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公开(公告)号：US07709641B2
公开(公告)日：2010-05-04
申请号：US11172289
申请日：2005-06-30
申请人： Sapna S. Shah , Neng-Yang Shih , Anandan Palani , Xianhai Huang , Dong Xiao , Sunil Paliwal , Hon-Chung Tsui , Michelle Laci Wrobleski , Ashwin U. Rao , Cheng Wang
发明人： Sapna S. Shah , Neng-Yang Shih , Anandan Palani , Xianhai Huang , Dong Xiao , Sunil Paliwal , Hon-Chung Tsui , Michelle Laci Wrobleski , Ashwin U. Rao , Cheng Wang
IPC分类号： C07F7/02 , C07D215/12 , C07D215/16 , C07D213/02 , C07D211/02 , C07D405/00
CPC分类号： C07D401/04 , A61K31/4178 , A61K31/451 , A61K31/4523 , A61K31/454 , A61K31/4545 , A61K31/573 , A61K45/06 , C07D211/56 , C07D211/60 , C07D211/66 , C07D211/76 , C07D413/04 , C07D417/04 , C07D498/20
摘要： A compound having the general structure shown in Formula I: or pharmaceutically acceptable salts and/or solvates thereof are useful in treating diseases or conditions mediated by NK1 receptors, for example various physiological disorders, symptoms or diseases, including emesis, depression, anxiety and cough.
摘要翻译： 具有式I所示的一般结构的化合物或其药学上可接受的盐和/或溶剂合物可用于治疗由NK1受体介导的疾病或病症，例如各种生理疾病，症状或疾病，包括呕吐，抑郁，焦虑和咳嗽 。
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公开(公告)号：US20120295879A1
公开(公告)日：2012-11-22
申请号：US13245403
申请日：2011-09-26
申请人： Anandan Palani , Xianhai Huang , Dong Xiao , Sapna S. Shah , Sunil Paliwal , Hon-Chung Tsui , Michelle Laci Wrobleski , Ashwin U. Rao , Cheng Wang , Neng-Yang Shih
发明人： Anandan Palani , Xianhai Huang , Dong Xiao , Sapna S. Shah , Sunil Paliwal , Hon-Chung Tsui , Michelle Laci Wrobleski , Ashwin U. Rao , Cheng Wang , Neng-Yang Shih
IPC分类号： A61K31/454 , A61K31/4523 , A61K31/451 , A61P25/22 , A61K31/573 , A61P1/18 , A61P11/14 , A61P25/24 , A61K31/4545 , A61K31/56
CPC分类号： C07D401/04 , A61K31/4178 , A61K31/451 , A61K31/4523 , A61K31/454 , A61K31/4545 , A61K31/573 , A61K45/06 , C07D211/56 , C07D211/60 , C07D211/66 , C07D211/76 , C07D413/04 , C07D417/04 , C07D498/20
摘要： A compound having the general structure shown in Formula I: or pharmaceutically acceptable salts and/or solvates thereof are useful in treating diseases or conditions mediated by NK1 receptors, for example various physiological disorders, symptoms or diseases, including emesis, depression, anxiety and cough.
摘要翻译： 具有式I所示的一般结构的化合物或其药学上可接受的盐和/或溶剂合物可用于治疗由NK1受体介导的疾病或病症，例如各种生理疾病，症状或疾病，包括呕吐，抑郁，焦虑和咳嗽 。
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公开(公告)号：US08026364B2
公开(公告)日：2011-09-27
申请号：US12750420
申请日：2010-03-30
申请人： Sapna S. Shah , Anandan Palani , Xianhai Huang , Dong Xiao , Sunil Paliwal , Hon-Chung Tsui , Michelle Laci Wrobleski , Ashwin U. Rao , Cheng Wang , Neng-Yang Shih
发明人： Sapna S. Shah , Anandan Palani , Xianhai Huang , Dong Xiao , Sunil Paliwal , Hon-Chung Tsui , Michelle Laci Wrobleski , Ashwin U. Rao , Cheng Wang , Neng-Yang Shih
IPC分类号： C07F7/02 , C07D215/12 , C07D215/16 , C07D213/02 , C07D211/02 , C07D405/00
CPC分类号： C07D401/04 , A61K31/4178 , A61K31/451 , A61K31/4523 , A61K31/454 , A61K31/4545 , A61K31/573 , A61K45/06 , C07D211/56 , C07D211/60 , C07D211/66 , C07D211/76 , C07D413/04 , C07D417/04 , C07D498/20
摘要： A compound having the general structure shown in Formula I: or pharmaceutically acceptable salt and/or solvates thereof are useful in treating diseases or conditions mediated by NK1 receptors, for example various physiological disorders, symptoms or diseases, including emesis, depression, anxiety and cough.
