公开(公告)号：US08440506B2

公开(公告)日：2013-05-14

申请号：US13546549

申请日：2012-07-11

申请人： Brent M. Roberts ,  Mihir K. Roy ,  Sriram Sriniyasan ,  Sridhar Narasimhan

发明人： Brent M. Roberts ,  Mihir K. Roy ,  Sriram Sriniyasan ,  Sridhar Narasimhan

IPC分类号： H01L21/44 ,  H01L21/48

CPC分类号： H01L23/49833 ,  H01L23/49811 ,  H01L23/49816 ,  H01L23/49827 ,  H01L2224/16225 ,  Y10T29/49133

摘要： A microelectronic package includes first substrate (120) having first surface area (125) and second substrate (130) having second surface area (135). The first substrate includes first set of interconnects (126) having first pitch (127) at first surface (121) and second set of interconnects (128) having second pitch (129) at second surface (222). The second substrate is coupled to the first substrate using the second set of interconnects and includes third set of interconnects (236) having third pitch (237) and internal electrically conductive layers (233, 234) connected to each other with microvia (240). The first pitch is smaller than the second pitch, the second pitch is smaller than the third pitch, and the first surface area is smaller than the second surface area.

摘要翻译： 微电子封装包括具有第一表面区域（125）的第一衬底（120）和具有第二表面区域（135）的第二衬底（130）。 第一衬底包括在第一表面处具有第一间距（127）的第一组互连（126）和在第二表面（222）处具有第二间距（129）的第二组互连（128）。 第二衬底使用第二组互连件耦合到第一衬底，并且包括具有第三间距（237）的第三组互连（236）和用微孔（240）彼此连接的内部导电层（233,234）。 第一间距小于第二间距，第二间距小于第三间距，第一表面积小于第二表面积。

公开(公告)号：US20060093678A1

公开(公告)日：2006-05-04

申请号：US11305620

申请日：2005-12-16

申请人： Donald Chickering ,  Shaina Reese ,  Sridhar Narasimhan ,  Julie Straub ,  Howard Bernstein ,  David Altreuter ,  Eric Huang

发明人： Donald Chickering ,  Shaina Reese ,  Sridhar Narasimhan ,  Julie Straub ,  Howard Bernstein ,  David Altreuter ,  Eric Huang

IPC分类号： A61K9/14

CPC分类号： B01D1/18 ,  A61K9/0075 ,  A61K9/145 ,  A61K9/1647 ,  A61K9/1694 ,  B01J2/04

摘要： Methods are provided for making a dry powder blend pharmaceutical formulation comprising (i) forming microparticles which comprise a pharmaceutical agent; (ii) providing at least one excipient in the form of particles having a volume average diameter that is greater than the volume average diameter of the microparticles; (iii) blending the microparticles with the excipient to form a powder blend; and (iv) jet milling the powder blend to deagglomerate at least a portion of any of the microparticles which have agglomerated, while substantially maintaining the size and morphology of the individual microparticles. Jet milling advantageously can eliminate the need for more complicated wet deagglomeration processes, can lower residual moisture and solvent levels in the microparticles (which leads to better stability and handling properties for dry powder formulations), and can improve wettability, suspendability, and content uniformity of dry powder blend formulations.

摘要翻译： 提供用于制备干粉混合物药物制剂的方法，其包含（i）形成包含药剂的微粒; （ii）提供至少一种具有体积平均直径大于微粒的体积平均直径的颗粒形式的赋形剂; （iii）将微粒与赋形剂混合以形成粉末混合物; 和（iv）喷射研磨粉末共混物以使至少一部分具有附聚的任何微粒分解，同时基本保持各个微粒的尺寸和形态。 喷射铣削有利地可以消除对更复杂的湿解聚过程的需要，可以降低微粒中的残留水分和溶剂水平（这导致干粉配方的更好的稳定性和处理性能），并且可以改善润湿性，悬浮性和含量均匀性 干粉混合配方。

公开(公告)号：US20050209099A1

公开(公告)日：2005-09-22

申请号：US11142917

申请日：2005-06-02

申请人： Donald Chickering ,  Sridhar Narasimhan ,  David Altreuter ,  Paul Kopesky ,  Mark Keegan ,  Julie Straub ,  Howard Bernstein

发明人： Donald Chickering ,  Sridhar Narasimhan ,  David Altreuter ,  Paul Kopesky ,  Mark Keegan ,  Julie Straub ,  Howard Bernstein

