公开(公告)号：US11885776B2

公开(公告)日：2024-01-30

申请号：US17511262

申请日：2021-10-26

申请人： SHIMADZU CORPORATION

发明人： Yusuke Yokoi

IPC分类号： G01N30/28 ,  G01N30/32 ,  G01N30/30 ,  G01N30/02

CPC分类号： G01N30/28 ,  G01N2030/027 ,  G01N2030/3084 ,  G01N2030/326

摘要： A chromatography analysis system includes a liquid delivery pump (2), an autosampler (4), a separation column (12), a column oven (6), a detector (8). The chromatography analysis system further comprising a shutdown execution part (22) configured to start shutdown to finally stop driving of the liquid delivery pump (2) and temperature control operation of the column oven (6) at a time when a predetermined situation occurs, by controlling operation of the liquid delivery pump (2) and the column oven (6), and a column protection temperature setter (24) configured to set a column protection temperature for preventing deterioration of the separation column (12) due to overheating. The shutdown execution part (22) is configured to stop driving of the heater (14) in a state where the liquid delivery pump (2) is driven when the shutdown is started, and then, stop driving of the liquid delivery pump (2) after a temperature of the internal space detected by the temperature sensor (18) becomes equal to or less than the column protection temperature.

公开(公告)号：US11841351B2

公开(公告)日：2023-12-12

申请号：US16606517

申请日：2017-04-25

申请人： SHIMADZU CORPORATION

发明人： Yukihiko Kudo

IPC分类号： G01N37/00 ,  G01N30/72 ,  G01N30/28 ,  G01N27/623 ,  G01N30/02

CPC分类号： G01N30/72 ,  G01N27/623 ,  G01N30/28 ,  G01N37/00 ,  G01N2030/025 ,  G01N2030/027

摘要： A response factor that is a signal strength ratio with respect to a reference compound for various compounds is previously stored in a response factor storage (22). When an operator instructs to estimate an analysis limit value, a measurement unit (1) performs GC-MS analysis on a sample containing the reference compound a plurality of times under control of an analysis controller (3). A signal strength calculator (23) obtains a signal strength value of the reference compound based on an analysis result of the measurement unit (1), a relative strength calculator (24) calculates a relative standard deviation from the plurality of measured signal strength values, and calculates the relative standard deviation of a target compound from the response factor of the target compound read from the response factor storage (22). An analysis limit value estimator (25) estimates a limit of detection (LOD) and the like from the relative standard deviation of the target compound by a known method, and displays the LOD on a display (6). Consequently, the analysis limit value can simply be obtained without actually measuring the target compound.

公开(公告)号：US11841349B2

公开(公告)日：2023-12-12

申请号：US17392048

申请日：2021-08-02

申请人： PERKINELMER U.S. LLC

发明人： Andrew Tipler

IPC分类号： G01N30/32 ,  G01N30/20 ,  G01N30/46 ,  G01N30/60 ,  G01N30/72 ,  G01N30/28

CPC分类号： G01N30/32 ,  G01N30/20 ,  G01N30/28 ,  G01N30/466 ,  G01N30/6095 ,  G01N30/7206 ,  G01N30/468 ,  G01N30/72 ,  G01N2030/208 ,  G01N2030/324 ,  G01N2030/328 ,  Y10T29/49 ,  Y10T137/0318

摘要： Certain embodiments described herein are directed to chromatography systems that include a microfluidic device. The microfluidic device can be fluidically coupled to a switching valve to provide for selective control of fluid flow in the chromatography system. In some examples, the microfluidic device may include a charging chamber, a bypass restrictor or other features that can provide for added control of the fluid flow in the system. Methods of using the devices and methods of calculating lengths and diameters to provide a desired flow rate are also described.

公开(公告)号：US20230243785A1

公开(公告)日：2023-08-03

申请号：US17980884

申请日：2022-11-04

申请人： SHIMADZU CORPORATION

发明人： Naoki YAEGUCHI

IPC分类号： G01N30/28

CPC分类号： G01N30/28 ,  G01N2030/027

摘要： Provided is a unit-type analyzer (1) including: a system controller (80); a plurality of analyzing units (60), with each analyzing unit including a main power switch (70) configured to turn on and off electric power to the analyzing unit, and a software switch (66) provided separately from the main power switch configured to turn on and off a communication with the system controller; and a software-switch operation-mode setter (65) configured to perform a setting for enabling or disabling an operation on the software switch included in each analyzing unit.

