公开(公告)号：US20190048313A1

公开(公告)日：2019-02-14

申请号：US16069774

申请日：2017-01-17

Applicant: AMORPHICAL LTD.

Inventor： Yosef Ben ,  Abraham Shahar ,  Amir Arav

IPC: C12N5/00

Abstract: Stabilized amorphous calcium carbonate (ACC) as a supplement of cell culture media and the cell culture medium supplements comprising stabilized ACC are provided. In particular the stabilized ACC is useful for enhancing the growth of cell and tissue cultures, gametes and embryos in vitro.

公开(公告)号：US12060573B2

公开(公告)日：2024-08-13

申请号：US16069774

申请日：2017-01-17

Applicant: AMORPHICAL LTD.

Inventor： Yosef Ben ,  Abraham Shahar ,  Amir Arav

IPC: C12N5/00 ,  C12N5/073 ,  C12N5/075 ,  C12N5/076 ,  C12N5/077 ,  C12N5/0775 ,  C12N5/0793

CPC classification number: C12N5/0018 ,  C12N5/0604 ,  C12N5/0609 ,  C12N5/061 ,  C12N5/0619 ,  C12N5/0658 ,  C12N5/0663 ,  C12N2500/14

Abstract: Stabilized amorphous calcium carbonate (ACC) as a supplement of cell culture media and the cell culture medium supplements comprising stabilized ACC are provided. In particular the stabilized ACC is useful for enhancing the growth of cell and tissue cultures, gametes and embryos in vitro.

公开(公告)号：US10758566B2

公开(公告)日：2020-09-01

申请号：US16069762

申请日：2017-01-17

Applicant: AMORPHICAL LTD.

Inventor： Yosef Ben ,  Abraham Shahar ,  Amir Arav

IPC: A61K33/10 ,  A61K9/00 ,  A61K9/06 ,  A61K9/10 ,  A61P21/00 ,  A61P15/08 ,  A61K47/02 ,  A61K47/12 ,  A61K47/24 ,  A61K47/26 ,  C12N5/073 ,  C12N5/076 ,  C12N5/071

Abstract: Stabilized amorphous calcium carbonate (ACC) for treatment of several neurological, muscular and infertility diseases and conditions is provided. In particular, the stabilized ACC may be used in the treatment of axonal defects and muscular dystrophy. In addition, provided are improved methods used in assistant reproductive technology. Examples of such methods are in vitro fertilization and improvement of sperm quality. The improved IVF method, for example, comprises addition of the stabilized ACC to the cell culture medium in which the stages of fertilization and embryo development occurs.

公开(公告)号：US11207347B2

公开(公告)日：2021-12-28

申请号：US16934689

申请日：2020-07-21

Applicant: AMORPHICAL LTD.

Inventor： Yosef Ben ,  Abraham Shahar ,  Amir Arav

IPC: A61K33/10 ,  A61K9/00 ,  A61K9/06 ,  A61K9/10 ,  A61P21/00 ,  A61P15/08 ,  A61K47/02 ,  A61K47/12 ,  A61K47/24 ,  A61K47/26 ,  C12N5/073 ,  C12N5/076 ,  C12N5/071

Abstract: Stabilized amorphous calcium carbonate (ACC) for treatment of several neurological, muscular and infertility diseases and conditions is provided. In particular, the stabilized ACC may be used in the treatment of axonal defects and muscular dystrophy. In addition, provided are improved methods used in assistant reproductive technology. Examples of such methods are in vitro fertilization and improvement of sperm quality. The improved IVF method, for example, comprises addition of the stabilized ACC to the cell culture medium in which the stages of fertilization and embryo development occurs.

公开(公告)号：US20200345764A1

公开(公告)日：2020-11-05

申请号：US16934689

申请日：2020-07-21

Applicant: AMORPHICAL LTD.

Inventor： Yosef Ben ,  Abraham Shahar ,  Amir Arav

IPC: A61K33/10 ,  A61K9/00 ,  A61K9/06 ,  A61K9/10 ,  A61P21/00 ,  A61P15/08 ,  A61K47/02 ,  A61K47/12 ,  A61K47/24 ,  A61K47/26 ,  C12N5/073 ,  C12N5/076 ,  C12N5/071

Abstract: Stabilized amorphous calcium carbonate (ACC) for treatment of several neurological, muscular and infertility diseases and conditions is provided. In particular, the stabilized ACC may be used in the treatment of axonal defects and muscular dystrophy. In addition, provided are improved methods used in assistant reproductive technology. Examples of such methods are in vitro fertilization and improvement of sperm quality. The improved IVF method, for example, comprises addition of the stabilized ACC to the cell culture medium in which the stages of fertilization and embryo development occurs.

公开(公告)号：US20220152094A1

公开(公告)日：2022-05-19

申请号：US17456693

申请日：2021-11-29

Applicant: AMORPHICAL LTD.

Inventor： Yosef Ben ,  Abraham Shahar ,  Amir Arav

IPC: A61K33/10 ,  A61K9/00 ,  A61K9/06 ,  A61K9/10 ,  A61P21/00 ,  A61P15/08 ,  A61K47/02 ,  A61K47/12 ,  A61K47/24 ,  A61K47/26 ,  C12N5/073 ,  C12N5/076 ,  C12N5/071

Abstract: Stabilized amorphous calcium carbonate (ACC) for treatment of several neurological, muscular and infertility diseases and conditions is provided. In particular, the stabilized ACC may be used in the treatment of axonal defects and muscular dystrophy. In addition, provided are improved methods used in assistant reproductive technology. Examples of such methods are in vitro fertilization and improvement of sperm quality. The improved IVF method, for example, comprises addition of the stabilized ACC to the cell culture medium in which the stages of fertilization and embryo development occurs.

公开(公告)号：US20190030068A1

公开(公告)日：2019-01-31

申请号：US16069762

申请日：2017-01-17

Applicant: AMORPHICAL LTD.

Inventor： Yosef Ben ,  Abraham Shahar ,  Amir Arav

IPC: A61K33/10 ,  A61P21/00 ,  A61K9/00 ,  C12N5/073 ,  C12N5/076 ,  C12N5/071 ,  A61P15/08 ,  A61K47/24 ,  A61K47/02 ,  A61K47/26 ,  A61K47/12

Abstract: Stabilized amorphous calcium carbonate (ACC) for treatment of several neurological, muscular and infertility diseases and conditions is provided. In particular, the stabilized ACC may be used in the treatment of axonal defects and muscular dystrophy. In addition, provided are improved methods used in assistant reproductive technology. Examples of such methods are in vitro fertilization and improvement of sperm quality. The improved IVF method, for example, comprises addition of the stabilized ACC to the cell culture medium in which the stages of fertilization and embryo development occurs.