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公开(公告)号：US07709641B2
公开(公告)日：2010-05-04
申请号：US11172289
申请日：2005-06-30
申请人： Sapna S. Shah , Neng-Yang Shih , Anandan Palani , Xianhai Huang , Dong Xiao , Sunil Paliwal , Hon-Chung Tsui , Michelle Laci Wrobleski , Ashwin U. Rao , Cheng Wang
发明人： Sapna S. Shah , Neng-Yang Shih , Anandan Palani , Xianhai Huang , Dong Xiao , Sunil Paliwal , Hon-Chung Tsui , Michelle Laci Wrobleski , Ashwin U. Rao , Cheng Wang
IPC分类号： C07F7/02 , C07D215/12 , C07D215/16 , C07D213/02 , C07D211/02 , C07D405/00
CPC分类号： C07D401/04 , A61K31/4178 , A61K31/451 , A61K31/4523 , A61K31/454 , A61K31/4545 , A61K31/573 , A61K45/06 , C07D211/56 , C07D211/60 , C07D211/66 , C07D211/76 , C07D413/04 , C07D417/04 , C07D498/20
摘要： A compound having the general structure shown in Formula I: or pharmaceutically acceptable salts and/or solvates thereof are useful in treating diseases or conditions mediated by NK1 receptors, for example various physiological disorders, symptoms or diseases, including emesis, depression, anxiety and cough.
摘要翻译： 具有式I所示的一般结构的化合物或其药学上可接受的盐和/或溶剂合物可用于治疗由NK1受体介导的疾病或病症，例如各种生理疾病，症状或疾病，包括呕吐，抑郁，焦虑和咳嗽 。
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公开(公告)号：US20120295879A1
公开(公告)日：2012-11-22
申请号：US13245403
申请日：2011-09-26
申请人： Anandan Palani , Xianhai Huang , Dong Xiao , Sapna S. Shah , Sunil Paliwal , Hon-Chung Tsui , Michelle Laci Wrobleski , Ashwin U. Rao , Cheng Wang , Neng-Yang Shih
发明人： Anandan Palani , Xianhai Huang , Dong Xiao , Sapna S. Shah , Sunil Paliwal , Hon-Chung Tsui , Michelle Laci Wrobleski , Ashwin U. Rao , Cheng Wang , Neng-Yang Shih
IPC分类号： A61K31/454 , A61K31/4523 , A61K31/451 , A61P25/22 , A61K31/573 , A61P1/18 , A61P11/14 , A61P25/24 , A61K31/4545 , A61K31/56
CPC分类号： C07D401/04 , A61K31/4178 , A61K31/451 , A61K31/4523 , A61K31/454 , A61K31/4545 , A61K31/573 , A61K45/06 , C07D211/56 , C07D211/60 , C07D211/66 , C07D211/76 , C07D413/04 , C07D417/04 , C07D498/20
摘要： A compound having the general structure shown in Formula I: or pharmaceutically acceptable salts and/or solvates thereof are useful in treating diseases or conditions mediated by NK1 receptors, for example various physiological disorders, symptoms or diseases, including emesis, depression, anxiety and cough.
摘要翻译： 具有式I所示的一般结构的化合物或其药学上可接受的盐和/或溶剂合物可用于治疗由NK1受体介导的疾病或病症，例如各种生理疾病，症状或疾病，包括呕吐，抑郁，焦虑和咳嗽 。
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公开(公告)号：US08026364B2
公开(公告)日：2011-09-27
申请号：US12750420
申请日：2010-03-30
申请人： Sapna S. Shah , Anandan Palani , Xianhai Huang , Dong Xiao , Sunil Paliwal , Hon-Chung Tsui , Michelle Laci Wrobleski , Ashwin U. Rao , Cheng Wang , Neng-Yang Shih
发明人： Sapna S. Shah , Anandan Palani , Xianhai Huang , Dong Xiao , Sunil Paliwal , Hon-Chung Tsui , Michelle Laci Wrobleski , Ashwin U. Rao , Cheng Wang , Neng-Yang Shih
IPC分类号： C07F7/02 , C07D215/12 , C07D215/16 , C07D213/02 , C07D211/02 , C07D405/00
CPC分类号： C07D401/04 , A61K31/4178 , A61K31/451 , A61K31/4523 , A61K31/454 , A61K31/4545 , A61K31/573 , A61K45/06 , C07D211/56 , C07D211/60 , C07D211/66 , C07D211/76 , C07D413/04 , C07D417/04 , C07D498/20
摘要： A compound having the general structure shown in Formula I: or pharmaceutically acceptable salt and/or solvates thereof are useful in treating diseases or conditions mediated by NK1 receptors, for example various physiological disorders, symptoms or diseases, including emesis, depression, anxiety and cough.
