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公开(公告)号：US20170038361A1
公开(公告)日：2017-02-09
申请号：US15173809
申请日：2016-06-06
Applicant: Axion BioSystems, Inc.
Inventor： Isaac Perry Clements , Amanda Jervis Preyer , Swaminathan Rajaraman , Daniel Christopher Millard , James David Ross
IPC: G01N33/483 , G01N21/01 , B01L3/00
CPC classification number: G01N33/4836 , B01L3/50853 , B01L2300/046 , B01L2300/0645 , B01L2300/0654 , B01L2300/0829 , G01N21/01 , G01N21/75 , G01N2021/015 , G01N2021/0346 , G01N2201/0446 , G01N2201/062
Abstract: An electro-optical stimulation and recording system is disclosed, including a substrate and a plurality of wells coupled to the substrate. The system also includes at least one electrode set disposed proximate a respective one of the plurality of wells, wherein the electrode set comprises at least one electrode configured to collect an electric signal associated with at least a portion of the respective well. The system also includes a light-emitting element set corresponding to a respective one of the wells and configured to deliver optical stimulation to at least a portion of the respective well.
Abstract translation: 公开了一种电光刺激和记录系统，包括衬底和耦合到衬底的多个阱。 所述系统还包括邻近所述多个孔中的相应一个孔设置的至少一个电极组，其中所述电极组包括至少一个电极，所述至少一个电极被配置为收集与相应的阱的至少一部分相关联的电信号。 该系统还包括对应于相应的一个孔的发光元件组，并且被配置为将光学刺激传送到相应孔的至少一部分。
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公开(公告)号：US20150362476A1
公开(公告)日：2015-12-17
申请号：US14738618
申请日：2015-06-12
Applicant: Axion BioSystems, Inc.
Inventor： Isaac Perry Clements , Amanda Jervis Preyer , Swaminathan Rajaraman , Daniel Christopher Millard , James David Ross
IPC: G01N33/483 , G01N21/75 , G01N21/01
CPC classification number: G01N33/4836 , B01L3/50853 , B01L2300/046 , B01L2300/0645 , B01L2300/0654 , B01L2300/0829 , G01N21/01 , G01N21/75 , G01N2021/015 , G01N2021/0346 , G01N2201/0446 , G01N2201/062
Abstract: An electro-optical stimulation and recording system is disclosed, including a substrate and a plurality of wells coupled to the substrate. The system also includes at least one electrode set disposed proximate a respective one of the plurality of wells, wherein the electrode set comprises at least one electrode configured to collect an electric signal associated with at least a portion of the respective well. The system also includes a light-emitting element set corresponding to a respective one of the wells and configured to deliver optical stimulation to at least a portion of the respective well.
Abstract translation: 公开了一种电光刺激和记录系统，包括衬底和耦合到衬底的多个阱。 所述系统还包括邻近所述多个孔中的相应一个孔设置的至少一个电极组，其中所述电极组包括至少一个电极，所述至少一个电极被配置为收集与相应的阱的至少一部分相关联的电信号。 该系统还包括对应于相应的一个孔的发光元件组，并且被配置为将光学刺激传送到相应孔的至少一部分。
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公开(公告)号：US20180064931A1
公开(公告)日：2018-03-08
申请号：US15697358
申请日：2017-09-06
Applicant: Axion BioSystems, Inc. , Virginia Commonwealth University
Inventor： Isaac Perry Clements , Andrew Willsie , James David Ross , Alex Weidenbach , Jonathan Isaacs
CPC classification number: A61N1/0556 , A61B5/04001 , A61B5/6877 , A61B5/6882 , A61N1/0558 , A61N1/36103
Abstract: An example device for repairing a nerve is described herein. The device can include a flexible carrier layer made of a biologic material, and a metallic support member including a plurality of micro-protrusions extending therefrom. The metallic support member can be at least partially integrated with the flexible carrier layer. Additionally, the flexible carrier layer can be configured to cover at least a portion of the nerve, and the micro-protrusions can be configured to attach to a superficial tissue of the nerve.
