利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

26 条记录 (耗时 0.044 秒)

    Genetically modified microorganisms capable of producing beta-glucans and methods for producing beta-glucans
    3.
    发明授权
    Genetically modified microorganisms capable of producing beta-glucans and methods for producing beta-glucans 有权
    能够产生β-葡聚糖的转基因微生物和生产β-葡聚糖的方法

    公开(公告)号：US09322041B2

    公开(公告)日：2016-04-26

    申请号：US13935043

    申请日：2013-07-03

    申请人： BASF SE ,  Wintershall Holding GmbH

    发明人： Beata Brockmann ,  Andrea Herold ,  Oskar Zelder ,  Stefan Haefner ,  Christian Fleck ,  Hartwig Schröder ,  Mari Granström ,  Julia Kristiane Schmidt

    IPC分类号： C12P19/04 ,  C12N15/80 ,  C12N9/10 ,  C08B37/00 ,  C08L5/00

    CPC分类号： C12P19/04 ,  C08B37/0024 ,  C08L5/00 ,  C12N9/1051 ,  C12N15/80 ,  C12P19/18 ,  C12Y204/01034 ,  Y02P20/52

    摘要： The present invention relates to genetically modified microorganisms capable of producing beta-glucans, characterized in that the genetically modified microorganism overexpresses (i) a polynucleotide encoding a polypeptide having 1,3-β-D-glucan synthase-activity, and/or (ii) a polypeptide having 1,3-β-D-glucan synthase-activity, compared to a corresponding non-modified control microorganism of the same strain. The present invention also relates to the use of a polynucleotide encoding a polypeptide having 1,3-β-D-glucan synthase-activity or the use of such a polypeptide for producing β-glucans. Furthermore, the present invention relates to methods for producing β-glucans comprising the introduction of a promoter upstream of a polynucleotide encoding a polypeptide having 1,3-β-D-glucan synthase-activity thereby increasing the expression of the polynucleotide, or a polynucleotide encoding a polypeptide having 1,3-β-D-glucan synthase-activity into a microorganism being able to synthesize β-glucans.

    摘要翻译： 本发明涉及能够产生β-葡聚糖的转基因微生物，其特征在于，遗传修饰的微生物过表达（i）编码具有1,3-葡聚糖合酶活性的多肽的多核苷酸和/或（ ii）与相同菌株的相应未修饰的对照微生物相比，具有1,3-葡聚糖 - D-葡聚糖合酶活性的多肽。 本发明还涉及编码具有1,3-葡萄糖 - D-葡聚糖合酶活性的多肽的多核苷酸的用途或这种多肽用于生产葡聚糖的用途。 此外，本发明涉及生产葡聚糖的方法，包括在编码具有1,3-葡萄糖-D-葡聚糖合酶活性的多肽的多核苷酸上游引入启动子，从而增加多核苷酸的表达，或 编码具有1,3-葡聚糖合酶活性的多肽的多核苷酸能够合成葡聚糖。

    GENE CLUSTER FOR BIOSYNTHESIS OF CORNEXISTIN AND HYDROXYCORNEXISTIN
    8.
    发明申请
    GENE CLUSTER FOR BIOSYNTHESIS OF CORNEXISTIN AND HYDROXYCORNEXISTIN 有权
    金丝桃素和羟基喹诺酮的生物合成基因组

    公开(公告)号：US20150275248A1

    公开(公告)日：2015-10-01

    申请号：US14441215

    申请日：2013-11-13

    申请人： BASF SE

    发明人： Oskar Zelder ,  Birgit Hoff ,  Hartwig Schroeder ,  Andrea Molt ,  Holger Hartmann ,  Klaus Ditrich ,  Michael Breuer ,  Rüdiger Reingrubber ,  Jakob Weber

    IPC分类号： C12P17/04 ,  C12N15/80

    CPC分类号： C12P17/04 ,  A01N37/42 ,  A01N37/46 ,  A01N63/04 ,  C07D307/93 ,  C07K14/37 ,  C12N15/52 ,  C12N15/67 ,  C12N15/80

    摘要： The invention pertains to the field of production of natural products and, in particular, in the field of production of cornexistin and hydroxycornexistin. It provides polynucleotides encoding polypeptides involved in the biosynthesis of cornexistin and hydroxycornexistin as well as vectors and recombinant microorganisms comprising such polynucleotides. Also provided are methods for the production of natural products, in particular methods for the production of cornexistin and hydroxycornexistin, using such polynucleotides and polpeptides encoded therein, as well as vectors and recombinant microorganisms comprising such polynucleotides and polypeptides.

    摘要翻译： 本发明涉及天然产物的生产领域，尤其涉及在玉米corn霉素和羟基角质素的生产领域。 它提供了编码涉及Cornexistin和羟基角质素的生物合成的多肽的多核苷酸以及包含这种多核苷酸的载体和重组微生物。 还提供了生产天然产物的方法，特别是使用这样的多核苷酸和其中编码的多肽以及包含这种多核苷酸和多肽的载体和重组微生物来生产玉米corn霉素和羟基角质柔比星的方法。

    PEF-TS EXPRESSION UNITS
    10.
    发明申请
    PEF-TS EXPRESSION UNITS 审中-公开
    PEF-TS表达单位

    公开(公告)号：US20140242704A1

    公开(公告)日：2014-08-28

    申请号：US14272781

    申请日：2014-05-08

    申请人： BASF SE

    发明人： Oskar Zelder ,  Corinna Klopprogge ,  Burkhard Kröger ,  Hartwig Schröder ,  Stefan Haefner

    IPC分类号： C12N15/63

    CPC分类号： C12N15/63 ,  C07K14/34 ,  C12N15/77 ,  C12P13/04

    摘要： The present invention relates to the use of nucleic acid sequences for regulating the transcription and expression of genes, the novel promoters and expression units themselves, methods for altering or causing the transcription rate and/or expression rate of genes, expression cassettes comprising the expression units, genetically modified microorganisms with altered or caused transcription rate and/or expression rate, and methods for preparing biosynthetic products by cultivating the genetically modified microorganisms.

    摘要翻译： 本发明涉及核酸序列用于调节基因的转录和表达，新型启动子和表达单元本身的用途，用于改变或引起基因的转录速率和/或表达速率的方法，包含表达单位的表达盒 具有改变或引起的转录速率和/或表达速率的转基因微生物，以及通过培养转基因微生物来制备生物合成产物的方法。