摘要翻译： 具有式I所示的一般结构的化合物或其药学上可接受的盐和/或溶剂合物可用于治疗由NK1受体介导的疾病或病症，例如各种生理疾病，症状或疾病，包括呕吐，抑郁，焦虑和咳嗽 。
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公开(公告)号：US08754216B2
公开(公告)日：2014-06-17
申请号：US13245403
申请日：2011-09-26
申请人： Sapna S. Shah , Anandan Palani , Xianhai Huang , Dong Xiao , Sunil Paliwal , Hon-Chung Tsui , Michelle Laci Wrobleski , Ashwin U. Rao , Cheng Wang , Neng-Yang Shih
发明人： Sapna S. Shah , Anandan Palani , Xianhai Huang , Dong Xiao , Sunil Paliwal , Hon-Chung Tsui , Michelle Laci Wrobleski , Ashwin U. Rao , Cheng Wang , Neng-Yang Shih
IPC分类号： C07F7/02 , C07D215/12 , C07D215/16 , C07D213/02 , C07D405/00
CPC分类号： C07D401/04 , A61K31/4178 , A61K31/451 , A61K31/4523 , A61K31/454 , A61K31/4545 , A61K31/573 , A61K45/06 , C07D211/56 , C07D211/60 , C07D211/66 , C07D211/76 , C07D413/04 , C07D417/04 , C07D498/20
摘要： A compound having the general structure shown in Formula I: or pharmaceutically acceptable salts and/or solvates thereof are useful in treating diseases or conditions mediated by NK1 receptors, for example various physiological disorders, symptoms or diseases, including emesis, depression, anxiety and cough.
摘要翻译： 具有式I所示的一般结构的化合物或其药学上可接受的盐和/或溶剂合物可用于治疗由NK1受体介导的疾病或病症，例如各种生理疾病，症状或疾病，包括呕吐，抑郁，焦虑和咳嗽 。
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公开(公告)号：US08273895B2
公开(公告)日：2012-09-25
申请号：US12967132
申请日：2010-12-14
申请人： Sunil Paliwal , Gregory A. Reichard , Cheng Wang , Dong Xiao , Hon-Chung Tsui , Neng-Yang Shih , Juan D. Arredondo , Michelle Laci Wrobleski , Anandan Palani
发明人： Sunil Paliwal , Gregory A. Reichard , Cheng Wang , Dong Xiao , Hon-Chung Tsui , Neng-Yang Shih , Juan D. Arredondo , Michelle Laci Wrobleski , Anandan Palani
IPC分类号： C07D211/20 , C07D207/12 , A61K31/45 , A61K31/451
CPC分类号： C07D498/10 , A61K31/166 , A61K31/40 , A61K31/4025 , A61K31/437 , A61K31/4375 , A61K31/438 , A61K31/451 , A61K31/454 , A61K31/4545 , A61K31/537 , A61K31/5377 , A61K31/573 , A61K45/06 , C07D207/14 , C07D207/50 , C07D211/28 , C07D211/32 , C07D211/42 , C07D211/56 , C07D211/60 , C07D211/72 , C07D211/76 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D413/10 , C07D413/12 , C07D471/10 , C07D487/10 , C07D491/10 , C07D513/10
摘要： A NK1 antagonist having the formula (I), wherein Ar1 and Ar2 are optionally substituted phenyl or heteroaryl, X1 is an ether, thio or imino linkage, R4 and R5 are not both H or alkyl, and the remaining variables are as defined in the specification, useful for treating a number of disorders, including emesis, depression, anxiety and cough. Pharmaceutical compositions. Methods of treatment and combinations with other agents are also disclosed.
摘要翻译： 具有式（I）的NK1拮抗剂，其中Ar1和Ar2是任选取代的苯基或杂芳基，X1是醚，硫代或亚氨基键，R4和R5不都是H或烷基，其余的变量如 规范，用于治疗许多疾病，包括呕吐，抑郁，焦虑和咳嗽。 药物组合物。 还公开了治疗方法和与其它药剂的组合。
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公开(公告)号：US07902366B2
公开(公告)日：2011-03-08
申请号：US11358827
申请日：2006-02-21
申请人： Sunil Paliwal , Gregory A. Reichard , Cheng Wang , Dong Xiao , Hon-Chung Tsui , Neng-Yang Shih , Juan D. Arredondo , Michelle Laci Wrobleski , Anandan Palani
发明人： Sunil Paliwal , Gregory A. Reichard , Cheng Wang , Dong Xiao , Hon-Chung Tsui , Neng-Yang Shih , Juan D. Arredondo , Michelle Laci Wrobleski , Anandan Palani
IPC分类号： A61K31/445 , C07D211/12
CPC分类号： C07D498/10 , A61K31/166 , A61K31/40 , A61K31/4025 , A61K31/437 , A61K31/4375 , A61K31/438 , A61K31/451 , A61K31/454 , A61K31/4545 , A61K31/537 , A61K31/5377 , A61K31/573 , A61K45/06 , C07D207/14 , C07D207/50 , C07D211/28 , C07D211/32 , C07D211/42 , C07D211/56 , C07D211/60 , C07D211/72 , C07D211/76 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D413/10 , C07D413/12 , C07D471/10 , C07D487/10 , C07D491/10 , C07D513/10
摘要： A NK1 antagonist having the formula (I), wherein Ar1 and Ar2 are optionally substituted phenyl or heteroaryl, X1 is an ether, thio or imino linkage, R4 and R5 are not both H or alkyl, and the remaining variables are as defined in the specification, useful for treating a number of disorders, including emesis, depression, anxiety and cough. Pharmaceutical compositions. Methods of treatment and combinations with other agents are also disclosed.
