公开(公告)号：US20130281814A1

公开(公告)日：2013-10-24

申请号：US13995807

申请日：2011-12-22

Applicant: Jason Tilt ,  Jeffrey S. Taggart ,  Lindsey Tufts, JR. ,  David L. Bacon ,  Paul Durant, JR. ,  Harold Wodlinger ,  Charulatha Ramanathan ,  Steven G. Arless

Inventor： Jason Tilt ,  Jeffrey S. Taggart ,  Lindsey Tufts, JR. ,  David L. Bacon ,  Paul Durant, JR. ,  Harold Wodlinger ,  Charulatha Ramanathan ,  Steven G. Arless

IPC: A61B5/00

CPC classification number: A61B5/6823 ,  A61B5/04085 ,  A61B5/6805 ,  A61B2560/0468 ,  A61B2562/0215 ,  A61B2562/046

Abstract: A sensor array system (10, 30) can include a substrate layer (12, 14) that includes a stretchable and conformable material that is configured to allow spaced apart and interconnected portions thereof to stretch and conform commensurate with movement of the substrate layer (12, 14), such as when attached to a patient's body. A plurality of electrodes (16) are disposed on a contact surface of the substrate layer (12, 14). Electrically conductive paths are also disposed on the substrate layer (14) and extending from each of the electrodes to which it is connected and terminating in an end thereof. The substrate layer may itself include more than one layer, such as including a flexible substrate layer (12) that is affixed to a stretchable material layer (14).

Abstract translation: 传感器阵列系统（10,30）可以包括基底层（12,14），其包括可拉伸和适形的材料，其被配置为允许其间隔开和互连的部分与衬底层（12）的运动相一致地伸展和相容 ，14），例如当附接到患者的身体时。 多个电极（16）设置在基底层（12,14）的接触表面上。 导电路径也设置在衬底层（14）上并且从其连接的每个电极延伸并在其末端终止。 衬底层本身可以包括多于一个层，例如包括固定到可拉伸材料层（14）上的柔性衬底层（12）。

公开(公告)号：US08478393B2

公开(公告)日：2013-07-02

申请号：US13128123

申请日：2009-11-10

Applicant: Charulatha Ramanathan ,  Harold M. Wodlinger ,  Ping Jia ,  Harris Gasparakis ,  Steven G. Arless ,  John E. Anderson ,  Soniya Bhojwani

Inventor： Charulatha Ramanathan ,  Harold M. Wodlinger ,  Ping Jia ,  Harris Gasparakis ,  Steven G. Arless ,  John E. Anderson ,  Soniya Bhojwani

IPC: A61B5/044

CPC classification number: A61B5/044 ,  A61B5/04012 ,  A61B5/726 ,  A61B5/7475 ,  G06F19/00

Abstract: A method for visualization of electrophysiology information can include storing electroanatomic data (14) in memory, the electroanatomic data representing electrical activity on a surface of an organ over a time period. An interval within the time period is selected in response to a user selection (28). Responsive to the user selection of the interval, a visual representation (26) of physiological information for the user selected interval is generated by applying at least one method to the electroanatomic data (14). The visual representation (26) is spatially represented on a graphical representation of a predetermined region of the surface of the organ.

Abstract translation: 用于可视化电生理学信息的方法可以包括将电解原始数据（14）存储在存储器中，电解原理数据表示在一段时间内在器官表面上的电活动。 响应于用户选择（28）选择该时间段内的间隔。 响应于用户对间隔的选择，通过对电解剖数据（14）应用至少一种方法来生成用户选择间隔的生理信息的视觉表示（26）。 视觉表示（26）在器官表面的预定区域的图形表示上空间地表示。

公开(公告)号：US07896870B2

公开(公告)日：2011-03-01

申请号：US11768259

申请日：2007-09-10

Applicant: Steven G. Arless ,  Fredric L. Milder ,  Marwan Abboud ,  Dan Wittenberger ,  Sean Carroll

Inventor： Steven G. Arless ,  Fredric L. Milder ,  Marwan Abboud ,  Dan Wittenberger ,  Sean Carroll

IPC: A61B18/02 ,  A61B18/12 ,  A61B18/18

CPC classification number: A61B18/02 ,  A61B18/1492 ,  A61B18/18 ,  A61B2017/00243 ,  A61B2018/0212 ,  A61B2018/0268