摘要翻译： 具有式I所示的一般结构的化合物或其药学上可接受的盐和/或溶剂合物可用于治疗由NK1受体介导的疾病或病症，例如各种生理疾病，症状或疾病，包括呕吐，抑郁，焦虑和咳嗽 。
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公开(公告)号：US08754216B2
公开(公告)日：2014-06-17
申请号：US13245403
申请日：2011-09-26
申请人： Sapna S. Shah , Anandan Palani , Xianhai Huang , Dong Xiao , Sunil Paliwal , Hon-Chung Tsui , Michelle Laci Wrobleski , Ashwin U. Rao , Cheng Wang , Neng-Yang Shih
发明人： Sapna S. Shah , Anandan Palani , Xianhai Huang , Dong Xiao , Sunil Paliwal , Hon-Chung Tsui , Michelle Laci Wrobleski , Ashwin U. Rao , Cheng Wang , Neng-Yang Shih
IPC分类号： C07F7/02 , C07D215/12 , C07D215/16 , C07D213/02 , C07D405/00
CPC分类号： C07D401/04 , A61K31/4178 , A61K31/451 , A61K31/4523 , A61K31/454 , A61K31/4545 , A61K31/573 , A61K45/06 , C07D211/56 , C07D211/60 , C07D211/66 , C07D211/76 , C07D413/04 , C07D417/04 , C07D498/20
摘要： A compound having the general structure shown in Formula I: or pharmaceutically acceptable salts and/or solvates thereof are useful in treating diseases or conditions mediated by NK1 receptors, for example various physiological disorders, symptoms or diseases, including emesis, depression, anxiety and cough.
摘要翻译： 具有式I所示的一般结构的化合物或其药学上可接受的盐和/或溶剂合物可用于治疗由NK1受体介导的疾病或病症，例如各种生理疾病，症状或疾病，包括呕吐，抑郁，焦虑和咳嗽 。
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公开(公告)号：US07354922B2
公开(公告)日：2008-04-08
申请号：US11291363
申请日：2005-12-01
申请人： Dong Xiao , Anandan Palani , Cheng Wang , Hon-Chung Tsui , Xianhai Huang , Sapna S. Shah , Ashwin U. Rao , Xiao Chen , Sunil Paliwal , Neng-Yang Shih
发明人： Dong Xiao , Anandan Palani , Cheng Wang , Hon-Chung Tsui , Xianhai Huang , Sapna S. Shah , Ashwin U. Rao , Xiao Chen , Sunil Paliwal , Neng-Yang Shih
IPC分类号： A01N43/58 , A01N43/60 , C07D245/00 , C07D241/36 , C07D471/00
CPC分类号： C07D471/08
摘要： A compound having the general structure shown in Formula (I): or pharmaceutically acceptable salts and/or solvates thereof are useful in treating diseases or conditions mediated by NK1 receptors, for example various physiological disorders, symptoms or diseases, including emesis, depression, anxiety and cough.
摘要翻译： 具有式（I）所示的一般结构的化合物或其药学上可接受的盐和/或溶剂化物可用于治疗由NK 1受体介导的疾病或病症，例如各种生理紊乱，症状或 疾病包括呕吐，抑郁，焦虑和咳嗽。
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公开(公告)号：US20060258665A1
公开(公告)日：2006-11-16
申请号：US11291363
申请日：2005-12-01
申请人： Dong Xiao , Anandan Palani , Cheng Wang , Hon-Chung Tsui , Xianhai Huang , Sapna Shah , Ashwin Rao , Xiao Chen , Sunil Paliwal , Neng-Yang Shih
发明人： Dong Xiao , Anandan Palani , Cheng Wang , Hon-Chung Tsui , Xianhai Huang , Sapna Shah , Ashwin Rao , Xiao Chen , Sunil Paliwal , Neng-Yang Shih
IPC分类号： A61K31/498 , C07D487/04
CPC分类号： C07D471/08
摘要： A compound having the general structure shown in Formula (I): or pharmaceutically acceptable salts and/or solvates thereof are useful in treating diseases or conditions mediated by NK1 receptors, for example various physiological disorders, symptoms or diseases, including emesis, depression, anxiety and cough.
摘要翻译： 具有式（I）所示的一般结构的化合物或其药学上可接受的盐和/或溶剂化物可用于治疗由NK 1受体介导的疾病或病症，例如各种生理紊乱，症状或 疾病包括呕吐，抑郁，焦虑和咳嗽。
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公开(公告)号：US20060223804A1
公开(公告)日：2006-10-05
申请号：US11172289
申请日：2005-06-30
申请人： Sapna Shah , Neng-Yang Shih , Anandan Palani , Xianhai Huang , Dong Xiao , Sunil Paliwal , Hon-Chung Tsui , Michelle Wrobleski , Ashwin Rao , Cheng Wang
发明人： Sapna Shah , Neng-Yang Shih , Anandan Palani , Xianhai Huang , Dong Xiao , Sunil Paliwal , Hon-Chung Tsui , Michelle Wrobleski , Ashwin Rao , Cheng Wang
IPC分类号： A61K31/53 , A61K31/454 , C07D413/02 , C07D403/02
CPC分类号： C07D401/04 , A61K31/4178 , A61K31/451 , A61K31/4523 , A61K31/454 , A61K31/4545 , A61K31/573 , A61K45/06 , C07D211/56 , C07D211/60 , C07D211/66 , C07D211/76 , C07D413/04 , C07D417/04 , C07D498/20
摘要： A compound having the general structure shown in Formula I: or pharmaceutically acceptable salts and/or solvates thereof are useful in treating diseases or conditions mediated by NK1 receptors, for example various physiological disorders, symptoms or diseases, including emesis, depression, anxiety and cough.
