公开(公告)号：US08901311B2

公开(公告)日：2014-12-02

申请号：US10518454

申请日：2003-06-20

Applicant: Alexander Straub

Inventor： Alexander Straub

IPC: C07D277/36

CPC classification number: C07D277/36

Abstract: The present invention relates to a process for preparing heterocyclic fluoroalkenyl sulfones and fluoroalkenyl sulfoxides by allowing the corresponding fluoroalkenyl thioethers to react with a salt of peroxomonosulfuric acid (H2SO5), optionally in the presence of a reaction assistant and optionally in the presence of a diluent.

Abstract translation: 本发明涉及一种制备杂环氟链烯基砜和氟烯基亚砜的方法，通过使相应的氟烯基硫醚任选在反应助剂存在下，任选地在稀释剂存在下，与碳酸二硫酸盐（H 2 SO 5）反应。

公开(公告)号：US07767702B2

公开(公告)日：2010-08-03

申请号：US10481297

申请日：2002-06-07

Applicant: Alexander Straub ,  Thomas Lampe ,  Josef Pernerstorfer ,  Elisabeth Perzborn ,  Jens Pohlmann ,  Susanne Röhrig ,  Karl-Heinz Schlemmer

Inventor： Alexander Straub ,  Thomas Lampe ,  Josef Pernerstorfer ,  Elisabeth Perzborn ,  Jens Pohlmann ,  Susanne Röhrig ,  Karl-Heinz Schlemmer

IPC: A61K31/421

CPC classification number: A61K31/422 ,  A61K31/421 ,  A61K31/5377 ,  A61K45/06 ,  A61K2300/00

Abstract: The invention relates to combinations of A) oxazolidinones of formula (I) and B) other active ingredients, to a method for producing said combinations and to the use thereof as medicaments, in particular for the treatment and/or prophylaxis of thrombo-embolic diseases.

Abstract translation: 本发明涉及式（I）的A）恶唑烷酮和B）其它活性成分的组合，用于制备所述组合的方法及其作为药物的用途，特别是用于治疗和/或预防血栓栓塞性疾病 。

公开(公告)号：US20100185015A1

公开(公告)日：2010-07-22

申请号：US12666013

申请日：2008-06-27

Applicant: Alexander Straub ,  Norbert Lui ,  Juergen Wieschemeyer ,  Ulrich Kloettschen ,  Eric Wihelus Petrus Damen

Inventor： Alexander Straub ,  Norbert Lui ,  Juergen Wieschemeyer ,  Ulrich Kloettschen ,  Eric Wihelus Petrus Damen

IPC: C07C209/68

CPC classification number: C07C209/68 ,  C07B37/04 ,  C07C211/52

Abstract: The present invention relates to a process for preparing biaryls using catalysts based on palladium compounds with phosphine ligands.

Abstract translation: 本发明涉及使用基于具有膦配体的钯化合物的催化剂制备联芳基的方法。

公开(公告)号：US20100056786A1

公开(公告)日：2010-03-04

申请号：US12373218

申请日：2007-07-12

Applicant: Alexander Straub

Inventor： Alexander Straub

IPC: C07D241/02 ,  C07D231/00 ,  C07D211/70 ,  C07D277/00 ,  C07D263/34

CPC classification number: C07D231/14

Abstract: The present invention relates to a novel process for preparing known fungicidally active alkylanilides from 2-alkylhaloaromatics and heterocyclylamides.

Abstract translation: 本发明涉及从2-烷基卤代芳烃和杂环基酰胺制备已知的杀真菌活性烷基苯胺的新方法。

公开(公告)号：US20080200674A1

公开(公告)日：2008-08-21

申请号：US12027553

申请日：2008-02-07

Applicant: Alexander Straub ,  Thomas Lampe ,  Jens Pohlmann ,  Susanne Rohrig ,  Elisabeth Perzborn ,  Karl-Heinz Schlemmer ,  Joseph Pernerstorfer

Inventor： Alexander Straub ,  Thomas Lampe ,  Jens Pohlmann ,  Susanne Rohrig ,  Elisabeth Perzborn ,  Karl-Heinz Schlemmer ,  Joseph Pernerstorfer

IPC: C07D413/14

CPC classification number: C07D498/04 ,  A61K31/5377 ,  C07D333/38 ,  C07D409/12 ,  C07D413/10 ,  C07D413/12 ,  C07D413/14 ,  C07D417/14 ,  C07D495/04

Abstract: The invention relates to the field of blood coagulation. Novel oxazolidinone derivatives of the general formula (I) processes for their preparation and their use as medicinally active compounds for the prophylaxis and/or treatment of disorders are described.

