公开(公告)号：US10099197B2

公开(公告)日：2018-10-16

申请号：US15036831

申请日：2014-11-20

Applicant: Avantium Technologies B.V.

Inventor： Roelandus Hendrikus Wilhelmus Moonen ,  Benno Hartog

IPC: B01J19/00

Abstract: A reactor system for high throughput applications includes a plurality of reactor assemblies, each reactor assembly including: a fluid source, which fluid source is adapted to provide a pressurized fluid to the flow-through reactors, a flow splitter which flow splitter includes a planar microfluidic chip, which microfluidic chip has a chip inlet channel and a plurality of chip outlet channels, which microfluidic chip further includes a plurality of flow restrictor channels, where each flow restrictor channel extends from said chip inlet channel to an associated chip outlet channel, where the chip inlet channel and the chip outlet channels each have a diameter, where the diameter of the chip inlet channel is the same or less than the length of said chip inlet channel and where the diameter of each chip outlet channel is the same or less than the length of said chip outlet channel.

公开(公告)号：US20150273427A1

公开(公告)日：2015-10-01

申请号：US14435298

申请日：2013-10-11

Applicant: AVANTIUM TECHNOLOGIES B.V.

Inventor： Roelandus Hendrikus Wilhelmus Moonen ,  René Emilio Bodenstaff ,  Benno Hartog

IPC: B01J19/00

CPC classification number: B01J19/0006 ,  B01J19/0013 ,  B01J19/0046 ,  B01J2219/00065 ,  B01J2219/00162 ,  B01J2219/00477 ,  B01J2219/00495 ,  B01L3/502746 ,  B01L2300/14 ,  B01L2400/0481 ,  B01L2400/0655 ,  F16K99/0011 ,  F16K99/0015 ,  F16K99/0026 ,  F16K99/0044 ,  F16K99/0061 ,  G05D16/185 ,  G05D16/2026 ,  G05D16/2093 ,  Y10T137/6416 ,  Y10T436/12

Abstract: A pressure controller for use in operating parallel reactors includes: a first restrictor channel, a second restrictor channel, a fluid passage, which fluid passage extends between the outlet of the first restrictor channel and the inlet of the second restrictor channel, a pressure control fluid source being adapted to provide a flow of pressure control fluid, having an entrance pressure at the inlet of the first restrictor channel and an exit pressure at the outlet of the second restrictor channel, the flow of pressure control fluid experiencing a first pressure drop Δρ1 over the first restrictor channel and a second pressure drop Δρ2 over the second restrictor channel, a connector connecting the fluid passage to the control chamber, the pressure control fluid at the connector having an intermediate pressure, the intermediate pressure being determined by the ratio between the first pressure drop Δρ1 and the second pressure drop Δ≦ρ2.

Abstract translation: 用于操作并联反应器的压力控制器包括：第一限流器通道，第二限流器通道，流体通道，该流体通道在第一限流器通道的出口和第二限流器通道的入口之间延伸，压力控制流体 源适于提供压力控制流体流，其具有在第一限流器通道的入口处的入口压力和在第二限流器通道的出口处的出口压力，压力控制流体的流动经历第一压降Dgr; 第一限流器通道上的第一压降和第二限压器通道上的第二压降＆amp; amp; 2，将流体通道连接到控制室的连接器，连接器处的压力控制流体具有中间压力，中间压力 由第一压降＆Dgr＆lt; 1和第二压降＆Dgr＆amp; NlE之间的比率确定; 2。

公开(公告)号：US10549253B2

公开(公告)日：2020-02-04

申请号：US16132552

申请日：2018-09-17

Applicant: Avantium Technologies B.V.

Inventor： Roelandus Hendrikus Wilhelmus Moonen ,  Benno Hartog

IPC: B01J19/00

Abstract: A reactor system for high throughput applications includes a plurality of reactor assemblies, each reactor assembly including: a fluid source, which fluid source is adapted to provide a pressurized fluid to the flow-through reactors, a flow splitter which flow splitter includes a planar microfluidic chip, which microfluidic chip has a chip inlet channel and a plurality of chip outlet channels, which microfluidic chip further includes a plurality of flow restrictor channels, where each flow restrictor channel extends from said chip inlet channel to an associated chip outlet channel, where the chip inlet channel and the chip outlet channels each have a diameter, where the diameter of the chip inlet channel is the same or less than the length of said chip inlet channel and where the diameter of each chip outlet channel is the same or less than the length of said chip outlet channel.

公开(公告)号：US20190022619A1

公开(公告)日：2019-01-24

申请号：US16132552

申请日：2018-09-17

Applicant: Avantium Technologies B.V.

