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公开(公告)号:US20130065963A1
公开(公告)日:2013-03-14
申请号:US13551086
申请日:2012-07-17
IPC分类号: A61K31/16 , A61K31/17 , C07C275/40 , C07C275/26 , A61P25/00 , C07C233/06 , C07C233/07 , A61K31/167 , A61P35/00 , C07C275/24 , C07C275/28
CPC分类号: C07C271/02 , A61K31/19 , C07C259/06 , C07C275/24 , C07C275/26 , C07C275/40 , C07C323/44 , C07C323/60 , C07C2603/74 , C07D215/48 , C07D215/54
摘要: The invention provides novel classes of HDAC inhibitors. Methods of sensitizing a cancer cell to the cytotoxic effects of radiotherapy are also provided as well as methods for treating cancer and methods for treating neurological diseases. Additionally, the invention further provides pharmaceutical compositions comprising an HDAC inhibitor of the invention, and kits comprising a container containing an HDAC inhibitor of the invention.
摘要翻译: 本发明提供了新型的HDAC抑制剂。 还提供了使癌细胞对放射治疗的细胞毒作用敏感的方法以及治疗癌症的方法和治疗神经疾病的方法。 另外,本发明还提供了包含本发明的HDAC抑制剂的药物组合物和包含含有本发明的HDAC抑制剂的容器的试剂盒。
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公开(公告)号:US20110098504A1
公开(公告)日:2011-04-28
申请号:US12911145
申请日:2010-10-25
IPC分类号: C07C275/28 , C07C275/18 , C07C237/00
CPC分类号: C07C271/02 , A61K31/19 , C07C259/06 , C07C275/24 , C07C275/26 , C07C275/40 , C07C323/44 , C07C323/60 , C07C2603/74 , C07D215/48 , C07D215/54
摘要: The invention provides novel classes of HDAC inhibitors. Methods of sensitizing a cancer cell to the cytotoxic effects of radiotherapy are also provided as well as methods for treating cancer and methods for treating neurological diseases. Additionally, the invention further provides pharmaceutical compositions comprising an HDAC inhibitor of the invention, and kits comprising a container containing an HDAC inhibitor of the invention.
摘要翻译: 本发明提供了新型的HDAC抑制剂。 还提供了使癌细胞对放射治疗的细胞毒作用敏感的方法以及治疗癌症的方法和治疗神经疾病的方法。 另外,本发明还提供了包含本发明的HDAC抑制剂的药物组合物和包含含有本发明的HDAC抑制剂的容器的试剂盒。
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公开(公告)号:US08222451B2
公开(公告)日:2012-07-17
申请号:US12911145
申请日:2010-10-25
IPC分类号: C07C275/04 , C07C275/22 , A61K31/155 , A61K31/16
CPC分类号: C07C271/02 , A61K31/19 , C07C259/06 , C07C275/24 , C07C275/26 , C07C275/40 , C07C323/44 , C07C323/60 , C07C2603/74 , C07D215/48 , C07D215/54
摘要: The invention provides novel classes of HDAC inhibitors. Methods of sensitizing a cancer cell to the cytotoxic effects of radiotherapy are also provided as well as methods for treating cancer and methods for treating neurological diseases. Additionally, the invention further provides pharmaceutical compositions comprising an HDAC inhibitor of the invention, and kits comprising a container containing an HDAC inhibitor of the invention.
摘要翻译: 本发明提供了新型的HDAC抑制剂。 还提供了使癌细胞对放射治疗的细胞毒作用敏感的方法以及治疗癌症的方法和治疗神经疾病的方法。 另外,本发明还提供了包含本发明的HDAC抑制剂的药物组合物和包含含有本发明的HDAC抑制剂的容器的试剂盒。
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公开(公告)号:US08748463B2
公开(公告)日:2014-06-10
申请号:US13551086
申请日:2012-07-17
IPC分类号: A61K31/16 , C07D277/02 , C07D263/02 , C07C233/08 , C07C233/14
CPC分类号: C07C271/02 , A61K31/19 , C07C259/06 , C07C275/24 , C07C275/26 , C07C275/40 , C07C323/44 , C07C323/60 , C07C2603/74 , C07D215/48 , C07D215/54
摘要: The invention provides novel classes of HDAC inhibitors. Methods of sensitizing a cancer cell to the cytotoxic effects of radiotherapy are also provided as well as methods for treating cancer and methods for treating neurological diseases. Additionally, the invention further provides pharmaceutical compositions comprising an HDAC inhibitor of the invention, and kits comprising a container containing an HDAC inhibitor of the invention.
