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    Hydroxylation of d-13-alkyl-17{60 -ethynyl-hydroxygon-4-en-3-one and derivatures thereof
    4.
    发明授权
    Hydroxylation of d-13-alkyl-17{60 -ethynyl-hydroxygon-4-en-3-one and derivatures thereof 失效
    d-13-烷基-17 {60-乙炔基 - 羟基-4-烯-3-酮及其衍生物的羟基化

    公开(公告)号：US3880895A

    公开(公告)日：1975-04-29

    申请号：US40701573

    申请日：1973-10-16

    Applicant: AMERICAN HOME PROD

    Inventor： GREENSPAN GEORGE ,  REES RICHARD W

    IPC: C07J1/00 ,  C12P33/00 ,  C07C169/20

    CPC classification number: C07J1/0096 ,  C12P33/00 ,  Y10S435/911

    Abstract: Incubation of d-13-methyl or ethyl-17 Alpha -ethynyl-17hydroxygon-4-en-3-ones with the fungus Botryodiplodia malorum produces the corresponding 1 Beta -hydroxy derivatives which have anti-estrogenic activity. The 13-methyl- Beta -hydroxy product is formed in admixture with the corresponding 11 Beta -hydroxy compound.

    Abstract translation: d-13-甲基或乙基-17α-乙炔基-17-羟基-4-烯-3-酮与真菌Botryodiplodia malorum的孵育产生相应的具有抗雌激素活性的1β-羟基衍生物。 13-甲基-β-羟基产物与相应的11β-羟基化合物混合形成。

    Microbiological reduction of 7-(2(3-hydroxy-1-octenyl)-5-oxo-3-cyclopentel-1-yl)-5-heptenoic acid and related compounds
    6.
    发明授权
    Microbiological reduction of 7-(2(3-hydroxy-1-octenyl)-5-oxo-3-cyclopentel-1-yl)-5-heptenoic acid and related compounds 失效
    7-（2（3-羟基-1-辛烯基）-5-氧代-3-环戊烯-1-基）-5-庚烯酸及相关化合物的微生物还原

    公开(公告)号：US3928134A

    公开(公告)日：1975-12-23

    申请号：US51712674

    申请日：1974-10-23

    Applicant: AMERICAN HOME PROD

    Inventor： GREENSPAN GEORGE ,  LEEMING MICHAEL R G

    IPC: C07C405/00 ,  C12P31/00 ,  C12D1/02

    CPC classification number: C12P31/00 ,  C07C405/00 ,  Y10S435/911

    Abstract: Reduction of 7-(2-((3R)-3-hydroxy-1-octenyl)-5-oxo-3cyclopenten-1-yl)-5-heptenoic acid, and its methyl ester, acetate by fungi of the genera Corynespora is disclosed. The product 7(2-((3R)-3-hydroxy-1-octenyl)-5-oxo-cyclopentyl)-5-heptenoic acid(11-deoxy-15-epi-PGE2), which is novel, is useful as an intermediate for the synthesis of other physiologically active prostaglandins.

    Abstract translation: 由属的真菌还原7-（2 - [（3R）-3-羟基-1-辛烯基] -5-氧代-3-环戊烯-1-基）-5-庚烯酸及其甲酯，乙酸酯 披露了蜡碱菌属。 新颖的7-（2 - [（3R）-3-羟基-1-辛烯基] -5-氧代 - 环戊基）-5-庚烯酸（11-脱氧-15-表 - PGE2）是有用的 作为合成其他生理活性前列腺素的中间体。

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