommens
发明人： Joe W. Gray , Colin Conrad Collins , Soo-in Hwang , Tony Godfrey , David Kowbel , Johanna Rommens
IPC分类号： C12Q1/68 , G01N33/574 , C12N5/06
CPC分类号： C12Q1/6886 , C07K14/47 , C07K14/4702 , C07K14/4705 , C07K14/82 , C12N9/1205 , C12N9/90 , C12Q2600/112 , C12Q2600/118 , G01N33/57484
摘要： The present invention relates to cDNA sequences from a region of amplification on chromosome 20 associated with disease. The sequences can be used in hybridization methods for the identification of chromosomal abnormalities associated with various diseases. The sequences can also be used for treatment of diseases.
摘要翻译： 本发明涉及与染色体20相关的扩增区域的cDNA序列。 该序列可以用于鉴定与各种疾病相关的染色体异常的杂交方法中。 序列也可用于治疗疾病。
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公开(公告)号：US07413899B2
公开(公告)日：2008-08-19
申请号：US11349066
申请日：2006-02-06
申请人： Joe W Gray , Colin Conrad Collins , Soo-in Hwang , Tony Godfrey , David Kowbel , Johanna Rommens
发明人： Joe W Gray , Colin Conrad Collins , Soo-in Hwang , Tony Godfrey , David Kowbel , Johanna Rommens
IPC分类号： C12N5/06
CPC分类号： C12Q1/6886 , C07K14/47 , C07K14/4702 , C07K14/4705 , C07K14/82 , C12N9/1205 , C12N9/90 , C12Q2600/112 , C12Q2600/118 , G01N33/57484
摘要： The present invention relates to cDNA sequences from a region of amplification on chromosome 20 associated with disease. The sequences can be used in hybridization methods for the identification of chromosomal abnormalities associated with various diseases. The sequences can also be used for treatment of diseases.
摘要翻译： 本发明涉及与染色体20相关的扩增区域的cDNA序列。 该序列可以用于鉴定与各种疾病相关的染色体异常的杂交方法中。 序列也可用于治疗疾病。
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公开(公告)号：US20060292591A1
公开(公告)日：2006-12-28
申请号：US11349066
申请日：2006-02-06
申请人： Joe Gray , Colin Collins , Soo-in Hwang , Tony Godfrey , David Kowbel , Johanna Rommens
发明人： Joe Gray , Colin Collins , Soo-in Hwang , Tony Godfrey , David Kowbel , Johanna Rommens
CPC分类号： C12Q1/6886 , C07K14/47 , C07K14/4702 , C07K14/4705 , C07K14/82 , C12N9/1205 , C12N9/90 , C12Q2600/112 , C12Q2600/118 , G01N33/57484
摘要： The present invention relates to cDNA sequences from a region of amplification on chromosome 20 associated with disease. The sequences can be used in hybridization methods for the identification of chromosomal abnormalities associated with various diseases. The sequences can also be used for treatment of diseases.
摘要翻译： 本发明涉及与染色体20相关的扩增区域的cDNA序列。 该序列可以用于鉴定与各种疾病相关的染色体异常的杂交方法中。 序列也可用于治疗疾病。
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8.发明申请Identification of markers in esophageal cancer, colon cancer, head and neck cancer, and melanoma 有权鉴定食管癌，结肠癌，头颈癌和黑色素瘤中的标志物公开(公告)号：US20060019290A1
公开(公告)日：2006-01-26
申请号：US11178134
申请日：2005-07-08
申请人： Tony Godfrey , Liqiang Xi , Siva Raja , Steven Hughes , William Gooding
发明人： Tony Godfrey , Liqiang Xi , Siva Raja , Steven Hughes , William Gooding
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/112 , C12Q2600/158 , C12Q2600/16
摘要： Methods for identifying expression of markers indicative of the presence of esophageal, a squamous cell cancer, a squamous cell cancer of the head and neck, colon cancer and melanoma are provided. Also provided are articles of manufacture useful in such methods and compositions containing primers and probes useful in such methods.
摘要翻译： 提供了用于鉴定指示存在食管，鳞状细胞癌，头颈部鳞状细胞癌，结肠癌和黑素瘤的标志物的表达的方法。 还提供了可用于这种方法的制品，和含有可用于这些方法的引物和探针的组合物。
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9.发明申请MULTIFOCAL HEPATOCELLULAR CARCINOMA MICRORNA EXPRESSION PATTERNS AND USES THEREOF 审中-公开多发性肝细胞癌细胞表达模式及其用途公开(公告)号：US20140113978A1
公开(公告)日：2014-04-24
申请号：US14115258
申请日：2012-05-01
CPC分类号： C12Q1/6886 , C12Q2600/158 , C12Q2600/178 , G16B40/00
摘要： The present invention is directed to methods and products for defining a biomarker of disease phenotype. The present invention further relates to methods and kits for determining a subject's risk of developing recurrent hepatocellular carcinoma based on a defined microRNA biomarker that reliably distinguishes hepatocellular carcinoma disease recurrence from non-recurrence. The invention also relates to methods of treating a patient having heptocellular carcinoma based on their risk of developing hepatocellular carcinoma disease recurrence.
摘要翻译： 本发明涉及用于定义疾病表型生物标志物的方法和产品。 本发明还涉及用于确定受试者基于定义的微小RNA生物标志物发展复发性肝细胞癌的风险的方法和试剂盒，其可靠地区分肝细胞癌疾病复发与非复发。 本发明还涉及基于其发生肝细胞癌疾病复发的风险来治疗患有肝细胞癌的患者的方法。
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公开(公告)号：US08101370B2
公开(公告)日：2012-01-24
申请号：US12127774
申请日：2008-05-27
申请人： Joe W. Gray , Colin Conrad Collins , Soo-in Hwang , Tony Godfrey , David Kowbel , Johanna Rommens
发明人： Joe W. Gray , Colin Conrad Collins , Soo-in Hwang , Tony Godfrey , David Kowbel , Johanna Rommens
IPC分类号： G01N33/53
CPC分类号： C12Q1/6886 , C07K14/47 , C07K14/4705 , C07K14/82 , C12N9/1205 , C12N9/90 , C12Q2600/112 , C12Q2600/118 , G01N33/6893 , Y10S436/813
摘要： The present invention relates to cDNA sequences from a region of amplification on chromosome 20 associated with disease. The sequences can be used in hybridization methods for the identification of chromosomal abnormalities associated with various diseases. The sequences can also be used for treatment of diseases.
摘要翻译： 本发明涉及与染色体20相关的扩增区域的cDNA序列。 该序列可以用于鉴定与各种疾病相关的染色体异常的杂交方法中。 序列也可用于治疗疾病。
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