公开(公告)号：US11149043B2

公开(公告)日：2021-10-19

申请号：US17227071

申请日：2021-04-09

Applicant: Calico Life Sciences LLC ,  AbbVie Inc.

Inventor： Michael J. Dart ,  Jennifer M. Frost ,  Yunsong Tong ,  Xiangdong Xu ,  Lei Shi ,  Kathleen Murauski ,  Marina Pliushchev ,  Brian S. Brown ,  Eric Voight ,  John T. Randolph

IPC: C07F9/12

Abstract: Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases, disorders and conditions.

公开(公告)号：US20160120841A1

公开(公告)日：2016-05-05

申请号：US14925649

申请日：2015-10-28

Applicant: AbbVie Inc.

Inventor： Philip R. Kym ,  Xueqing Wang ,  Xenia B. Searle ,  Bo Liu ,  Ming C. Yeung ,  Robert J. Altenbach ,  Eric Voight ,  Andrew Bogdan ,  John R. Koenig

IPC: A61K31/353 ,  A61K45/06 ,  C07D405/14 ,  A61K31/4433 ,  C07D491/052 ,  A61K31/435 ,  A61K31/4025 ,  A61K31/453 ,  C07D413/14 ,  A61K31/5377 ,  A61K31/397 ,  C07D491/107 ,  C07D407/12 ,  A61K31/436

CPC classification number: C07D407/12 ,  A61K31/00 ,  A61K31/353 ,  A61K31/397 ,  A61K31/4025 ,  A61K31/435 ,  A61K31/436 ,  A61K31/4433 ,  A61K31/453 ,  A61K31/5377 ,  A61K45/06 ,  C07D405/14 ,  C07D413/14 ,  C07D491/052 ,  C07D491/107 ,  A61K2300/00

Abstract: The invention provides for compounds of formula (I) wherein R1, X, Y, R4, R5, R6, R7, R8, R9, R10, R11, R12, R13, R14, m, and R″ have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions mediated and modulated by CFTR, including cystic fibrosis, Sjögren's syndrome, pancreatic insufficiency, chronic obstructive lung disease, and chronic obstructive airway disease. Also provided are pharmaceutical compositions comprised of one or more compounds of formula (I).

Abstract translation: 本发明提供式（I）化合物，其中R1，X，Y，R4，R5，R6，R7，R8，R9，R10，R11，R12，R13，R14，m和R“具有定义的任何值 在本说明书及其药学上可接受的盐中，其可用作治疗由CFTR介导和调节的疾病和病症的药剂，包括囊性纤维化，Siegren综合征，胰腺功能不全，慢性阻塞性肺病和慢性阻塞性气道疾病。 还提供了由一种或多种式（I）化合物组成的药物组合物。

公开(公告)号：US20220251123A1

公开(公告)日：2022-08-11

申请号：US17446807

申请日：2021-09-02

Applicant: Calico Life Sciences LLC ,  AbbVie Inc.

Inventor： Kathleen Ann Martin ,  Carmela Sidrauski ,  Michael J. Dart ,  Jennifer M. Frost ,  Yunsong Tong ,  Xiangdong Xu ,  Lei Shi ,  Kathleen Murauski ,  Marina Pliushchev ,  Brian S. Brown ,  Eric Voight ,  John T. Randolph

IPC: C07F9/12

Abstract: Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases, disorders and conditions.

公开(公告)号：US10053474B2

公开(公告)日：2018-08-21

申请号：US15588037

申请日：2017-05-05

Applicant: AbbVie Inc.

Inventor： Jaclyn Chau ,  Hui-Ju J. Chen ,  David A. DeGoey ,  John Hartung ,  Nathan Ide ,  Vikram Kalthod ,  Allan C. Krueger ,  Yi-Yin Ku ,  Tongmei Li ,  John T. Randolph ,  Rolf Wagner ,  Geoff T. Halvorsen ,  Christopher C. Marvin ,  Eric Voight ,  Brian S. Brown ,  Steven R. Martinez ,  Anurupa Shrestha ,  Howard R. Heyman

IPC: A61K31/675 ,  C07F9/02 ,  C07F9/08 ,  C07F9/6512 ,  C07H19/10

CPC classification number: C07F9/08 ,  C07F9/6512 ,  C07H19/10

Abstract: The present invention features compounds effective in inhibiting active against Hepatitis C virus (“HCV”) polymerase. The invention also features processes of making such compounds, compositions comprising such compounds, and methods of using such compounds to treat HCV infection.

