公开(公告)号：US11737466B2

公开(公告)日：2023-08-29

申请号：US16708653

申请日：2019-12-10

Applicant: National Taiwan University ,  ACADEMIA SINICA

Inventor： Chi-Te Liu ,  Wen-Chin Yang ,  Yen-Yu Liu ,  Chu-Ning Huang ,  Chan-Pin Lin

IPC: A01N63/22 ,  A01N65/12

CPC classification number: A01N63/22 ,  A01N65/12

Abstract: The present invention provides a method of improving the ability of plants to resistance diseases, comprising using a strain of Bacillus amyloliquefaciens and a Bidens plant extract; and the Bidens plant extract enhances the ability of the Bacillus amyloliquefaciens to inhibit the growth of the Acidovorax avenae subsp. citrulli, increases the metabolic activity of the Bacillus amyloliquefaciens, increases the amount of the biofilm formation of the Bacillus amyloliquefaciens, and maintains the alive number of the Bacillus amyloliquefaciens.

公开(公告)号：US10568897B2

公开(公告)日：2020-02-25

申请号：US15589963

申请日：2017-05-08

Applicant: ACADEMIA SINICA

Inventor： Wen-Chin Yang ,  Lee-Tian Chang

IPC: A61K36/00 ,  A61K31/7028 ,  A23K20/163 ,  A23K20/10 ,  A23K50/75 ,  A61K36/28 ,  A23K10/30 ,  A23K50/70 ,  A23K20/00 ,  A23K50/80 ,  A23K20/195

Abstract: A composition for use in prevention, inhibition and/or treatment of coccidiosis in an animal is disclosed. The composition comprises an effective amount of Bidens pilosa, an active constituent thereof, or an active compound isolated therefrom. In another aspect, a composition for use in enhancing growth in an animal is disclosed. The composition comprising an animal feed and an effective amount of Bidens pilosa, or an isolated active constituent comprising a polyacetylenic compound.

公开(公告)号：US10987369B2

公开(公告)日：2021-04-27

申请号：US15302938

申请日：2015-04-09

Applicant: ACADEMIA SINICA

Inventor： Wen-Chin Yang ,  Lee-Tian Chang

IPC: A61K31/7028 ,  A61K38/43 ,  A61K31/7105 ,  A61K31/341 ,  A61K31/216 ,  A61K31/235 ,  A61K31/58 ,  A61K31/155 ,  A61K31/4439 ,  A61K45/06 ,  C12N15/113 ,  G01N33/68

Abstract: A Pdia4 inhibitor for use in preventing, alleviating and/or treating diabetes and/or diabetes-related complications in a subject in need thereof is disclosed, wherein the Pdia4 inhibitor does not comprise cytopiloyene. A Pdia4 inhibitor and one other anti-diabetic agent for use in combination therapy in preventing, alleviating, treating diabetes and diabetes-related complications, and/or reversing diabetes in a subject in need thereof is also disclosed, wherein the Pdia4 inhibitors for use in combination therapy may comprise cytopiloyene. Also disclosed are methods for diagnosing, treating and monitoring diabetes, and methods of screening for a Pdia4 inhibitor and/or an anti-diabetic agent.

公开(公告)号：US09072312B2

公开(公告)日：2015-07-07

申请号：US14354995

申请日：2012-10-27

Applicant: ACADEMIA SINICA

Inventor： Wen-Chin Yang ,  Lee-Tian Chang

IPC: A01N65/00 ,  A23K1/17 ,  A61K36/00 ,  A61K36/28 ,  A23K1/14 ,  A23K1/16 ,  A23K1/18 ,  A61K31/7028

CPC classification number: A61K31/7028 ,  A23K10/30 ,  A23K20/00 ,  A23K20/10 ,  A23K20/163 ,  A23K20/195 ,  A23K50/70 ,  A23K50/75 ,  A23K50/80 ,  A23V2002/00 ,  A23V2200/32 ,  A61K36/00 ,  A61K36/28

Abstract: A composition for use in prevention, inhibition and/or treatment of coccidiosis in an animal is disclosed. The composition comprises an effective amount of Bidens pilosa, an active constituent thereof, or an active compound isolated therefrom. In another aspect, a composition for use in preventing and/or treating coccidiosis, and/or enhancing growth in an animal is disclosed, the composition comprising an animal feed and an effective amount of Bidens pilosa, or an isolated active constituent comprising a polyacetylenic compound.

