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20 条记录 (耗时 0.015 秒)

    Process for preparing cyclic polyethers
    1.
    发明授权
    Process for preparing cyclic polyethers 失效
    制备环状聚醚的方法

    公开(公告)号：US4562272A

    公开(公告)日：1985-12-31

    申请号：US248268

    申请日：1981-03-27

    申请人： Arnold M. Harrison ,  Leonard Kaplan

    发明人： Arnold M. Harrison ,  Leonard Kaplan

    IPC分类号： C07D323/00 ,  C08G65/00

    CPC分类号： C07D323/00 ,  C08G65/00

    摘要： The invention relates to a process for preparing cyclic polyethers from cyclic alkylene carbonates in the presence of a solvent, wherein the process is carried out in the presence of a solvent selected from the group containing a carbonyl moiety, nitrile moiety or mixture thereof. In addition, ionic catalysts may be employed to increase the selectivity to cyclic polyether.

    摘要翻译： 本发明涉及在溶剂存在下由环状碳酸亚烷基酯制备环状聚醚的方法，其中所述方法在选自含有羰基部分，腈部分或其混合物的溶剂的存在下进行。 此外，可以使用离子催化剂来增加对环状聚醚的选择性。

    Gelled immunomodulating topical compositions and a method of treating warts and other human papilloma virus skin infections
    3.
    发明申请
    Gelled immunomodulating topical compositions and a method of treating warts and other human papilloma virus skin infections 审中-公开
    凝胶免疫调节局部组合物和治疗疣和其他人乳头状瘤病毒皮肤感染的方法

    公开(公告)号：US20060211766A1

    公开(公告)日：2006-09-21

    申请号：US11228569

    申请日：2005-09-16

    申请人： Leonard Kaplan ,  William Levis

    发明人： Leonard Kaplan ,  William Levis

    IPC分类号： A61K31/215 ,  A61K31/135 ,  A61K31/12 ,  A61K31/05

    CPC分类号： A61K31/05 ,  A61K9/0014 ,  A61K31/12 ,  A61K31/135 ,  A61K31/215 ,  A61K47/10 ,  A61K47/14 ,  A61K47/26

    摘要： Topical drug compositions of this invention contain delayed type contact sensitizing haptens in a unique non-flowable, non-toxic, non-volatile, anhydrous gel composition to achieve retained site application on warts and other human papilloma virus (HPV) skin infections. The preferred gelled compositions contain, but are not limited to, the sensitizing haptens, squaric acid dibutylester and diphenylcyclopropenone in optimized blends of Polysorbate 80, Isopropyl myristate uniquely gelled with Polyoxyl 40 stearate to form a penetrant of keratinized epitheliiuim of warts for direct application wherein virucidal pharlacologic action is induced by Th-1 cell mediated immune responses with resultant releases of CD4 helper T cells, CD8 killer T cells and cytokines to attack the human papilloma viruses. The commonly used vehicles with these contact sensitizers are acetone, petrolatum, or water containing emulsion creams which do not have the capacity to penetrate the keratinized wart surfaces and are therefore minimally effective in treating warts.

    摘要翻译： 本发明的局部药物组合物在独特的不可流动，无毒，不挥发的无水凝胶组合物中含有延迟型接触敏化半抗原，以实现对疣和其它人乳头状瘤病毒（HPV）皮肤感染的保留位点应用。 优选的胶凝组合物包含但不限于敏化半抗原，方酸二丁酯和二苯基环丙烯酮在聚山梨醇酯80，肉豆蔻酸异丙酯的独特凝胶化与聚氧乙烯40硬脂酸酯的优化共混物中，以形成用于直接施用的疣的角质化上皮细胞的渗透剂，其中杀病毒 由Th-1细胞介导的免疫应答引起药物作用，产生CD4辅助T细胞，CD8杀伤T细胞和细胞因子的释放以攻击人乳头状瘤病毒。 具有这些接触敏化剂的常用车辆是丙酮，凡士林或含乳液乳液，其不具有穿透角质化疣表面的能力，因此在治疗疣中最不有效。