摘要翻译： 具有式（I）的NK1拮抗剂，其中Ar1和Ar2是任选取代的苯基或杂芳基，X1是醚，硫代或亚氨基键，R4和R5不都是H或烷基，其余的变量如 规范，用于治疗许多疾病，包括呕吐，抑郁，焦虑和咳嗽。 药物组合物。 还公开了治疗方法和与其它药剂的组合。
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公开(公告)号：US07049320B2
公开(公告)日：2006-05-23
申请号：US10321687
申请日：2002-12-17
申请人： Sunil Paliwal , Gregory A. Reichard , Cheng Wang , Dong Xiao , Hon-Chung Tsui , Neng-Yang Shih , Juan D. Arredondo , Michelle Laci Wrobleski , Anandan Palani
发明人： Sunil Paliwal , Gregory A. Reichard , Cheng Wang , Dong Xiao , Hon-Chung Tsui , Neng-Yang Shih , Juan D. Arredondo , Michelle Laci Wrobleski , Anandan Palani
IPC分类号： A61K31/44 , C07D221/20
CPC分类号： C07D498/10 , A61K31/166 , A61K31/40 , A61K31/4025 , A61K31/437 , A61K31/4375 , A61K31/438 , A61K31/451 , A61K31/454 , A61K31/4545 , A61K31/537 , A61K31/5377 , A61K31/573 , A61K45/06 , C07D207/14 , C07D207/50 , C07D211/28 , C07D211/32 , C07D211/42 , C07D211/56 , C07D211/60 , C07D211/72 , C07D211/76 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D413/10 , C07D413/12 , C07D471/10 , C07D487/10 , C07D491/10 , C07D513/10
摘要： A NK1 antagonist having the formula (I), wherein Ar1 and Ar2 are optionally substituted phenyl or heteroaryl, X1 is an ether, thio or imino linkage, R4 and R5 are not both H or alkyl, and the remaining variables are as defined in the specification, useful for treating a number of disorders, including emesis, depression, anxiety and cough. Pharmaceutical compositions. Methods of treatment and combinations with other agents are also disclosed.
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公开(公告)号：US20110098468A1
公开(公告)日：2011-04-28
申请号：US12967132
申请日：2010-12-14
申请人： Sunil Paliwal , Gregory A. Reichard , Cheng Wang , Dong Xiao , Hon-Chung Tsui , Neng-Yang Shih , Juan D. Arredondo , Michelle Laci Wrobleski , Anandan Palani
发明人： Sunil Paliwal , Gregory A. Reichard , Cheng Wang , Dong Xiao , Hon-Chung Tsui , Neng-Yang Shih , Juan D. Arredondo , Michelle Laci Wrobleski , Anandan Palani
IPC分类号： C07D207/14 , C07D207/12 , C07D263/20 , C07D401/04 , C07D211/40 , C07D413/12 , C07D487/10
CPC分类号： C07D498/10 , A61K31/166 , A61K31/40 , A61K31/4025 , A61K31/437 , A61K31/4375 , A61K31/438 , A61K31/451 , A61K31/454 , A61K31/4545 , A61K31/537 , A61K31/5377 , A61K31/573 , A61K45/06 , C07D207/14 , C07D207/50 , C07D211/28 , C07D211/32 , C07D211/42 , C07D211/56 , C07D211/60 , C07D211/72 , C07D211/76 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D413/10 , C07D413/12 , C07D471/10 , C07D487/10 , C07D491/10 , C07D513/10
摘要： A NK1 antagonist having the formula (I), wherein Ar1 and Ar2 are optionally substituted phenyl or heteroaryl, X1 is an ether, thio or imino linkage, R4 and R5 are not both H or alkyl, and the remaining variables are as defined in the specification, useful for treating a number of disorders, including emesis, depression, anxiety and cough. Pharmaceutical compositions. Methods of treatment and combinations with other agents are also disclosed.