Abstract translation: 公开了用于预防，抑制和/或治疗动物的球虫病的组合物。 该组合物包含有效量的Bidens pilosa，其活性组分或与其分离的活性化合物。 在另一方面，公开了一种用于预防和/或治疗球虫病和/或增强动物生长的组合物，所述组合物包含动物饲料和有效量的Bidens pilosa或包含聚乙炔化合物的分离的活性成分 。

公开(公告)号：US08575116B1

公开(公告)日：2013-11-05

申请号：US13964583

申请日：2013-08-12

Applicant: Academia Sinica

Inventor： Wen-Chin Yang

IPC: A61K31/7028

CPC classification number: A61K31/7004 ,  A61K39/395 ,  A61K2300/00

Abstract: Pharmaceutical compositions and methods for protecting against atrophy of pancreatic islets in a human with metabolic syndromes are disclosed. The method comprises administering to the mammal a pharmaceutical composition comprising a compound having a chemical structure of formula (I) in an effective amount and a pharmaceutically acceptable carrier: wherein R is H or COCH2COOH; m=3 or 4; n=0 or 1; o=2; and p=1 or 2.

Abstract translation: 公开了用于保护具有代谢综合征的人胰岛胰岛的萎缩的药物组合物和方法。 该方法包括向哺乳动物施用包含具有式（I）化学结构的化合物和药学上可接受的载体的药物组合物：其中R是H或COCH 2 COOH; m = 3或4; n = 0或1; o = 2; 和p = 1或2。

公开(公告)号：US12293831B2

公开(公告)日：2025-05-06

申请号：US17782595

申请日：2020-12-02

Applicant: ACADEMIA SINICA

Inventor： Wen-Chin Yang ,  Yang-Han Lee ,  Yu-Chuan Liang ,  Frederick Kin Hing Phoa ,  Lee-Tian Chang ,  Cheng-Chih Hsu ,  Jia-Kun Chen ,  Shau-Ping Lin ,  Chiao-Ling Hsiao

IPC: G16H50/80 ,  A01K1/00 ,  A01K31/18 ,  A01K31/22 ,  G16H50/20 ,  C12Q1/04

Abstract: A system for use in a poultry house includes a control server, a network gateway disposed in the poultry house and equipping with a wireless communication capability; a movable sensor module disposed in the poultry house, wherein the movable sensor module is movable within the poultry house for obtaining a plurality of environmental parameters associated with specific locations within the poultry house, and a sampling machine disposed in the poultry house for obtaining a sample of poultry waste on the ground of the poultry house. The movable sensor module transmits the environmental parameters to the network gateway, and the network gateway transmits the environmental parameters to the control server for processing the environmental parameters.

公开(公告)号：US20140308378A1

公开(公告)日：2014-10-16

申请号：US14354995

申请日：2012-10-27

Applicant: ACADEMIA SINICA

Inventor： Wen-Chin Yang ,  Lee-Tian Chang

IPC: A61K31/7028 ,  A23K1/17 ,  A61K36/28

CPC classification number: A61K31/7028 ,  A23K10/30 ,  A23K20/00 ,  A23K20/10 ,  A23K20/163 ,  A23K20/195 ,  A23K50/70 ,  A23K50/75 ,  A23K50/80 ,  A23V2002/00 ,  A23V2200/32 ,  A61K36/00 ,  A61K36/28

Abstract: A composition for use in prevention, inhibition and/or treatment of coccidiosis in an animal is disclosed. The composition comprises an effective amount of Bidens pilosa, an active constituent thereof, or an active compound isolated therefrom. In another aspect, a composition for use in preventing and/or treating coccidiosis, and/or enhancing growth in an animal is disclosed, the composition comprising an animal feed and an effective amount of Bidens pilosa, or an isolated active constituent comprising a polyacetylenic compound.

Abstract translation: 公开了用于预防，抑制和/或治疗动物的球虫病的组合物。 该组合物包含有效量的Bidens pilosa，其活性组分或与其分离的活性化合物。 在另一方面，公开了一种用于预防和/或治疗球虫病和/或增强动物生长的组合物，所述组合物包含动物饲料和有效量的Bidens pilosa或包含聚乙炔化合物的分离的活性成分 。