Abstract: A catheter includes a cryoablation tip with an ablation assembly for heating tissue. The cryoablation tip may be implemented with a cooling chamber and have an RF electrode at its distal end. The electrode may be operated to warm cryogenically-cooled tissue, or the coolant may be controlled in combination with an RF treatment regimen to enhance the lesion size, speed or placement of multi-lesion or single lesion cycles. In one embodiment a microwave energy source operates to extend beyond the thermal conduction depth, or penetrate the ice ball and be absorbed in tissue beyond an ice boundary, thus extending a dimension of treatment. Also, the cooling and application of RF energy can be controlled to position the ablation region away from the surface contacted by the electrode thereby leaving surface tissue unharmed while ablating at depth or to provide an ablation band of greater uniformity with increasing depth.

Abstract translation: 导管包括具有用于加热组织的消融组件的冷冻消融尖端。 冷冻消融尖端可以用冷却室实现，并且在其远端具有RF电极。 可以操作电极以温热低温冷却的组织，或者可以与RF治疗方案结合控制冷却剂，以增强病变大小，速度或多损伤或单个病变周期的放置。 在一个实施例中，微波能量源的作用是延伸超过热传导深度，或者穿透冰球并被吸收在超过冰界的组织中，从而延伸处理的尺寸。 此外，可以控制RF能量的冷却和施加，以使消融区域远离与电极接触的表面，从而在深度消融时使表面组织不受伤害，或者提供具有更高均匀度的消融带，并且随着深度增加。

公开(公告)号：US06772766B2

公开(公告)日：2004-08-10

申请号：US10372883

申请日：2003-02-24

Applicant: Richard Gallo ,  Daniel Nahon ,  Mathieu-Philippe Aubert ,  Philippe Marchand ,  Marwan Abboud ,  Steven G. Arless ,  Marc Dubuc ,  Sean Carroll ,  Dan Wittenberger ,  John W. Lehmann

Inventor： Richard Gallo ,  Daniel Nahon ,  Mathieu-Philippe Aubert ,  Philippe Marchand ,  Marwan Abboud ,  Steven G. Arless ,  Marc Dubuc ,  Sean Carroll ,  Dan Wittenberger ,  John W. Lehmann

IPC: A61B1900

CPC classification number: A61B18/02 ,  A61B2017/00292 ,  A61B2018/0212 ,  A61F2250/0067

Abstract: A method of promoting blood vessel growth includes the steps of providing a cryocatheter having a thermally transmission region; placing the cryocatheter proximate an area of tissue to be treated; cooling the thermally transmissive region of the cryocatheter proximate the area of tissue to a temperature sufficient to injure the area of tissue; allowing the area of tissue to warm; and removing the cryocatheter from the area of tissue. Prior, during or after the cooling step, the area of tissue can be mechanically traumatized, and drugs can be injected into the tissue.

Abstract translation: 促进血管生长的方法包括提供具有热传递区域的低温摄取机的步骤; 将低温套管放置在待处理组织的一个区域附近; 将靠近组织区域的低温热管的热传导区域冷却到足以损伤组织面积的温度; 允许组织的面积温暖​​; 并从组织区域移除低温切片机。 之前，在冷却步骤期间或之后，组织的面积可以被机械地创伤，药物可以被注射到组织中。

公开(公告)号：US06241718B1

公开(公告)日：2001-06-05

申请号：US09201068

申请日：1998-11-30

Applicant: Steven G. Arless ,  Daniel Nahon ,  Jean-Francois Tanguay

Inventor： Steven G. Arless ,  Daniel Nahon ,  Jean-Francois Tanguay

IPC: A61M3100

CPC classification number: A61B18/02 ,  A61B2017/22002 ,  A61B2017/22051 ,  A61B2018/0022 ,  A61B2018/0212 ,  A61B2018/0262

Abstract: A method for inhibiting restenosis includes applying cryogenic energy to a treatment site for a predetermined amount of time. In one embodiment, the treatment site, e.g., a region of an artery dilated by means of a balloon catheter, is cooled to a temperature of about minus fifty degrees Celsius for about two minutes. The application of cryogenic energy inhibits restenosis of the dilated region of the vessel.

