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公开(公告)号：US09809577B2
公开(公告)日：2017-11-07
申请号：US15103749
申请日：2014-12-11
Applicant: BIOGEN MA INC.
Inventor： Brian T. Hopkins , Bin Ma , Timothy Raymond Chan , Lihong Sun , Lei Zhang , Gnanasambandam Kumaravel , Joseph P. Lyssikatos , Kevin Koch , Hua Miao
IPC: C07D403/12 , C07D417/14 , C07D495/04 , C07D409/14 , C07D401/14 , C07D513/04 , C07D413/14 , C07D417/12 , C07D487/04
CPC classification number: C07D403/12 , A61K31/506 , C07D239/30 , C07D401/14 , C07D409/14 , C07D413/14 , C07D417/12 , C07D417/14 , C07D487/04 , C07D495/04 , C07D513/04 , C07F5/027
Abstract: The present invention provides compounds and compositions thereof which are useful as inhibitors of Bruton's tyrosine kinase and which exhibit desirable characteristics for the same.
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公开(公告)号：US09944666B2
公开(公告)日：2018-04-17
申请号：US15368454
申请日：2016-12-02
Applicant: BIOGEN MA INC.
Inventor： Kevin M. Guckian , Gnanasambandam Kumaravel , Bin Ma , Sha Mi , Hairuo Peng , Zhaohui Shao , Lihong Sun , Arthur G. Taveras , Zhili Xin , Lei Zhang
IPC: C07D401/04 , C07D215/38 , C07D217/12 , A61K31/47 , C07F7/08 , A61K45/06 , C07C229/50 , A61K31/196 , C07D215/12 , A61K31/4545 , A61K31/506 , C07D295/096 , A61K31/495 , C07D213/74 , A61K31/496 , A61K31/551 , C07D239/42 , C07D241/20 , A61K31/497 , C07D211/14 , A61K31/451 , C07D205/04 , A61K31/397 , C07D401/06 , A61K31/4709 , C07D491/107 , C07D209/52 , A61K31/403 , C07D451/02 , A61K31/439 , A61K31/695 , C07C233/60 , C07D451/14
CPC classification number: C07F7/081 , A61K31/195 , A61K31/196 , A61K31/397 , A61K31/403 , A61K31/41 , A61K31/439 , A61K31/451 , A61K31/4545 , A61K31/47 , A61K31/4709 , A61K31/4725 , A61K31/495 , A61K31/496 , A61K31/497 , A61K31/506 , A61K31/551 , A61K31/5513 , A61K31/695 , A61K45/06 , C07C211/38 , C07C217/58 , C07C229/46 , C07C229/50 , C07C233/60 , C07C233/61 , C07C235/66 , C07C2102/10 , C07C2102/42 , C07C2102/44 , C07C2102/50 , C07C2103/62 , C07C2601/10 , C07C2601/14 , C07C2602/08 , C07C2602/10 , C07C2602/42 , C07C2602/44 , C07C2602/46 , C07C2602/50 , C07C2603/62 , C07C2603/74 , C07D205/04 , C07D209/52 , C07D211/14 , C07D213/74 , C07D215/12 , C07D215/20 , C07D215/38 , C07D217/22 , C07D239/42 , C07D241/20 , C07D295/096 , C07D401/04 , C07D401/06 , C07D451/02 , C07D451/14 , C07D471/08 , C07D491/107 , C07F7/0805 , A61K2300/00
Abstract: Compounds of formula (I) can modulate the activity of one or more SIP receptors and/or the activity of autotaxin (ATX).
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公开(公告)号：US20170158687A1
公开(公告)日：2017-06-08
申请号：US15296601
申请日：2016-10-18
Applicant: BIOGEN MA INC.