Abstract translation: 本发明涉及血液凝固领域。 描述了通式（I）的新型恶唑烷酮衍生物的制备及其作为用于预防和/或治疗病症的药物活性化合物的用途。

公开(公告)号：US20060258724A1

公开(公告)日：2006-11-16

申请号：US11460529

申请日：2006-07-27

Applicant: Alexander Straub ,  Thomas Lampe ,  Jens Pohlmann ,  Susanne Rohrig ,  Elisabeth Perzborn ,  Karl-Heinz Schlemmer ,  Joseph Pernerstorfer

Inventor： Alexander Straub ,  Thomas Lampe ,  Jens Pohlmann ,  Susanne Rohrig ,  Elisabeth Perzborn ,  Karl-Heinz Schlemmer ,  Joseph Pernerstorfer

IPC: A61K31/422 ,  C07D413/02

CPC classification number: C07D498/04 ,  A61K31/5377 ,  C07D333/38 ,  C07D409/12 ,  C07D413/10 ,  C07D413/12 ,  C07D413/14 ,  C07D417/14 ,  C07D495/04

Abstract: The invention relates to the field of blood coagulation. Novel oxazolidinone derivatives of the general formula (I) processes for their preparation and their use as medicinally active compounds for the prophylaxis and/or treatment of disorders are described.

Abstract translation: 本发明涉及血液凝固领域。 描述了通式（I）的新型恶唑烷酮衍生物的制备及其作为用于预防和/或治疗病症的药物活性化合物的用途。

公开(公告)号：US06933295B2

公开(公告)日：2005-08-23

申请号：US10484369

申请日：2002-07-03

Applicant: Alexander Straub ,  Thomas Lampe ,  Jens Pohlmann ,  Susanne Röhrig ,  Stephan Jordan ,  Elisabeth Perzborn ,  Karl-Heinz Schlemmer

Inventor： Alexander Straub ,  Thomas Lampe ,  Jens Pohlmann ,  Susanne Röhrig ,  Stephan Jordan ,  Elisabeth Perzborn ,  Karl-Heinz Schlemmer

IPC: C07D473/00 ,  A61K31/4025 ,  A61K31/4035 ,  A61K31/4155 ,  A61K31/4178 ,  A61K31/4184 ,  A61K31/422 ,  A61K31/437 ,  A61K31/4439 ,  A61K31/454 ,  A61K31/496 ,  A61K31/506 ,  A61K31/52 ,  A61K31/5377 ,  A61P7/02 ,  A61P9/00 ,  A61P9/08 ,  A61P9/10 ,  A61P11/00 ,  A61P19/02 ,  A61P25/28 ,  A61P35/00 ,  C07D209/46 ,  C07D209/48 ,  C07D213/81 ,  C07D409/12 ,  C07D409/14 ,  C07D413/14 ,  C07D471/04 ,  C07D471/14 ,  C07D521/00 ,  C07D487/04

CPC classification number: C07D231/12 ,  C07D233/56 ,  C07D249/08 ,  C07D409/12 ,  C07D409/14 ,  C07D471/14

Abstract: The invention relates to the field of blood clotting, to novel compounds of formula (I), to a method for their production and to the use of these compounds as active ingredients in medicaments for preventing and/or treating diseases. The compounds are factor Xa inhibitors.

Abstract translation: 本发明涉及血液凝固领域，关于式（I）的新化合物，其制备方法和这些化合物作为用于预防和/或治疗疾病的药物中的活性成分的用途。 化合物是因子Xa抑制剂。

公开(公告)号：US06919345B2

公开(公告)日：2005-07-19

申请号：US10477446

申请日：2002-04-30

Applicant: Johannes-Peter Stasch ,  Achim Feurer ,  Stefan Weigand ,  Elke Stahl ,  Dietmar Flubacher ,  Cristina Alonso-Alija ,  Frank Wunder ,  Dieter Lang ,  Klaus Dembowsky ,  Alexander Straub ,  Elisabeth Perzborn

Inventor： Johannes-Peter Stasch ,  Achim Feurer ,  Stefan Weigand ,  Elke Stahl ,  Dietmar Flubacher ,  Cristina Alonso-Alija ,  Frank Wunder ,  Dieter Lang ,  Klaus Dembowsky ,  Alexander Straub ,  Elisabeth Perzborn