Abstract translation: 抑制再狭窄的方法包括将低温能量施加到治疗部位预定的时间量。 在一个实施方案中，将治疗部位，例如通过气囊导管扩张的动脉区域冷却至约零摄氏度的温度约2分钟。 应用低温能抑制血管扩张区域的再狭窄。

公开(公告)号：US08725241B2

公开(公告)日：2014-05-13

申请号：US13128136

申请日：2009-11-09

Applicant: Charulatha Ramanathan ,  Harold M. Wodlinger ,  Ping Jia ,  Harris Gasparakis ,  John E. Anderson ,  Steven G. Arless

Inventor： Charulatha Ramanathan ,  Harold M. Wodlinger ,  Ping Jia ,  Harris Gasparakis ,  John E. Anderson ,  Steven G. Arless

IPC: A61B5/044

CPC classification number: A61B5/042 ,  A61B5/04021 ,  A61B2018/00839 ,  G06F19/00 ,  G16H40/63 ,  G16H50/50

Abstract: Systems and methods can be utilized to visualize physiological data relative to a surface region (e.g., an organ) of a patient. A computer-implemented method can include storing electroanatomic data in memory representing electrical activity for a predetermined surface region of the patient and providing an interactive graphical representation of the predetermined surface region of the patient. A user input is received to define location data corresponding to a user-selected location for at least one virtual electrode on the graphical representation of the predetermined surface region of the patient. A visual representation of physiological data for the predetermined surface region of the patient is generated based on the location data and the electroanatomic data.

Abstract translation: 系统和方法可用于相对于患者的表面区域（例如器官）可视化生理数据。 计算机实现的方法可以包括将电原子数据存储在表示患者的预定表面区域的电活动的存储器中，并提供患者的预定表面区域的交互式图形表示。 接收用户输入以在患者的预定表面区域的图形表示上定义对应于至少一个虚拟电极的用户选择位置的位置数据。 基于位置数据和电子解剖数据生成患者的预定表面区域的生理数据的视觉表示。

公开(公告)号：US08287526B2

公开(公告)日：2012-10-16

申请号：US13301978

申请日：2011-11-22

Applicant: Steven G. Arless ,  Fredric L. Milder ,  Marwan Abboud ,  Dan Wittenberger ,  Sean Carroll

Inventor： Steven G. Arless ,  Fredric L. Milder ,  Marwan Abboud ,  Dan Wittenberger ,  Sean Carroll

IPC: A61B18/02

CPC classification number: A61B18/02 ,  A61B18/1492 ,  A61B18/18 ,  A61B2017/00243 ,  A61B2018/0212 ,  A61B2018/0268

Abstract: A catheter includes a cryoablation tip with an electrically-driven ablation assembly for heating tissue. The cryoablation tip may be implemented with a cooling chamber through which a controllably injected coolant circulates to lower the tip temperature, and having an RF electrode at its distal end. The RF electrode may be operated to warm cryogenically-cooled tissue, or the coolant may be controlled to conductively cool the tissue in coordination with an RF treatment regimen.

Abstract translation: 导管包括具有用于加热组织的电驱动消融组件的冷冻消融尖端。 冷冻消融尖端可以用冷却室来实现，通过该冷却室可控制地注入的冷却剂循环以降低尖端温度，并且在其远端具有RF电极。 可以操作RF电极以温热低温冷却的组织，或者可以控制冷却剂以与RF治疗方案协调地导电地冷却组织。

公开(公告)号：US06546932B1

公开(公告)日：2003-04-15

申请号：US09543108

申请日：2000-04-05

Applicant: Daniel Nahon ,  Mathieu-Philippe Aubert ,  Philippe Marchand ,  Marwan Abboud ,  Steven G. Arless ,  Richard Gallo ,  Marc Dubuc ,  Sean Carroll ,  Dan Wittenberger ,  John W. Lehmann

Inventor： Daniel Nahon ,  Mathieu-Philippe Aubert ,  Philippe Marchand ,  Marwan Abboud ,  Steven G. Arless ,  Richard Gallo ,  Marc Dubuc ,  Sean Carroll ,  Dan Wittenberger ,  John W. Lehmann

IPC: A61B1900

CPC classification number: A61B18/02 ,  A61B2017/00292 ,  A61B2018/0212 ,  A61F2250/0067

Abstract: A method of promoting blood vessel growth includes the steps of providing a cryocatheter having a thermally transmission region; placing the cryocatheter proximate an area of tissue to be treated; cooling the thermally transmissive region of the cryocatheter proximate the area of tissue to a temperature sufficient to injure the area of tissue; allowing the area of tissue to warm; and removing the cryocatheter from the area of tissue. Prior, during or after the cooling step, the area of tissue can be mechanically traumatized, and drugs can be injected into the tissue.