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公开(公告)号：US09360469B1
公开(公告)日：2016-06-07
申请号：US15041589
申请日：2016-02-11
Applicant: Axion BioSystems, Inc.
Inventor： Isaac Perry Clements , Amanda Jervis Preyer , Swaminathan Rajaraman , Daniel Christopher Millard , James David Ross
IPC: G01N21/01 , G01N33/483
CPC classification number: G01N33/4836 , B01L3/50853 , B01L2300/046 , B01L2300/0645 , B01L2300/0654 , B01L2300/0829 , G01N21/01 , G01N21/75 , G01N2021/015 , G01N2021/0346 , G01N2201/0446 , G01N2201/062
Abstract: An electro-optical stimulation and recording system is disclosed, including a substrate and a plurality of wells coupled to the substrate. The system also includes at least one electrode set disposed proximate a respective one of the plurality of wells, wherein the electrode set comprises at least one electrode configured to collect an electric signal associated with at least a portion of the respective well. The system also includes a light-emitting element set corresponding to a respective one of the wells and configured to deliver optical stimulation to at least a portion of the respective well.
Abstract translation: 公开了一种电光刺激和记录系统，包括衬底和耦合到衬底的多个阱。 所述系统还包括邻近所述多个孔中的相应一个孔设置的至少一个电极组，其中所述电极组包括至少一个电极，所述至少一个电极被配置为收集与相应的阱的至少一部分相关联的电信号。 该系统还包括对应于相应的一个孔的发光元件组，并且被配置为将光学刺激传送到相应孔的至少一部分。
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公开(公告)号：US20200003753A1
公开(公告)日：2020-01-02
申请号：US16434281
申请日：2019-06-07
Applicant: Axion BioSystems, Inc.
Inventor： Isaac Perry Clements , Amanda Jervis Preyer , Swaminathan Rajaraman , Daniel Christopher Millard , James David Ross
IPC: G01N33/483 , B01L3/00 , G01N21/01 , G01N21/75
Abstract: An electro-optical stimulation and recording system is disclosed, including a substrate and a plurality of wells coupled to the substrate. The system also includes at least one electrode set disposed proximate a respective one of the plurality of wells, wherein the electrode set comprises at least one electrode configured to collect an electric signal associated with at least a portion of the respective well. The system also includes a light-emitting element set corresponding to a respective one of the wells and configured to deliver optical stimulation to at least a portion of the respective well.
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Patent Agency Ranking
公开(公告)号：US09279797B2
公开(公告)日：2016-03-08
申请号：US14738618
申请日：2015-06-12
Applicant: Axion Biosystems, Inc.
Inventor： Isaac Perry Clements , Amanda Jervis Preyer , Swaminathan Rajaraman , Daniel Christopher Millard , James David Ross
IPC: G01N27/327 , G01N33/483 , G01N21/01 , G01N21/75 , G01N21/03
CPC classification number: G01N33/4836 , B01L3/50853 , B01L2300/046 , B01L2300/0645 , B01L2300/0654 , B01L2300/0829 , G01N21/01 , G01N21/75 , G01N2021/015 , G01N2021/0346 , G01N2201/0446 , G01N2201/062
Abstract: An electro-optical stimulation and recording system is disclosed, including a substrate and a plurality of wells coupled to the substrate. The system also includes at least one electrode set disposed proximate a respective one of the plurality of wells, wherein the electrode set comprises at least one electrode configured to collect an electric signal associated with at least a portion of the respective well. The system also includes a light-emitting element set corresponding to a respective one of the wells and configured to deliver optical stimulation to at least a portion of the respective well.
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公开(公告)号：US12196741B2
公开(公告)日：2025-01-14
申请号：US17425571
申请日：2020-01-27
Applicant: AXION BIOSYSTEMS, INC.
