公开(公告)号：US10513693B2

公开(公告)日：2019-12-24

申请号：US15127181

申请日：2015-03-18

Applicant: BASF SE

Inventor： Esther Dantas Costa ,  Oskar Zelder ,  Hartwig Schröder ,  Stefan Haefner ,  Joanna Martyna Krawczyk ,  Gregory Von Abendroth ,  Christian Riedele ,  Torsten Renz

IPC: C12N9/04 ,  C12N9/10 ,  C12P7/46 ,  C07K14/285

Abstract: The present invention relates to a process for producing an organic acid by fermentation, comprising the process steps: I) cultivating microorganisms in a culture medium to which are fed, as assimilable carbon sources, glycerol and a further carbonaceous compound, to allow the microorganisms to produce the organic acid, thereby obtaining a fermentation broth comprising the organic acid; II) recovering the organic acid or the salt thereof from the fermentation broth obtained in process step I); wherein, at least for a certain period of time in process step I), the consumption rate of the further carbonaceous compound (CRc.c.; in g per liter per hour) is lower than the maximum theoretical consumption rate of the further carbonaceous compound (CRc.c. max; in g per liter per hour).

公开(公告)号：US20180030418A1

公开(公告)日：2018-02-01

申请号：US15127181

申请日：2015-03-18

Applicant: BASF SE

Inventor： Esther Dantas Costa ,  Oskar Zelder ,  Hartwig Schröder ,  Stefan Haefner ,  Joanna Martyna Krawczyk ,  Gregory Von Abendroth ,  Christian Riedele ,  Torsten Renz

IPC: C12N9/04 ,  C12N9/10

CPC classification number: C12N9/0006 ,  C07K14/285 ,  C12N9/1029 ,  C12P7/46 ,  C12Y101/01027 ,  C12Y203/01054

Abstract: The present invention relates to a process for producing an organic acid by fermentation, comprising the process steps: I) cultivating microorganisms in a culture medium to which are fed, as assimilable carbon sources, glycerol and a further carbonaceous compound, to allow the microorganisms to produce the organic acid, thereby obtaining a fermentation broth comprising the organic acid; II) recovering the organic acid or the salt thereof from the fermentation broth obtained in process step I); wherein, at least for a certain period of time in process step I), the consumption rate of the further carbonaceous compound (CRc.c.; in g per liter per hour) is lower than the maximum theoretical consumption rate of the further carbonaceous compound (CRc.c. max; in g per liter per hour).