Abstract translation: 促进血管生长的方法包括以下步骤：提供具有热传递区域的低温容器; 将低温套管放置在待处理组织的一个区域附近; 将靠近组织区域的低温热管的热传导区域冷却到足以损伤组织面积的温度; 允许组织的面积温暖​​; 并从组织区域移除低温切片机。 之前，在冷却步骤期间或之后，组织的面积可以被机械地创伤，药物可以被注射到组织中。

公开(公告)号：US09655561B2

公开(公告)日：2017-05-23

申请号：US13995807

申请日：2011-12-22

Applicant: Jason Tilk ,  Jeffrey S. Taggart ,  Lindsey Tufts, Jr. ,  David L. Bacon ,  Paul Durant, Jr. ,  Harold Wodlinger ,  Charulatha Ramanathan ,  Steven G. Arless

Inventor： Jason Tilk ,  Jeffrey S. Taggart ,  Lindsey Tufts, Jr. ,  David L. Bacon ,  Paul Durant, Jr. ,  Harold Wodlinger ,  Charulatha Ramanathan ,  Steven G. Arless

IPC: A61B5/04 ,  A61B5/00 ,  A61B5/0408

CPC classification number: A61B5/6823 ,  A61B5/04085 ,  A61B5/6805 ,  A61B2560/0468 ,  A61B2562/0215 ,  A61B2562/046

Abstract: A sensor array system (10, 30) can include a substrate layer (12, 14) that includes a stretchable and conformable material that is configured to allow spaced apart and interconnected portions thereof to stretch and conform commensurate with movement of the substrate layer (12, 14), such as when attached to a patient's body. A plurality of electrodes (16) are disposed on a contact surface of the substrate layer (12, 14). Electrically conductive paths are also disposed on the substrate layer (14) and extending from each of the electrodes to which it is connected and terminating in an end thereof. The substrate layer may itself include more than one layer, such as including a flexible substrate layer (12) that is affixed to a stretchable material layer (14).

公开(公告)号：US20120101398A1

公开(公告)日：2012-04-26

申请号：US13128123

申请日：2009-11-10

Applicant: Charulatha Ramanathan ,  Harold M. Wodlinger ,  Ping Jia ,  Harris Gasparakis ,  Steven G. Arless ,  John E. Anderson ,  Soniya Bhojwani

Inventor： Charulatha Ramanathan ,  Harold M. Wodlinger ,  Ping Jia ,  Harris Gasparakis ,  Steven G. Arless ,  John E. Anderson ,  Soniya Bhojwani

IPC: A61B5/044

CPC classification number: A61B5/044 ,  A61B5/04012 ,  A61B5/726 ,  A61B5/7475 ,  G06F19/00

Abstract: A method for visualization of electrophysiology information can include storing electroanatomic data (14) in memory, the electroanatomic data representing electrical activity on a surface of an organ over a time period. An interval within the time period is selected in response to a user selection (28). Responsive to the user selection of the interval, a visual representation (26) of physiological information for the user selected interval is generated by applying at least one method to the electroanatomic data (14). The visual representation (26) is spatially represented on a graphical representation of a predetermined region of the surface of the organ.

Abstract translation: 用于可视化电生理学信息的方法可以包括将电解原始数据（14）存储在存储器中，电解原理数据表示在一段时间内在器官表面上的电活动。 响应于用户选择（28）选择该时间段内的间隔。 响应于用户对间隔的选择，通过对电解剖数据（14）应用至少一种方法来生成用户选择间隔的生理信息的视觉表示（26）。 视觉表示（26）在器官表面的预定区域的图形表示上空间地表示。