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1.发明授权2-amino-5-cyano-4-quinolydihydropyridine esters, processes for their preparation and their use in medicaments 失效2-氨基-5-氰基-4-喹喔啉二氢吡啶酯，其制备方法及其在药物中的应用
公开(公告)号：US5504209A
公开(公告)日：1996-04-02
申请号：US230281
申请日：1994-04-20
申请人： Jurgen Stoltefuss , Siegfried Goldmann , Alexander Straub , Martin Bechem , Rainer Gross , Siegbert Hebisch , Joachim Hutter , Howard-Paul Rounding
发明人： Jurgen Stoltefuss , Siegfried Goldmann , Alexander Straub , Martin Bechem , Rainer Gross , Siegbert Hebisch , Joachim Hutter , Howard-Paul Rounding
IPC分类号： A61K31/47 , C07D401/04 , C07D401/14 , C07D405/14 , C07D409/14 , C07D417/14
CPC分类号： C07D401/04
摘要： The present invention relates to new 2-amino-5-cyano-4-quinolyl-l, 4-dihydropyridine esters of the general formula (I) ##STR1## in which R.sub.1 to R.sub.3 have the meaning given in the description, to processes for their preparation and to their use in medicaments, especially in agents for the treatment of cardiac circulatory disorders.
摘要翻译： 本发明涉及通式（I）的新的2-氨基-5-氰基-4-喹啉基-1,4-二氢吡啶酯，其中R1至R3具有说明书中给出的含义， 其制备方法及其在药物中的用途，特别是用于治疗心脏循环障碍的药剂。
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2.发明授权
公开(公告)号：US5225558A
公开(公告)日：1993-07-06
申请号：US886644
申请日：1992-05-20
申请人： Jurgen Stoltefuss , Siegfried Goldmann , Alexander Straub , Horst Boshagen , Martin Bechem , Rainer Gross , Siegbert Hebisch , Joachim Hutter , Howard-Paul Rounding
发明人： Jurgen Stoltefuss , Siegfried Goldmann , Alexander Straub , Horst Boshagen , Martin Bechem , Rainer Gross , Siegbert Hebisch , Joachim Hutter , Howard-Paul Rounding
IPC分类号： A61K31/47 , A61K31/445 , A61K31/4709 , A61P9/00 , A61P9/04 , C07D20060101 , C07D211/90 , C07D215/12 , C07D215/14 , C07D215/48 , C07D261/06 , C07D261/08 , C07D401/04 , C07D409/04 , C07D409/12 , C07D409/14
CPC分类号： C07D401/04 , C07D215/14
摘要： The present invention relates to new 2-amino-5-cyano-4-quinoline-1,4-dihydropyridines, processes for their preparation and their use in medicaments, in particular in agents for the treatment of cardiovascular diseases.
摘要翻译： 本发明涉及新的2-氨基-5-氰基-4-喹啉-1,4-二氢吡啶，其制备方法及其在药物中的用途，特别是用于治疗心血管疾病的药剂。
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公开(公告)号：US5514803A
公开(公告)日：1996-05-07
申请号：US230178
申请日：1994-04-20
申请人： Jurgen Stoltefuss , Siegfried Goldmann , Alexander Straub , Martin Bechem , Rainer Gross , Siegbert Hebisch , Joachim Hutter , Howard-Paul Rounding
发明人： Jurgen Stoltefuss , Siegfried Goldmann , Alexander Straub , Martin Bechem , Rainer Gross , Siegbert Hebisch , Joachim Hutter , Howard-Paul Rounding
IPC分类号： A61K31/47 , C07D401/04 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D491/04 , C07D491/048 , C07F9/58 , C07D403/02
CPC分类号： C07D401/04 , C07D491/04
摘要： The invention relates to new 2,6-disubstituted 4-quinolyl-dihydropyridines ##STR1## in which R.sub.1 to R.sub.5 have the meaning indicated in the description,processes for their preparation and their use in medicaments, in particular in compositions for the treatment of cardiovascular disorders.
