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公开(公告)号：US07709641B2
公开(公告)日：2010-05-04
申请号：US11172289
申请日：2005-06-30
申请人： Sapna S. Shah , Neng-Yang Shih , Anandan Palani , Xianhai Huang , Dong Xiao , Sunil Paliwal , Hon-Chung Tsui , Michelle Laci Wrobleski , Ashwin U. Rao , Cheng Wang
发明人： Sapna S. Shah , Neng-Yang Shih , Anandan Palani , Xianhai Huang , Dong Xiao , Sunil Paliwal , Hon-Chung Tsui , Michelle Laci Wrobleski , Ashwin U. Rao , Cheng Wang
IPC分类号： C07F7/02 , C07D215/12 , C07D215/16 , C07D213/02 , C07D211/02 , C07D405/00
CPC分类号： C07D401/04 , A61K31/4178 , A61K31/451 , A61K31/4523 , A61K31/454 , A61K31/4545 , A61K31/573 , A61K45/06 , C07D211/56 , C07D211/60 , C07D211/66 , C07D211/76 , C07D413/04 , C07D417/04 , C07D498/20
摘要： A compound having the general structure shown in Formula I: or pharmaceutically acceptable salts and/or solvates thereof are useful in treating diseases or conditions mediated by NK1 receptors, for example various physiological disorders, symptoms or diseases, including emesis, depression, anxiety and cough.
摘要翻译： 具有式I所示的一般结构的化合物或其药学上可接受的盐和/或溶剂合物可用于治疗由NK1受体介导的疾病或病症，例如各种生理疾病，症状或疾病，包括呕吐，抑郁，焦虑和咳嗽 。
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公开(公告)号：US20120295879A1
公开(公告)日：2012-11-22
申请号：US13245403
申请日：2011-09-26
申请人： Anandan Palani , Xianhai Huang , Dong Xiao , Sapna S. Shah , Sunil Paliwal , Hon-Chung Tsui , Michelle Laci Wrobleski , Ashwin U. Rao , Cheng Wang , Neng-Yang Shih
发明人： Anandan Palani , Xianhai Huang , Dong Xiao , Sapna S. Shah , Sunil Paliwal , Hon-Chung Tsui , Michelle Laci Wrobleski , Ashwin U. Rao , Cheng Wang , Neng-Yang Shih
IPC分类号： A61K31/454 , A61K31/4523 , A61K31/451 , A61P25/22 , A61K31/573 , A61P1/18 , A61P11/14 , A61P25/24 , A61K31/4545 , A61K31/56
CPC分类号： C07D401/04 , A61K31/4178 , A61K31/451 , A61K31/4523 , A61K31/454 , A61K31/4545 , A61K31/573 , A61K45/06 , C07D211/56 , C07D211/60 , C07D211/66 , C07D211/76 , C07D413/04 , C07D417/04 , C07D498/20
摘要： A compound having the general structure shown in Formula I: or pharmaceutically acceptable salts and/or solvates thereof are useful in treating diseases or conditions mediated by NK1 receptors, for example various physiological disorders, symptoms or diseases, including emesis, depression, anxiety and cough.
摘要翻译： 具有式I所示的一般结构的化合物或其药学上可接受的盐和/或溶剂合物可用于治疗由NK1受体介导的疾病或病症，例如各种生理疾病，症状或疾病，包括呕吐，抑郁，焦虑和咳嗽 。
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公开(公告)号：US08026364B2
公开(公告)日：2011-09-27
申请号：US12750420
申请日：2010-03-30
申请人： Sapna S. Shah , Anandan Palani , Xianhai Huang , Dong Xiao , Sunil Paliwal , Hon-Chung Tsui , Michelle Laci Wrobleski , Ashwin U. Rao , Cheng Wang , Neng-Yang Shih
发明人： Sapna S. Shah , Anandan Palani , Xianhai Huang , Dong Xiao , Sunil Paliwal , Hon-Chung Tsui , Michelle Laci Wrobleski , Ashwin U. Rao , Cheng Wang , Neng-Yang Shih
IPC分类号： C07F7/02 , C07D215/12 , C07D215/16 , C07D213/02 , C07D211/02 , C07D405/00
CPC分类号： C07D401/04 , A61K31/4178 , A61K31/451 , A61K31/4523 , A61K31/454 , A61K31/4545 , A61K31/573 , A61K45/06 , C07D211/56 , C07D211/60 , C07D211/66 , C07D211/76 , C07D413/04 , C07D417/04 , C07D498/20
摘要： A compound having the general structure shown in Formula I: or pharmaceutically acceptable salt and/or solvates thereof are useful in treating diseases or conditions mediated by NK1 receptors, for example various physiological disorders, symptoms or diseases, including emesis, depression, anxiety and cough.