摘要翻译: 本发明提供了新型的HDAC抑制剂。 还提供了使癌细胞对放射治疗的细胞毒作用敏感的方法以及治疗癌症的方法和治疗神经疾病的方法。 另外,本发明还提供了包含本发明的HDAC抑制剂的药物组合物和包含含有本发明的HDAC抑制剂的容器的试剂盒。
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公开(公告)号:US07507828B2
公开(公告)日:2009-03-24
申请号:US10843229
申请日:2004-05-11
申请人: Alan P. Kozikowski , Bin Chen
发明人: Alan P. Kozikowski , Bin Chen
IPC分类号: C07D217/12 , C07D215/14 , C07D213/02 , C07C321/22 , C07C321/02
CPC分类号: C07C271/02 , A61K31/19 , C07C259/06 , C07C275/24 , C07C275/26 , C07C275/40 , C07C323/44 , C07C323/60 , C07C2603/74 , C07D215/48 , C07D215/54
摘要: One aspect of the invention relates to HDAC inhibitors. Methods of sensitizing a cancer cell to the cytotoxic effects of radiotherapy are also provided. The invention also provides methods for treating cancer and methods for treating neurological diseases. Additionally, the invention further provides pharmaceutical compositions comprising an HDAC inhibitor of the invention, and kits comprising a container containing an HDAC inhibitor of the invention.
摘要翻译: 本发明的一个方面涉及HDAC抑制剂。 还提供了使癌细胞对放射治疗的细胞毒性作用敏感的方法。 本发明还提供了治疗癌症的方法和治疗神经疾病的方法。 另外,本发明还提供了包含本发明的HDAC抑制剂的药物组合物和包含含有本发明的HDAC抑制剂的容器的试剂盒。
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公开(公告)号:US20090163543A1
公开(公告)日:2009-06-25
申请号:US12339492
申请日:2008-12-19
申请人: Alan P. Kozikowski , Bin Chen
发明人: Alan P. Kozikowski , Bin Chen
IPC分类号: A61K31/47 , C07C275/24 , A61K31/17 , C07C275/28 , A61P43/00 , A61K31/166 , C07C321/10 , C12N5/06 , C07D215/48
CPC分类号: C07C271/02 , A61K31/19 , C07C259/06 , C07C275/24 , C07C275/26 , C07C275/40 , C07C323/44 , C07C323/60 , C07C2603/74 , C07D215/48 , C07D215/54
摘要: One aspect of the invention relates to HDAC inhibitors. Methods of sensitizing a cancer cell to the cytotoxic effects of radiotherapy are also provided. The invention also provides methods for treating cancer and methods for treating neurological diseases. Additionally, the invention further provides pharmaceutical compositions comprising an HDAC inhibitor of the invention, and kits comprising a container containing an HDAC inhibitor of the invention.
摘要翻译: 本发明的一个方面涉及HDAC抑制剂。 还提供了使癌细胞对放射治疗的细胞毒性作用敏感的方法。 本发明还提供了治疗癌症的方法和治疗神经疾病的方法。 另外,本发明还提供了包含本发明的HDAC抑制剂的药物组合物和包含含有本发明的HDAC抑制剂的容器的试剂盒。
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公开(公告)号:US08067600B2
公开(公告)日:2011-11-29
申请号:US12339492
申请日:2008-12-19
申请人: Alan P. Kozikowski , Bin Chen
发明人: Alan P. Kozikowski , Bin Chen
IPC分类号: C07D217/12 , C07D215/14 , A61K31/47
CPC分类号: C07C271/02 , A61K31/19 , C07C259/06 , C07C275/24 , C07C275/26 , C07C275/40 , C07C323/44 , C07C323/60 , C07C2603/74 , C07D215/48 , C07D215/54
摘要: One aspect of the invention relates to HDAC inhibitors. Methods of sensitizing a cancer cell to the cytotoxic effects of radiotherapy are also provided. The invention also provides methods for treating cancer and methods for treating neurological diseases. Additionally, the invention further provides pharmaceutical compositions comprising an HDAC inhibitor of the invention, and kits comprising a container containing an HDAC inhibitor of the invention.