摘要翻译： 本发明涉及新的2,6-二取代的4-喹啉基 - 二氢吡啶（I），其中R1至R5具有说明书中所示的含义，其制备方法及其在药物中的用途，特别是用于 治疗心血管疾病。
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4.发明授权2-amino-4-heteroaryl-1,4-dihydropyridines and their use in medicaments 失效2-氨基-4-杂芳基-1,4-二氢吡啶及其在药物中的用途
公开(公告)号：US5434153A
公开(公告)日：1995-07-18
申请号：US230468
申请日：1994-04-20
申请人： Alexander Straub , Siegfried Goldmann , Jurgen Stoltefuss , Martin Bechem , Rainer Gross , Siegbert Hebisch , Joachim Hutter , Howard-Paul Rounding
发明人： Alexander Straub , Siegfried Goldmann , Jurgen Stoltefuss , Martin Bechem , Rainer Gross , Siegbert Hebisch , Joachim Hutter , Howard-Paul Rounding
IPC分类号： A61K31/455 , A61K31/44 , A61K31/4427 , A61K31/4433 , A61K31/495 , A61K31/50 , A61K31/502 , A61P9/00 , A61P9/04 , C07D237/28 , C07D401/04 , C07D409/04 , C07D413/04 , C07D417/04 , C07D471/04 , C07D491/04 , C07D491/048 , C07D495/04 , C07D519/00 , C07F9/59 , A61K31/435
CPC分类号： C07D409/04 , C07D417/04 , C07D471/04 , C07D491/04 , C07D495/04
摘要： The present invention relates to new 2-amino-4-hetero-aryl-1,4-dihydropyridines of the general formula (I) ##STR1## in which R.sub.1 to R.sub.4 have the meaning given in the description, processes for their preparation and their use in medicaments, in particular in compositions for the treatment of cardiovascular disorders.
摘要翻译： 本发明涉及通式（I）的新的2-氨基-4-杂芳基-1,4-二氢吡啶，其中R1至R4具有说明书中给出的含义， 制剂及其在药物中的用途，特别是用于治疗心血管疾病的组合物。
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5.发明授权Process for preparing 1,4-dihydro-2-amino-3-carboxy-5-cyano-pyridine derivatives 失效1,4-二氢-2-氨基-3-羧基-5-氰基 - 吡啶衍生物的制备方法
公开(公告)号：US5432282A
公开(公告)日：1995-07-11
申请号：US298013
申请日：1994-08-30
申请人： Jurgen Stoltefuss , Siegfried Goldmann , Alexander Straub , Horst Boshagen , Martin Bechem , Rainer Gross , Siegbert Hebisch , Joachim Hutter , Howard-Paul Rounding
发明人： Jurgen Stoltefuss , Siegfried Goldmann , Alexander Straub , Horst Boshagen , Martin Bechem , Rainer Gross , Siegbert Hebisch , Joachim Hutter , Howard-Paul Rounding
IPC分类号： A61K31/47 , A61K31/445 , A61K31/4709 , A61P9/00 , A61P9/04 , C07D20060101 , C07D211/90 , C07D215/12 , C07D215/14 , C07D215/48 , C07D261/06 , C07D261/08 , C07D401/04 , C07D409/04 , C07D409/12 , C07D409/14 , C07D211/84
CPC分类号： C07D401/04 , C07D215/14
摘要： The present invention relates to new 2-amino-5-cyano-4-quinoline-1,4-dihydropyridines, processes for their preparation and their use in medicaments, in particular in agents for the treatment of cardiovascular diseases.
