公开(公告)号：US10034840B2

公开(公告)日：2018-07-31

申请号：US15168270

申请日：2016-05-31

Applicant: 3M INNOVATIVE PROPERTIES COMPANY

Inventor： James P. Dizio ,  Elizabeth E. Johnson ,  Zheng Z. Wu ,  Amy Preszler Prince

IPC: A61K9/70 ,  A61K31/165 ,  C09J4/06 ,  C09J133/08 ,  C09J133/10 ,  A61K31/27 ,  A61L24/06 ,  C08F220/18 ,  C08F220/56 ,  C08F218/08

CPC classification number: A61K9/7061 ,  A61K31/165 ,  A61K31/27 ,  A61L24/06 ,  C08F220/18 ,  C08F2220/1858 ,  C09J4/06 ,  C09J133/08 ,  C09J133/10 ,  C08F218/08 ,  C08F220/56

Abstract: A stable transdermal adhesive composition comprising: an adhesive comprising a washed polymerization reaction product of at least two ethylenically unsaturated monomers; and at least one pharmaceutically active compound which is susceptible to oxidative degradation; wherein the at least two ethylenically unsaturated monomers, if present in the adhesive as unreacted monomers, are present at a level of less than 200 ppm of total unreacted monomer, based upon the total weight of the adhesive, methods of making the composition, a transdermal drug delivery device using the composition, methods of making the device, and methods of delivery the pharmaceutically active compound are provided.

公开(公告)号：US10376473B2

公开(公告)日：2019-08-13

申请号：US16042361

申请日：2018-07-23

Applicant: 3M INNOVATIVE PROPERTIES COMPANY

Inventor： James P. DiZio ,  Elizabeth E. Johnson ,  Zheng Z. Wu ,  Amy Preszler Prince

IPC: A61K9/70 ,  A61K31/165 ,  C09J4/06 ,  C09J133/08 ,  C09J133/10 ,  A61K31/27 ,  A61L24/06 ,  C08F220/18

Abstract: A stable transdermal adhesive composition comprising: an adhesive comprising a washed polymerization reaction product of at least two ethylenically unsaturated monomers; and at least one pharmaceutically active compound which is susceptible to oxidative degradation; wherein the at least two ethylenically unsaturated monomers, if present in the adhesive as unreacted monomers, are present at a level of less than 200 ppm of total unreacted monomer, based upon the total weight of the adhesive, methods of making the composition, a transdermal drug delivery device using the composition, methods of making the device, and methods of delivery the pharmaceutically active compound are provided.