公开(公告)号：US10961213B2

公开(公告)日：2021-03-30

申请号：US16480407

申请日：2018-01-16

Applicant: BASF SE

Inventor： Martin John McLaughlin ,  Karsten Koerber ,  Birgit Gockel ,  Devendra Vyas ,  Arun Narine

IPC: C07D307/79

Abstract: The present invention relates to a process for preparing benzylic amides of formula I wherein the variables have the meaning as defined in the description, by reductive amidation of a nitrile of formula II wherein the variables have the meanings given for formula I, with an activated carbonyl compound of formula III, and which nitrile is obtained by reaction of a compound of formula IV with a halogen compound of formula V, wherein X is a halogen atom, preferably bromo, which halogen compound V in turn is obtained by Sandmeyer reaction of an aniline derivative of formula VI novel compounds of formula I, and processes for preparing compounds of formula XII wherein the variables have the meaning as defined in the description by condensing compounds of formula I with compounds of formula X and subjecting the resulting α,β-unsaturated ketone of formula XI to a reaction with hydroxylamine to yield compounds of formula XII.

公开(公告)号：US20180297979A1

公开(公告)日：2018-10-18

申请号：US15764414

申请日：2016-09-29

Applicant: BASF SE

Inventor： Martin John McLaughlin ,  Karsten Koerber ,  Birgit Gockel ,  Wolfgang von Deyn

IPC: C07D401/06 ,  A01N43/54 ,  A01N25/02 ,  A01N25/08

Abstract: Provided herein are imino compounds of formula I and stereoisomers, tautomers and salts thereof. Further provided herein are agricultural and veterinary compositions including the compounds. Also provided herein are methods related to the use of these compounds, and the stereoisomers, tautomers and/or salts thereof, for combating invertebrate pests. Further provided herein are methods for combating invertebrate pests, wherein the methods include applying such compounds, steroisomers, tautomers, and salts.

公开(公告)号：US20180086715A9

公开(公告)日：2018-03-29

申请号：US15329104

申请日：2015-07-30

Applicant: BASF SE

Inventor： Birgit Gockel ,  Daniel Saelinger ,  Sebastian Soergel ,  Michael Rack

IPC: C07D231/14 ,  C07D405/06 ,  C07D401/12 ,  C07D403/12

CPC classification number: C07D231/14 ,  C07D401/12 ,  C07D403/12 ,  C07D405/06

Abstract: The present invention relates to a process for preparing a pyrazole compound of formula V, the process including cyclizing a hydrazone substituted α,β-unsaturated carbonyl compound of formula IV by reacting it with a suitable reagent, e.g. a reducing agent, an organometallic reagent or a nucleophilic reagent. The compounds of formula V are versatile reaction tools for the preparation of pyrazole derived fine chemicals. The present invention also relates to pyrazole compounds of formulae Va, Vb, Vc, and VI.

公开(公告)号：US20230242493A1

公开(公告)日：2023-08-03

申请号：US17766286

申请日：2020-10-20

Applicant: BASF SE

Inventor： Birgit Gockel ,  Volker Maywald ,  Manfred Ehresmann ,  Daniel Saelinger ,  Roland Goetz ,  Jan Haller

IPC: C07D257/04

CPC classification number: C07D257/04

Abstract: Process for making a compound represented by formula (3), comprising the following steps: a) reacting an azide compound with a compound represented by formula (1) to yield compound (2), compound (2) being a compound represented by formula (2) or its salts, b) methylating compound (2) obtained in step a) using a methylating agent to obtain compound (3), wherein R1 denotes a hydrocarbon rest, and wherein in step a) a solvent system A and in step b) a solvent system B is used, wherein both solvent systems A and B comprise one dipolar aprotic solvent or a mixture of dipolar aprotic solvents as the main component, and wherein steps a) and b) are carried without isolating the compound (2) obtained in step a).

公开(公告)号：US20220017439A1

公开(公告)日：2022-01-20

申请号：US17295102

申请日：2019-11-25

Applicant: BASF SE

Inventor： Karsten Koerber ,  Michael Rack ,  Pascal Bindschaedler ,  Martin John McLaughlin ,  Birgit Gockel ,  Devendra Vyas ,  Sebastian Soergel

IPC: C07C17/35 ,  B01J23/44 ,  B01J21/18

Abstract: The invention relates to a process for the preparation of 5-bromo-1,3-dichloro-2-fluoro-benzene by diazotization and reduction of 6-bromo-2,4-dichloro-3-fluoro-aniline, which is obtained by bromination of 2,4-dichloro-3-fluoro-aniline, which is obtained by reduction of 1,3-dichloro-2-fluoro-4-nitro-benzene, and a process for preparing active compounds of formula V (Formula V) wherein the variables are defined in the specification by further transforming 5-bromo-1,3-dichloro-2-fluoro-benzene obtained from 2,4-dichloro-3-fluoro-aniline by the process according to the invention.

