公开(公告)号：US20210093792A1

公开(公告)日：2021-04-01

申请号：US17035851

申请日：2020-09-29

Applicant: AMGEN INC.

Inventor： Emil Finkelstein ,  Soren Forbech Skall ,  Lars Eilertsen ,  Rasmus Ohlenschlæger ,  Joshua J. Dudman ,  Anders Grove Sund ,  Steve Sanchez

IPC: A61M5/315

Abstract: A drug delivery device and method of using the same may include a housing having an opening and a drug storage container including a delivery member with an insertion end configured to extend at least partially through the opening. The drug storage container may be coupled with the housing such as to substantially prevent relative movement therebetween. A guard may be positioned adjacent to the opening and operably coupled with the plunger biasing member such that a relative movement between the guard and the housing permits release of a plunger biasing member to urge a plunger in to expel a drug from the drug storage container. A lock component may be configured to resist the relative movement between the guard and the housing until the lock component is released by a user force, whereafter the user force drives the housing and the drug storage container toward an injection site.

公开(公告)号：US20220281146A1

公开(公告)日：2022-09-08

申请号：US17687725

申请日：2022-03-07

Applicant: AMGEN INC.

Inventor： Emil Finkelstein ,  Jan Jensen

IPC: B29C45/14 ,  A61M5/315

Abstract: A method of manufacturing a plunger of a drug delivery device includes forming a plunger body. The method includes loading the plunger body into a cavity of a first molding tool of a molding system. The cavity is at least partially defined by a first molding portion and a second molding portion. The method includes coupling a second molding tool to the first molding tool to form a plurality of channels defined by grooves in the first and second molding tools, and injecting molten plastic into the plurality of channels to form an overmolded plunger body. The overmolded plunger body includes a head coupled to the first end of the plunger body and a foot coupled to the second end of the plunger body. The foot is at least partially coupled to the inner wall and the head is coupled to the outer wall of the plunger body.

公开(公告)号：US20210121633A1

公开(公告)日：2021-04-29

申请号：US17035927

申请日：2020-09-29

Applicant: AMGEN INC.

Inventor： Emil Finkelstein ,  Lars Eilertsen ,  Michael Sorensen ,  Tobias Maduro Norbo

IPC: A61M5/24 ,  A61M5/315

Abstract: A drug delivery device may include a housing having an opening and a drug storage container having a body portion with a proximal end and a distal end and a delivery member extending from the distal end of the body portion. The device may also include a plunger moveable toward the distal end of the drug storage container to expel a drug from the drug storage container through the delivery member and a plunger biasing member configured to urge the plunger toward the distal end of the drug storage container. The device may further include a container holder configured to support the drug storage container with respect to the housing such that a resultant force acting on the drug storage container from the plunger biasing member is at least substantially completely borne by the distal end of the body portion of the drug storage container.

公开(公告)号：US20210093797A1

公开(公告)日：2021-04-01

申请号：US17036690

申请日：2020-09-29

Applicant: AMGEN INC.

Inventor： Emil Finkelstein ,  Soren Forbech Skall ,  Lars Eilertsen ,  Rasmus Øhlenschlæger

IPC: A61M5/315 ,  A61M5/20

Abstract: A drug delivery device may include a housing having an opening and a drug storage container including a delivery member with an insertion end configured to extend at least partially through the opening. A biasing member may initially be retained in an energized state, and may be released to drive a plunger to expel a drug from the drug storage container. The plunger may be configured to selectively rotate from an initial rotational position to a second rotational position under a biasing force exerted by the biasing member, and translate linearly in a distal direction to drive the stopper through the drug storage container after rotating from the initial rotational position to the second rotational position. A releaser member may have an initial position wherein the releaser member retains the biasing member in the energized state, and a second position wherein the releaser member generates an audible end-of-dose signal.

公开(公告)号：US20210093796A1

公开(公告)日：2021-04-01

申请号：US17036217

申请日：2020-09-29

Applicant: AMGEN INC.

Inventor： Emil Finkelstein ,  Lars Eilertsen ,  Michael Sorensen ,  Tobias Maduro Norbo

IPC: A61M5/315 ,  A61M5/20

Abstract: A drug delivery device may include a housing having an opening and a drug storage container including a delivery member having an insertion end configured to extend at least partially through the opening during a delivery state. The device may also include a guard moveably positioned adjacent to the opening and a plunger having a generally cylindrical body portion extending along a longitudinal axis of the container and at least one flange extending radially outwardly from the body portion, wherein the plunger is moveable toward the distal end of the container to expel a drug through the delivery member. The device may further include a plunger biasing member configured to urge the plunger toward the distal end of the container and a releaser member defining a guide configured to receive the at least one flange and an indicator configured to generate an audible signal indicating an end of drug delivery.

公开(公告)号：US20250099682A1

公开(公告)日：2025-03-27

申请号：US18975470

申请日：2024-12-10

Applicant: AMGEN INC.

