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公开(公告)号：US11149043B2
公开(公告)日：2021-10-19
申请号：US17227071
申请日：2021-04-09
发明人： Michael J. Dart , Jennifer M. Frost , Yunsong Tong , Xiangdong Xu , Lei Shi , Kathleen Murauski , Marina Pliushchev , Brian S. Brown , Eric Voight , John T. Randolph
IPC分类号： C07F9/12
摘要： Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases, disorders and conditions.
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公开(公告)号：US20210169892A1
公开(公告)日：2021-06-10
申请号：US16761354
申请日：2018-11-02
发明人： Kathleen Ann Martin , Carmela Sidrauski , Jennifer M. Frost , Yunsong Tong , Xiangdong Xu , SeungWon Chung , Qingwei I. Zhang , Lei Shi , Kathleen J. Murauski , Michael J. Dart , John T. Randolph
IPC分类号： A61K31/538 , A61K45/06 , C07D317/46 , C07D209/08 , C07D413/06 , C07D265/36 , C07D217/16 , C07D311/66 , C07D413/12 , C07D319/20 , C07D307/85 , C07D209/42 , C07D493/04 , C07D405/12 , C07C235/22 , A61K31/36 , A61K31/4045 , A61K31/472 , A61K31/353 , A61K31/357 , A61K31/343 , A61K31/404
摘要： Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases, disorders and conditions.
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公开(公告)号：US20240018133A1
公开(公告)日：2024-01-18
申请号：US18462918
申请日：2023-09-07
发明人： Kathleen Ann Martin , Carmela Sidrauski , Jennifer M. Frost , Yunsong Tong , Xiangdong Xu , SeungWon Chung , Qingwei Zhang , Lei Shi , Kathleen J. Murauski , Michael J. Dart , John T. Randolph , Hanae Benelkebir
IPC分类号： C07D413/12 , C07D209/08 , C07D265/36 , C07D307/83 , C07D307/85 , C07D311/24 , C07D317/68 , C07D319/20 , C07D405/12 , C07D405/14 , C07D417/12 , C07D493/04 , C07D493/08
CPC分类号： C07D413/12 , C07D209/08 , C07D265/36 , C07D307/83 , C07D307/85 , C07D311/24 , C07D317/68 , C07D319/20 , C07D405/12 , C07D405/14 , C07D417/12 , C07D493/04 , C07D493/08 , A61K45/06
摘要： Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases, disorders and conditions.
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公开(公告)号：US20210230195A1
公开(公告)日：2021-07-29
申请号：US17227071
申请日：2021-04-09
发明人： Kathleen Ann Martin , Carmela Sidrauski , Michael J. Dart , Jennifer M. Frost , Yunsong Tong , Xiangdong Xu , Lei Shi , Kathleen Murauski , Marina Pliushchev , Brian S. Brown , Eric Voight , John T. Randolph
IPC分类号： C07F9/12
摘要： Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases, disorders and conditions.
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公开(公告)号：US20200345727A1
公开(公告)日：2020-11-05
申请号：US16761390
申请日：2018-11-02
发明人： Kathleen Ann Martin , Carmela Sidrauski , Jennifer M. Frost , Marina Pliushchev , Yunsong Tong , Lawrence A. Black , Xiangdong Xu , Lei Shi , Qingwei I. Zhang , SeungWon Chung , Ramzi Farah Sweis , Michael J. Dart , John T. Randolph , Kathleen J. Murauski
IPC分类号： A61K31/4965 , A61K45/06 , C07D261/18 , C07D263/34 , C07D241/20 , A61K31/421 , A61K31/42 , A61K31/437 , C07D471/04 , C07D487/04 , C07D333/38 , C07D307/68 , A61K31/381 , A61K31/519 , A61K31/341 , A61K31/415 , A61K31/426 , A61K31/425 , C07D275/03 , C07D277/56 , C07D231/14 , C07D495/04 , A61K31/4985 , C07D237/20 , C07D413/04 , C07D285/06 , C07D317/46 , A61K31/36 , A61K31/4245 , A61K31/422 , A61K31/4196 , C07D249/10 , C07D217/26 , A61K31/472 , A61K31/196 , C07C233/62 , C07D401/04 , A61K31/4427 , A61K31/5355
摘要： Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases; disorders and conditions.
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公开(公告)号：US20240000792A1
公开(公告)日：2024-01-04
申请号：US18463183
申请日：2023-09-07
发明人： Kathleen Ann Martin , Carmela Sidrauski , Jennifer M. Frost , Yunsong Tong , Xiangdong Xu , SeungWon Chung , Qingwei Zhang , Lei Shi , Kathleen J. Murauski , Michael J. Dart , John T. Randolph
IPC分类号： A61K31/538 , A61K31/343 , A61K31/353 , A61K31/357 , A61K31/36 , A61K31/404 , A61K31/4045 , A61K31/472 , A61K45/06 , C07C235/22 , C07D209/08 , C07D209/42 , C07D217/16 , C07D265/36 , C07D307/85 , C07D311/66 , C07D317/46 , C07D319/20 , C07D405/12 , C07D413/06 , C07D413/12 , C07D493/04
CPC分类号： A61K31/538 , A61K31/343 , A61K31/353 , A61K31/357 , A61K31/36 , A61K31/404 , A61K31/4045 , A61K31/472 , A61K45/06 , C07C235/22 , C07D209/08 , C07D209/42 , C07D217/16 , C07D265/36 , C07D307/85 , C07D311/66 , C07D317/46 , C07D319/20 , C07D405/12 , C07D413/06 , C07D413/12 , C07D493/04
摘要： Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases, disorders and conditions.