摘要翻译： 本发明涉及新的2-氨基-5-氰基-4-喹啉-1,4-二氢吡啶，其制备方法及其在药物中的用途，特别是用于治疗心血管疾病的药剂。
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6.发明授权4-bicyclically substituted dihydropyridines, and their use in medicaments 失效4-双环取代的二氢吡啶，以及它们在药物中的用途
公开(公告)号：US5721248A
公开(公告)日：1998-02-24
申请号：US644880
申请日：1996-05-10
申请人： Alexander Straub , Siegfried Goldmann , Jurgen Stoltefuss , Martin Bechem , Klaus Dembowsky , Rainer Gross , Siegbert Hebisch , Joachim Hutter , Howard-Paul Rounding
发明人： Alexander Straub , Siegfried Goldmann , Jurgen Stoltefuss , Martin Bechem , Klaus Dembowsky , Rainer Gross , Siegbert Hebisch , Joachim Hutter , Howard-Paul Rounding
IPC分类号： A61K31/40 , A61K31/403 , A61K31/4035 , A61K31/404 , A61K31/435 , A61K31/44 , A61K31/4427 , A61K31/443 , A61K31/4433 , A61K31/455 , A61K31/495 , A61P9/08 , A61P9/10 , C07C45/71 , C07C45/74 , C07C47/546 , C07C47/575 , C07C49/835 , C07C323/09 , C07C323/62 , C07D209/08 , C07D209/44 , C07D209/48 , C07D211/84 , C07D211/90 , C07D215/14 , C07D241/42 , C07D241/48 , C07D307/79 , C07D311/04 , C07D311/08 , C07D311/18 , C07D311/20 , C07D311/22 , C07D311/32 , C07D311/42 , C07D311/58 , C07D311/76 , C07D333/54 , C07D333/62 , C07D335/06 , C07D401/04 , C07D405/04 , C07D409/04 , C07D471/04 , C07D491/04 , C07D491/048 , C07D495/04 , C07D519/00 , C07F9/24 , A61K31/47
CPC分类号： C07D307/79 , C07C323/62 , C07C45/71 , C07C45/74 , C07C47/575 , C07C49/835 , C07D209/48 , C07D211/90 , C07D215/14 , C07D241/48 , C07D311/18 , C07D311/32 , C07D311/58 , C07D311/76 , C07D333/54 , C07D333/62 , C07D335/06 , C07D401/04 , C07D405/04 , C07D409/04 , C07D471/04 , C07D491/04 , C07D495/04 , C07F9/242
摘要： The invention relates to new 4-bicyclically substituted dihydropyridines of the general formula (I) ##STR1## in which R.sub.1 to R.sub.5 have the meaning given in the description, processes for their preparation and their use in medicaments, in particular in agents for the treatment of cardiovascular diseases.
摘要翻译： 本发明涉及在描述中给出的通式（I）的新的4-双环取代的二氢吡啶，其制备方法及其在药物中的用途，特别是用于治疗心血管疾病的药剂。
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7.发明授权3-phenyl-1,7-naphthyridine and cinnoline-5-carboxyaldehyde intermediates for medicaments 失效3-苯基-1,7-萘啶和噌啉-5-甲醛中间体
公开(公告)号：US5410055A
公开(公告)日：1995-04-25
申请号：US230579
申请日：1994-04-21
申请人： Alexander Straub , Jurgen Stoltefuss , Siegfried Goldmann , Rainer Gross , Martin Bechem , Siegbert Hebisch , Joachim Hutter , Howard-Paul Rounding
发明人： Alexander Straub , Jurgen Stoltefuss , Siegfried Goldmann , Rainer Gross , Martin Bechem , Siegbert Hebisch , Joachim Hutter , Howard-Paul Rounding
IPC分类号： A61K31/455 , A61K31/44 , A61K31/4427 , A61K31/50 , A61P9/04 , C07D213/75 , C07D237/28 , C07D401/04 , C07D471/04 , C07D491/04 , C07D491/048 , C07D519/00 , C07D409/04
CPC分类号： C07D401/04 , C07D471/04 , C07D491/04
摘要： The invention relates to new 4-cinnolinyl- and 4-naphthyridinyl-dihydropyridines of the general formula I ##STR1## in which R.sup.1 to R.sup.5 have the meaning given in the description, to processes for their preparation and intermediates thereof and to their use in medicaments, in particular in compositions having positively inotropic action.