IPC: A61K31/506 ,  A61K45/00 ,  A61P9/00 ,  A61P9/10 ,  A61P9/12 ,  A61P15/10 ,  A61P25/00 ,  A61P29/00 ,  C07D471/04 ,  A71K31/4162

CPC classification number: C07D471/04

Abstract: This invention relates to pyrazol pyridine derivatives of formula (I) wherein R1 is a radical of the formula −O—SO2—R3 in which R3 is optionally substituted C1—6—alkyl, optionally substituted C3—8—cycloalkyl, or optionally substituted phenyl; R2 is H, optionally substituted C1—6—alkyl —CO—or optionally substituted C1—6—alkyl—SO2— ; as well as salts, stereoisomers, tautomers, and hydrates thereof. Pharmaceutical compositions containing these materials and methods of using them in medical treatment are also described and claimed.

Abstract translation: 本发明涉及式（I）的吡唑吡啶衍生物，其中R 1是式-O-SO 2 -R 3的基团， 其中R 3是任选取代的C 1-6 - 烷基，任选取代的C 3-8 - 环烷基或任选取代的苯基; R 2是H，任选取代的C 1-6 - 烷基-CO-或任选取代的C 1-6 - 烷基-SSO > 2 - ; 以及其盐，立体异构体，互变异构体及其水合物。 还描述和要求保护含有这些材料的药物组合物及其在医疗中的使用方法。

公开(公告)号：US5504209A

公开(公告)日：1996-04-02

申请号：US230281

申请日：1994-04-20

Applicant: Jurgen Stoltefuss ,  Siegfried Goldmann ,  Alexander Straub ,  Martin Bechem ,  Rainer Gross ,  Siegbert Hebisch ,  Joachim Hutter ,  Howard-Paul Rounding

Inventor： Jurgen Stoltefuss ,  Siegfried Goldmann ,  Alexander Straub ,  Martin Bechem ,  Rainer Gross ,  Siegbert Hebisch ,  Joachim Hutter ,  Howard-Paul Rounding

IPC: A61K31/47 ,  C07D401/04 ,  C07D401/14 ,  C07D405/14 ,  C07D409/14 ,  C07D417/14

CPC classification number: C07D401/04

Abstract: The present invention relates to new 2-amino-5-cyano-4-quinolyl-l, 4-dihydropyridine esters of the general formula (I) ##STR1## in which R.sub.1 to R.sub.3 have the meaning given in the description, to processes for their preparation and to their use in medicaments, especially in agents for the treatment of cardiac circulatory disorders.

Abstract translation: 本发明涉及通式（I）的新的2-氨基-5-氰基-4-喹啉基-1,4-二氢吡啶酯，其中R1至R3具有说明书中给出的含义， 其制备方法及其在药物中的用途，特别是用于治疗心脏循环障碍的药剂。

公开(公告)号：US5502062A

公开(公告)日：1996-03-26

申请号：US230187

申请日：1994-04-20

Applicant: Ju/ rgen Stoltefuss ,  Siegfried Goldmann ,  Alexander Straub ,  Martin Bechem ,  Rainer Gross ,  Siegbert Hebisch ,  Joachim Hu/ tter ,  Howard-Paul Rounding

Inventor： Ju/ rgen Stoltefuss ,  Siegfried Goldmann ,  Alexander Straub ,  Martin Bechem ,  Rainer Gross ,  Siegbert Hebisch ,  Joachim Hu/ tter ,  Howard-Paul Rounding

IPC: A61K31/47 ,  A61K31/43 ,  A61P9/00 ,  A61P9/04 ,  C07D401/04 ,  C07D401/14 ,  C07D409/14 ,  C07D491/04 ,  C07D491/048 ,  C07D491/08 ,  A61K31/44

CPC classification number: C07D401/04 ,  C07D491/04

Abstract: The present invention relates to new 2-amino-4-quinolyl-1,4-dihydropyridines of the general formula (I) ##STR1## in which R.sub.1 -R.sub.4 have the meaning given in the description, to processes for their preparation and to their use in medicaments, especially in agents for the treatment of cardiac circulatory disorders.

Abstract translation: 本发明涉及通式（I）的新的2-氨基-4-喹啉基-1,4-二氢吡啶，其中R1-R4具有说明书中给出的含义，其制备方法 以及它们在药物中的用途，特别是用于治疗心脏循环障碍的药物。