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    Antibiotic 107891, its factors A1 and A2, pharmaceutically acceptable salts and compositions, and use thereof
    3.
    发明申请
    Antibiotic 107891, its factors A1 and A2, pharmaceutically acceptable salts and compositions, and use thereof 有权
    抗生素107891，其因子A1和A2，药学上可接受的盐和组合物及其用途

    公开(公告)号：US20050203005A1

    公开(公告)日：2005-09-15

    申请号：US11035296

    申请日：2005-01-12

    申请人： Ameriga Lazzarini ,  Luciano Gastaldo ,  Gianpaolo Candiani ,  Ismaela Ciciliato ,  Daniele Losi ,  Flavia Marinelli ,  Enrico Selva ,  Franco Parenti

    发明人： Ameriga Lazzarini ,  Luciano Gastaldo ,  Gianpaolo Candiani ,  Ismaela Ciciliato ,  Daniele Losi ,  Flavia Marinelli ,  Enrico Selva ,  Franco Parenti

    IPC分类号： A61K38/12 ,  C07K7/64

    CPC分类号： C07K14/37 ,  A61K38/00

    摘要： The invention relates to an antibiotic substance of microbial origin, arbitrarily denominated antibiotic 107891 which is produced by fermentation of Microbispora sp. ATCC PTA-5024, the pharmaceutically acceptable salts and compositions thereof, and their use as an antibacterial agent having inhibitory activity versus susceptible microbes. Antibiotic 107891, which is a complex comprising two Factors, denominated Factors A1 and A2, has a peptide structure containing lanthionine and methyllanthionine as constituents which are typical characteristics of the antibiotics of the lantibiotics group. Antibiotic 107891 and its Factors A1 and A2 show a good antibacterial activity against Gram-positive bacteria including methicillin resistant and vancomycin resistant strains, and is active also against some Gram-negative bacteria such as M. catharralis, Neisseria species and H. influenzae and Mycobacteria.

    摘要翻译： 本发明涉及微生物来源的抗生素物质，其是通过微生物种的发酵产生的任意计数的抗生素107891。 ATCC PTA-5024，其药学上可接受的盐和组合物，以及它们作为对易感微生物具有抑制活性的抗菌剂的用途。 抗生素107891是包含两个因子A1和A2的因子的复合物，其具有含有羊毛硫氨酸和甲基青蒿素作为组分的肽结构，它们是羊毛硫抗生素组抗生素的典型特征。 抗生素107891及其因子A1和A2对抗革兰氏阳性菌（包括甲氧西林抗性和万古霉素抗性菌株）具有良好的抗菌活性，并且还对一些革兰氏阴性细菌（例如M.catharralis，奈瑟氏球菌和流感嗜血杆菌和分枝杆菌 。

    Antibiotic 107891, its factors A1 and A2, pharmaceutically acceptable salts and compositions, and use thereof
    4.
    发明授权
    Antibiotic 107891, its factors A1 and A2, pharmaceutically acceptable salts and compositions, and use thereof 有权
    抗生素107891，其因子A1和A2，药学上可接受的盐和组合物及其用途

    公开(公告)号：US07351687B2

    公开(公告)日：2008-04-01

    申请号：US11045628

    申请日：2005-01-26

    申请人： Ameriga Lazzarini ,  Luciano Gastaldo ,  Gianpaolo Candiani ,  Ismaela Ciciliato ,  Daniele Losi ,  Flavia Marinelli ,  Enrico Selva ,  Franco Parenti

    发明人： Ameriga Lazzarini ,  Luciano Gastaldo ,  Gianpaolo Candiani ,  Ismaela Ciciliato ,  Daniele Losi ,  Flavia Marinelli ,  Enrico Selva ,  Franco Parenti

    IPC分类号： A61K38/04

    CPC分类号： C12P21/02 ,  A61K38/00 ,  C07K14/001 ,  C07K14/195 ,  C12R1/01

    摘要： The invention relates to an antibiotic substance of microbial origin, arbitrarily denominated antibiotic 107891 which is produced by fermentation of Microbispora sp. ATCC PTA-5024, the pharmaceutically acceptable salts and compositions thereof, and their use as an antibacterial agent having inhibitory activity versus susceptible microbes. Antibiotic 107891, which is a complex comprising two Factors, denominated Factors A1 and A2, has a peptide structure containing lanthionine and methyllanthionine as constituents which are typical characteristics of the antibiotics of the lantibiotics group. Antibiotic 107891 and its Factors A1 and A2 show a good antibacterial activity against Gram-positive bacteria including methicillin resistant and vancomycin resistant strains, and is active also against some Gram-negative bacteria such as M. catharralis, Neisseria species and H. influenzae and Mycobacteria.

