公开(公告)号：US10053474B2

公开(公告)日：2018-08-21

申请号：US15588037

申请日：2017-05-05

Applicant: AbbVie Inc.

Inventor： Jaclyn Chau ,  Hui-Ju J. Chen ,  David A. DeGoey ,  John Hartung ,  Nathan Ide ,  Vikram Kalthod ,  Allan C. Krueger ,  Yi-Yin Ku ,  Tongmei Li ,  John T. Randolph ,  Rolf Wagner ,  Geoff T. Halvorsen ,  Christopher C. Marvin ,  Eric Voight ,  Brian S. Brown ,  Steven R. Martinez ,  Anurupa Shrestha ,  Howard R. Heyman

IPC: A61K31/675 ,  C07F9/02 ,  C07F9/08 ,  C07F9/6512 ,  C07H19/10

CPC classification number: C07F9/08 ,  C07F9/6512 ,  C07H19/10

Abstract: The present invention features compounds effective in inhibiting active against Hepatitis C virus (“HCV”) polymerase. The invention also features processes of making such compounds, compositions comprising such compounds, and methods of using such compounds to treat HCV infection.

公开(公告)号：US20170057981A1

公开(公告)日：2017-03-02

申请号：US15254342

申请日：2016-09-01

Applicant: AbbVie Inc.

Inventor： Hui-Ju J. Chen ,  David A. DeGoey ,  John Hartung ,  Nathan Ide ,  Vikram Kalthod ,  Allan C. Krueger ,  Yi-Yin Ku ,  Tongmei Li ,  John T. Randolph ,  Rolf Wagner ,  Jaclyn Chau ,  Geoff T. Halvorsen ,  Christopher C. Marvin ,  Eric Voight

IPC: C07F9/08

CPC classification number: C07F9/08 ,  C07F9/6512 ,  C07H19/10

Abstract: The present invention features compounds effective in inhibiting active against Hepatitis C virus (“HCV”) polymerase. The invention also features processes of making such compounds, compositions comprising such compounds, and methods of using such compounds to treat HCV infection.

Abstract translation: 本发明的特征在于有效抑制丙型肝炎病毒（“HCV”）聚合酶的活性的化合物。 本发明还涉及制备这些化合物的方法，包含这些化合物的组合物，以及使用这些化合物治疗HCV感染的方法。

公开(公告)号：US20160145197A1

公开(公告)日：2016-05-26

申请号：US14951364

申请日：2015-11-24

Applicant: AbbVie Inc.

Inventor： Yi-Yin Ku ,  Steven Hannick ,  Ashok K. Gupta

IPC: C07C231/12 ,  C07C49/697 ,  B01J31/24 ,  C07C233/23 ,  C07D207/27 ,  C07C233/14 ,  C07C49/755

CPC classification number: C07C231/12 ,  B01J31/2404 ,  B01J2531/822 ,  B01J2531/842 ,  C07C49/697 ,  C07C49/755 ,  C07C231/14 ,  C07C233/06 ,  C07C233/14 ,  C07C233/23 ,  C07C233/59 ,  C07C233/60 ,  C07D207/24 ,  C07D207/27 ,  C07D207/38

Abstract: The present invention provides a process for preparing a bicyclic amine derivative of the formula (Ia) or (Ib), comprising the rhodium-catalyzed asymmetric hydrogenation of an enamine of the formula (II), in the presence of a chiral ligand, wherein the chiral ligand is a chiral phosphine ligand.

Abstract translation: 本发明提供了制备式（Ia）或（Ib）的双环胺衍生物的方法，其包括在手性配体的存在下铑催化的式（Ⅱ）烯胺的不对称氢化，其中 手性配体是手性膦配体。

公开(公告)号：US20150183783A1

公开(公告)日：2015-07-02

申请号：US14644970

申请日：2015-03-11

Applicant: AbbVie Inc.

Inventor： Vincent S. Chan ,  Alan C. Christesen ,  Timothy A. Grieme ,  Yi-Yin Ku ,  Mathew M. Mulhern ,  Yu-Ming M. Pu

IPC: C07D471/04 ,  C07C69/78

CPC classification number: C07D471/04 ,  C07C67/00 ,  C07C67/10 ,  C07C69/78 ,  C07C69/76

Abstract: Provided herein is a process for the preparation of an apoptosis-inducing agent, and chemical intermediates thereof. Also provided herein are novel chemical intermediates related to the process provided herein.

Abstract translation: 本文提供了一种制备凋亡诱导剂及其化学中间体的方法。 本文还提供了与本文提供的方法相关的新型化学中间体。

公开(公告)号：US09238652B2

公开(公告)日：2016-01-19

申请号：US14637639

申请日：2015-03-04

Applicant: AbbVie Inc.

