公开(公告)号：US20170340700A1

公开(公告)日：2017-11-30

申请号：US15403595

申请日：2017-01-11

Applicant: Academia Sinica

Inventor： Jyh-Yih CHEN ,  Chen-Hung TING

IPC: A61K38/17 ,  A61K45/06

CPC classification number: A61K38/1706 ,  A61K45/06

Abstract: The preset invention relates to a new approach for treating a cancer, particularly a malignant tumor, a multidrug-resistant (MDR) cancer, a recurrent cancer or a metastatic cancer, using a specific cationic antimicrobial peptide (CAP), tilapia piscidin 4 (TP4), which is derived from Nile Tilapia (Oreochromis niloticus). Also provided is a method for treating a breast cancer, particularly triple negative breast cancer (TNBC) with TP4.

公开(公告)号：US20160303190A1

公开(公告)日：2016-10-20

申请号：US15098486

申请日：2016-04-14

Applicant: Academia Sinica ,  National Taiwan Ocean University

Inventor： Jyh-Yih CHEN ,  Chang-Jer WU

IPC: A61K38/17 ,  A61K45/06

CPC classification number: A61K38/1706

Abstract: The preset invention relates to a new method or composition for treating a gastric ulcer, preventing or treating an infection of H. pylori, particularly multidrug resistant H. pylori, using an antimicrobial peptide, a functional derivate, fragment or variant thereof, wherein the antimicrobial peptide is selected from the group consisting of Epi-1, TPs and combination thereof.

Abstract translation: 本发明涉及使用抗微生物肽，功能衍生物，片段或变体治疗胃溃疡，预防或治疗幽门螺杆菌感染特别是多药耐药性幽门螺杆菌的新方法或组合物，其中抗微生物剂 肽选自Epi-1，TP及其组合。

公开(公告)号：US20160113252A1

公开(公告)日：2016-04-28

申请号：US14920497

申请日：2015-10-22

Applicant: Yu-Ho Lin ,  ACADEMIA SINICA

Inventor： Yu-Ho LIN ,  Jyh-Yih CHEN

IPC: A01K67/027 ,  C07K14/46 ,  C12N15/85

CPC classification number: A01K67/0275 ,  A01K2217/052 ,  A01K2217/206 ,  A01K2227/40 ,  A01K2267/02 ,  A01K2267/0393 ,  C07K14/461 ,  C12N15/8509 ,  C12N2830/008

Abstract: The preset invention relates to a promoter to target a fluorescent protein to the muscles of fish, such as A. nigrofasciatus, for ornamental purposes, which is a Mlc3 (myosin, light polypeptide 3, skeletal muscle) promoter. The Mlc3 promoter has the nucleotides of tilapia (Oreochromis niloticus) myosin light chain 3 (Mlc3) promoter region, which is potential to be a tilapia Mlc3 promoter to enhance protein expression in muscle of fish, particularly for the generation of ornamental fish.

Abstract translation: 本发明涉及将荧光蛋白靶向鱼（例如黑曲霉）的肌肉用于观赏目的的启动子，其为Mlc3（肌球蛋白，轻链多肽3，骨骼肌）启动子。 Mlc3启动子具有罗非鱼（Oreochromis niloticus）肌球蛋白轻链3（Mlc3）启动子区的核苷酸，其可能是罗非鱼Mlc3启动子，以增强鱼肌肉中的蛋白质表达，特别是用于产生观赏鱼。

公开(公告)号：US20160082146A1

公开(公告)日：2016-03-24

申请号：US14857189

申请日：2015-09-17

Applicant: ACADEMIA SINICA

Inventor： Jyh-Yih CHEN ,  Chang-Jer WU ,  Han-Ning HUANG

IPC: A61L26/00 ,  A61L15/32 ,  A61L15/22 ,  A61L15/46

CPC classification number: A61L26/0047 ,  A61L15/32 ,  A61L15/325 ,  A61L15/46 ,  A61L26/0033 ,  A61L26/0066 ,  A61L2300/252 ,  A61L2300/404 ,  A61L2300/412

Abstract: The preset invention relates to a new method for wound healing, particularly in burns, comprising Epinecidin-1 (Epi-1) or Pardaxin (GE33), optionally in the incorporation into collagen.

Abstract translation: 本发明涉及一种新的伤口愈合方法，特别是在包含Epinecidin-1（Epi-1）或Pardaxin（GE33））的烧伤中，任选地并入胶原蛋白。

公开(公告)号：US20160310564A1

公开(公告)日：2016-10-27

申请号：US15137281

申请日：2016-04-25

Applicant: Academia Sinica ,  National Taiwan Ocean University

Inventor： Jyh-Yih CHEN ,  Chang-Jer WU

IPC: A61K38/17

CPC classification number: A61K38/1706

Abstract: The preset invention relates to a new method for enhancing wound healing comprising administering a subject in need thereof with a therapeutically effective amount of a tilapia piscidin (TP), which is selected from the group consisting of TP1, TP2, TP3, TP4, TP5 and combination thereof. A composition or pharmaceutical composition comprising the TP are also provided.

Abstract translation: 本发明涉及一种用于增强伤口愈合的新方法，包括给予有需要的受试者治疗有效量的选自TP1，TP2，TP3，TP4，TP5和 的组合。 还提供了包含TP的组合物或药物组合物。