公开(公告)号：US09527010B2

公开(公告)日：2016-12-27

申请号：US12566701

申请日：2009-09-25

申请人： Alan M. Williams ,  Adam Kaletski ,  Lisa Stack ,  Daniel Go ,  John Krasnansky ,  David A. Wareheim ,  Bin Lin

发明人： Alan M. Williams ,  Adam Kaletski ,  Lisa Stack ,  Daniel Go ,  John Krasnansky ,  David A. Wareheim ,  Bin Lin

IPC分类号： B01D35/14 ,  C02F1/00 ,  C12M1/00 ,  B01D15/18 ,  G01N30/28 ,  G01N30/46 ,  G01N30/24 ,  G01N30/34 ,  B01D15/36

CPC分类号： B01D15/1871 ,  B01D15/1864 ,  B01D15/362 ,  G01N30/24 ,  G01N30/28 ,  G01N30/34 ,  G01N30/465 ,  B01D15/363

摘要： A separation system comprises (i) at least two separation units, each separation unit comprising a fluid inlet and a fluid outlet, wherein the separation units are connected in series outlet to inlet to form a line of separation units, and (ii) sensing and adjustment means, provided in-line between each separation unit, for continuously monitoring and adjusting at least one environmental property parameter of fluid flowing from one separation unit to a subsequent separation unit in the line of separation units. Uses of the separation system and a method for purification of a liquid containing a desired species, using separation units and in-line adjustment of a fluid flow or flows, are also disclosed.

摘要翻译： 分离系统包括（i）至少两个分离单元，每个分离单元包括流体入口和流体出口，其中分离单元以串联出口连接到入口以形成一行分离单元，以及（ii）感测和 在每个分离单元之间在线设置的调节装置，用于连续地监测和调节从一个分离单元流向分离单元的后续分离单元的流体的至少一个环境属性参数。 还公开了分离系统的使用以及使用分离单元和流体流或流的在线调节来纯化含有所需物质的液体的方法。

公开(公告)号：US09423383B2

公开(公告)日：2016-08-23

申请号：US14275334

申请日：2014-05-12

申请人： Andrew Tipler

发明人： Andrew Tipler

IPC分类号： G01N30/32 ,  G01N30/20 ,  G01N30/28 ,  G01N30/46 ,  G01N30/60 ,  G01N30/72

CPC分类号： G01N30/32 ,  G01N30/20 ,  G01N30/28 ,  G01N30/466 ,  G01N30/468 ,  G01N30/6095 ,  G01N30/72 ,  G01N30/7206 ,  G01N2030/208 ,  G01N2030/324 ,  G01N2030/328 ,  Y10T29/49 ,  Y10T137/0318

摘要： Certain embodiments described herein are directed to chromatography systems that include a microfluidic device. The microfluidic device can be fluidically coupled to a switching valve to provide for selective control of fluid flow in the chromatography system. In some examples, the microfluidic device may include a charging chamber, a bypass restrictor or other features that can provide for added control of the fluid flow in the system. Methods of using the devices and methods of calculating lengths and diameters to provide a desired flow rate are also described.

摘要翻译： 本文所述的某些实施方案涉及包括微流体装置的色谱系统。 微流体装置可以流体耦合到切换阀，以提供色谱系统中流体流动的选择性控制。 在一些示例中，微流体装置可以包括充电室，旁路限流器或可以提供对系统中的流体流的附加控制的其它特征。 还描述了使用这些装置的方法和计算长度和直径以提供期望流速的方法。

公开(公告)号：US20150268137A1

公开(公告)日：2015-09-24

申请号：US14634856

申请日：2015-03-01

申请人： Andrew Tipler

发明人： Andrew Tipler

IPC分类号： G01N1/22 ,  G01N27/62 ,  G01N30/28

CPC分类号： G01N1/2226 ,  G01N27/626 ,  G01N30/28 ,  G01N2001/2229 ,  G01N2030/025

摘要： Certain embodiments described herein are directed to devices, systems and methods that are configured to control flow of an explosive carrier gas in a sampling system. In some examples, a flow control device configured to provide release of explosive carrier gas in less than an explosive amount to void space in the sampling system is described. Systems and methods using the flow control device are also disclosed.

