公开(公告)号：US20180055887A1

公开(公告)日：2018-03-01

申请号：US15684207

申请日：2017-08-23

Applicant: ACADEMIA SINICA

Inventor： Jean LU ,  Hsiao-Chun HUANG ,  Pei-Lun LAI

IPC: A61K35/28 ,  C12N5/0775

CPC classification number: A61K35/28 ,  A61K35/33 ,  A61K35/545 ,  A61K2035/124 ,  C12N5/0663 ,  C12N5/0664 ,  C12N5/0667 ,  C12N2500/38 ,  C12N2501/065 ,  C12N2501/115 ,  C12N2501/119 ,  C12N2501/15 ,  C12N2501/155 ,  C12N2501/235 ,  C12N2501/727 ,  C12N2501/999 ,  C12N2502/1358 ,  C12N2502/1382 ,  C12N2506/1307 ,  C12N2506/45

Abstract: The present invention generally relates to a method for preparing induced mesenchymal stem cells (iMSCs) and its applications. The iMSCs, like MSCs, can differentiate into multiple lineages, which may be beneficial for disease treatments. In addition, the present invention also provides a method for improving the MSC's functional characteristics such that the MSCs are more suitable for cell therapy or in vitro applications.

公开(公告)号：US20210246422A1

公开(公告)日：2021-08-12

申请号：US17251335

申请日：2019-06-14

Applicant: ACADEMIA SINICA

Inventor： Joyce Jean LU ,  Hsiao-Chun HUANG ,  Pei-Lun LAI ,  Chi-Hou NG

IPC: C12N5/079 ,  A61K35/30

Abstract: The present invention generally relates to a method for generating induced oligodendrocyte-lineage cells (induced OLGs) and treatment using such cells. The induced OLGs are useful in cell therapy, in particular for demyelinating diseases.