摘要翻译： 具有式I所示的一般结构的化合物或其药学上可接受的盐和/或溶剂合物可用于治疗由NK1受体介导的疾病或病症，例如各种生理疾病，症状或疾病，包括呕吐，抑郁，焦虑和咳嗽 。
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公开(公告)号：US08754216B2
公开(公告)日：2014-06-17
申请号：US13245403
申请日：2011-09-26
申请人： Sapna S. Shah , Anandan Palani , Xianhai Huang , Dong Xiao , Sunil Paliwal , Hon-Chung Tsui , Michelle Laci Wrobleski , Ashwin U. Rao , Cheng Wang , Neng-Yang Shih
发明人： Sapna S. Shah , Anandan Palani , Xianhai Huang , Dong Xiao , Sunil Paliwal , Hon-Chung Tsui , Michelle Laci Wrobleski , Ashwin U. Rao , Cheng Wang , Neng-Yang Shih
IPC分类号： C07F7/02 , C07D215/12 , C07D215/16 , C07D213/02 , C07D405/00
CPC分类号： C07D401/04 , A61K31/4178 , A61K31/451 , A61K31/4523 , A61K31/454 , A61K31/4545 , A61K31/573 , A61K45/06 , C07D211/56 , C07D211/60 , C07D211/66 , C07D211/76 , C07D413/04 , C07D417/04 , C07D498/20
摘要： A compound having the general structure shown in Formula I: or pharmaceutically acceptable salts and/or solvates thereof are useful in treating diseases or conditions mediated by NK1 receptors, for example various physiological disorders, symptoms or diseases, including emesis, depression, anxiety and cough.
摘要翻译： 具有式I所示的一般结构的化合物或其药学上可接受的盐和/或溶剂合物可用于治疗由NK1受体介导的疾病或病症，例如各种生理疾病，症状或疾病，包括呕吐，抑郁，焦虑和咳嗽 。
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公开(公告)号：US07354922B2
公开(公告)日：2008-04-08
申请号：US11291363
申请日：2005-12-01
申请人： Dong Xiao , Anandan Palani , Cheng Wang , Hon-Chung Tsui , Xianhai Huang , Sapna S. Shah , Ashwin U. Rao , Xiao Chen , Sunil Paliwal , Neng-Yang Shih
发明人： Dong Xiao , Anandan Palani , Cheng Wang , Hon-Chung Tsui , Xianhai Huang , Sapna S. Shah , Ashwin U. Rao , Xiao Chen , Sunil Paliwal , Neng-Yang Shih
IPC分类号： A01N43/58 , A01N43/60 , C07D245/00 , C07D241/36 , C07D471/00
CPC分类号： C07D471/08
摘要： A compound having the general structure shown in Formula (I): or pharmaceutically acceptable salts and/or solvates thereof are useful in treating diseases or conditions mediated by NK1 receptors, for example various physiological disorders, symptoms or diseases, including emesis, depression, anxiety and cough.
