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公开(公告)号：US20210220358A1
公开(公告)日：2021-07-22
申请号：US17055488
申请日：2019-05-14
IPC分类号： A61K31/506 , A61K31/5377 , A61K9/00 , A61P11/14 , A61P11/06 , A61P11/00
摘要： The present invention relates to use 1,3-thiazol-2-yl substituted benzamide compounds of general formula (I) as described and defined herein, to pharmaceutical compositions and combinations comprising said compounds for the treatment or prophylaxis of diseases which are associated with nerve fibre sensitization, in particular for treatment and prophylaxis of Chronic Cough (CC), Idiopathic Pulmonary Fibrosis (IPF), Chronic Obstructive Pulmonary Disorder (COPD), and asthma.
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公开(公告)号：US20200375986A1
公开(公告)日：2020-12-03
申请号：US16761713
申请日：2018-10-31
发明人： Nicole BIBER , Damian BROCKSCHNIEDER , Florian KÖLLING , Jörg MEDING , Hideki MIYATAKE ONDOZABAL , Thomas NEUBAUER , Martina SCHÄFER , Dmitry ZUBOV , Carsten TERJUNG
IPC分类号： A61K31/4985 , A61K45/06 , C07D487/04 , A61P11/00
摘要： The invention relates to prolyl endopeptidase (PREP) inhibitors which contain a condensed 2,4-dihydro-3H-1,2,4-triazol-3-one ring system, methods for producing same, the use thereof alone or in combinations for treating and/or preventing diseases, and the use thereof for producing drugs for treating and/or preventing diseases, in particular for treating and/or preventing inflammatory lung diseases (COPD).
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![SUBSTITUTED 5,6,7,8-TETRAHYDRO[1,2,4]TRIAZOLO[4,3-A]PYRIDINE-3(2H)-ONES AND 2,5,6,7-TETRAHYDRO-3H-PYRROLO[2,1-C][1,2,4]TRIAZOL-3-ONES, AND USE THEREOF](/abs-image/US/2019/05/30/US20190160048A1/abs.jpg.150x150.jpg)
公开(公告)号：US20190160048A1
公开(公告)日：2019-05-30
申请号：US16300480
申请日：2017-05-08
发明人： Nicole BIBER , Damian BROCKSCHNIEDER , Kersten Matthias GERICKE , Florian KÖLLING , Klemens LUSTIG , Jörg MEDING , Heinrich MEIER , Thomas NEUBAUER , Martina SCHÄFER , Andreas TIMMERMANN , Dmitry ZUBOV , Carsten TERJUNG , Niels LINDNER , Volker BADOCK , Dieter MOOSMAYER , Hideki MIYATAKE ONDOZABAL , Steven MOORE , Alexander SCHULZ
IPC分类号： A61K31/437 , A61P29/00 , A61P11/00 , C07D471/04 , A61K31/506
摘要： The present application relates to novel substituted 5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyridin-3(2H)-ones and 2,5,6,7-tetrahydro-3H-pyrrolo[2,1-c][1,2,4]triazol-3-ones, to processes for preparation thereof, to the use thereof, alone or in combinations, for treatment and/or prophylaxis of diseases, and to the use thereof for production of medicaments for treatment and/or prophylaxis of diseases, especially for treatment and/or prophylaxis of lung inflammation disorders.
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公开(公告)号：US20170240566A1
公开(公告)日：2017-08-24
申请号：US15503578
申请日：2015-08-25
发明人： Alexandros VAKALOPOULOS , Gaelle VALOT , Markus FOLLMANN , Damian BROCKSCHNIEDER , Johannes-Peter STASCH , Tobias MARQUARDT , Adrian TERSTEEGEN , Frank WUNDER , Lisa DIETZ , Dieter LANG , Ursula KRENZ
IPC分类号： C07D519/00 , A61K31/519 , C07D487/04 , A61K45/06
CPC分类号： C07D519/00 , A61K31/519 , A61K45/06 , C07D487/04
摘要： The present application relates to novel amino-substituted fused pyrimidines, to processes for their preparation, to their use alone or in combinations for the treatment and/or prophylaxis of diseases, and to their use for producing medicaments for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular disorders.
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公开(公告)号：US20170233413A1
公开(公告)日：2017-08-17
申请号：US15503448
申请日：2015-08-25
发明人： Walter HÜBSCH , Alexandros VAKALOPOULOS , Markus FOLLMANN , Gaelle VALOT , Johannes-Peter STASCH , Damian BROCKSCHNIEDER , Tobias MARQUARDT , Frank WUNDER , Adrian TERSTEEGEN , Lisa DIETZ , Dieter LANG , Niels LINDNER
IPC分类号： C07D519/00 , C07D487/04 , A61K9/08 , A61K31/519 , A61K9/20 , A61K9/00
CPC分类号： C07D519/00 , A61K9/0053 , A61K9/08 , A61K9/20 , A61K31/519 , C07D471/04 , C07D487/04
摘要： The present application relates to novel substituted fused pyrimidines, to processes for their preparation, to their use alone or in combinations for the treatment and/or prophylaxis of diseases, and to their use for producing medicaments for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular disorders.
