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公开(公告)号：US20160304917A1
公开(公告)日：2016-10-20
申请号：US14914855
申请日：2014-08-18
Applicant: BASF SE
Inventor： Joanna Martyna Krawczyk , Stefan Haefner , Hartwig Schröder , Oskar Zelder , Jonathan Thomas Fabarius
CPC classification number: C12P13/06 , C12N9/0016 , C12R1/01 , C12Y104/01001
Abstract: The present invention relates to a modified microorganism having, compared to its wildtype, an increased activity of the enzyme that is encoded by the alaD-gene. The present invention also relates to a method for producing an alanine and to the use of modified microorganisms.
Abstract translation: 本发明涉及一种经修饰的微生物，其与野生型相比具有增加由alaD基因编码的酶的活性。 本发明还涉及丙氨酸的生产方法和改性微生物的使用。
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公开(公告)号：US10273485B2
公开(公告)日：2019-04-30
申请号：US15116600
申请日：2015-02-06
Applicant: BASF SE
Inventor： Joanna Martyna Krawczyk , Stefan Haefner , Hartwig Schröder , Esther Dantas Costa , Oskar Zelder , Gregory Von Abendroth , Christoph Wittmann , René Stellmacher , Judith Becker
Abstract: The present invention relates to a modified microorganism having, compared to its wild-type, a reduced activity of the enzyme that is encoded by the wcaJ-gene. The present invention also relates to a method for producing an organic compound and to the use of a modified microorganism.
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公开(公告)号：US10287571B2
公开(公告)日：2019-05-14
申请号：US15308874
申请日：2015-05-07
Applicant: BASF SE
Inventor： Joanna Martyna Krawczyk , Stefan Haefner , Hartwig Schroeder , Oskar Zelder
IPC: A61K38/00 , C12N15/10 , C12P7/46 , C07K14/195 , C12N15/74
Abstract: The present invention relates to a modified microorganism having, compared to its wildtype, —a reduced activity of an enzyme encoded by the ptsA-gene, —a reduced activity of an enzyme encoded by the ptsH-gene or —a reduced activity of an enzyme encoded by the ptsA-gene and a reduced activity of an enzyme encoded by the ptsH-gene, wherein the wildtype from which the modified microorganism has been derived belongs to the family of Pasteurellaceae. The present invention also relates to a method for producing succinic acid and to the use of modified microorganisms.
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公开(公告)号：US09850506B2
公开(公告)日：2017-12-26
申请号：US15116896
申请日：2015-05-02
Applicant: BASF SE
Inventor： Joanna Martyna Krawczyk , Stefan Haefner , Hartwig Schröder , Esther Dantas Costa , Oskar Zelder , Gregory Von Abendroth
IPC: C12P7/46
CPC classification number: C12P7/46 , C07K14/285 , C12N1/20 , C12N15/52
Abstract: The present invention relates to a modified microorganism having, compared to its wild-type, a reduced activity of the enzyme that is encoded by the fruA-gene. The present invention also relates to a method for producing an organic compound and to the use of modified microorganisms.
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公开(公告)号：US10287558B2
公开(公告)日：2019-05-14
申请号：US15116669
申请日：2015-02-02
Applicant: BASF SE
Inventor： Joanna Martyna Krawczyk , Stefan Haefner , Hartwig Schröder , Esther Dantas Costa , Oskar Zelder , Gregory Von Abendroth , Christoph Wittmann , René Stellmacher , Judith Becker , Anna Lange , Benjamin J. Lyons , Thomas J. Lyons , Eudes De Crecy , Ewa Hughes
Abstract: The present invention relates to a modified microorganism having, compared to its wild-type, a reduced activity of the enzyme that is encoded by the pykA-gene. The present invention also relates to a method for producing an organic compound and to the use of modified microorganisms.
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Patent Agency Ranking
公开(公告)号：US20170166937A1
公开(公告)日：2017-06-15
申请号：US15116896
申请日：2015-05-02
Applicant: BASF SE
Inventor： Joanna Martyna Krawczyk , Stefan Haefner , Hartwig Schröder , Esther Dantas Costa , Oskar Zelder , Gregory Von Abendroth
IPC: C12P7/46
CPC classification number: C12P7/46 , C07K14/285 , C12N1/20 , C12N15/52
Abstract: The present invention relates to a modified microorganism having, compared to its wild-type, a reduced activity of the enzyme that is encoded by the fruA-gene. The present invention also relates to a method for producing an organic compound and to the use of modified microorganisms.