    摘要翻译： 本发明涉及微生物来源的抗生素物质，其是通过微生物种的发酵产生的任意计数的抗生素107891。 ATCC PTA-5024，其药学上可接受的盐和组合物，以及它们作为对易感微生物具有抑制活性的抗菌剂的用途。 抗生素107891是包含两个因子A1和A2的因子的复合物，其具有含有羊毛硫氨酸和甲基青蒿素作为组分的肽结构，它们是羊毛硫抗生素组抗生素的典型特征。 抗生素107891及其因子A1和A2对抗革兰氏阳性菌（包括甲氧西林抗性和万古霉素抗性菌株）具有良好的抗菌活性，并且还对一些革兰氏阴性细菌（例如M.catharralis，奈瑟氏球菌和流感嗜血杆菌和分枝杆菌 。

    Antibiotic 107891, its factors a1 and a2, pharmaceutically acceptable salts and compositions, and use thereof
    6.
    发明申请
    Antibiotic 107891, its factors a1 and a2, pharmaceutically acceptable salts and compositions, and use thereof 有权
    抗生素107891，其因子a1和a2，药学上可接受的盐和组合物及其用途

    公开(公告)号：US20060183673A1

    公开(公告)日：2006-08-17

    申请号：US10521336

    申请日：2004-07-12

    申请人： Ameriga Lazzarini ,  Luciano Gastaldo ,  Gianpaolo Candiani ,  Ismaela Ciciliato ,  Daniele Losi ,  Flavia Marinelli ,  Enrico Selva ,  Franco Parenti

    发明人： Ameriga Lazzarini ,  Luciano Gastaldo ,  Gianpaolo Candiani ,  Ismaela Ciciliato ,  Daniele Losi ,  Flavia Marinelli ,  Enrico Selva ,  Franco Parenti

    IPC分类号： A61K38/12 ,  C07K7/64

    CPC分类号： C12R1/01 ,  A23K20/195 ,  A61K38/00 ,  C07K14/37 ,  C12P1/06

    摘要： The invention relates to an antibiotic substance of microbial origin, arbitrarily denominated antibiotic 107891 which is produced by fermentation of Microbispora sp. ATCC PTA-5024, the pharmaceutically acceptable salts and compositions thereof, and their use as an antibacterial agent having inhibitory activity versus susceptible microbes. Antibiotic 107891, which is a complex comprising two Factors, denominated Factors A1 and A2, has a peptide structure containing lanthionine and methyllanthionine as constituents which are typical characteristics of the antibiotics of the lantibiotics group. Antibiotic 107891 and its Factors A1 and A2 show a good antibacterial activity against Gram-positive bacteria including methicillin resistant and vancomycin resistant strains, and is active also against some Gram-negative bacteria such as M. catharralis, Neisseria species and H. influenzae and Mycobacteria.

    摘要翻译： 本发明涉及微生物来源的抗生素物质，其是通过微生物种的发酵产生的任意计数的抗生素107891。 ATCC PTA-5024，其药学上可接受的盐和组合物，以及它们作为对易感微生物具有抑制活性的抗菌剂的用途。 抗生素107891是包含两个因子A1和A2的因子的复合物，其具有含有羊毛硫氨酸和甲基青蒿素作为组分的肽结构，它们是羊毛硫抗生素组抗生素的典型特征。 抗生素107891及其因子A1和A2对抗革兰氏阳性菌（包括甲氧西林抗性和万古霉素抗性菌株）具有良好的抗菌活性，并且还对一些革兰氏阴性细菌（例如M.catharralis，奈瑟氏球菌和流感嗜血杆菌和分枝杆菌 。