公开(公告)号：US10975036B2

公开(公告)日：2021-04-13

申请号：US16074537

申请日：2017-01-25

Applicant: BASF SE

Inventor： Eric George Klauber ,  Michael Rack ,  Sebastian Soergel ,  Birgit Gockel ,  Roland Goetz

IPC: C07D231/14 ,  C07C251/76 ,  C07D401/12 ,  B01J21/18 ,  B01J23/42 ,  C07C249/16 ,  C07D403/12

Abstract: The present invention relates to a catalytic process for preparing pyrazoles of formula V comprising the step of cyclizing hydrazone substituted α,β-unsaturated carbonyl compounds by reacting them with hydrogen in a reaction mixture comprising as components (a) a hydrogenation catalyst, (b) an acid selected from Brønsted acids, ammonium salts of Brønsted acids, and Lewis acids, (c) a protic solvent, and optionally (d) an aprotic solvent.

公开(公告)号：US10513498B2

公开(公告)日：2019-12-24

申请号：US16292773

申请日：2019-03-05

Applicant: BASF SE

Inventor： Birgit Gockel ,  Daniel Saelinger ,  Sebastian Soergel ,  Michael Rack

IPC: C07D231/14 ,  C07D401/12 ,  C07D405/06 ,  C07D403/12

Abstract: The present invention relates to a process for preparing a pyrazole compound of formula V, which comprises cyclizing a hydrazone substituted α,β-unsaturated carbonyl compound of formula IV by reacting it with a suitable reagent, e.g. a reducing agent, an organometallic reagent or a nucleophilic reagent. The compounds of formula V are versatile reaction tools for the preparation of pyrazole derived fine chemicals. The present invention also relates to pyrazole compounds of formulae Va, Vb, Vc, and VI.

公开(公告)号：US20220024864A1

公开(公告)日：2022-01-27

申请号：US17296683

申请日：2019-12-11

Applicant: BASF SE

Inventor： Volker Maywald ,  Roland Goetz ,  Daniel Saelinger ,  Birgit Gockel ,  Manfred Ehresmann ,  Markus Jegelka ,  Joaquim Henrique Teles

IPC: C07C263/10

Abstract: A method for manufacturing an isocyanate compound represented by formula (2) (2) wherein R1 represents a methyl group, an ethyl group, a cyclopropyl group, a chlorine atom, a bromine atom, or a methoxy group; and R2 represents an alkyl group having 1 to 6 carbon atoms, comprising reacting an aniline compound represented by formula (1) (1) wherein R1 and R2 are defined as above with a phosgene compound at a temperature of from 40° C. to the boiling point of the inert solvent in at least one kind of inert solvent.

公开(公告)号：US10526264B2

公开(公告)日：2020-01-07

申请号：US16315417

申请日：2017-06-23

Applicant: BASF SE

Inventor： Martin John McLaughlin ,  Karsten Koerber ,  Birgit Gockel ,  Pascal Bindschaedler ,  Sebastian Soergel ,  Devendra Vyas ,  Johannes Roeckl

IPC: C07C33/00 ,  C07C17/00 ,  C07C25/00 ,  C07C45/00 ,  C07C63/00 ,  C07C33/48 ,  C07C49/813 ,  C07C45/51 ,  C07C63/74 ,  C07C17/263 ,  C07C25/24

Abstract: Compounds of formula I a process for preparation of compounds of formula I; precursor compounds of formula II a process for preparation of precursor compounds of formula II; compounds of formula III a process for the preparation of compounds of formula IV from compounds of formula III and the use of compounds of formula I for the preparation of compounds of formula IV.

公开(公告)号：US20190008162A1

公开(公告)日：2019-01-10

申请号：US15754074

申请日：2016-08-08

Applicant: BASF SE

Inventor： Birgit Gockel ,  Joachim Dickhaut ,  Daniel Saelinger

IPC: A01N65/00 ,  A01H1/06 ,  A01H6/60

Abstract: A method for controlling pests of a cotton plant is disclosed. The method includes the step of contacting the cotton plant, parts of it, or its propagation material with components of the ginkgo tree selected from bilobalide, ginkgolide A, ginkgolide B, ginkgolide C, ginkgolide J, ginkgolide M, and mixtures thereof. The use of components of the ginkgo tree for controlling pests in a cotton plant, parts of it, or its propagation material, is also disclosed. A pesticide including one or more components of the ginkgo tree selected from bilobalide, ginkgolide A, ginkgolide B, ginkgolide C, ginkgolide J, and ginkgolide M is further disclosed.