IPC分类号： A61K9/16 ,  B01D1/18 ,  B01J2/04 ,  F26B3/12 ,  F26B17/10 ,  B01J23/00

CPC分类号： F26B17/102 ,  A61K9/1647 ,  A61K9/1688 ,  B01D1/18 ,  B01J2/04 ,  F26B3/12

摘要： Methods and apparatus are provided for making particles comprising: (a) spraying an emulsion, solution, or suspension, which comprises a solvent and a bulk material (e.g., a pharmaceutical agent), through an atomizer and into a primary drying chamber, having a drying gas flowing therethrough, to form droplets comprising the solvent and bulk material dispersed in the drying gas; (b) evaporating, in the primary drying chamber, at least a portion of the solvent into the drying gas to solidify the droplets and form particles dispersed in drying gas; and (c) flowing the particles and at least a portion of the drying gas through a jet mill to deagglomerate or grind the particles. By coupling spray drying with “in-line” jet milling, a single step process is created from two separate unit operations, and an additional collection step is advantageously eliminated. The one-step, in-line process has further advantages in time and cost of processing.

摘要翻译： 提供了用于制备颗粒的方法和装置，包括：（a）通过雾化器喷雾包含溶剂和散装材料（例如药剂）的乳液，溶液或悬浮液，并进入初级干燥室，其具有 干燥气体流过其中以形成包含分散在干燥气体中的溶剂和散装材料的液滴; （b）在初级干燥室中将至少一部分溶剂蒸发到干燥气体中以固化液滴并形成分散在干燥气体中的颗粒; 和（c）使颗粒和至少一部分干燥气体流过喷射磨机以使颗粒解聚或研磨。 通过将喷雾干燥与“直列式”喷射研磨相结合，由两个单独的单元操作产生单步骤，有利地消除了另外的收集步骤。 一步一步的在线过程在处理时间和成本方面具有进一步的优势。

公开(公告)号：US09478476B2

公开(公告)日：2016-10-25

申请号：US13976098

申请日：2011-12-16

申请人： Debendra Mallik ,  Sridhar Narasimhan ,  Mathew J. Manusharow ,  Thomas A. Boyd

发明人： Debendra Mallik ,  Sridhar Narasimhan ,  Mathew J. Manusharow ,  Thomas A. Boyd

IPC分类号： H01L23/48 ,  H01L23/34 ,  H01L23/36 ,  H01L21/50 ,  H01L23/367 ,  H01L23/42 ,  H01L23/498 ,  H01L25/065

CPC分类号： H01L23/34 ,  H01L21/50 ,  H01L23/36 ,  H01L23/3675 ,  H01L23/42 ,  H01L23/49833 ,  H01L25/0655 ,  H01L2224/16225 ,  H01L2224/73253 ,  H01L2924/01327 ,  H01L2924/00

摘要： A package for a microelectronic die (110) includes a first substrate (120) adjacent to a first surface (112) of the die, a second substrate (130) adjacent to the first substrate, and a heat spreader (140) adjacent to a second surface (111) of the die. The heat spreader makes contact with both the first substrate and the second substrate.

摘要翻译： 用于微电子管芯（110）的封装包括邻近管芯的第一表面（112）的第一衬底（120），与第一衬底相邻的第二衬底（130）和邻近第一衬底的散热器 模具的第二表面（111）。 散热器与第一基板和第二基板接触。

公开(公告)号：US08955091B2

公开(公告)日：2015-02-10

申请号：US13459475

申请日：2012-04-30

申请人： Kailash Kailash ,  Chakkaravarthy Periyasamy Balaiah ,  Sushil Pangeni ,  Amit Sinha ,  Samuel John Crank ,  Manoj Apte ,  Sridhar Narasimhan

发明人： Kailash Kailash ,  Chakkaravarthy Periyasamy Balaiah ,  Sushil Pangeni ,  Amit Sinha ,  Samuel John Crank ,  Manoj Apte ,  Sridhar Narasimhan

IPC分类号： G06F21/00

CPC分类号： H04L63/1425 ,  H04L41/0213 ,  H04L41/069 ,  H04L41/5096 ,  H04L43/0817 ,  H04L61/2514 ,  H04L63/1433

摘要： A system includes an enterprise network including an internal management system communicatively coupled thereon, the enterprise network includes security and the internal management system is disposed behind the security; a cloud system external to the enterprise network and communicatively coupled to the enterprise network, at least one user associated with the enterprise network is configured to communicate through the cloud system for cloud-based services, and the cloud system is configured to log data associated with the at least one user for the cloud-based services; and an external service bridge located in the enterprise network behind the security, the external service bridge is configured to securely communicate with the cloud system to receive the log data and to communicate with the internal management system to provide the log data thereto.