摘要翻译: 本发明的一个方面涉及HDAC抑制剂。 还提供了使癌细胞对放射治疗的细胞毒性作用敏感的方法。 本发明还提供了治疗癌症的方法和治疗神经疾病的方法。 另外,本发明还提供了包含本发明的HDAC抑制剂的药物组合物和包含含有本发明的HDAC抑制剂的容器的试剂盒。
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公开(公告)号:US07842835B2
公开(公告)日:2010-11-30
申请号:US10614498
申请日:2003-07-07
IPC分类号: C07C275/04 , A61K31/17
CPC分类号: C07C271/02 , A61K31/19 , C07C259/06 , C07C275/24 , C07C275/26 , C07C275/40 , C07C323/44 , C07C323/60 , C07C2603/74 , C07D215/48 , C07D215/54
摘要: The invention provides novel classes of HDAC inhibitors. Methods of sensitizing a cancer cell to the cytotoxic effects of radiotherapy are also provided as well as methods for treating cancer and methods for treating neurological diseases. Additionally, the invention further provides pharmaceutical compositions comprising an HDAC inhibitor of the invention, and kits comprising a container containing an HDAC inhibitor of the invention.
摘要翻译: 本发明提供了新型的HDAC抑制剂。 还提供了使癌细胞对放射治疗的细胞毒作用敏感的方法以及治疗癌症的方法和治疗神经疾病的方法。 另外,本发明还提供了包含本发明的HDAC抑制剂的药物组合物和包含含有本发明的HDAC抑制剂的容器的试剂盒。
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公开(公告)号:US11253851B2
公开(公告)日:2022-02-22
申请号:US16876124
申请日:2020-05-18
申请人: Zengxin Chen , Changchun Zhou , Shenglu Li , Jingzhe Chen , Bin Chen , Chen Li , Hao Wei
发明人: Zengxin Chen , Changchun Zhou , Shenglu Li , Jingzhe Chen , Bin Chen , Chen Li , Hao Wei
摘要: An initial positioning system and method for liquid measuring and taking. The system comprises a measuring passage, a variable pressure chamber, and a piston, an initial end of the measuring passage being in communication with the upper part of the variable pressure chamber; the piston reciprocates in the variable pressure chamber to cause a change between positive pressure and negative pressure in the variable pressure chamber; the initial positioning system further comprises a pressure relief port located on the wall of the variable pressure chamber and capable of communicating with the outside of the variable pressure chamber; when the piston is located at the pressure relief port, and the inside and outside of the variable pressure chamber are in communication, the maximum volume of the liquid that can be accommodated in the variable pressure chamber is not smaller than one third of the total volume of the variable pressure chamber.
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10.
公开(公告)号:US09107226B2
公开(公告)日:2015-08-11
申请号:US13415279
申请日:2012-03-08
申请人: George Calcev , Bin Chen , Erik Colban , George Cummings , Ronald Xuzhuang Mao
发明人: George Calcev , Bin Chen , Erik Colban , George Cummings , Ronald Xuzhuang Mao
CPC分类号: H04W74/085 , H04W4/70 , H04W72/04 , H04W74/0866
摘要: An apparatus for managing contention in a communications system, the apparatus comprising a processor and a non-transitory computer readable storage medium storing programming for execution by the processor. The programming may include instructions to receive a ranging code from a device in a ranging channel, the ranging code corresponding to a current ranging attempt. The programming may further include instructions to broadcast a message acknowledging reception of the ranging code. The programming may further include instructions to receive a ranging request message from the device, the ranging request message comprising a ranging retries parameter that specifies a number of ranging retries that the device performed during the current ranging attempt.
摘要翻译: 一种用于管理通信系统中的争用的装置,所述装置包括处理器和存储由处理器执行的程序的非暂时计算机可读存储介质。 编程可以包括从测距信道中的设备接收测距码的指令,测距码对应于当前测距尝试。 节目还可以包括广播确认接收测距码的消息的指令。 所述编程可以进一步包括从所述设备接收测距请求消息的指令,所述测距请求消息包括测距重试参数,所述测距重试参数指定所述设备在当前测距尝试期间执行的测距重试次数。
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