Inventor： Roelandus Hendrikus Wilhelmus Moonen ,  Benno Hartog

IPC: B01J19/00

Abstract: A reactor system for high throughput applications includes a plurality of reactor assemblies, each reactor assembly including: a fluid source, which fluid source is adapted to provide a pressurized fluid to the flow-through reactors, a flow splitter which flow splitter includes a planar microfluidic chip, which microfluidic chip has a chip inlet channel and a plurality of chip outlet channels, which microfluidic chip further includes a plurality of flow restrictor channels, where each flow restrictor channel extends from said chip inlet channel to an associated chip outlet channel, where the chip inlet channel and the chip outlet channels each have a diameter, where the diameter of the chip inlet channel is the same or less than the length of said chip inlet channel and where the diameter of each chip outlet channel is the same or less than the length of said chip outlet channel.

公开(公告)号：US09868104B2

公开(公告)日：2018-01-16

申请号：US14435298

申请日：2013-10-11

Applicant: Avantium Technologies B.V.

Inventor： Roelandus Hendrikus Wilhelmus Moonen ,  René Emilio Bodenstaff ,  Benno Hartog

IPC: B01J19/00 ,  B01L3/00 ,  F16K99/00 ,  G05D16/18 ,  G05D16/20

CPC classification number: B01J19/0006 ,  B01J19/0013 ,  B01J19/0046 ,  B01J2219/00065 ,  B01J2219/00162 ,  B01J2219/00477 ,  B01J2219/00495 ,  B01L3/502746 ,  B01L2300/14 ,  B01L2400/0481 ,  B01L2400/0655 ,  F16K99/0011 ,  F16K99/0015 ,  F16K99/0026 ,  F16K99/0044 ,  F16K99/0061 ,  G05D16/185 ,  G05D16/2026 ,  G05D16/2093 ,  Y10T137/6416 ,  Y10T436/12

Abstract: A pressure controller for use in operating parallel reactors, the pressure controller including a reference pressure controller, the reference pressure controller including: a first restrictor channel, a second restrictor channel, a fluid passage, which fluid passage extends between the outlet of the first restrictor channel and the inlet of the second restrictor channel, a pressure control fluid source being adapted to provide a flow of pressure control fluid, having an entrance pressure at the inlet of the first restrictor channel and an exit pressure at the outlet of the second restrictor channel, the flow of pressure control fluid experiencing a first pressure drop Δρ1 over the first restrictor channel and a second pressure drop Δρ2 over the second restrictor channel, a connector connecting the fluid passage to the control chamber, the pressure control fluid at the connector having an intermediate pressure, the intermediate pressure being determined by the ratio between the first pressure drop Δρ1 and the second pressure drop Δρ2, a controllable thermal device, the thermal device being adapted to heat and/or cool the first restrictor channel and/or the second restrictor channel, therewith influencing the ratio between the first pressure drop Δρ1 and the second pressure drop Δρ2.

公开(公告)号：US20160288081A1

公开(公告)日：2016-10-06

申请号：US15036831

申请日：2014-11-20

Applicant: AVANTIUM TECHNOLOGIES B.V.

Inventor： Roelandus Hendrikus Wilhelmus Moonen ,  Benno Hartog

IPC: B01J19/00

CPC classification number: B01J19/0093 ,  B01J19/0046 ,  B01J2219/00286 ,  B01J2219/00418 ,  B01J2219/00808 ,  B01J2219/00813 ,  B01J2219/00817 ,  B01J2219/0086 ,  B01J2219/00869 ,  B01J2219/00896 ,  B01J2219/00898 ,  B01J2219/00959 ,  B01J2219/00963 ,  B01J2219/00984

Abstract: A reactor system for high throughput applications includes a plurality of reactor assemblies, each reactor assembly including: a fluid source, which fluid source is adapted to provide a pressurized fluid to the flow-through reactors, a flow splitter which flow splitter includes a planar microfluidic chip, which microfluidic chip has a chip inlet channel and a plurality of chip outlet channels, which microfluidic chip further includes a plurality of flow restrictor channels, where each flow restrictor channel extends from said chip inlet channel to an associated chip outlet channel, where the chip inlet channel and the chip outlet channels each have a diameter, where the diameter of the chip inlet channel is the same or less than the length of said chip inlet channel and where the diameter of each chip outlet channel is the same or less than the length of said chip outlet channel.

Abstract translation: 用于高通量应用的反应器系统包括多个反应器组件，每个反应器组件包括：流体源，该流体源适于向流通反应器提供加压流体;分流器，其分流器包括平面微流体 该微流体芯片具有芯片入口通道和多个芯片出口通道，该微流体芯片还包括多个限流器通道，其中每个限流器通道从所述芯片入口通道延伸到相关的芯片出口通道，其中 芯片进口通道和芯片出口通道各自具有直径，其中芯片入口通道的直径等于或小于所述芯片入口通道的长度，并且其中每个芯片出口通道的直径相同或小于 所述芯片出口通道的长度。