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公开(公告)号：US09850506B2
公开(公告)日：2017-12-26
申请号：US15116896
申请日：2015-05-02
申请人： BASF SE
发明人： Joanna Martyna Krawczyk , Stefan Haefner , Hartwig Schröder , Esther Dantas Costa , Oskar Zelder , Gregory Von Abendroth
IPC分类号： C12P7/46
CPC分类号： C12P7/46 , C07K14/285 , C12N1/20 , C12N15/52
摘要： The present invention relates to a modified microorganism having, compared to its wild-type, a reduced activity of the enzyme that is encoded by the fruA-gene. The present invention also relates to a method for producing an organic compound and to the use of modified microorganisms.
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公开(公告)号：US10273485B2
公开(公告)日：2019-04-30
申请号：US15116600
申请日：2015-02-06
申请人： BASF SE
发明人： Joanna Martyna Krawczyk , Stefan Haefner , Hartwig Schröder , Esther Dantas Costa , Oskar Zelder , Gregory Von Abendroth , Christoph Wittmann , René Stellmacher , Judith Becker
摘要： The present invention relates to a modified microorganism having, compared to its wild-type, a reduced activity of the enzyme that is encoded by the wcaJ-gene. The present invention also relates to a method for producing an organic compound and to the use of a modified microorganism.
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公开(公告)号：US10287558B2
公开(公告)日：2019-05-14
申请号：US15116669
申请日：2015-02-02
申请人： BASF SE
发明人： Joanna Martyna Krawczyk , Stefan Haefner , Hartwig Schröder , Esther Dantas Costa , Oskar Zelder , Gregory Von Abendroth , Christoph Wittmann , René Stellmacher , Judith Becker , Anna Lange , Benjamin J. Lyons , Thomas J. Lyons , Eudes De Crecy , Ewa Hughes
摘要： The present invention relates to a modified microorganism having, compared to its wild-type, a reduced activity of the enzyme that is encoded by the pykA-gene. The present invention also relates to a method for producing an organic compound and to the use of modified microorganisms.
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公开(公告)号：US20170166937A1
公开(公告)日：2017-06-15
申请号：US15116896
申请日：2015-05-02
申请人： BASF SE
发明人： Joanna Martyna Krawczyk , Stefan Haefner , Hartwig Schröder , Esther Dantas Costa , Oskar Zelder , Gregory Von Abendroth
IPC分类号： C12P7/46
CPC分类号： C12P7/46 , C07K14/285 , C12N1/20 , C12N15/52
摘要： The present invention relates to a modified microorganism having, compared to its wild-type, a reduced activity of the enzyme that is encoded by the fruA-gene. The present invention also relates to a method for producing an organic compound and to the use of modified microorganisms.
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公开(公告)号：US10513693B2
公开(公告)日：2019-12-24
申请号：US15127181
申请日：2015-03-18
申请人： BASF SE
发明人： Esther Dantas Costa , Oskar Zelder , Hartwig Schröder , Stefan Haefner , Joanna Martyna Krawczyk , Gregory Von Abendroth , Christian Riedele , Torsten Renz
IPC分类号： C12N9/04 , C12N9/10 , C12P7/46 , C07K14/285
摘要： The present invention relates to a process for producing an organic acid by fermentation, comprising the process steps: I) cultivating microorganisms in a culture medium to which are fed, as assimilable carbon sources, glycerol and a further carbonaceous compound, to allow the microorganisms to produce the organic acid, thereby obtaining a fermentation broth comprising the organic acid; II) recovering the organic acid or the salt thereof from the fermentation broth obtained in process step I); wherein, at least for a certain period of time in process step I), the consumption rate of the further carbonaceous compound (CRc.c.; in g per liter per hour) is lower than the maximum theoretical consumption rate of the further carbonaceous compound (CRc.c. max; in g per liter per hour).
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公开(公告)号：US20180030418A1
公开(公告)日：2018-02-01
申请号：US15127181
申请日：2015-03-18
申请人： BASF SE
发明人： Esther Dantas Costa , Oskar Zelder , Hartwig Schröder , Stefan Haefner , Joanna Martyna Krawczyk , Gregory Von Abendroth , Christian Riedele , Torsten Renz
CPC分类号： C12N9/0006 , C07K14/285 , C12N9/1029 , C12P7/46 , C12Y101/01027 , C12Y203/01054
摘要： The present invention relates to a process for producing an organic acid by fermentation, comprising the process steps: I) cultivating microorganisms in a culture medium to which are fed, as assimilable carbon sources, glycerol and a further carbonaceous compound, to allow the microorganisms to produce the organic acid, thereby obtaining a fermentation broth comprising the organic acid; II) recovering the organic acid or the salt thereof from the fermentation broth obtained in process step I); wherein, at least for a certain period of time in process step I), the consumption rate of the further carbonaceous compound (CRc.c.; in g per liter per hour) is lower than the maximum theoretical consumption rate of the further carbonaceous compound (CRc.c. max; in g per liter per hour).
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公开(公告)号：US20160362696A1
公开(公告)日：2016-12-15
申请号：US15116600
申请日：2015-02-06
申请人： BASF SE
发明人： Joanna Martyna Krawczyk , Stefan Haefner , Hartwig Schröder , Esther Dantas Costa , Oskar Zelder , Gregory Von Abendroth , Christoph Wittmann , René Stellmacher , Judith Becker
CPC分类号： C12N15/52 , C12N1/02 , C12N9/0006 , C12N9/1029 , C12N9/1288 , C12N15/74 , C12P7/46 , C12Y101/01 , C12Y203/01054 , C12Y207/08031
摘要： The present invention relates to a modified microorganism having, compared to its wild-type, a reduced activity of the enzyme that is encoded by the wcaJ-gene. The present invention also relates to a method for producing an organic compound and to the use of a modified microorganism.
摘要翻译： 本发明涉及与其野生型相比具有由wcaJ基因编码的酶的活性降低的修饰微生物。 本发明还涉及有机化合物的制造方法和改性微生物的用途。
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公开(公告)号：US20160348082A1
公开(公告)日：2016-12-01
申请号：US15116669
申请日：2015-02-02
申请人： BASF SE
发明人： Joanna Martyna Krawczyk , Stefan Haefner , Hartwig Schröder , Esther Dantas Costa , Oakar Zelder , Gregory von Abendroth , Christoph Wittmann , René Stellmacher , Judith Becker , Anna Lange , Benjamin J. Lyons , Thomas J. Lyons , Eudes De Crecy , Ewa Hughes
CPC分类号： C12N9/1205 , C12N15/52 , C12P7/46 , C12Y207/0104
摘要： The present invention relates to a modified microorganism having, compared to its wild-type, a reduced activity of the enzyme that is encoded by the pykA-gene. The present invention also relates to a method for producing an organic compound and to the use of modified microorganisms.
摘要翻译： 本发明涉及与其野生型相比具有由pykA基因编码的酶的活性降低的修饰微生物。 本发明还涉及一种生产有机化合物的方法和使用改性微生物。
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