Inventor： Kevin M. Guckian , Gnanasambandam Kumaravel , Bin Ma , Sha Mi , Hairuo Peng , Zhaohui Shao , Lihong Sun , Arthur G. Taveras , Deping Wang , Zhili Xin , Lei Zhang
IPC: C07D451/02 , C07D401/06 , A61K45/06 , A61K31/4725 , C07D217/22 , A61K31/472
CPC classification number: C07D451/02 , A61K31/136 , A61K31/196 , A61K31/439 , A61K31/445 , A61K31/46 , A61K31/472 , A61K31/4725 , A61K31/5375 , A61K31/55 , A61K45/06 , C07B2200/07 , C07C217/22 , C07C229/46 , C07C229/48 , C07C255/59 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2602/42 , C07D209/52 , C07D211/34 , C07D211/62 , C07D217/22 , C07D221/22 , C07D223/06 , C07D295/096 , C07D401/06 , C07D471/08 , Y02A50/401
Abstract: Disclosed are bicyclic aryl compounds of formula (I), that can modulate the activity of the autotaxin (ATX) enzyme. This invention further relates to compounds that are ATX inhibitors, and methods of making and using such compounds in the treatment of demyelination due to injury or disease, as well as for treating proliferative disorders such as cancer.
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公开(公告)号：US11572356B2
公开(公告)日：2023-02-07
申请号：US17004411
申请日：2020-08-27
Applicant: BIOGEN MA INC.
Inventor： Brian T. Hopkins , Bin Ma , Timothy Raymond Chan , Lihong Sun , Lei Zhang , Gnanasambandam Kumaravel , Joseph P. Lyssikatos , Kevin Koch , Hua Miao
IPC: C07D403/12 , C07D417/14 , C07D495/04 , C07D409/14 , C07D401/14 , C07D513/04 , C07D413/14 , A61K31/506 , C07D239/30 , C07F5/02 , C07D417/12 , C07D487/04
Abstract: The present invention provides compounds and compositions thereof which are useful as inhibitors of Bruton's tyrosine kinase and which exhibit desirable characteristics for the same.
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公开(公告)号：US20190218204A1
公开(公告)日：2019-07-18
申请号：US16108755
申请日：2018-08-22
Applicant: BIOGEN MA INC.
Inventor： Brian T. Hopkins , Bin Ma , Timothy Raymond Chan , Lihong Sun , Lei Zhang , Gnanasambandam Kumaravel , Joseph P. Lyssikatos , Kevin Koch , Hua Miao
IPC: C07D403/12 , C07F5/02 , C07D239/30 , A61K31/506 , C07D487/04 , C07D513/04 , C07D401/14 , C07D417/14 , C07D417/12 , C07D409/14 , C07D413/14 , C07D495/04
Abstract: The present invention provides compounds and compositions thereof which are useful as inhibitors of Bruton's tyrosine kinase and which exhibit desirable characteristics for the same.
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Patent Agency Ranking
公开(公告)号：US10273234B2
公开(公告)日：2019-04-30
申请号：US14420020
申请日：2013-08-05
Applicant: BIOGEN MA INC.
Inventor： Kevin Guckian , Gnanasambandam Kumaravel , Bin Ma , Lihong Sun , Zhili Xin , Lei Zhang
IPC: C07D471/08 , A61K31/122 , C07C229/48 , C07D223/06 , C07D205/04 , C07D207/16 , C07D209/52 , C07D211/62 , A61K45/06 , A61K31/397 , A61K31/403 , A61K31/44 , A61K31/55 , A61K31/196 , A61K31/40 , A61K31/439 , A61K31/445 , C07C211/38 , C07D207/08
Abstract: Compounds of formula (I) can modulate the activity of one or more SIP receptors and/or the activity of autotaxin (ATX).
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公开(公告)号：US10081619B2
公开(公告)日：2018-09-25
申请号：US15699857
申请日：2017-09-08
Applicant: BIOGEN MA INC.
Inventor： Brian T. Hopkins , Bin Ma , Timothy Raymond Chan , Lihong Sun , Lei Zhang , Gnanasambandam Kumaravel , Joseph P. Lyssikatos , Kevin Koch , Hua Miao
IPC: C07D403/12 , C07D487/04 , C07D401/14 , C07D413/14 , C07D409/14 , C07D417/12 , C07D417/14 , C07D495/04 , C07D513/04
CPC classification number: C07D403/12 , A61K31/506 , C07D239/30 , C07D401/14 , C07D409/14 , C07D413/14 , C07D417/12 , C07D417/14 , C07D487/04 , C07D495/04 , C07D513/04 , C07F5/027
Abstract: The present invention provides compounds and compositions thereof which are useful as inhibitors of Bruton's tyrosine kinase and which exhibit desirable characteristics for the same.