摘要翻译： 具有式I所示的一般结构的化合物或其药学上可接受的盐和/或溶剂合物可用于治疗由NK 1受体介导的疾病或病症，例如各种生理疾病，症状或疾病， 包括呕吐，抑郁，焦虑和咳嗽。
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公开(公告)号：US07750015B2
公开(公告)日：2010-07-06
申请号：US11600216
申请日：2006-11-15
申请人： Anandan Palani , Dong Xiao , Xianhai Huang , Ashwin U. Rao , Xiao Chen , Jun Qin , Ying R. Huang , Robert G. Aslanian , Sylvia J. Degrado
发明人： Anandan Palani , Dong Xiao , Xianhai Huang , Ashwin U. Rao , Xiao Chen , Jun Qin , Ying R. Huang , Robert G. Aslanian , Sylvia J. Degrado
IPC分类号： C07D491/052 , A61K31/519 , A61P9/00 , A61P25/00 , A61P35/00 , A61P29/00 , A61P11/00 , A61P1/00 , A61P3/10
CPC分类号： C07D491/052
摘要： The present invention provides compounds of Formula (I): and pharmaceutically acceptable salts, solvates, esters, and tautomers thereof, wherein: Q is selected from the group consisting of: L is selected from the group consisting of: pharmaceutically compositions comprising one or more compounds of formula (I), and methods of using the compounds of formula (I).
摘要翻译： 本发明提供式（I）化合物及其药学上可接受的盐，溶剂合物，酯和互变异构体，其中：Q选自：L选自：包含一种或多种 式（I）化合物和使用式（I）化合物的方法。
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公开(公告)号：US20100227873A1
公开(公告)日：2010-09-09
申请号：US12770931
申请日：2010-04-30
申请人： Anandan Palani , Jing Su , Dong Xiao , Xianhai Huang , Ashwin U. Rao , Xiao Chen , Haiqun Tang , Jun Qin , Ying R. Huang , Robert G. Aslanian , Brian A. McKittrick , Syliva J. Degrado
发明人： Anandan Palani , Jing Su , Dong Xiao , Xianhai Huang , Ashwin U. Rao , Xiao Chen , Haiqun Tang , Jun Qin , Ying R. Huang , Robert G. Aslanian , Brian A. McKittrick , Syliva J. Degrado
IPC分类号： A61K31/519 , C07D491/052 , A61P9/00 , A61P25/00 , A61P35/00 , A61P29/00 , A61P11/00 , A61P1/00 , A61P3/10 , A61P7/00
CPC分类号： C07D491/04 , C07D471/04
摘要： The present invention provides compounds of Formula (I): and pharmaceutically acceptable salts, solvates, esters, and tautomers thereof, wherein: Q is selected from the group consisting of: and L is selected from the group consisting of: pharmaceutically compositions comprising one or more compounds of formula (I), and methods of using the compounds of formula (I).
摘要翻译： 本发明提供式（I）的化合物及其药学上可接受的盐，溶剂合物，酯和互变异构体，其中：Q选自：和L选自：药物组合物，其包含一种或多种 更多的式（I）化合物和使用式（I）化合物的方法。
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公开(公告)号：US20110152259A1
公开(公告)日：2011-06-23
申请号：US13033895
申请日：2011-02-24
申请人： Anandan Palani , Jing Su , Dong Xiao , Xianhai Huang , Ashwin U. Rao , Xiao Chen , Haiqun Tang , Jun Qin , Ying R. Huang , Robert G. Aslanian , Brain A. McKittrick , Syliva J. Degrado
发明人： Anandan Palani , Jing Su , Dong Xiao , Xianhai Huang , Ashwin U. Rao , Xiao Chen , Haiqun Tang , Jun Qin , Ying R. Huang , Robert G. Aslanian , Brain A. McKittrick , Syliva J. Degrado
IPC分类号： A61K31/5377 , C07D491/052 , A61K31/519 , C07D413/14 , A61P3/00 , A61P7/00 , A61P35/00 , A61P11/00
CPC分类号： C07D491/04 , C07D471/04
摘要： The present invention provides compounds of Formula (I): and pharmaceutically acceptable salts, solvates, esters, and tautomers thereof, wherein: Q is selected from the group consisting of: and L is selected from the group consisting of: pharmaceutically compositions comprising one or more compounds of formula (I), and methods of using the compounds of formula (I).
摘要翻译： 本发明提供式（I）的化合物及其药学上可接受的盐，溶剂合物，酯和互变异构体，其中：Q选自：和L选自：药物组合物，其包含一种或多种 更多的式（I）化合物和使用式（I）化合物的方法。
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