公开(公告)号：US20170057981A1

公开(公告)日：2017-03-02

申请号：US15254342

申请日：2016-09-01

Applicant: AbbVie Inc.

Inventor： Hui-Ju J. Chen ,  David A. DeGoey ,  John Hartung ,  Nathan Ide ,  Vikram Kalthod ,  Allan C. Krueger ,  Yi-Yin Ku ,  Tongmei Li ,  John T. Randolph ,  Rolf Wagner ,  Jaclyn Chau ,  Geoff T. Halvorsen ,  Christopher C. Marvin ,  Eric Voight

IPC: C07F9/08

CPC classification number: C07F9/08 ,  C07F9/6512 ,  C07H19/10

Abstract: The present invention features compounds effective in inhibiting active against Hepatitis C virus (“HCV”) polymerase. The invention also features processes of making such compounds, compositions comprising such compounds, and methods of using such compounds to treat HCV infection.

Abstract translation: 本发明的特征在于有效抑制丙型肝炎病毒（“HCV”）聚合酶的活性的化合物。 本发明还涉及制备这些化合物的方法，包含这些化合物的组合物，以及使用这些化合物治疗HCV感染的方法。

公开(公告)号：US20210230195A1

公开(公告)日：2021-07-29

申请号：US17227071

申请日：2021-04-09

Applicant: Calico Life Sciences LLC ,  AbbVie Inc.

Inventor： Kathleen Ann Martin ,  Carmela Sidrauski ,  Michael J. Dart ,  Jennifer M. Frost ,  Yunsong Tong ,  Xiangdong Xu ,  Lei Shi ,  Kathleen Murauski ,  Marina Pliushchev ,  Brian S. Brown ,  Eric Voight ,  John T. Randolph

IPC: C07F9/12

Abstract: Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases, disorders and conditions.

公开(公告)号：US20190224220A1

公开(公告)日：2019-07-25

申请号：US16164073

申请日：2017-04-20

Applicant: AbbVie Inc.

Inventor： Philip R. Kym ,  Eric Voight

IPC: A61K31/661 ,  C07F9/12

Abstract: The present disclosure relates to (a) carbidopa prodrugs, (b) pharmaceutical combinations and compositions comprising a carbidopa prodrug and/or an L-dopa prodrug, and (c) methods of treating Parkinson's disease and associated conditions comprising administering a carbidopa prodrug and an L-dopa prodrug to a subject with Parkinson's disease.

公开(公告)号：US20180022763A1

公开(公告)日：2018-01-25

申请号：US15588037

申请日：2017-05-05

Applicant: AbbVie Inc.

Inventor： Jaclyn Chau ,  Hui-Ju J. Chen ,  David A. DeGoey ,  John Hartung ,  Nathan Ide ,  Vikram Kalthod ,  Allan C. Krueger ,  Yi-Yin Ku ,  Tongmei Li ,  John T. Randolph ,  Rolf Wagner ,  Geoff T. Halvorsen ,  Christopher C. Marvin ,  Eric Voight ,  Brian S. Brown ,  Steven R. Martinez ,  Anurupa Shrestha ,  Howard R. Heyman

IPC: C07F9/08 ,  C07F9/6512 ,  C07H19/10

CPC classification number: C07F9/08 ,  C07F9/6512 ,  C07H19/10

Abstract: The present invention features compounds effective in inhibiting active against Hepatitis C virus (“HCV”) polymerase. The invention also features processes of making such compounds, compositions comprising such compounds, and methods of using such compounds to treat HCV infection.

公开(公告)号：US09676797B2

公开(公告)日：2017-06-13

申请号：US15254342

申请日：2016-09-01

Applicant: AbbVie Inc.

Inventor： Hui-Ju J. Chen ,  David A. DeGoey ,  John Hartung ,  Nathan Ide ,  Vikram Kalthod ,  Allan C. Krueger ,  Yi-Yin Ku ,  Tongmei Li ,  John T. Randolph ,  Rolf Wagner ,  Jaclyn Chau ,  Geoff T. Halvorsen ,  Christopher C. Marvin ,  Eric Voight

IPC: A61K31/675 ,  C07F9/02 ,  C07F9/08 ,  C07F9/6512

CPC classification number: C07F9/08 ,  C07F9/6512 ,  C07H19/10

Abstract: The present invention features compounds effective in inhibiting active against Hepatitis C virus (“HCV”) polymerase. The invention also features processes of making such compounds, compositions comprising such compounds, and methods of using such compounds to treat HCV infection.