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公开(公告)号：US20180093973A1
公开(公告)日：2018-04-05
申请号：US15699857
申请日：2017-12-20
Applicant: BIOGEN MA INC.
Inventor： Brian T. Hopkins , Bin Ma , Timothy Raymond Chan , Lihong Sun , Lei Zhang , Gnanasambandam Kumaravel , Joseph P. Lyssikatos , Kevin Koch , Hua Miao
IPC: C07D403/12 , C07D487/04 , C07D401/14 , C07D413/14 , C07D409/14 , C07D417/14 , C07D495/04 , C07D513/04 , C07D417/12
CPC classification number: C07D403/12 , A61K31/506 , C07D239/30 , C07D401/14 , C07D409/14 , C07D413/14 , C07D417/12 , C07D417/14 , C07D487/04 , C07D495/04 , C07D513/04 , C07F5/027
Abstract: The present invention provides compounds and compositions thereof which are useful as inhibitors of Bruton's tyrosine kinase and which exhibit desirable characteristics for the same.
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9.发明授权公开(公告)号：US09499485B2
公开(公告)日：2016-11-22
申请号：US14420025
申请日：2013-08-05
Applicant: BIOGEN MA INC.
Inventor： Kevin Guckian , Gnanasambandam Kumaravel , Bin Ma , Lihong Sun , Zhili Xin , Lei Zhang
IPC: C07D451/02 , C07D211/62 , A61K31/122 , A61K45/06 , A61K31/192 , A61K31/216 , A61K31/439 , A61K31/445 , A61K31/45 , C07C229/14 , C07C229/48 , C07D211/60 , A61K31/196 , A61K31/197 , A61K31/198 , A61K31/46 , C07D211/34 , C07D451/14
CPC classification number: C07D211/62 , A61K31/122 , A61K31/192 , A61K31/196 , A61K31/197 , A61K31/198 , A61K31/216 , A61K31/439 , A61K31/445 , A61K31/45 , A61K31/46 , A61K45/06 , C07C229/14 , C07C229/48 , C07C2601/14 , C07D211/34 , C07D211/60 , C07D451/02 , C07D451/14 , A61K2300/00
Abstract: Compounds of formula (I) can modulate the activity of one or more SIP receptors and/or the activity of autotaxin (ATX).
Abstract translation: 式（I）化合物可以调节一种或多种SIP受体的活性和/或自分泌素（ATX）的活性。
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公开(公告)号：US09771326B2
公开(公告)日：2017-09-26
申请号：US14443944
申请日：2013-11-20
Applicant: BIOGEN MA INC.
Inventor： Hairuo Peng , Zhili Xin , Lihong Sun , Timothy Chan , Gnanasambandam Kumaravel , Arthur G. Taveras
IPC: C07D211/62 , C07D401/10 , C07D237/14 , C07D215/14 , C07D401/04 , C07D239/34 , C07D417/04 , C07D417/06 , C07C229/14 , C07D249/06 , C07C229/48 , C07C229/50 , C07D487/04 , C07D205/04 , C07D207/16 , C07D277/28 , C07D209/44 , C07D211/34 , C07D211/46 , C07D213/38 , C07D213/65 , A61K31/196 , A61K31/197 , A61K31/397 , A61K31/40 , A61K31/427 , A61K31/445 , A61K31/4545 , A61K31/50 , A61K31/505 , A61K45/06
CPC classification number: C07D211/62 , A61K31/196 , A61K31/197 , A61K31/397 , A61K31/40 , A61K31/427 , A61K31/445 , A61K31/4545 , A61K31/50 , A61K31/505 , A61K45/06 , C07B2200/07 , C07C229/14 , C07C229/48 , C07C229/50 , C07C2601/14 , C07C2602/44 , C07D205/04 , C07D207/16 , C07D209/44 , C07D211/34 , C07D211/46 , C07D213/38 , C07D213/65 , C07D215/14 , C07D237/14 , C07D239/34 , C07D249/06 , C07D277/28 , C07D401/04 , C07D401/10 , C07D417/04 , C07D417/06 , C07D487/04
Abstract: Compounds of formula (I), and pharmaceutically acceptable salts thereof, can modulate the activity of one or more SIP receptors and/or the activity of autotaxin (ATX).
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