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公开(公告)号：US11534605B2
公开(公告)日：2022-12-27
申请号：US16877554
申请日：2020-05-19
Applicant: Battelle Memorial Institute
Inventor： Chad E. Bouton , Gaurav Sharma , Andrew Sweeney , Amy M. Heintz , Stephanie Kute , Nicholas Annetta , Thomas D. Haubert , Steven M. Risser , Jeffrey Friend , John Bartholomew , Rachel Thurston , Alexander C. Morrow , George Brand , Jeffrey Ellis , Matthew Mowrer , Raymond Zaborski
Abstract: The present disclosure relates to neuromuscular stimulation and sensing cuffs. The neuromuscular stimulation cuff has at least two fingers and a plurality of electrodes disposed on each finger. More generally, the neuromuscular stimulation cuff includes an outer, reusable component and an inner, disposable component. One or more electrodes are housed within the reusable component. The neuromuscular stimulation cuff may be produced by providing an insulating substrate layer, forming a conductive circuit on the substrate layer to form a conductive circuit layer, adhering a cover layer onto the conductive circuit layer to form a flexible circuit, and cutting at least one flexible finger from the flexible circuit. The neuromuscular stimulation cuff employs a flexible multi-electrode design which allows for reanimation of complex muscle movements in a patient, including individual finger movement.
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公开(公告)号：US20180154133A1
公开(公告)日：2018-06-07
申请号：US15872734
申请日：2018-01-16
Applicant: Battelle Memorial Institute
Inventor： Chad E. Bouton , Jeffrey Friend , Gaurav Sharma , Andrew Sweeney , Amy M. Heinz , Stephanie Kute , Nicholas Annetta , Thomas D. Haubert , Steven M. Risser , Alexander Morrow , Raymond Richard Zaborski , George Naegele Brand , Matthew Edward Mowrer
CPC classification number: A61N1/0484 , A61N1/0456 , A61N1/36003 , G06F3/015 , G06F3/017
Abstract: The present disclosure relates to neuromuscular stimulation and sensing cuffs. The neuromuscular stimulation cuff has at least two fingers and a plurality of electrodes disposed on each finger. More generally, the neuromuscular stimulation cuff includes an outer, reusable component and an inner, disposable component. One or more electrodes are housed within the reusable component. The neuromuscular stimulation cuff may be produced by providing an insulating substrate layer, forming a conductive circuit on the substrate layer to form a conductive circuit layer, adhering a cover layer onto the conductive circuit layer to form a flexible circuit, and cutting at least one flexible finger from the flexible circuit. The neuromuscular stimulation cuff employs a flexible multi-electrode design which allows for reanimation of complex muscle movements in a patient, including individual finger movement.
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公开(公告)号：US20130084579A1
公开(公告)日：2013-04-04
申请号：US13622740
申请日：2012-09-19
Applicant: Battelle Memorial Institute
Inventor： Herbert S. Bresler , Kevin M. Taylor , John S. Laudo , Thomas D. Haubert
IPC: G01N33/94
CPC classification number: G01N33/94 , B01L3/50215 , G01N33/5011 , G01N33/582
Abstract: Methods for determining the efficacy of a given drug for a specific patient with cancer in vitro prior to, or after, the initiation of treatment of the patient are disclosed. Blood from the cancer patient is separated into an assay test tube and a control test tube. The blood in the assay test tube is exposed to a cancer drug. The two test tubes are then visually examined and compared to determine the effect of the cancer drug on cancer cells, other rare cells in the blood, or on normal constituents of the blood of a cancer patient.
Abstract translation: 公开了在开始治疗患者之前或之后确定给定药物对特定癌症患者的功效的方法。 将来自癌症患者的血液分离成测定试管和对照试管。 测定试管中的血液暴露于癌症药物。 然后目视检查并比较两个试管，以确定癌症药物对癌细胞，血液中的其它罕见细胞或癌症患者血液正常成分的影响。
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公开(公告)号：US20230020138A1
公开(公告)日：2023-01-19
申请号：US17945486
申请日：2022-09-15
Applicant: BATTELLE MEMORIAL INSTITUTE
Inventor： Chad E. Bouton , Gaurav Sharma , Andrew Sweeney , Amy M. Heintz , Stephanie Kute , Nicholas Annetta , Thomas D. Haubert , Steven M. Risser , Jeffrey Friend , John Bartholomew , Rachel Thurston , Alexander C. Morrow , George Brand , Jeffrey Ellis , Matthew Mowrer , Raymond Zaborski
Abstract: The present disclosure relates to neuromuscular stimulation and sensing cuffs. The neuromuscular stimulation cuff has at least two fingers and a plurality of electrodes disposed on each finger. More generally, the neuromuscular stimulation cuff includes an outer, reusable component and an inner, disposable component. One or more electrodes are housed within the reusable component. The neuromuscular stimulation cuff may be produced by providing an insulating substrate layer, forming a conductive circuit on the substrate layer to form a conductive circuit layer, adhering a cover layer onto the conductive circuit layer to form a flexible circuit, and cutting at least one flexible finger from the flexible circuit. The neuromuscular stimulation cuff employs a flexible multi-electrode design which allows for reanimation of complex muscle movements in a patient, including individual finger movement.