    Catalytic process for polyhydric alcohols and derivatives
    7.
    发明授权
    Catalytic process for polyhydric alcohols and derivatives 失效
    多元醇及其衍生物的催化方法

    公开(公告)号：US4224237A

    公开(公告)日：1980-09-23

    申请号：US61456

    申请日：1979-07-27

    申请人： Leonard Kaplan

    发明人： Leonard Kaplan

    IPC分类号： C07C29/151 ,  C07C29/158 ,  C07C27/06 ,  C07C29/16

    CPC分类号： C07C29/1514 ,  C07C29/1512 ,  C07C29/158

    摘要： This invention relates to the manufacture of such valuable chemicals as polyhydric alcohols, their ether and ester derivatives, oligomers of such alcohols and monohydric alcohols and their ether and ester derivatives by reacting hydrogen and oxides of carbon in the presence of a rhodium carbonyl complex dissolved in a sulfone solvent.

    摘要翻译： 本发明涉及这样的有价值的化学品的制造，如多元醇，它们的醚和酯​​衍生物，这些醇和一元醇的低聚物及其醚和酯衍生物，其通过氢和碳氧化物在羰基铑化合物的存在下溶解在 砜溶剂。

    Topical immune competency diagnostic compositions and methods of use
    9.
    发明申请
    Topical immune competency diagnostic compositions and methods of use 审中-公开
    局部免疫能力诊断成分及使用方法

    公开(公告)号：US20050260136A1

    公开(公告)日：2005-11-24

    申请号：US10849703

    申请日：2004-05-20

    申请人： Leonard Kaplan ,  William Levis

    发明人： Leonard Kaplan ,  William Levis

    IPC分类号： A61K49/00

    CPC分类号： A61K49/0006

    摘要： The compositions and methods of this invention are used to assess the level of immune competence of tested individuals based on the degree of immune response as a surrogate marker of CD4 T Cell lymphocytes as measured by the intensity of the resultant skin reaction score following controlled topical application of a unique anhydrous composition containing a contact sensitizer. The results of assessment are useful in determining appropriate treatment of immuno-compromised patients. Preferred compositions contain, but are not limited to, Diphenylcyclpropenone as a preferred embodiment of the class of contact sensitizing agents applied to the skin in an optimally prepared formulation preferably containing about 0.4% of the contact sensitizer.

    摘要翻译： 本发明的组合物和方法用于基于作为CD4 T细胞淋巴细胞的替代标志物的免疫应答程度来评估测试个体的免疫能力水平，如通过受控局部应用后所得皮肤反应评分的强度所测量的 含有接触敏化剂的独特的无水组合物。 评估结果可用于确定免疫受损患者的适当治疗。 优选的组合物包含但不限于二苯基环丙烯酮，作为在优选含有约0.4％的接触敏化剂的最佳制剂制剂中施用于皮肤的接触敏化剂类的优选实施方案。

    Process for making ethylene glycol derivatives
    10.
    发明授权
    Process for making ethylene glycol derivatives 失效
    制备乙二醇衍生物的方法

    公开(公告)号：US4415747A

    公开(公告)日：1983-11-15

    申请号：US307074

    申请日：1981-09-29

    申请人： Leonard Kaplan

    发明人： Leonard Kaplan

    IPC分类号： C07C69/76

    CPC分类号： C07C69/76

    摘要： This process is concerned with the reductive coupling of .alpha.-halo ethers and/or .alpha.-halo esters to make ethylene glycol derivatives by carrying out the reductive coupling process in the presence of an iron compound having iron in an oxidation state of zero.

    摘要翻译： 该方法涉及通过在具有0的氧化态的铁的铁化合物的存在下进行还原偶联方法来进行α-卤代醚和/或α-卤代醇的还原偶联以制备乙二醇衍生物。