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公开(公告)号：US20220251123A1
公开(公告)日：2022-08-11
申请号：US17446807
申请日：2021-09-02
发明人： Kathleen Ann Martin , Carmela Sidrauski , Michael J. Dart , Jennifer M. Frost , Yunsong Tong , Xiangdong Xu , Lei Shi , Kathleen Murauski , Marina Pliushchev , Brian S. Brown , Eric Voight , John T. Randolph
IPC分类号： C07F9/12
摘要： Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases, disorders and conditions.
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公开(公告)号：US20200347043A1
公开(公告)日：2020-11-05
申请号：US16863747
申请日：2020-04-30
发明人： Kathleen Ann Martin , Carmela Sidrauski , Lei Shi , Kathleen J. Murauski , Xiangdong Xu , Yunsong Tong , John T. Randolph , Michael J. Dart , Hanae Benelkebir , Steven Edeson , Kathryn Starbuck
IPC分类号： C07D413/12 , A61P25/28 , A61K45/06 , A61K31/422 , C07D405/12 , A61K31/4155 , A61K31/403 , C07D311/24 , A61K31/353 , C07D311/22 , A61K31/4433 , A61K31/4245 , C07C235/36 , A61K31/165 , C07D493/08 , A61K31/4025 , C07C235/40 , C07D405/06 , A61K31/397 , C07D407/12 , C07D271/10 , C07D471/04 , A61K31/437
摘要： Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases, disorders and conditions.
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公开(公告)号：US20240307382A1
公开(公告)日：2024-09-19
申请号：US18330185
申请日：2023-06-06
发明人： Kathleen Ann Martin , Carmela Sidrauski , Jennifer M. Frost , Marina Pliushchev , Yunsong Tong , Lawrence A. Black , Xiangdong Xu , Lei Shi , Qingwei Zhang , SeungWon Chung , Ramzi Farah Sweis , Michael J. Dart , John T. Randolph , Kathleen J. Murauski
IPC分类号： A61K31/4965 , A61K31/196 , A61K31/341 , A61K31/36 , A61K31/381 , A61K31/415 , A61K31/4196 , A61K31/42 , A61K31/421 , A61K31/422 , A61K31/4245 , A61K31/425 , A61K31/426 , A61K31/437 , A61K31/4427 , A61K31/472 , A61K31/4985 , A61K31/519 , A61K31/5355 , A61K45/06 , C07C233/62 , C07D217/26 , C07D231/14 , C07D237/20 , C07D241/20 , C07D249/10 , C07D261/18 , C07D263/34 , C07D275/03 , C07D277/56 , C07D285/06 , C07D307/68 , C07D317/46 , C07D333/38 , C07D401/04 , C07D413/04 , C07D471/04 , C07D487/04 , C07D495/04
CPC分类号： A61K31/4965 , A61K31/196 , A61K31/341 , A61K31/36 , A61K31/381 , A61K31/415 , A61K31/4196 , A61K31/42 , A61K31/421 , A61K31/422 , A61K31/4245 , A61K31/425 , A61K31/426 , A61K31/437 , A61K31/4427 , A61K31/472 , A61K31/4985 , A61K31/519 , A61K31/5355 , A61K45/06 , C07C233/62 , C07D217/26 , C07D231/14 , C07D237/20 , C07D241/20 , C07D249/10 , C07D261/18 , C07D263/34 , C07D275/03 , C07D277/56 , C07D285/06 , C07D307/68 , C07D317/46 , C07D333/38 , C07D401/04 , C07D413/04 , C07D471/04 , C07D487/04 , C07D495/04
摘要： Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases; disorders and conditions.
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公开(公告)号：US20210363136A1
公开(公告)日：2021-11-25
申请号：US16863737
申请日：2020-04-30
发明人： Kathleen Ann Martin , Carmela Sidrauski , Jennifer M. Frost , Yunsong Tong , Xiangdong Xu , SeungWon Chung , Qingwei I Zhang , Lei Shi , Kathleen J. Murauski , Michael J. Dart , John T. Randolph , Hanae Benelkebir
IPC分类号： C07D413/12 , C07D317/68 , C07D311/24 , C07D209/08 , C07D265/36 , C07D307/83 , C07D307/85 , C07D319/20 , C07D493/04 , C07D405/12 , C07D417/12 , C07D493/08 , C07D405/14
摘要： Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases, disorders and conditions.
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