摘要翻译： 具有式（I）所示的一般结构的化合物或其药学上可接受的盐和/或溶剂化物可用于治疗由NK 1受体介导的疾病或病症，例如各种生理紊乱，症状或 疾病包括呕吐，抑郁，焦虑和咳嗽。
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公开(公告)号：US07750015B2
公开(公告)日：2010-07-06
申请号：US11600216
申请日：2006-11-15
申请人： Anandan Palani , Dong Xiao , Xianhai Huang , Ashwin U. Rao , Xiao Chen , Jun Qin , Ying R. Huang , Robert G. Aslanian , Sylvia J. Degrado
发明人： Anandan Palani , Dong Xiao , Xianhai Huang , Ashwin U. Rao , Xiao Chen , Jun Qin , Ying R. Huang , Robert G. Aslanian , Sylvia J. Degrado
IPC分类号： C07D491/052 , A61K31/519 , A61P9/00 , A61P25/00 , A61P35/00 , A61P29/00 , A61P11/00 , A61P1/00 , A61P3/10
CPC分类号： C07D491/052
摘要： The present invention provides compounds of Formula (I): and pharmaceutically acceptable salts, solvates, esters, and tautomers thereof, wherein: Q is selected from the group consisting of: L is selected from the group consisting of: pharmaceutically compositions comprising one or more compounds of formula (I), and methods of using the compounds of formula (I).
摘要翻译： 本发明提供式（I）化合物及其药学上可接受的盐，溶剂合物，酯和互变异构体，其中：Q选自：L选自：包含一种或多种 式（I）化合物和使用式（I）化合物的方法。
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公开(公告)号：US20110152259A1
公开(公告)日：2011-06-23
申请号：US13033895
申请日：2011-02-24
申请人： Anandan Palani , Jing Su , Dong Xiao , Xianhai Huang , Ashwin U. Rao , Xiao Chen , Haiqun Tang , Jun Qin , Ying R. Huang , Robert G. Aslanian , Brain A. McKittrick , Syliva J. Degrado
发明人： Anandan Palani , Jing Su , Dong Xiao , Xianhai Huang , Ashwin U. Rao , Xiao Chen , Haiqun Tang , Jun Qin , Ying R. Huang , Robert G. Aslanian , Brain A. McKittrick , Syliva J. Degrado
IPC分类号： A61K31/5377 , C07D491/052 , A61K31/519 , C07D413/14 , A61P3/00 , A61P7/00 , A61P35/00 , A61P11/00
CPC分类号： C07D491/04 , C07D471/04
摘要： The present invention provides compounds of Formula (I): and pharmaceutically acceptable salts, solvates, esters, and tautomers thereof, wherein: Q is selected from the group consisting of: and L is selected from the group consisting of: pharmaceutically compositions comprising one or more compounds of formula (I), and methods of using the compounds of formula (I).
摘要翻译： 本发明提供式（I）的化合物及其药学上可接受的盐，溶剂合物，酯和互变异构体，其中：Q选自：和L选自：药物组合物，其包含一种或多种 更多的式（I）化合物和使用式（I）化合物的方法。
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公开(公告)号：US07737155B2
公开(公告)日：2010-06-15
申请号：US11771538
申请日：2007-06-29
申请人： Anandan Palani , Dong Xiao , Xianhai Huang , Ashwin U. Rao , Xiao Chen , Jun Qin , Ying R. Huang , Robert G. Aslanian
发明人： Anandan Palani , Dong Xiao , Xianhai Huang , Ashwin U. Rao , Xiao Chen , Jun Qin , Ying R. Huang , Robert G. Aslanian
IPC分类号： C07D491/052 , A61K31/519 , A61P9/00 , A61P25/00 , A61P33/00 , A61P29/00 , A61P1/00 , A61P3/10
CPC分类号： C07D491/04 , C07D471/04
摘要： The present invention provides compounds of Formula (I): and pharmaceutically acceptable salts, solvates, esters, and tautomers thereof, wherein: Q is selected from the group consisting of: and L is selected from the group consisting of: pharmaceutically compositions comprising one or more compounds of formula (I), and methods of using the compounds of formula (I).
