公开(公告)号：US08607829B2

公开(公告)日：2013-12-17

申请号：US12526050

申请日：2008-01-11

申请人： Alan M. Williams ,  Kyril Dambuleff ,  Kathryn Taylor ,  John Davis ,  Adam Kaletski ,  Daniel Go ,  Scott R. Muller

发明人： Alan M. Williams ,  Kyril Dambuleff ,  Kathryn Taylor ,  John Davis ,  Adam Kaletski ,  Daniel Go ,  Scott R. Muller

IPC分类号： B65B1/20

CPC分类号： B01D15/14 ,  B01D15/206 ,  G01N30/56 ,  G01N2030/565

摘要： This invention provides for the fully automated, hands free, packing of chromatography columns by means of delivering a pre-calculated volume of slurry and using two different packing modalities to stop the packing when either 1) this volume has been delivered in the column, or 2) when the adapter is moved to reach a bed height corresponding to the pre-calculated volume. Thus, a chromatography column can be packed in a fully automated fashion and such a column is 1) stable and 2) has the desired performance characteristic.

公开(公告)号：US20100313992A1

公开(公告)日：2010-12-16

申请号：US12526050

申请日：2008-01-11

申请人： Alan M. Williams ,  Kyril Dambuleff ,  Kathryn Taylor ,  John Davis ,  Adam Kaletski ,  Daniel Go ,  Scott R. Muller

发明人： Alan M. Williams ,  Kyril Dambuleff ,  Kathryn Taylor ,  John Davis ,  Adam Kaletski ,  Daniel Go ,  Scott R. Muller

IPC分类号： B65B3/04

CPC分类号： B01D15/14 ,  B01D15/206 ,  G01N30/56 ,  G01N2030/565

摘要： This invention provides for the fully automated, hands free, packing of chromatography columns by means of delivering a pre-calculated volume of slurry and using two different packing modalities to stop the packing when either 1) this volume has been delivered in the column, or 2) when the adapter is moved to reach a bed height corresponding to the pre-calculated volume. Thus, a chromatography column can be packed in a fully automated fashion and such a column is 1) stable and 2) has the desired performance characteristic.

摘要翻译： 本发明通过递送预先计算的浆料体积并使用两种不同的包装形式来完全自动化，免提，填充色谱柱，以便在1）该体积已经在柱中输送时，或者 2）当适配器移动达到与预先计算的体积相对应的床高时。 因此，色谱柱可以以完全自动化的方式包装，并且这样的柱是1）稳定的，2）具有期望的性能特征。

公开(公告)号：US09527010B2

公开(公告)日：2016-12-27

申请号：US12566701

申请日：2009-09-25

申请人： Alan M. Williams ,  Adam Kaletski ,  Lisa Stack ,  Daniel Go ,  John Krasnansky ,  David A. Wareheim ,  Bin Lin

发明人： Alan M. Williams ,  Adam Kaletski ,  Lisa Stack ,  Daniel Go ,  John Krasnansky ,  David A. Wareheim ,  Bin Lin

IPC分类号： B01D35/14 ,  C02F1/00 ,  C12M1/00 ,  B01D15/18 ,  G01N30/28 ,  G01N30/46 ,  G01N30/24 ,  G01N30/34 ,  B01D15/36

CPC分类号： B01D15/1871 ,  B01D15/1864 ,  B01D15/362 ,  G01N30/24 ,  G01N30/28 ,  G01N30/34 ,  G01N30/465 ,  B01D15/363

摘要： A separation system comprises (i) at least two separation units, each separation unit comprising a fluid inlet and a fluid outlet, wherein the separation units are connected in series outlet to inlet to form a line of separation units, and (ii) sensing and adjustment means, provided in-line between each separation unit, for continuously monitoring and adjusting at least one environmental property parameter of fluid flowing from one separation unit to a subsequent separation unit in the line of separation units. Uses of the separation system and a method for purification of a liquid containing a desired species, using separation units and in-line adjustment of a fluid flow or flows, are also disclosed.

摘要翻译： 分离系统包括（i）至少两个分离单元，每个分离单元包括流体入口和流体出口，其中分离单元以串联出口连接到入口以形成一行分离单元，以及（ii）感测和 在每个分离单元之间在线设置的调节装置，用于连续地监测和调节从一个分离单元流向分离单元的后续分离单元的流体的至少一个环境属性参数。 还公开了分离系统的使用以及使用分离单元和流体流或流的在线调节来纯化含有所需物质的液体的方法。