公开(公告)号：US20240218015A1

公开(公告)日：2024-07-04

申请号：US18598901

申请日：2024-03-07

Applicant: Ajinomoto Co., Inc.

Inventor： Yutaka MATSUDA ,  Yuichi NAKAHARA ,  Kei YAMADA ,  Keisuke KATO ,  Yuta ENDO ,  Brian Alan MENDELSOHN

IPC: C07K1/04 ,  C07K1/02

CPC classification number: C07K1/045 ,  C07K1/02

Abstract: A method for producing an intermediate antibody regioselectively modified, which comprises:



(1) mixing a solution comprising an antibody material and a solution comprising a reagent for regioselectively modifying an antibody in a micromixer to form a mixture comprising the antibody material and the reagent,
wherein the reagent comprises a compound comprising an affinity substance to an antibody and a reactive group to an antibody; and
(2) passing the mixture through a reaction channel to allow the antibody material and the reagent to react in the reaction channel to form a solution comprising an intermediate antibody regioselectively modified,
wherein the processes (1) and (2) are continuously performed in a flow microreactor,
is capable of rapidly producing a desired antibody derivative regioselectively having a functional substance or functional substances.

公开(公告)号：US20230079759A1

公开(公告)日：2023-03-16

申请号：US18056531

申请日：2022-11-17

Applicant: Ajinomoto Co., Inc.

Inventor： Takashi HASHIMOTO ,  Yuichi NAKAHARA ,  Akira IMAIZUMI ,  Ippei INOUE ,  Hiroshi UMISHIO ,  Megumi YAMADA

IPC: G01N29/44 ,  G01N29/036 ,  G01N29/02

Abstract: A compatibility prediction method includes predicting compatibility between a prediction target food and a prediction target drink using: a model for predicting the compatibility between the prediction target food and the prediction target drink, and measurements that are values related to predetermined information obtained when a measuring instrument measures aroma components of the prediction target food and the prediction target drink or calculations calculated based on the measurements.

公开(公告)号：US20210253651A1

公开(公告)日：2021-08-19

申请号：US17242379

申请日：2021-04-28

Applicant: Ajinomoto Co., Inc.

Inventor： Ippei INOUE ,  Yuichi NAKAHARA

IPC: C07K14/47 ,  A61K47/42

Abstract: An organic compound-encapsulating ferritin may be prepared by: (1) mixing an organic compound with ferritin in a buffer to obtain a mixture of the organic compound and ferritin; and (2) incubating the mixture in the buffer, wherein the buffer has a pH of 3 or more and less than 13, and the buffer has a pH of 3 or more and less than 7 when the organic compound has a pKa less than 7, and has a pH of 6 or more and less than 13 when the organic compound has a pKa of 7 or more.

公开(公告)号：US20240018272A1

公开(公告)日：2024-01-18

申请号：US18460810

申请日：2023-09-05

Applicant: AJINOMOTO CO., INC.

Inventor： Yuichi NAKAHARA ,  Yuta ENDO ,  Ippei INOUE ,  Takahiro OKASORA ,  Junko YAMAZAKI HOSHIDA ,  Sachise KARAKAWA

IPC: C07K17/04 ,  C07K14/435

CPC classification number: C07K17/04 ,  C07K14/435

Abstract: the present invention provides a method for producing a protein having a supramolecular structure in which a bioactive substance is encapsulated, comprising: (I) bringing a subunit of a protein, which forms a supramolecular structure, a bioactive substance, and a solution for forming the protein having the supramolecular structure from the subunit into contact with one another in a flow micro mixer.

公开(公告)号：US20210253629A1

公开(公告)日：2021-08-19

申请号：US17308594

申请日：2021-05-05

Applicant: AJINOMOTO CO., INC.

Inventor： Daisuke EJIMA ,  Yuichi NAKAHARA ,  Keisuke KATO ,  Masayo DATE

IPC: C07K1/113 ,  B01J19/24

Abstract: The present invention provides a method for producing a refolded protein, the method comprising a step for mixing, inside a micro mixer, a buffer and a solubilization solution for a protein that has lost higher order structure or that has become insoluble.