Inventor： Michael Antony Clements , Isaac Perry Clements , Thomas J. O'Brien , James David Ross , Daniel Christopher Millard , Andrew Willsie , Edgar A. Brown , Robert Dixon Grier, Jr. , Amanda Jervis Preyer , Denise Danielle Sullivan
IPC: G01N33/483 , G01N21/59 , G01N27/02 , G01N33/487
Abstract: A scalable, real-time, label-free, electrode- or optical-based cell monitoring system for integration into a cell culture incubator is described herein. An example system includes (1) cell culture consumables with integrated electrodes and/or optics for growing and monitoring cells, (2) incubator trays for consumable organization and recording, and (3) a system console, external to the incubator, for connecting multiple incubator trays. Without perturbing the cell culture, the system is capable of monitoring multiple culture attributes for each cell culture consumable simultaneously. These attributes can include, but are not limited to, cell growth, proliferation, morphology, media pH, or media oxygen. The system can support multiple trays, which permits monitoring dozens to hundreds of consumables simultaneously, including a mixture of consumables of various sizes. In addition to monitoring adherent cells, the disclosed technology can be readily adapted for monitoring of cell suspensions.
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公开(公告)号：US10989703B2
公开(公告)日：2021-04-27
申请号：US16434281
申请日：2019-06-07
Applicant: Axion BioSystems, Inc.
Inventor： Isaac Perry Clements , Amanda Jervis Preyer , Swaminathan Rajaraman , Daniel Christopher Millard , James David Ross
Abstract: An electro-optical stimulation and recording system is disclosed, including a substrate and a plurality of wells coupled to the substrate. The system also includes at least one electrode set disposed proximate a respective one of the plurality of wells, wherein the electrode set comprises at least one electrode configured to collect an electric signal associated with at least a portion of the respective well. The system also includes a light-emitting element set corresponding to a respective one of the wells and configured to deliver optical stimulation to at least a portion of the respective well.
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公开(公告)号：US10317391B2
公开(公告)日：2019-06-11
申请号：US15173809
申请日：2016-06-06
Applicant: Axion BioSystems, Inc.
Inventor： Isaac Perry Clements , Amanda Jervis Preyer , Swaminathan Rajaraman , Daniel Christopher Millard , James David Ross
Abstract: An electro-optical stimulation and recording system is disclosed, including a substrate and a plurality of wells coupled to the substrate. The system also includes at least one electrode set disposed proximate a respective one of the plurality of wells, wherein the electrode set comprises at least one electrode configured to collect an electric signal associated with at least a portion of the respective well. The system also includes a light-emitting element set corresponding to a respective one of the wells and configured to deliver optical stimulation to at least a portion of the respective well.
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公开(公告)号：US20160161465A1
公开(公告)日：2016-06-09
申请号：US15041589
申请日：2016-02-11
Applicant: Axion BioSystems, Inc.
Inventor： Isaac Perry Clements , Amanda Jervis Preyer , Swaminathan Rajaraman , Daniel Christopher Millard , James David Ross
IPC: G01N33/483 , G01N21/01
CPC classification number: G01N33/4836 , B01L3/50853 , B01L2300/046 , B01L2300/0645 , B01L2300/0654 , B01L2300/0829 , G01N21/01 , G01N21/75 , G01N2021/015 , G01N2021/0346 , G01N2201/0446 , G01N2201/062
Abstract: An electro-optical stimulation and recording system is disclosed, including a substrate and a plurality of wells coupled to the substrate. The system also includes at least one electrode set disposed proximate a respective one of the plurality of wells, wherein the electrode set comprises at least one electrode configured to collect an electric signal associated with at least a portion of the respective well. The system also includes a light-emitting element set corresponding to a respective one of the wells and configured to deliver optical stimulation to at least a portion of the respective well.
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