公开(公告)号：US20170226200A1

公开(公告)日：2017-08-10

申请号：US15270945

申请日：2016-09-20

Applicant: AbbVie, Inc.

Inventor： Tariq GHAYUR ,  Junjian Liu ,  Peter C. Isakson

IPC: C07K16/24 ,  G01N33/68 ,  A61K45/06 ,  C07K16/46 ,  A61K39/395

CPC classification number: C07K16/244 ,  A61K39/3955 ,  A61K45/06 ,  A61K47/6845 ,  A61K49/00 ,  A61K51/1021 ,  A61K2039/505 ,  C07K16/241 ,  C07K16/245 ,  C07K16/468 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/33 ,  C07K2317/35 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2317/732 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2317/94 ,  G01N33/53 ,  G01N33/56966 ,  G01N33/6857 ,  G01N33/6863 ,  G01N33/6869 ,  G01N2333/525 ,  G01N2333/54 ,  G01N2333/545 ,  G01N2800/24 ,  G01N2800/7028

Abstract: Engineered multivalent and multispecific binding proteins, methods of making, and their uses in the prevention, diagnosis, and/or treatment of disease are provided.

公开(公告)号：US20140308286A1

公开(公告)日：2014-10-16

申请号：US14219511

申请日：2014-03-19

Applicant: AbbVie Inc.

Inventor： Tariq Ghayur ,  Jochen G. Salfeld ,  Michael J. McPherson ,  Maria C. Harris ,  Junjian Liu ,  Peter C. Isakson ,  Jijie Gu

IPC: C07K16/24 ,  C07K16/44 ,  C07K16/22

CPC classification number: C07K16/241 ,  C07K16/22 ,  C07K16/2803 ,  C07K16/2875 ,  C07K16/44 ,  C07K16/468 ,  C07K2317/31 ,  C07K2317/73

Abstract: The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.

Abstract translation: 本发明涉及工程化的多价和多特异性结合蛋白，制备方法，具体涉及用于预防，诊断和/或治疗疾病的用途。

公开(公告)号：US20160176958A1

公开(公告)日：2016-06-23

申请号：US14950761

申请日：2015-11-24

Applicant: AbbVie Inc.

Inventor： Lorenzo Benatuil ,  Tariq Ghayur ,  Carrie L. Goodreau ,  Peter C. Isakson ,  Jochen Salfeld

IPC: C07K16/24

CPC classification number: C07K16/241 ,  A61K47/6845 ,  A61K51/1021 ,  A61K2039/505 ,  C07K2317/14 ,  C07K2317/24 ,  C07K2317/52 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/76 ,  C07K2317/92 ,  G01N33/6863 ,  G01N2333/7151 ,  Y02A50/386 ,  Y02A50/41 ,  Y02A50/412 ,  Y02A50/58

Abstract: Isolated binding proteins, e.g., antibodies or antigen binding portions thereof, which bind to tumor necrosis factor-alpha (TNF-α), e.g., human TNF-α, and related antibody-based compositions and molecules are disclosed. Also disclosed are pharmaceutical compositions comprising the antibodies, as well as therapeutic and diagnostic methods for using the antibodies.

Abstract translation: 公开了与肿瘤坏死因子-α（TNF-α）结合的分离的结合蛋白，例如结合肿瘤坏死因子-α（TNF-α）的抗体或其抗原结合部分以及相关的基于抗体的组合物和分子。 还公开了包含抗体的药物组合物，以及使用抗体的治疗和诊断方法。

公开(公告)号：US20150315283A1

公开(公告)日：2015-11-05

申请号：US14687392

申请日：2015-04-15

Applicant: AbbVie Inc.

Inventor： Tariq Ghayur ,  Peter C. Isakson ,  Lisa M. Olson ,  Chengbin Wu ,  Margaret Hugunin ,  Rajesh V. Kamath ,  Carolyn A. Cuff ,  Hamish J. Allen

IPC: C07K16/28 ,  C07K16/22 ,  G01N33/68 ,  A61K39/395 ,  A61K45/06 ,  C07K16/24 ,  A61K47/48

CPC classification number: C07K16/2887 ,  A61K39/3955 ,  A61K45/06 ,  A61K47/6845 ,  A61K2039/505 ,  A61K2039/70 ,  C07K16/22 ,  C07K16/241 ,  C07K16/244 ,  C07K16/245 ,  C07K16/247 ,  C07K16/248 ,  C07K16/2866 ,  C07K16/468 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/35 ,  C07K2317/64 ,  C07K2317/73 ,  C07K2317/732 ,  C07K2317/734 ,  C07K2317/76 ,  C07K2317/92 ,  G01N33/6869 ,  G01N2333/545 ,  Y02A50/386 ,  Y02A50/41 ,  Y02A50/412 ,  Y02A50/58

Abstract: The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.

公开(公告)号：US20140335014A1

公开(公告)日：2014-11-13

申请号：US14248223

申请日：2014-04-08

Applicant: AbbVie, Inc.

Inventor： Tariq Ghayur ,  Peter C. Isakson ,  Lisa M. Olson ,  Chengbin Wu ,  Margaret Hugunin ,  Rajesh V. Kamath ,  Carolyn A. Cuff ,  Hamish Allen

IPC: C07K16/46 ,  G01N33/68 ,  A61K45/06 ,  A61K47/48 ,  C07K16/24 ,  A61K39/395

CPC classification number: C07K16/2887 ,  A61K39/3955 ,  A61K45/06 ,  A61K47/6845 ,  A61K2039/505 ,  A61K2039/70 ,  C07K16/22 ,  C07K16/241 ,  C07K16/244 ,  C07K16/245 ,  C07K16/247 ,  C07K16/248 ,  C07K16/2866 ,  C07K16/468 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/35 ,  C07K2317/64 ,  C07K2317/73 ,  C07K2317/732 ,  C07K2317/734 ,  C07K2317/76 ,  C07K2317/92 ,  G01N33/6869 ,  G01N2333/545 ,  Y02A50/386 ,  Y02A50/41 ,  Y02A50/412 ,  Y02A50/58

Abstract: The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.

Abstract translation: 本发明涉及工程化的多价和多特异性结合蛋白，制备方法，具体涉及用于预防，诊断和/或治疗疾病的用途。

公开(公告)号：US09493560B2

公开(公告)日：2016-11-15

申请号：US14135107

申请日：2013-12-19

Applicant: AbbVie, Inc.

Inventor： Tariq Ghayur ,  Junjian Liu ,  Peter C. Isakson

IPC: A61K39/395 ,  A61K39/40 ,  C07K16/24 ,  C07K16/46 ,  G01N33/53 ,  G01N33/68 ,  A61K45/06 ,  A61K47/48 ,  A61K49/00 ,  A61K51/10 ,  G01N33/569 ,  C07K16/00

CPC classification number: C07K16/244 ,  A61K39/3955 ,  A61K45/06 ,  A61K47/6845 ,  A61K49/00 ,  A61K51/1021 ,  C07K16/241 ,  C07K16/245 ,  C07K16/468 ,  C07K2317/35 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2317/94 ,  G01N33/53 ,  G01N33/56966 ,  G01N33/6857 ,  G01N33/6869 ,  G01N2333/54 ,  G01N2333/545 ,  G01N2800/24 ,  G01N2800/7028

Abstract: Engineered multivalent and multispecific binding proteins, methods of making, and their uses in the prevention, diagnosis, and/or treatment of disease are provided.