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    CHARGE-SENSITIVE OPTICAL DETECTION OF BINDING KINETICS BETWEEN PHAGE DISPLAYED PEPTIDE LIGANDS AND PROTEIN TARGETS
    4.
    发明公开
    CHARGE-SENSITIVE OPTICAL DETECTION OF BINDING KINETICS BETWEEN PHAGE DISPLAYED PEPTIDE LIGANDS AND PROTEIN TARGETS 审中-公开

    公开(公告)号：US20240272082A1

    公开(公告)日：2024-08-15

    申请号：US18689180

    申请日：2022-08-26

    Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY

    Inventor： Shaopeng Wang ,  Runli Liang

    IPC: G01N21/77 ,  G01N27/30 ,  G01N33/543

    CPC classification number: G01N21/7703 ,  G01N27/305 ,  G01N33/5438

    Abstract: Provided herein are systems for the label-free detection of target molecules in samples. The systems include a sensor probe positioned in a sensing region and configured to bind to receptors for the target molecules. The systems also include electrodes configured to expose the sensor probe to an alternating electric field, and a light source optically coupled to the sensor probe and configured to provide light along a length of the sensor probe. In addition, the systems also include a position sensitive photodetector configured to detect a position of light exiting the sensor probe, and a processor configured to assess, based at least in part on the position of the light exiting the sensor probe, an amplitude of oscillation of the sensor at a frequency of the alternating electric field and a direction of a displacement of the sensor. Additional systems and related methods are also provided.

    Charge-sensitive optical detection of binding kinetics between phage displayed peptide ligands and protein targets
    6.
    发明授权
    Charge-sensitive optical detection of binding kinetics between phage displayed peptide ligands and protein targets 有权

    公开(公告)号：US12259330B2

    公开(公告)日：2025-03-25

    申请号：US18689180

    申请日：2022-08-26

    Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY

    Inventor： Shaopeng Wang ,  Runli Liang

    IPC: G01N21/77 ,  G01N27/30 ,  G01N33/543

    Abstract: Provided herein are systems for the label-free detection of target molecules in samples. The systems include a sensor probe positioned in a sensing region and configured to bind to receptors for the target molecules. The systems also include electrodes configured to expose the sensor probe to an alternating electric field, and a light source optically coupled to the sensor probe and configured to provide light along a length of the sensor probe. In addition, the systems also include a position sensitive photodetector configured to detect a position of light exiting the sensor probe, and a processor configured to assess, based at least in part on the position of the light exiting the sensor probe, an amplitude of oscillation of the sensor at a frequency of the alternating electric field and a direction of a displacement of the sensor. Additional systems and related methods are also provided.

    EVANESCENT SCATTERING IMAGING OF SINGLE MOLECULES
    7.
    发明申请
    EVANESCENT SCATTERING IMAGING OF SINGLE MOLECULES 有权

    公开(公告)号：US20240410826A1

    公开(公告)日：2024-12-12

    申请号：US18691592

    申请日：2022-09-27

    Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY

    Inventor： Shaopeng Wang ,  Pengfei Zhang

    IPC: G01N21/47 ,  G01N21/17 ,  G01N21/27 ,  G02B21/06 ,  G02B21/34

    Abstract: Provided herein are methods of detecting single molecules that include binding single molecules in a sample solution to a first surface of an optically transparent substrate include the optically transparent substrate is free of a metallic coating. In some embodiments, the methods include irradiating the first surface of the substrate with an incident light having an incident angle selected to achieve total internal reflection of the incident light, thereby scattering light from the first surface and from the single molecules bound to the surface in which a wavelength of the incident light is between 10 nm and 350 μm and the optically transparent substrate has a refractive index at the wavelength of the incident light exceeding that of the sample solution, and collecting an image that captures interference between evanescent light scattered from the single molecules and the first surface. Systems and additional methods are also provided.

    PLASMONIC IMAGING AND DETECTION OF SINGLE DNA MOLECULES
    9.
    发明申请
    PLASMONIC IMAGING AND DETECTION OF SINGLE DNA MOLECULES 审中-公开
    PLASMONIC成像和检测单个DNA分子

    公开(公告)号：US20160299069A1

    公开(公告)日：2016-10-13

    申请号：US15038629

    申请日：2015-01-02

    Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY

    Inventor： Nongjian Tao ,  Hui Yu ,  Xiaonan Shan ,  Shaopeng Wang

    IPC: G01N21/552

    CPC classification number: G01N21/553 ,  C12M41/46 ,  G01N21/552

    Abstract: Method and system to remove background noise with a differential approach in optical imaging is disclosed. The differential approach moves the sample position laterally over a small distance, and a differential image is generated from the images recorded before and after the lateral translation. This approach can significantly improve the image quality of objects, including single DNA molecules, for label-free optical imaging techniques, such as surface plasmon resonance imaging. Disclosed imaging technique provides high-resolution genome-wide restriction maps of single DNA molecules.

    Abstract translation: 公开了在光学成像中用差分方法去除背景噪声的方法和系统。 差分方法将样本位置横向移动一小段距离，并且从侧向平移之前和之后记录的图像产生差分图像。 这种方法可以显着提高物体（包括单个DNA分子）的图像质量，用于无标记光学成像技术，如表面等离子体共振成像。 公开的成像技术提供了单分子DNA分子的高分辨率全基因组限制性图谱。

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