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公开(公告)号：US20230295267A1
公开(公告)日：2023-09-21
申请号：US18206963
申请日：2023-06-07
Applicant: AMGEN INC.
Inventor： Jeonghoon SUN , Lei-Ting Tony TAM , Mark Leo MICHAELS , Thomas Charles BOONE , Rohini R. DESHPANDE , Yue-Sheng LI , Huiquan HAN
IPC: C07K14/71 , C07K14/495
CPC classification number: C07K14/71 , C07K14/495 , A61K38/00
Abstract: The present invention provides stabilized activin IIB receptor polypeptides and proteins capable of binding and inhibiting the activities of activin A, myostatin, or GDF-11. The present invention also provides polynucleotides, vectors and host cells capable of producing the stabilized polypeptides and proteins. Compositions and methods for treating muscle-wasting diseases and metabolic disorders are also provided.
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Patent Agency Ranking
公开(公告)号：US20180105589A1
公开(公告)日：2018-04-19
申请号：US15696138
申请日：2017-09-05
Applicant: AMGEN INC.
Inventor： Thomas M. DILLON , Pavel BONDARENKO , Jette WYPYCH , Martin J. ALLEN , Alain BALLAND , Margaret Speed RICCI , Amy GUO , Wenyan SHEN , Jeonghoon SUN , Christopher J. VEZINA
CPC classification number: C07K16/245 , C07K16/00 , C07K16/2863 , C07K16/2866 , C07K16/2875 , C07K2317/53 , C07K2317/56
Abstract: The present invention is generally directed to methods of producing an increase in the enrichment and/or recovery of preferred forms of monoclonal antibodies. More particularly, the invention relates to methods for eliminating disulfide heterogeneity in the hinge region of recombinant IgG2 antibody proteins.
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3.发明申请VARIANTS OF TISSUE INHIBITOR OF METALLOPROTEINASE TYPE THREE (TIMP-3), COMPOSITIONS AND METHODS 审中-公开金属蛋白酶三类（TIMP-3）组织抑制剂的变体，组成和方法公开(公告)号：US20140274874A1
公开(公告)日：2014-09-18
申请号：US14207178
申请日：2014-03-12
Applicant: AMGEN INC.
Inventor： Randal R. KETCHEM , Jason Charles O'NEILL , Jeonghoon SUN
IPC: C07K14/47
CPC classification number: C07K14/8146 , A61K38/00
Abstract: There are disclosed TIMP-3 muteins, variants and derivatives, nucleic acids encoding them, and methods of making and using them.
Abstract translation: 公开了TIMP-3突变蛋白，变体和衍生物，编码它们的核酸，以及制备和使用它们的方法。
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4.发明公开公开(公告)号：US20240010708A1
公开(公告)日：2024-01-11
申请号：US18238696
申请日：2023-08-28
Applicant: AMGEN INC.
Inventor： Jeonghoon SUN , Jason Charles O'NEILL , Randal R. KETCHEM , Randy Ira HECHT , Edward J. BELOUSKI , Mark Leo MICHAELS
IPC: C07K14/81
CPC classification number: C07K14/8146 , A61K38/00
Abstract: There are disclosed TIMP-3 muteins, variants and derivatives, nucleic acids encoding them, and methods of making and using them.
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公开(公告)号：US20200283504A9
公开(公告)日：2020-09-10
申请号：US16388561
申请日：2019-04-18
Applicant: AMGEN INC.
Inventor： Jeonghoon SUN , Lei-Ting Tony TAM , Mark Leo MICHAELS , Thomas Charles BOONE , Rohini DESHPANDE , Yue-Sheng LI , Huiquan HAN
IPC: C07K14/71 , C07K14/495
Abstract: The present invention provides stabilized activin IIB receptor polypeptides and proteins capable of binding and inhibiting the activities of activin A, myostatin, or GDF-11. The present invention also provides polynucleotides, vectors and host cells capable of producing the stabilized polypeptides and proteins. Compositions and methods for treating muscle-wasting diseases and metabolic disorders are also provided.
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公开(公告)号：US20190389932A1
公开(公告)日：2019-12-26
申请号：US16388561
申请日：2019-04-18
Applicant: AMGEN INC.
Inventor： Jeonghoon SUN , Lei-Ting Tony TAM , Mark Leo MICHAELS , Thomas Charles BOONE , Rohini DESHPANDE , Yue-Sheng LI , Huiquan HAN
IPC: C07K14/71 , C07K14/495
Abstract: The present invention provides stabilized activin IIB receptor polypeptides and proteins capable of binding and inhibiting the activities of activin A, myostatin, or GDF-11. The present invention also provides polynucleotides, vectors and host cells capable of producing the stabilized polypeptides and proteins. Compositions and methods for treating muscle-wasting diseases and metabolic disorders are also provided.
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