摘要翻译： 一种系统包括企业网络，其中包括通信耦合的内部管理系统，企业网络包括安全性，并且内部管理系统被布置在安全性后面; 企业网络外部并通信耦合到企业网络的云系统，至少一个与企业网络相关联的用户被配置为通过云系统进行通信以进行基于云的服务，并且云系统被配置为记录与 用于基于云的服务的至少一个用户; 位于企业网络背后的外部服务桥，外部服务网桥被配置为与云系统安全通信，接收日志数据，并与内部管理系统通信，提供日志数据。

公开(公告)号：US20140026179A1

公开(公告)日：2014-01-23

申请号：US13728631

申请日：2012-12-27

申请人： Srikanth Devarajan ,  Sridhar Narasimhan ,  Amit Sinha ,  Manoj Apte

发明人： Srikanth Devarajan ,  Sridhar Narasimhan ,  Amit Sinha ,  Manoj Apte

IPC分类号： H04L29/06

CPC分类号： H04L63/0227 ,  G06F21/51 ,  G06F21/56 ,  H04L63/168

摘要： A cloud-based secure Web gateway, a cloud-based secure Web method, and a network deliver a secure Web gateway (SWG) as a cloud-based service to organizations and provide dynamic user identification and policy enforcement therein. As a cloud-based service, the SWG systems and methods provide scalability and capability of accommodating multiple organizations therein with proper isolation therebetween. There are two basic requirements for the cloud-based SWG: (i) Having some means of forwarding traffic from the organization or its users to the SWG nodes, and (ii) Being able to authenticate the organization and users for policy enforcement and access logging. The SWG systems and methods dynamically associate traffic to users regardless of the source (device, location, encryption, application type, etc.), and once traffic is tagged to a user/organization, various polices can be enforced and audit logs of user access can be maintained.

摘要翻译： 基于云的安全Web网关，基于云的安全Web方法和网络向组织提供作为基于云的服务的安全Web网关（SWG），并在其中提供动态用户标识和策略实施。 作为基于云的服务，SWG系统和方法提供了可扩展性和容纳多个组织的能力，其间具有适当的隔离。 基于云的SWG有两个基本要求：（i）具有将流量从组织或其用户转发到SWG节点的方法，以及（ii）能够对组织和用户进行身份验证以进行策略执行和访问日志记录 。 无论源（设备，位置，加密，应用程序类型等），SWG系统和方法都会将流量动态地关联到用户，一旦流量被标记给用户/组织，就可以执行各种策略并审核用户访问日志 可以维护。

公开(公告)号：US20130291087A1

公开(公告)日：2013-10-31

申请号：US13459475

申请日：2012-04-30

申请人： Kailash KAILASH ,  Chakkaravarthy Periyasamy BALAIAH ,  Sushil PANGENI ,  Amit SINHA ,  Samuel John CRANK ,  Manoj APTE ,  Sridhar NARASIMHAN

发明人： Kailash KAILASH ,  Chakkaravarthy Periyasamy BALAIAH ,  Sushil PANGENI ,  Amit SINHA ,  Samuel John CRANK ,  Manoj APTE ,  Sridhar NARASIMHAN

IPC分类号： G06F21/00 ,  H04L9/00

CPC分类号： H04L63/1425 ,  H04L41/0213 ,  H04L41/069 ,  H04L41/5096 ,  H04L43/0817 ,  H04L61/2514 ,  H04L63/1433

摘要： A system includes an enterprise network including an internal management system communicatively coupled thereon, the enterprise network includes security and the internal management system is disposed behind the security; a cloud system external to the enterprise network and communicatively coupled to the enterprise network, at least one user associated with the enterprise network is configured to communicate through the cloud system for cloud-based services, and the cloud system is configured to log data associated with the at least one user for the cloud-based services; and an external service bridge located in the enterprise network behind the security, the external service bridge is configured to securely communicate with the cloud system to receive the log data and to communicate with the internal management system to provide the log data thereto.

摘要翻译： 一种系统包括企业网络，其中包括通信耦合的内部管理系统，企业网络包括安全性，并且内部管理系统被布置在安全性后面; 企业网络外部并通信耦合到企业网络的云系统，至少一个与企业网络相关联的用户被配置为通过云系统进行通信以进行基于云的服务，并且云系统被配置为记录与 用于基于云的服务的至少一个用户; 位于企业网络背后的外部服务桥，外部服务网桥被配置为与云系统安全通信，接收日志数据，并与内部管理系统通信，提供日志数据。

公开(公告)号：US20060093677A1

公开(公告)日：2006-05-04

申请号：US11305461

申请日：2005-12-16

申请人： Donald Chickering ,  Shaina Reese ,  Sridhar Narasimhan ,  Julie Straub ,  Howard Bernstein ,  David Altreuter ,  Eric Huang

发明人： Donald Chickering ,  Shaina Reese ,  Sridhar Narasimhan ,  Julie Straub ,  Howard Bernstein ,  David Altreuter ,  Eric Huang