摘要翻译： 本文描述的某些实施例涉及被配置为控制采样系统中的爆炸载气的流动的装置，系统和方法。 在一些示例中，描述了一种流量控制装置，其构造成以小于爆炸量的爆炸载体气体释放到采样系统中的空隙空间。 还公开了使用流量控制装置的系统和方法。

公开(公告)号：US08305581B2

公开(公告)日：2012-11-06

申请号：US12960042

申请日：2010-12-03

申请人： James Anderson ,  Raaidah Saari-Nordhaus ,  Washington Mendoza ,  Josef Bystron ,  Dirk Helgemo ,  Dennis McCreary

发明人： James Anderson ,  Raaidah Saari-Nordhaus ,  Washington Mendoza ,  Josef Bystron ,  Dirk Helgemo ,  Dennis McCreary

IPC分类号： G01N21/00

CPC分类号： G01N30/82 ,  G01N30/28 ,  G01N30/74 ,  G01N30/78 ,  G01N2030/322 ,  G01N2030/621

摘要： Methods and apparatus for analyzing a sample using at least one detector are disclosed.

摘要翻译： 公开了使用至少一个检测器分析样品的方法和装置。

公开(公告)号：US20120222470A1

公开(公告)日：2012-09-06

申请号：US13472322

申请日：2012-05-15

申请人： Takaaki Suzuki ,  Masato Fukuda ,  Masahito Ito

发明人： Takaaki Suzuki ,  Masato Fukuda ,  Masahito Ito

IPC分类号： G01N30/02

CPC分类号： G01N30/8665 ,  G01N30/16 ,  G01N30/28 ,  G01N30/52 ,  G01N30/8658 ,  G01N30/8693 ,  G01N2030/027

摘要： Provided is a liquid chromatograph system and method configured to accurately obtain measurements by minimizing deviations in measurements due to a transfer from one measurement method to another measurement method. An aspect of the system and method includes minimizing deviations in measurements when a measurement method from a measurement system of a liquid chromatograph is transferred to measurement system under high pressure and high velocity. Such a transfer includes deviations due to differences in analysis conditions. The present subject matter uses a dwell volume value so as to minimize a deviation of measurement result due to methods before and after transfer. Another aspect includes calculating a correction value when there is a deviation in the measurement result, and automatically reflecting the correction value for the method transfer.

摘要翻译： 提供了一种液相色谱系统和方法，其被配置为通过使由于从一种测量方法转移到另一种测量方法的测量中的偏差最小化来精确地获得测量。 该系统和方法的一个方面包括当来自液相色谱仪的测量系统的测量方法在高压和高速下传递到测量系统时，测量的偏差最小化。 这种转移包括由于分析条件的差异导致的偏差。 本主题使用停留体积值，以便最小化由于传送之前和之后的方法导致的测量结果的偏差。 另一方面包括当测量结果存在偏差时计算校正值，并自动反映方法传送的校正值。

公开(公告)号：US08205485B2

公开(公告)日：2012-06-26

申请号：US12470164

申请日：2009-05-21

申请人： Takaaki Suzuki ,  Masato Fukuda ,  Masahito Ito

发明人： Takaaki Suzuki ,  Masato Fukuda ,  Masahito Ito

IPC分类号： G01N30/00

CPC分类号： G01N30/8665 ,  G01N30/16 ,  G01N30/28 ,  G01N30/52 ,  G01N30/8658 ,  G01N30/8693 ,  G01N2030/027

摘要： Provided is a liquid chromatograph system and method configured to accurately obtain measurements by minimizing deviations in measurements due to a transfer from one measurement method to another measurement method. An aspect of the system and method includes minimizing deviations in measurements when a measurement method from a measurement system of a liquid chromatograph is transferred to measurement system under high pressure and high velocity. Such a transfer includes deviations due to differences in analysis conditions. The present subject matter uses a dwell volume value so as to minimize a deviation of measurement result due to methods before and after transfer. Another aspect includes calculating a correction value when there is a deviation in the measurement result, and automatically reflecting the correction value for the method transfer.

摘要翻译： 提供了一种液相色谱系统和方法，其被配置为通过使由于从一种测量方法转移到另一种测量方法的测量中的偏差最小化来精确地获得测量。 该系统和方法的一个方面包括当来自液相色谱仪的测量系统的测量方法在高压和高速下传递到测量系统时，测量的偏差最小化。 这种转移包括由于分析条件的差异导致的偏差。 本主题使用停留体积值，以便最小化由于传送之前和之后的方法导致的测量结果的偏差。 另一方面包括当测量结果存在偏差时计算校正值，并自动反映方法传送的校正值。