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![N-SUBSTITUTED 8-[(2,6-DIFLUOROBENZYL)OXY]-2,6-DIMETHYLIMIDAZO[1,2-A]PYRAZIN-3-CARBOXAMIDE DERIVATIVES AS STIMULATORS OF SOLUBLE GUANYLATE CYCLASE (SGC) FOR THE TREATMENT OF CARDIOVASCULAR DISEASES](/abs-image/US/2018/01/25/US20180022751A1/abs.jpg.150x150.jpg)
公开(公告)号：US20180022751A1
公开(公告)日：2018-01-25
申请号：US15548310
申请日：2016-02-02
发明人： Alexandros VAKALOPOULOS , Damian BROCKSCHNIEDER , Frank WUNDER , Johannes-Peter STASCH , Tobias MARQUARDT , Lisa DIETZ , Min Jian Volkhart LI
IPC分类号： C07D487/04 , A61K45/06 , A61K31/695 , A61K31/4985 , C07B59/00 , C07F7/08
CPC分类号： C07D487/04 , A61K31/4985 , A61K31/695 , A61K45/06 , C07B59/002 , C07B2200/05 , C07F7/0812
摘要： The present application relates to novel substituted imidazo[1,2-a]pyrazine carboxamides, to processes for their preparation, to their use, alone or in combinations, for the treatment and/or prophylaxis of diseases, and to their use for producing medicaments for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular disorders.
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![HETEROARYL-SUBSTITUTED IMIDAZO[1,2-A]PYRIDINES AND THEIR USE](/abs-image/US/2017/10/26/US20170304278A1/abs.jpg.150x150.jpg)
公开(公告)号：US20170304278A1
公开(公告)日：2017-10-26
申请号：US15531948
申请日：2015-11-30
发明人： Alexandros VAKALOPOULOS , Damian BROCKSCHNIEDER , Frank WUNDER , Johannes-Peter STASCH , Tobias MARQUARDT , Lisa DIETZ , Volkhart Min-Jian LI
IPC分类号： A61K31/437 , C07D471/04 , B01J31/14 , C07F5/02 , A61K31/03
CPC分类号： A61K31/437 , A61K31/03 , B01J31/146 , C07D471/04 , C07F5/025
摘要： The present application relates to novel heteroaryl-substituted imidazo[1,2-a]pyridines, to processes for preparation thereof, to the use thereof, alone or in combinations, for the treatment and/or prophylaxis of diseases, and to the use thereof for production of medicaments for the treatment and/or prophylaxis of diseases, especially for the treatment and/or prophylaxis of cardiovascular disorders.
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![Substituted pyrazolo[1,5-a]-pyridine-3-carboxamides and use thereof](/abs-image/US/2018/02/08/US20180037580A1/abs.jpg.150x150.jpg)
公开(公告)号：US20180037580A1
公开(公告)日：2018-02-08
申请号：US15548158
申请日：2016-02-02
发明人： Alexandros VAKALOPOULOS , Damian BROCKSCHNIEDER , Frank WUNDER , Johannes-Peter STASCH , Tobias MARQUARDT , Lisa DIETZ , Min Jian Volkhart LI
IPC分类号： C07D471/04
CPC分类号： C07D471/04
摘要： The present application relates to novel substituted pyrazolo[1,5-a]pyridine-3-carboxamides, to processes for their preparation, to their use, alone or in combinations, for the treatment and/or prophylaxis of diseases, and to their use for producing medicaments for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular disorders.
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![SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINES AND IMIDAZO[1,2-A]PYRAZINES AND THEIR USE](/abs-image/US/2017/11/02/US20170313700A1/abs.jpg.150x150.jpg)
公开(公告)号：US20170313700A1
公开(公告)日：2017-11-02
申请号：US15531993
申请日：2015-11-30
发明人： Alexandros VAKALOPOULOS , Damian BROCKSCHNIEDER , Frank WUNDER , Johannes-Peter STASCH , Tobias MARQUARDT , Lisa DIETZ , Volkhart Min-Jian LI
IPC分类号： C07D471/04 , A61K45/06 , A61K31/5377 , A61K31/53 , A61K31/519 , A61K31/496 , A61K9/00 , A61K31/444 , A61K31/437 , A61K9/20 , A61K9/08 , C07D519/00 , A61K31/506
CPC分类号： C07D471/04 , A61K9/0019 , A61K9/0053 , A61K9/08 , A61K9/20 , A61K31/437 , A61K31/444 , A61K31/4738 , A61K31/496 , A61K31/506 , A61K31/519 , A61K31/53 , A61K31/5377 , A61K45/06 , C07D487/04 , C07D519/00
摘要： The present application relates to novel substituted pyrazolo[1,5-a]pyridines and imidazo[1,2-a]pyrazines, to processes for preparation thereof, to the use thereof, alone or in combinations, for treatment and/or prophylaxis of diseases, and to the use thereof for production of medicaments for treatment and/or prophylaxis of diseases, especially for treatment and/or prophylaxis of cardiovascular disorders.
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![BENZYL-1H-PYRAZOLO[3,4-B]PYRIDINES AND USE THEREOF](/abs-image/US/2016/05/26/US20160145271A1/abs.jpg.150x150.jpg)
公开(公告)号：US20160145271A1
公开(公告)日：2016-05-26
申请号：US14903347
申请日：2014-07-08
发明人： Alexandros VAKALOPOULOS , Alexey GROMOV , Markus FOLLMANN , Damian BROCKSCHNIEDER , Johannes-Peter STASCH , Tobias MARQUARDT , Adrian TERSTEEGEN , Frank WUNDER , Gorden REDLICH , Dieter LANG , Volkhart Min-Jian LI
IPC分类号： C07D519/00 , A61K45/06 , A61K31/53
CPC分类号： C07D519/00 , A61K31/53 , A61K45/06 , C07D519/04
摘要： The present application relates to novel benzyl-1H-pyrazolo[3,4-b]pyridines, to processes for their preparation, to their use alone or in combinations for the treatment and/or prophylaxis of diseases, and to their use for producing medicaments for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular disorders.
摘要翻译： 本申请涉及新的苄基-1H-吡唑并[3,4-b]吡啶，其制备方法，单独使用或组合用于治疗和/或预防疾病及其用于制备药物的用途 用于治疗和/或预防疾病，特别是用于治疗和/或预防心血管疾病。
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