摘要翻译： 本发明涉及通式Ⅰ的新的4-噌啉基和4-萘啶基 - 二氢吡啶，其中R1至R5具有说明书中给出的含义，其制备方法及其中间体以及它们的 用于药物，特别是在具有正性肌力作用的组合物中。
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8.发明授权
公开(公告)号：US5380851A
公开(公告)日：1995-01-10
申请号：US6432
申请日：1993-01-21
申请人： Jurgen Stoltefuss , Siegfried Goldmann , Alexander Straub , Horst Boshagen , Martin Bechem , Rainer Gross , Siegbert Hebisch , Joachim Hutter , Howard-Paul Rounding
发明人： Jurgen Stoltefuss , Siegfried Goldmann , Alexander Straub , Horst Boshagen , Martin Bechem , Rainer Gross , Siegbert Hebisch , Joachim Hutter , Howard-Paul Rounding
IPC分类号： A61K31/47 , A61K31/445 , A61K31/4709 , A61P9/00 , A61P9/04 , C07D20060101 , C07D211/90 , C07D215/12 , C07D215/14 , C07D215/48 , C07D261/06 , C07D261/08 , C07D401/04 , C07D409/04 , C07D409/12 , C07D409/14 , C07D215/00 , C07D215/16 , C07D409/06
CPC分类号： C07D401/04 , C07D215/14
摘要： The present invention relates to new 2-amino-5-cyano-4-quinoline-1,4-dihydropyridines, processes for their preparation and their use in medicaments, in particular in agents for the treatment of cardiovascular diseases.
摘要翻译： 本发明涉及新的2-氨基-5-氰基-4-喹啉-1,4-二氢吡啶，其制备方法及其在药物中的用途，特别是用于治疗心血管疾病的药剂。
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9.发明授权Quinolyl-dihydropyridine esters, processes for their preparation, and their use in medicaments 失效醌基 - 二氢吡啶酯，其制备方法及其在药物中的用途
公开(公告)号：US5508406A
公开(公告)日：1996-04-16
申请号：US230266
申请日：1994-04-20
申请人： Jurgen Stoltefuss , Siegfried Goldmann , Alexander Straub , Martin Bechem , Rainer Gross , Siegbert Hebisch , Joachim Hutter , Howard-Paul Rounding
发明人： Jurgen Stoltefuss , Siegfried Goldmann , Alexander Straub , Martin Bechem , Rainer Gross , Siegbert Hebisch , Joachim Hutter , Howard-Paul Rounding
IPC分类号： A61K31/47 , A61P9/00 , A61P9/04 , C07D401/04 , C07D401/14 , C07D405/14 , C07D409/14 , C07D417/14 , C07D491/04 , C07D491/048
CPC分类号： C07D401/04 , C07D401/14 , C07D417/14 , C07D491/04
摘要： The invention relates to new 4-quinolyl-dihydropyridine esters of the general formula (I) ##STR1## in which R.sub.1 to R.sub.6 have the meaning given in the description, to processes for their preparation and to their use in medicaments, especially in agents for the treatment of cardiac circulatory disorders.
摘要翻译： 本发明涉及通式（I）的新的4-喹啉基 - 二氢吡啶酯，其中R1至R6具有说明书中给出的含义，其制备方法及其在药物中的用途，特别是 用于治疗心脏循环障碍的药物。
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10.发明授权
公开(公告)号：US5504210A
公开(公告)日：1996-04-02
申请号：US230286
申请日：1994-04-20
申请人： Jurgen Stoltefuss , Siegfried Goldmann , Alexander Straub , Martin Bechem , Rainer Gross , Siegbert Hebisch , Joachim Hutter , Howard-Paul Rounding
发明人： Jurgen Stoltefuss , Siegfried Goldmann , Alexander Straub , Martin Bechem , Rainer Gross , Siegbert Hebisch , Joachim Hutter , Howard-Paul Rounding
IPC分类号： A61K31/47 , C07C47/06 , C07D215/20 , C07D215/36 , C07D215/48 , C07D401/04 , C07D401/14 , C07D491/04 , C07D491/048
CPC分类号： C07D401/04 , C07D401/14 , C07D491/04
摘要： The invention relates to new 3-quinolyl-substituted dihydropyridines, processes for their preparation and their use in medicaments, in particular in agents for the treatment of cardiovascular diseases.
摘要翻译： 本发明涉及新的3-喹啉基取代的二氢吡啶，其制备方法及其在药物中的用途，特别是用于治疗心血管疾病的药剂。
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