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公开(公告)号：US20140193422A1
公开(公告)日：2014-07-10
申请号：US14211438
申请日：2014-03-14
Applicant: Bristol-Myers Squibb Company
Inventor： Maria Jure-Kunkel , Laura J. Hefta , Marc Santoro , Subinay Ganguly , Edward L. Halk
IPC: C07K16/30
CPC classification number: C07K16/2878 , A61K39/0011 , A61K39/12 , A61K39/39 , A61K2039/505 , A61K2039/53 , A61K2039/55516 , C07K16/30 , C07K2317/21 , C07K2317/33 , C07K2317/51 , C07K2317/515 , C07K2317/565 , C07K2317/75 , C07K2317/92 , C12N2740/15034 , A61K2300/00
Abstract: Fully human antibodies and antigen-binding portions thereof that bind to human 4-1BB and that allow binding of human 4-1BB to a human 4-1BB ligand. In one aspect, the antibody is an IgG4 antibody. Also provided is a method for treating a disease in a subject comprising administering a therapeutically effective amount of the antibody to said subject.
Abstract translation: 与人4-1BB结合并允许人4-1BB与人4-1BB配体结合的完全人抗体及其抗原结合部分。 一方面，抗体是IgG4抗体。 还提供了治疗受试者疾病的方法，包括向所述受试者施用治疗有效量的抗体。
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Patent Agency Ranking
公开(公告)号：US20160368998A1
公开(公告)日：2016-12-22
申请号：US15174268
申请日：2016-06-06
Applicant: Bristol-Myers Squibb Company
Inventor： Maria JURE-KUNKEL , Laura J. Hefta , Marc Santoro , Subinay Ganguly , Edward L. Halk
IPC: C07K16/28
CPC classification number: C07K16/2878 , A61K39/0011 , A61K39/12 , A61K39/39 , A61K2039/505 , A61K2039/53 , A61K2039/55516 , C07K16/30 , C07K2317/21 , C07K2317/33 , C07K2317/51 , C07K2317/515 , C07K2317/565 , C07K2317/75 , C07K2317/92 , C12N2740/15034 , A61K2300/00
Abstract: Fully human antibodies and antigen-binding portions thereof that bind to human 4-1BB and that allow binding of human 4-1BB to a human 4-1BB ligand. In one aspect, the antibody is an IgG4 antibody. Also provided is a method for treating a disease in a subject comprising administering a therapeutically effective amount of the antibody to said subject.
Abstract translation: 与人4-1BB结合并允许人4-1BB与人4-1BB配体结合的完全人抗体及其抗原结合部分。 一方面，抗体是IgG4抗体。 还提供了治疗受试者疾病的方法，包括向所述受试者施用治疗有效量的抗体。
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公开(公告)号：US20190062445A1
公开(公告)日：2019-02-28
申请号：US16136876
申请日：2018-09-20
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Maria Jure-Kunkel , Laura J. Hefta , Marc Santoro , Subinay Ganguly , Edward L. Halk
Abstract: Fully human antibodies and antigen-binding portions thereof that bind to human 4-1BB and that allow binding of human 4-1BB to a human 4-1BB ligand. In one aspect, the antibody is an IgG4 antibody. Also provided is a method for treating a disease in a subject comprising administering a therapeutically effective amount of the antibody to said subject.
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公开(公告)号：US11827695B2
公开(公告)日：2023-11-28
申请号：US17152051
申请日：2021-01-19
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Michael K. Ahlijanian , Jere Ernest Meredith, Jr. , Nino Devidze , John David Graef , Edward L. Halk
IPC: C07K16/18 , A61K39/395 , A61P25/16 , A61P25/28
CPC classification number: C07K16/18 , A61K39/3955 , A61P25/16 , A61P25/28 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/33 , C07K2317/565 , C07K2317/92
Abstract: Disclosed herein are anti-α-synuclein antibodies which preferentially bind to oligomeric α-synuclein over monomeric α-synuclein, therapeutic compositions comprising the antibodies, and methods of using the antibodies to treat synucleinopathies.
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公开(公告)号：US11142570B2
公开(公告)日：2021-10-12
申请号：US16486238
申请日：2018-02-16
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Michael K. Ahlijanian , Jere Ernest Meredith, Jr. , Nino Devidze , John David Graef , Edward L. Halk
IPC: C07K16/18 , A61K39/395
Abstract: Disclosed herein are anti-α-synuclein antibodies which preferentially bind to oligomeric α-synuclein over monomeric α-synuclein, therapeutic compositions comprising the antibodies, and methods of using the antibodies to treat synucleinopathies.
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公开(公告)号：US09382328B2
公开(公告)日：2016-07-05
申请号：US14211438
申请日：2014-03-14
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Maria Jure-Kunkel , Laura J. Hefta , Marc Santoro , Subinay Ganguly , Edward L. Halk
CPC classification number: C07K16/2878 , A61K39/0011 , A61K39/12 , A61K39/39 , A61K2039/505 , A61K2039/53 , A61K2039/55516 , C07K16/30 , C07K2317/21 , C07K2317/33 , C07K2317/51 , C07K2317/515 , C07K2317/565 , C07K2317/75 , C07K2317/92 , C12N2740/15034 , A61K2300/00
Abstract: Fully human antibodies and antigen-binding portions thereof that bind to human 4-1BB and that allow binding of human 4-1BB to a human 4-1BB ligand. In one aspect, the antibody is an IgG4 antibody. Also provided is a method for treating a disease in a subject comprising administering a therapeutically effective amount of the antibody to said subject.
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