Inventor： Emil Finkelstein ,  Lars Eilertsen ,  Michael Sorensen ,  Tobias Maduro Norbo

IPC: A61M5/24 ,  A61M5/315

Abstract: A drug delivery device may include a housing having an opening and a drug storage container having a body portion with a proximal end and a distal end and a delivery member extending from the distal end of the body portion. The device may also include a plunger moveable toward the distal end of the drug storage container to expel a drug from the drug storage container through the delivery member and a plunger biasing member configured to urge the plunger toward the distal end of the drug storage container. The device may further include a container holder configured to support the drug storage container with respect to the housing such that a resultant force acting on the drug storage container from the plunger biasing member is at least substantially completely borne by the distal end of the body portion of the drug storage container.

公开(公告)号：US20250026055A1

公开(公告)日：2025-01-23

申请号：US18903590

申请日：2024-10-01

Applicant: AMGEN INC.

Inventor： Emil Finkelstein ,  Jan Jensen

IPC: B29C45/14 ,  A61M5/315 ,  B29K705/00 ,  B29L31/00

Abstract: A method of manufacturing a plunger of a drug delivery device includes forming a plunger body. The method includes loading the plunger body into a cavity of a first molding tool of a molding system. The cavity is at least partially defined by a first molding portion and a second molding portion. The method includes coupling a second molding tool to the first molding tool to form a plurality of channels defined by grooves in the first and second molding tools, and injecting molten plastic into the plurality of channels to form an overmolded plunger body. The overmolded plunger body includes a head coupled to the first end of the plunger body and a foot coupled to the second end of the plunger body. The foot is at least partially coupled to the inner wall and the head is coupled to the outer wall of the plunger body.

公开(公告)号：US12128593B2

公开(公告)日：2024-10-29

申请号：US17687725

申请日：2022-03-07

Applicant: AMGEN INC.

Inventor： Emil Finkelstein ,  Jan Jensen

IPC: B29C45/14 ,  A61M5/315 ,  B29K705/00 ,  B29L31/00

CPC classification number: B29C45/14598 ,  A61M5/31511 ,  B29C45/14065 ,  B29C45/14221 ,  A61M2207/00 ,  B29C2045/14155 ,  B29K2705/00 ,  B29L2031/7544

Abstract: A method of manufacturing a plunger of a drug delivery device includes forming a plunger body. The method includes loading the plunger body into a cavity of a first molding tool of a molding system. The cavity is at least partially defined by a first molding portion and a second molding portion. The method includes coupling a second molding tool to the first molding tool to form a plurality of channels defined by grooves in the first and second molding tools, and injecting molten plastic into the plurality of channels to form an overmolded plunger body. The overmolded plunger body includes a head coupled to the first end of the plunger body and a foot coupled to the second end of the plunger body. The foot is at least partially coupled to the inner wall and the head is coupled to the outer wall of the plunger body.

公开(公告)号：US12208245B2

公开(公告)日：2025-01-28

申请号：US17035927

申请日：2020-09-29

Applicant: AMGEN INC.

Inventor： Emil Finkelstein ,  Lars Eilertsen ,  Michael Sorensen ,  Tobias Maduro Norbo

IPC: A61M5/24 ,  A61M5/315

Abstract: A drug delivery device may include a housing having an opening and a drug storage container having a body portion with a proximal end and a distal end and a delivery member extending from the distal end of the body portion. The device may also include a plunger moveable toward the distal end of the drug storage container to expel a drug from the drug storage container through the delivery member and a plunger biasing member configured to urge the plunger toward the distal end of the drug storage container. The device may further include a container holder configured to support the drug storage container with respect to the housing such that a resultant force acting on the drug storage container from the plunger biasing member is at least substantially completely borne by the distal end of the body portion of the drug storage container.

公开(公告)号：US11878149B2

公开(公告)日：2024-01-23

申请号：US17036129

申请日：2020-09-29

Applicant: AMGEN INC.

Inventor： Emil Finkelstein ,  Soren Forbech Skall ,  Lars Eilertsen ,  Matias Melander ,  Jan Jensen

IPC: A61M5/315 ,  A61M5/20 ,  A61M5/31 ,  A61M5/32

CPC classification number: A61M5/31536 ,  A61M5/20 ,  A61M5/3137 ,  A61M5/3157 ,  A61M5/3204 ,  A61M2205/581 ,  A61M2205/582

Abstract: A drug delivery device may include a housing defining a longitudinal axis and having an opening and a drug storage container including a delivery member having an insertion end configured to extend at least partially through the opening during a delivery state. The device may also include plunger moveable toward the distal end of the drug storage container to expel a drug from the drug storage container through the delivery member, the plunger including a body portion having an inner wall defining an axial chamber and an outer wall cooperating with the inner wall to define a body thickness. The device may further include a plunger biasing member disposed at least partially within the axial chamber, the plunger biasing member configured to urge the plunger toward the distal end of the drug storage container.