公开(公告)号：US20030215791A1

公开(公告)日：2003-11-20

申请号：US10277916

申请日：2002-10-23

Applicant: Applied Spectral Imaging Ltd.

Inventor： Yuval Garini ,  Nir Katzir ,  Irit Bar-Am ,  Uri Milman ,  Eli Horn ,  Yacov Malinovich ,  Terry Hammill ,  Vladimir Cherepakhin

IPC: C12Q001/70 ,  C12Q001/68 ,  G01N033/53 ,  G01N033/554 ,  G01N033/569 ,  G06F019/00 ,  G01N033/48 ,  G01N033/50

CPC classification number: B82Y5/00 ,  B82Y10/00 ,  G01N33/54306 ,  G01N33/54366 ,  G01N33/54373

Abstract: A method of detecting the presence, absence and/or level of a plurality of analytes-of-interest in a sample, the method comprisES: (a) providing a plurality of objects, each of the plurality of objects having a predetermined, measurable and different imagery characteristic, and further having a predetermined and specific affinity to one analyte of the plurality of analytes-of-interest, each the imagery characteristic corresponding to one the predetermined specific affinity, hence each the imagery characteristic corresponds to one analyte of the plurality of analytes-of interest; (b) providing at least one affinity moiety having a predetermined and specific affinity or predetermined and specific affinities to the plurality of analytes-of-interest, each the affinity moiety having a predetermined, measurable response to light; (c) combining the objects, the at least one affinity moiety and the sample under conditions for affinity binding; and (d) simultaneously determining, for each object of the plurality of objects an imagery characteristic, and for at least a portion of the at least one affinity moiety a response to light, thereby detecting the presence, absence and/or level of the plurality of analytes-of-interest in the sample.

Abstract translation: 一种检测样本中多个感兴趣分析物的存在，不存在和/或等级的方法，所述方法包括：（a）提供多个对象，所述多个对象中的每一个具有预定的，可测量的和 不同的图像特征，并且还对多个感兴趣分析物中的一个分析物具有预定和特异性的亲和力，每个图像特征对应于一个预定的特异亲和力，因此每个图像特征对应于多个 分析物 - 兴趣; （b）提供至少一个亲和部分，其具有对多个感兴趣分析物的预定和特异性亲和力或预定和特异性亲和力，每个亲和部分具有对光的预定的可测量响应; （c）在用于亲和结合的条件下将所述目标，所述至少一个亲和部分和所述样品组合; 以及（d）对于所述多个对象的每个对象同时确定图像特征，以及对所述至少一个亲和部分的至少一部分对光的响应，从而检测所述多个对象的存在，不存在和/或等级 的样品中感兴趣的分析物。

公开(公告)号：US20020141624A1

公开(公告)日：2002-10-03

申请号：US10155647

申请日：2002-05-28

Applicant: Applied Spectral Imaging Ltd.

Inventor： Amir Gil ,  Tamir Gil ,  Eli Horn ,  Yuval Garini

IPC: G06K009/00

CPC classification number: A61B5/0084 ,  A61B5/0075 ,  A61B5/0456 ,  A61B5/14553 ,  A61B5/4064 ,  A61B5/7285 ,  A61B6/541

Abstract: A synchronizing imaging apparatus to obtain images from an object undergoing variations according to a cycle with the apparatus comprising an acquisition device to acquire a plurality of pre-images at respective phases over each one of a plurality of cycles, and an image matcher to match together the pre-images from different ones of said cycles according to respective phases within said cycles, to create a representation of said cycle.

Abstract translation: 一种同步成像装置，用于根据周期从经历变化的对象获得图像，该装置包括：采集装置，用于在多个周期中的每一个周期获取各个相位的多个预图像;以及图像匹配器，以一起匹配 根据所述循环内的各个相位，来自不同的所述循环的预图像，以创建所述周期的表示。

公开(公告)号：US20020099295A1

公开(公告)日：2002-07-25

申请号：US09776871

申请日：2001-02-06

Applicant: Applied Spectral Imaging Ltd.

Inventor： Amir Gil ,  Tamir Gil ,  Eli Horn ,  Yuval Garini

IPC: A61B005/00

CPC classification number: A61B5/14553 ,  A61B5/0042 ,  A61B5/0066 ,  A61B5/0073 ,  A61B5/0075 ,  A61B5/0084 ,  A61B5/0086 ,  A61B5/4064 ,  A61B5/4094

Abstract: A method of functional brain mapping of a subject is disclosed. The method is effected by (a) illuminating an exposed cortex of a brain or portion thereof of the subject with incident light; (b) acquiring a reflectance spectrum of each picture element of at least a portion of the exposed cortex of the subject; (c) stimulating the brain of the subject; (d) during or after step (c) acquiring at least one additional reflectance spectrum of each picture element of at least the portion of the exposed cortex of the subject; and (e) generating an image highlighting differences among spectra of the exposed cortex acquired in steps (b) and (d), so as to highlight functional brain regions. Algorithms for calculating oxygen saturation and blood volume maps which can be used to practice the method are also disclosed. Systems for practicing the method are also disclosed.

Abstract translation: 公开了一种对象的功能性脑图谱的方法。 该方法通过以下方式实现：（a）用入射光照射受试者的大脑或其部分的暴露皮层; （b）获取被摄体的暴露皮质的至少一部分的每个图像元素的反射光谱; （c）刺激受试者的大脑; （d）在步骤（c）期间或之后（c）获取受试者暴露皮层的至少部分的每个图像元素的至少一个附加反射光谱; 和（e）产生突出显示在步骤（b）和（d）中获得的暴露皮质的光谱之间的差异的图像，以便突出功能性脑区域。 还公开了可用于实践该方法的用于计算氧饱和度和血容量图的算法。 还公开了用于实施该方法的系统。