Inventor： Jufang Barkalow ,  Jean-Christophe Califano ,  Vincent S. Chan ,  Alan C. Christesen ,  Timothy A. Grieme ,  Yi-Yin Ku ,  Mathew M. Mulhern ,  Yu-Ming M. Pu

IPC: C07D471/04

CPC classification number: C07D471/04

Abstract: Provided herein is a process for the preparation of an apoptosis-inducing agent, and chemical intermediates thereof. Also provided herein are novel chemical intermediates related to the process provided herein.

公开(公告)号：US20150252042A1

公开(公告)日：2015-09-10

申请号：US14637639

申请日：2015-03-04

Applicant: AbbVie Inc.

Inventor： Jufang Barkalow ,  Jean-Christophe Califano ,  Vincent S. Chan ,  Alan C. Christesen ,  Timothy A. Grieme ,  Yi-Yin Ku ,  Mathew M. Mulhern ,  Yu-Ming M. Pu

IPC: C07D471/04

CPC classification number: C07D471/04

Abstract: Provided herein is a process for the preparation of an apoptosis-inducing agent, and chemical intermediates thereof. Also provided herein are novel chemical intermediates related to the process provided herein.

公开(公告)号：US09006438B2

公开(公告)日：2015-04-14

申请号：US14207179

申请日：2014-03-12

Applicant: AbbVie Inc.

Inventor： Vincent S. Chan ,  Alan C. Christesen ,  Timothy A. Grieme ,  Yi-Yin Ku ,  Mathew M. Mulhern ,  Yu-Ming M. Pu

IPC: C07D471/04 ,  C07C67/10

CPC classification number: C07D471/04 ,  C07C67/00 ,  C07C67/10 ,  C07C69/78 ,  C07C69/76

Abstract: Provided herein is a process for the preparation of an apoptosis-inducing agent, and chemical intermediates thereof. Also provided herein are novel chemical intermediates related to the process provided herein.

Abstract translation: 本文提供了一种制备凋亡诱导剂及其化学中间体的方法。 本文还提供了与本文提供的方法相关的新型化学中间体。

公开(公告)号：US20180022763A1

公开(公告)日：2018-01-25

申请号：US15588037

申请日：2017-05-05

Applicant: AbbVie Inc.

Inventor： Jaclyn Chau ,  Hui-Ju J. Chen ,  David A. DeGoey ,  John Hartung ,  Nathan Ide ,  Vikram Kalthod ,  Allan C. Krueger ,  Yi-Yin Ku ,  Tongmei Li ,  John T. Randolph ,  Rolf Wagner ,  Geoff T. Halvorsen ,  Christopher C. Marvin ,  Eric Voight ,  Brian S. Brown ,  Steven R. Martinez ,  Anurupa Shrestha ,  Howard R. Heyman

IPC: C07F9/08 ,  C07F9/6512 ,  C07H19/10

CPC classification number: C07F9/08 ,  C07F9/6512 ,  C07H19/10

Abstract: The present invention features compounds effective in inhibiting active against Hepatitis C virus (“HCV”) polymerase. The invention also features processes of making such compounds, compositions comprising such compounds, and methods of using such compounds to treat HCV infection.

公开(公告)号：US09676797B2

公开(公告)日：2017-06-13

申请号：US15254342

申请日：2016-09-01

Applicant: AbbVie Inc.

Inventor： Hui-Ju J. Chen ,  David A. DeGoey ,  John Hartung ,  Nathan Ide ,  Vikram Kalthod ,  Allan C. Krueger ,  Yi-Yin Ku ,  Tongmei Li ,  John T. Randolph ,  Rolf Wagner ,  Jaclyn Chau ,  Geoff T. Halvorsen ,  Christopher C. Marvin ,  Eric Voight

IPC: A61K31/675 ,  C07F9/02 ,  C07F9/08 ,  C07F9/6512

CPC classification number: C07F9/08 ,  C07F9/6512 ,  C07H19/10

Abstract: The present invention features compounds effective in inhibiting active against Hepatitis C virus (“HCV”) polymerase. The invention also features processes of making such compounds, compositions comprising such compounds, and methods of using such compounds to treat HCV infection.

公开(公告)号：US09199992B2

公开(公告)日：2015-12-01

申请号：US14644970

申请日：2015-03-11

Applicant: AbbVie Inc.

Inventor： Vincent S. Chan ,  Alan C. Christesen ,  Timothy A. Grieme ,  Yi-Yin Ku ,  Mathew M. Mulhern ,  Yu-Ming M. Pu

IPC: C07D471/04 ,  C07C67/10 ,  C07C67/00 ,  C07C69/78

CPC classification number: C07D471/04 ,  C07C67/00 ,  C07C67/10 ,  C07C69/78 ,  C07C69/76

Abstract: Provided herein is a process for the preparation of an apoptosis-inducing agent, and chemical intermediates thereof. Also provided herein are novel chemical intermediates related to the process provided herein.