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公开(公告)号：US20200276438A1
公开(公告)日：2020-09-03
申请号：US16877554
申请日：2020-05-19
Applicant: Battelle Memorial Institute
Inventor： Chad E. Bouton , Gaurav Sharma , Andrew Sweeney , Amy M. Heintz , Stephanie Kute , Nicholas Annetta , Thomas D. Haubert , Steven M. Risser , Jeffrey Friend , John Bartholomew , Rachel Thurston , C. Alexander Morrow , George Brand , Jeffrey Ellis , Matthew Mowrer , Raymond Zaborski
IPC: A61N1/05 , A61B5/0488 , A61N1/04 , A61B5/00 , A61B5/0478 , A61B5/0482 , A61B5/11
Abstract: The present disclosure relates to neuromuscular stimulation and sensing cuffs. The neuromuscular stimulation cuff has at least two fingers and a plurality of electrodes disposed on each finger. More generally, the neuromuscular stimulation cuff includes an outer, reusable component and an inner, disposable component. One or more electrodes are housed within the reusable component. The neuromuscular stimulation cuff may be produced by providing an insulating substrate layer, forming a conductive circuit on the substrate layer to form a conductive circuit layer, adhering a cover layer onto the conductive circuit layer to form a flexible circuit, and cutting at least one flexible finger from the flexible circuit. The neuromuscular stimulation cuff employs a flexible multi-electrode design which allows for reanimation of complex muscle movements in a patient, including individual finger movement.
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Patent Agency Ranking
公开(公告)号：US20180154140A1
公开(公告)日：2018-06-07
申请号：US15578816
申请日：2016-06-02
Applicant: Battelle Memorial Institute
Inventor： Chad E. Bouton , Gaurav Sharma , Andrew Sweeney , Amy M. Heintz , Stephanie Kute , Nicholas Annetta , Thomas D. Haubert , Steven M. Risser , Jeffrey Friend , John Bartholomew , Rachel Thurston , C. Alexander Morrow , George Brand , Jeffrey Ellis , Matthew Mowrer , Raymond Zaborski
IPC: A61N1/05 , A61B5/0478 , A61B5/00 , A61B5/0488 , A61B5/11 , A61N1/04
CPC classification number: A61N1/0556 , A61B5/0478 , A61B5/0482 , A61B5/0488 , A61B5/11 , A61B5/1127 , A61B5/4836 , A61B5/686 , A61N1/0452 , A61N1/0456 , A61N1/0476 , A61N1/048 , A61N1/0484 , A61N1/36003
Abstract: The present disclosure relates to neuromuscular stimulation and sensing cuffs. The neuromuscular stimulation cuff has at least two fingers and a plurality of electrodes disposed on each finger. More generally, the neuromuscular stimulation cuff includes an outer, reusable component and an inner, disposable component. One or more electrodes are housed within the reusable component. The neuromuscular stimulation cuff may be produced by providing an insulating substrate layer, forming a conductive circuit on the substrate layer to form a conductive circuit layer, adhering a cover layer onto the conductive circuit layer to form a flexible circuit, and cutting at least one flexible finger from the flexible circuit. The neuromuscular stimulation cuff employs a flexible multi-electrode design which allows for reanimation of complex muscle movements in a patient, including individual finger movement.
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公开(公告)号：US20130084594A1
公开(公告)日：2013-04-04
申请号：US13622645
申请日：2012-09-19
Applicant: Battelle Memorial Institute
Inventor： Herbert S. Bresler , Kevin M. Taylor , John S. Laudo , Thomas D. Haubert
IPC: C12Q1/02
CPC classification number: C12Q1/025 , B01L3/50215 , G01N33/5011 , G01N33/582
Abstract: Methods for determining the efficacy of a given drug for a specific patient with cancer in vitro prior to, or after, the initiation of treatment of the patient are disclosed. Blood from the cancer patient is separated into an assay test tube and a control test tube. The blood in the assay test tube is exposed to a cancer drug. The two test tubes are then visually examined and compared to determine the effect of the cancer drug on cancer cells, other rare cells in the blood, or on normal constituents of the blood of a cancer patient.