摘要翻译： 具有式（I）的NK1拮抗剂，其中Ar1和Ar2是任选取代的苯基或杂芳基，X1是醚，硫代或亚氨基键，R4和R5不都是H或烷基，其余的变量如 规范，用于治疗许多疾病，包括呕吐，抑郁，焦虑和咳嗽。 药物组合物。 还公开了治疗方法和与其它药剂的组合。
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公开(公告)号：US07122677B2
公开(公告)日：2006-10-17
申请号：US10292618
申请日：2002-11-12
申请人： Gregory A. Reichard , Sunil Paliwal , Neng-Yang Shih , Dong Xiao , Hon-Chung Tsui , Sapna Majmundar Shah , Cheng Wang , Michelle Laci Wrobleski
发明人： Gregory A. Reichard , Sunil Paliwal , Neng-Yang Shih , Dong Xiao , Hon-Chung Tsui , Sapna Majmundar Shah , Cheng Wang , Michelle Laci Wrobleski
IPC分类号： C07D207/00 , C07D209/96 , C07D225/00 , C07D215/00 , A01N57/00
CPC分类号： C07D207/26 , C07D207/273 , C07D207/38 , C07D401/04
摘要： A NK1 antagonist having the formula (I), wherein Ar1 and Ar2 are optionally substituted phenyl or heteroaryl, X1 is an ether, thio or imino linkage, R4 and R5 are not both H or alkyl, and the remaining variables are as defined in the in the specification, useful for treating a number of disorders, including emesis, depression, anxiety and cough. Pharmaceuticals compositions. Methods of treatment and combinations with other agents are also disclosed.
摘要翻译： 具有式（I）的NK 1拮抗剂，其中Ar 1和Ar 2是任选取代的苯基或杂芳基，X 1 硫醚或亚氨基连接，R 4和R 5不都是H或烷基，而其余的变量如 规范，用于治疗许多疾病，包括呕吐，抑郁，焦虑和咳嗽。 药物组合物。 还公开了治疗方法和与其它药剂的组合。
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公开(公告)号：US06878732B2
公开(公告)日：2005-04-12
申请号：US10386577
申请日：2003-03-12
IPC分类号： A61K31/075 , A61K31/122 , A61K31/135 , A61K31/15 , A61K31/165 , A61K31/17 , A61K31/196 , A61K31/27 , A61K31/397 , A61K31/40 , A61K31/4015 , A61K31/403 , A61K31/4178 , A61K31/4184 , A61K31/4196 , A61K31/423 , A61K31/4453 , A61K31/498 , A61K31/5375 , A61K31/538 , A61K31/573 , A61K45/00 , A61P1/00 , A61P1/08 , A61P3/04 , A61P11/00 , A61P11/14 , A61P13/00 , A61P13/10 , A61P25/00 , A61P25/04 , A61P25/06 , A61P25/18 , A61P25/20 , A61P25/22 , A61P25/24 , A61P25/32 , A61P25/36 , A61P43/00 , C07C43/174 , C07C43/178 , C07C49/753 , C07C215/42 , C07C217/52 , C07C229/48 , C07C233/23 , C07C233/39 , C07C237/04 , C07C237/08 , C07C237/20 , C07C237/24 , C07C239/12 , C07C251/42 , C07C251/44 , C07C251/50 , C07C271/22 , C07C271/24 , C07C271/34 , C07C275/26 , C07D205/12 , C07D207/26 , C07D207/27 , C07D209/54 , C07D235/02 , C07D241/38 , C07D249/12 , C07D253/06 , C07D263/52 , C07D265/34 , C07D295/18 , C07D295/185 , C07D295/20 , C07D295/215 , C07D403/06 , C07J7/00 , A61K31/415 , C07D233/02 , C07D233/04
CPC分类号： C07D207/27 , C07C43/1747 , C07C43/1788 , C07C49/753 , C07C217/52 , C07C229/48 , C07C233/23 , C07C237/04 , C07C237/20 , C07C239/12 , C07C251/44 , C07C271/22 , C07C271/24 , C07C271/34 , C07C275/26 , C07C2601/04 , C07D205/12 , C07D209/54 , C07D235/02 , C07D241/38 , C07D253/06 , C07D263/52 , C07D265/34 , C07D295/185 , C07D295/215
摘要： A NK1 antagonist having the formula (I), with the variables defined herein, which is useful for treating a number of disorders, including emesis, depression, anxiety and cough:
摘要翻译： 具有式（I）的NK1拮抗剂，具有本文定义的变量，其可用于治疗许多障碍，包括呕吐，抑郁，焦虑和咳嗽：
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