摘要翻译： 本发明提供式（I）的化合物及其药学上可接受的盐，溶剂合物，酯和互变异构体，其中：Q选自：和L选自：药物组合物，其包含一种或多种 更多的式（I）化合物和使用式（I）化合物的方法。
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公开(公告)号：US20100227873A1
公开(公告)日：2010-09-09
申请号：US12770931
申请日：2010-04-30
申请人： Anandan Palani , Jing Su , Dong Xiao , Xianhai Huang , Ashwin U. Rao , Xiao Chen , Haiqun Tang , Jun Qin , Ying R. Huang , Robert G. Aslanian , Brian A. McKittrick , Syliva J. Degrado
发明人： Anandan Palani , Jing Su , Dong Xiao , Xianhai Huang , Ashwin U. Rao , Xiao Chen , Haiqun Tang , Jun Qin , Ying R. Huang , Robert G. Aslanian , Brian A. McKittrick , Syliva J. Degrado
IPC分类号： A61K31/519 , C07D491/052 , A61P9/00 , A61P25/00 , A61P35/00 , A61P29/00 , A61P11/00 , A61P1/00 , A61P3/10 , A61P7/00
CPC分类号： C07D491/04 , C07D471/04
摘要： The present invention provides compounds of Formula (I): and pharmaceutically acceptable salts, solvates, esters, and tautomers thereof, wherein: Q is selected from the group consisting of: and L is selected from the group consisting of: pharmaceutically compositions comprising one or more compounds of formula (I), and methods of using the compounds of formula (I).
摘要翻译： 本发明提供式（I）的化合物及其药学上可接受的盐，溶剂合物，酯和互变异构体，其中：Q选自：和L选自：药物组合物，其包含一种或多种 更多的式（I）化合物和使用式（I）化合物的方法。
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公开(公告)号：US08927559B2
公开(公告)日：2015-01-06
申请号：US13878654
申请日：2011-10-06
申请人： Robert G. Aslanian , Christopher W. Boyce , Robert D. Mazzola, Jr. , Brian A. McKittrick , Kevin D. McCormick , Anandan Palani , Jun Qin , Haiqun Tang , Dong Xiao , Younong Yu , John P. Caldwell , Elizabeth Helen Kelley , Hongjun Zhang , Phieng Siliphaivanh , Rachel N. MacCoss , Joey L. Methot , Jolicia Polivina Gauuan , Qin Jiang , Andrew J. Leyhane , Purakkattle Johny Biju , Li Dong , Xianhai Huang , Ning Shao , Wei Zhou , Pawan K. Dhondi , Ashwin U. Rao
发明人： Robert G. Aslanian , Christopher W. Boyce , Robert D. Mazzola, Jr. , Brian A. McKittrick , Kevin D. McCormick , Anandan Palani , Jun Qin , Haiqun Tang , Dong Xiao , Younong Yu , John P. Caldwell , Elizabeth Helen Kelley , Hongjun Zhang , Phieng Siliphaivanh , Rachel N. MacCoss , Joey L. Methot , Jolicia Polivina Gauuan , Qin Jiang , Andrew J. Leyhane , Purakkattle Johny Biju , Li Dong , Xianhai Huang , Ning Shao , Wei Zhou , Pawan K. Dhondi , Ashwin U. Rao
IPC分类号： A01N43/54 , A61K31/517 , C07D239/72 , C07D401/00
CPC分类号： C07D239/91 , A61K31/517 , A61K31/5395 , A61K31/55 , A61K45/06 , C07D401/10 , C07D401/14 , C07D403/04 , C07D403/10 , C07D403/14 , C07D405/10 , C07D413/04 , C07D413/10 , C07D413/14 , C07D417/04 , C07D417/10 , C07D471/04 , C07D498/10
摘要： This application provides for compounds of the formula Formula I or a pharmaceutically acceptable salt thereof, wherein the individual variables are defined herein, as well as processes to prepare these compounds, pharmaceutical compositions comprising the same and their use in treating disease state associated with the CRTH2 receptor.
摘要翻译： 本申请提供式I化合物或其药学上可接受的盐，其中各个变量在本文中定义，以及制备这些化合物的方法，包含其的药物组合物及其用于治疗与CRTH2相关的疾病状态 受体。
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