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公开(公告)号：US10765859B2
公开(公告)日：2020-09-08
申请号：US15578816
申请日：2016-06-02
Applicant: Battelle Memorial Institute
Inventor： Chad E. Bouton , Gaurav Sharma , Andrew Sweeney , Amy M. Heintz , Stephanie Kute , Nicholas Annetta , Thomas D. Haubert , Steven M. Risser , Jeffrey Friend , John Bartholomew , Rachel Thurston , C. Alexander Morrow , George Brand , Jeffrey Ellis , Matthew Mowrer , Raymond Zaborski
IPC: A61N1/05 , A61B5/0488 , A61N1/04 , A61B5/00 , A61B5/0478 , A61B5/0482 , A61B5/11 , A61N1/36
Abstract: The present disclosure relates to neuromuscular stimulation and sensing cuffs. The neuromuscular stimulation cuff has at least two fingers and a plurality of electrodes disposed on each finger. More generally, the neuromuscular stimulation cuff includes an outer, reusable component and an inner, disposable component. One or more electrodes are housed within the reusable component. The neuromuscular stimulation cuff may be produced by providing an insulating substrate layer, forming a conductive circuit on the substrate layer to form a conductive circuit layer, adhering a cover layer onto the conductive circuit layer to form a flexible circuit, and cutting at least one flexible finger from the flexible circuit. The neuromuscular stimulation cuff employs a flexible multi-electrode design which allows for reanimation of complex muscle movements in a patient, including individual finger movement.
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公开(公告)号：US09884179B2
公开(公告)日：2018-02-06
申请号：US14728512
申请日：2015-06-02
Applicant: Battelle Memorial Institute
Inventor： Chad E. Bouton , Jeffrey Friend , Gaurav Sharma , Andrew Sweeney , Amy M. Heintz , Stephanie Kute , Nicholas Annetta , Thomas D. Haubert , Steven M. Risser , Alexander Morrow , Raymond Richard Zaborski , George Naegele Brand , Matthew Edward Mowrer
CPC classification number: A61N1/0484 , A61N1/0456 , A61N1/36003 , G06F3/015 , G06F3/017
Abstract: The present disclosure relates to neuromuscular stimulation and sensing cuffs. The neuromuscular stimulation cuff has at least two fingers and a plurality of electrodes disposed on each finger. More generally, the neuromuscular stimulation cuff includes an outer, reusable component and an inner, disposable component. One or more electrodes are housed within the reusable component. The neuromuscular stimulation cuff may be produced by providing an insulating substrate layer, forming a conductive circuit on the substrate layer to form a conductive circuit layer, adhering a cover layer onto the conductive circuit layer to form a flexible circuit, and cutting at least one flexible finger from the flexible circuit. The neuromuscular stimulation cuff employs a flexible multi-electrode design which allows for reanimation of complex muscle movements in a patient, including individual finger movement.
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公开(公告)号：US20240207605A1
公开(公告)日：2024-06-27
申请号：US18413464
申请日：2024-01-16
Applicant: Battelle Memorial Institute
Inventor： Chad E. Bouton , Jeffrey Friend , Gaurav Sharma , Andrew Sweeney , Amy M. Heintz , Stephanie Kute , Nicholas Annetta , Thomas D. Haubert , Steven M. Risser , Alexander Morrow , Raymond Richard Zaborski , George Naegele Brand , Matthew Edward Mowrer
CPC classification number: A61N1/0484 , A61N1/0456 , A61N1/36003 , G06F3/015 , G06F3/017
Abstract: The present disclosure relates to neuromuscular stimulation and sensing cuffs. The neuromuscular stimulation cuff has at least two fingers and a plurality of electrodes disposed on each finger. More generally, the neuromuscular stimulation cuff includes an outer, reusable component and an inner, disposable component. One or more electrodes are housed within the reusable component. The neuromuscular stimulation cuff may be produced by providing an insulating substrate layer, forming a conductive circuit on the substrate layer to form a conductive circuit layer, adhering a cover layer onto the conductive circuit layer to form a flexible circuit, and cutting at least one flexible finger from the flexible circuit. The neuromuscular stimulation cuff employs a flexible multi-electrode design which allows for reanimation of complex muscle movements in a patient, including individual finger movement.
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