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    Methods for Predicting and Preventing Metastasis in Triple Negative Breast Cancers
    1.
    发明申请
    Methods for Predicting and Preventing Metastasis in Triple Negative Breast Cancers 审中-公开
    预防和预防三重阴性乳腺癌转移的方法

    公开(公告)号：US20150377888A1

    公开(公告)日：2015-12-31

    申请号：US14764326

    申请日：2014-01-31

    申请人： INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) ,  UNIVERSITE DE RENNES I ,  ECOLES DES HAUTES ETUDES EN SANTE PUBLIQUE (EHESP) ,  CENTRE EUGENE MARQUIS ,  CHU DE RENNES ,  UNIVERSITE DES ANTILLES ET DE LA GUYANE

    发明人： Patrick Legembre ,  Marine Malleter ,  Sébastien Tauzin ,  Florence Godey ,  Jean Leveque

    IPC分类号： G01N33/574 ,  C07K16/24

    CPC分类号： G01N33/57415 ,  C07K16/241 ,  C07K2317/40 ,  C07K2319/30 ,  G01N2333/70575 ,  G01N2800/54

    摘要： In particular the present invention relates to a method for predicting the risk of relapse and distant metastasis in a patient suffering from a triple negative breast cancer comprising the step of i) determining the level of soluble CD95L in a blood sample obtained from the patient ii) comparing the level determined at step i) with a predetermined reference value and iii) concluding that the patient will exhibit an increased risk of relapse and distant metastasis when the level determined at step i) is higher than the predetermined reference value or concluding that the patient will exhibit a decreased risk of relapse and distant metastasis when the level determined at step i) is lower than the predetermined reference value. The present invention also relates to a method of preventing metastases in a subject suffering from triple negative breast cancer comprising the steps consisting of i) predicting the risk of relapse and distant metastasis by the method according to the invention and ii) administering the subject with a therapeutically effective amount of a CD95 antagonist when it is concluded at step i) that the subject will exhibit an increased risk of relapse and distant metastasis.

    摘要翻译： 特别地，本发明涉及用于预测患有三阴性乳腺癌的患者的复发和远处转移的风险的方法，包括以下步骤：i）确定从患者获得的血液样品中的可溶性CD95L水平ii） 将步骤i）中确定的水平与预定的参考值进行比较，以及iii）当步骤i）确定的水平高于预定的参考值时，推断出患者将呈现复发和远处转移的风险增加，或者得出结论：患者 当步骤i）确定的水平低于预定的参考值时，将呈现复发和远处转移的风险降低。 本发明还涉及一种预防患有三阴性乳腺癌的受试者转移的方法，其包括以下步骤：i）通过本发明的方法预测复发和远处转移的风险，以及ii） 治疗有效量的CD95拮抗剂，当在步骤i）得出结论时，受试者将表现出增加的复发和远处转移的风险。