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公开(公告)号：US10513693B2
公开(公告)日：2019-12-24
申请号：US15127181
申请日：2015-03-18
Applicant: BASF SE
Inventor： Esther Dantas Costa , Oskar Zelder , Hartwig Schröder , Stefan Haefner , Joanna Martyna Krawczyk , Gregory Von Abendroth , Christian Riedele , Torsten Renz
IPC: C12N9/04 , C12N9/10 , C12P7/46 , C07K14/285
Abstract: The present invention relates to a process for producing an organic acid by fermentation, comprising the process steps: I) cultivating microorganisms in a culture medium to which are fed, as assimilable carbon sources, glycerol and a further carbonaceous compound, to allow the microorganisms to produce the organic acid, thereby obtaining a fermentation broth comprising the organic acid; II) recovering the organic acid or the salt thereof from the fermentation broth obtained in process step I); wherein, at least for a certain period of time in process step I), the consumption rate of the further carbonaceous compound (CRc.c.; in g per liter per hour) is lower than the maximum theoretical consumption rate of the further carbonaceous compound (CRc.c. max; in g per liter per hour).
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公开(公告)号：US20180030418A1
公开(公告)日：2018-02-01
申请号：US15127181
申请日：2015-03-18
Applicant: BASF SE
Inventor： Esther Dantas Costa , Oskar Zelder , Hartwig Schröder , Stefan Haefner , Joanna Martyna Krawczyk , Gregory Von Abendroth , Christian Riedele , Torsten Renz
CPC classification number: C12N9/0006 , C07K14/285 , C12N9/1029 , C12P7/46 , C12Y101/01027 , C12Y203/01054
Abstract: The present invention relates to a process for producing an organic acid by fermentation, comprising the process steps: I) cultivating microorganisms in a culture medium to which are fed, as assimilable carbon sources, glycerol and a further carbonaceous compound, to allow the microorganisms to produce the organic acid, thereby obtaining a fermentation broth comprising the organic acid; II) recovering the organic acid or the salt thereof from the fermentation broth obtained in process step I); wherein, at least for a certain period of time in process step I), the consumption rate of the further carbonaceous compound (CRc.c.; in g per liter per hour) is lower than the maximum theoretical consumption rate of the further carbonaceous compound (CRc.c. max; in g per liter per hour).
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9.发明申请Genetically Modified Microorganism for Improved Production of Fine Chemicals on Sucrose 审中-公开用于改善蔗糖精细化学品生产的转基因微生物公开(公告)号：US20170073665A1
公开(公告)日：2017-03-16
申请号：US15308874
申请日：2015-05-07
Applicant: BASF SE
Inventor： Joanna Martyna Krawczyk , Stefan Haefner , Hartwig Schroeder , Oskar Zelder
CPC classification number: C12N15/102 , C07K14/195 , C12N15/74 , C12N2510/02 , C12P7/46 , C12Y207/11
Abstract: The present invention relates to a modified microorganism having, compared to its wildtype,—a reduced activity of an enzyme encoded by the ptsA-gene,—a reduced activity of an enzyme encoded by the ptsH-gene or—a reduced activity of an enzyme encoded by the ptsA-gene and a reduced activity of an enzyme encoded by the ptsH-gene, wherein the wildtype from which the modified microorganism has been derived belongs to the family of Pasteurellaceae. The present invention also relates to a method for producing succinic acid and to the use of modified microorganisms.
Abstract translation: 本发明涉及一种经修饰的微生物，其与野生型相比具有降低的由ptsA基因编码的酶的活性， - 由ptsH基因编码的酶的活性降低或酶活性降低 由ptsA基因编码并且由ptsH基因编码的酶的活性降低，其中来源于修饰微生物的野生型属于巴氏杆菌科。 本发明还涉及生产琥珀酸的方法和使用改性微生物。
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公开(公告)号：US20160362696A1
公开(公告)日：2016-12-15
申请号：US15116600
申请日：2015-02-06
Applicant: BASF SE
Inventor： Joanna Martyna Krawczyk , Stefan Haefner , Hartwig Schröder , Esther Dantas Costa , Oskar Zelder , Gregory Von Abendroth , Christoph Wittmann , René Stellmacher , Judith Becker
CPC classification number: C12N15/52 , C12N1/02 , C12N9/0006 , C12N9/1029 , C12N9/1288 , C12N15/74 , C12P7/46 , C12Y101/01 , C12Y203/01054 , C12Y207/08031
Abstract: The present invention relates to a modified microorganism having, compared to its wild-type, a reduced activity of the enzyme that is encoded by the wcaJ-gene. The present invention also relates to a method for producing an organic compound and to the use of a modified microorganism.
Abstract translation: 本发明涉及与其野生型相比具有由wcaJ基因编码的酶的活性降低的修饰微生物。 本发明还涉及有机化合物的制造方法和改性微生物的用途。
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