IPC分类号： A61K9/14

CPC分类号： B01D1/18 ,  A61K9/0075 ,  A61K9/145 ,  A61K9/1647 ,  A61K9/1694 ,  B01J2/04

摘要： Methods are provided for making a dry powder blend pharmaceutical formulation comprising (i) forming microparticles which comprise a pharmaceutical agent; (ii) providing at least one excipient in the form of particles having a volume average diameter that is greater than the volume average diameter of the microparticles; (iii) blending the microparticles with the excipient to form a powder blend; and (iv) jet milling the powder blend to deagglomerate at least a portion of any of the microparticles which have agglomerated, while substantially maintaining the size and morphology of the individual microparticles. Jet milling advantageously can eliminate the need for more complicated wet deagglomeration processes, can lower residual moisture and solvent levels in the microparticles (which leads to better stability and handling properties for dry powder formulations), and can improve wettability, suspendability, and content uniformity of dry powder blend formulations.

公开(公告)号：US06921458B2

公开(公告)日：2005-07-26

申请号：US10752861

申请日：2004-01-07

申请人： Donald E. Chickering, III ,  Sridhar Narasimhan ,  David Altreuter ,  Paul Kopesky ,  Mark Keegan ,  Julie A. Straub ,  Howard Bernstein

发明人： Donald E. Chickering, III ,  Sridhar Narasimhan ,  David Altreuter ,  Paul Kopesky ,  Mark Keegan ,  Julie A. Straub ,  Howard Bernstein

IPC分类号： A61K9/16 ,  B01D1/18 ,  B01J2/04 ,  F26B3/12 ,  F26B17/10 ,  B01D1/16

CPC分类号： F26B17/102 ,  A61K9/1647 ,  A61K9/1688 ,  B01D1/18 ,  B01J2/04 ,  F26B3/12

摘要： Methods and apparatus are provided for making particles comprising: (a) spraying an emulsion, solution, or suspension, which comprises a solvent and a bulk material (e.g., a pharmaceutical agent), through an atomizer and into a primary drying chamber, having a drying gas flowing therethrough, to form droplets comprising the solvent and bulk material dispersed in the drying gas; (b) evaporating, in the primary drying chamber, at least a portion of the solvent into the drying gas to solidify the droplets and form particles dispersed in drying gas; and (c) flowing the particles and at least a portion of the drying gas through a jet mill to deagglomerate or grind the particles. By coupling spray drying with “in-line” jet milling, a single step process is created from two separate unit operations, and an additional collection step is advantageously eliminated. The one-step, in-line process has further advantages in time and cost of processing.

公开(公告)号：US20050079138A1

公开(公告)日：2005-04-14

申请号：US10955261

申请日：2004-09-30

申请人： Donald Chickering ,  Shaina Reese ,  Sridhar Narasimhan ,  Julie Straub ,  Howard Bernstein ,  David Altreuter ,  Eric Huang ,  Luis Brito ,  Rajeev Jain

发明人： Donald Chickering ,  Shaina Reese ,  Sridhar Narasimhan ,  Julie Straub ,  Howard Bernstein ,  David Altreuter ,  Eric Huang ,  Luis Brito ,  Rajeev Jain

IPC分类号： A61K9/00 ,  A61K9/14 ,  A61K9/16 ,  B01D1/18 ,  B01J2/04 ,  A61L9/04

CPC分类号： B01D1/18 ,  A61K9/0075 ,  A61K9/145 ,  A61K9/1647 ,  A61K9/1694 ,  B01J2/04

摘要： Methods are provided for making a dry powder blend pharmaceutical formulation, comprising the steps of: (a) providing microparticles which comprise a pharmaceutical agent; (b) blending the microparticles with at least one excipient in the form of particles to form a powder blend; and (c) jet milling the powder blend to form a dry powder blend pharmaceutical formulation having improved dispersibility, suspendability, or wettability as compared to the microparticles of step (a) or the powder blend of step (b). The method can further include dispersing the dry powder blend pharmaceutical formulation in a liquid pharmaceutically acceptable vehicle to make an formulation suitable for injection. Alternatively, the method can further include processing the dry powder blend pharmaceutical formulation into a solid oral dosage form. In one embodiment, the microparticles of step (a) are formed by a solvent precipitation or crystallization process.

摘要翻译： 提供用于制备干粉混合药物制剂的方法，包括以下步骤：（a）提供包含药剂的微粒; （b）将微粒与颗粒形式的至少一种赋形剂混合以形成粉末混合物; 和（c）与步骤（a）的微粒或步骤（b）的粉末混合物相比，喷粉研磨粉末混合物以形成具有改善的分散性，悬浮性或润湿性的干粉混合物药物制剂。 该方法还可以包括将干粉混合物药物制剂分散在液体药学上可接受的载体中以制备适于注射的制剂。 或者，该方法还可以包括将干粉混合药物制剂加工成固体口服剂型。 在一个实施方案中，步骤（a）的微粒通过溶剂沉淀或结晶过程形成。