公开(公告)号：US20210395200A1

公开(公告)日：2021-12-23

申请号：US17292123

申请日：2019-11-15

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Adrian Ortiz ,  Alina Borovika ,  Sergei Kolotuchin ,  Michael R. Luzung ,  Jeffrey A. Nye ,  Yichen Tan ,  Serge Zaretsky ,  Jason J. Zhu ,  Martin D. Eastgate

IPC: C07D207/273

Abstract: Highly efficient processes are provided for preparing key intermediates in the synthesis of compounds (I). The process are broadly applicable and can provide selected components having a variety of substituents. Some intermediates are claimed.

公开(公告)号：US10106560B2

公开(公告)日：2018-10-23

申请号：US15623570

申请日：2017-06-15

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Adrian Ortiz ,  Carlos A. Guerrero ,  Bin Zheng ,  Jason J. Zhu ,  Michael Anthony Schmidt ,  Michael R. Luzung ,  Martin D. Eastgate

IPC: C07D417/12 ,  C07F7/18 ,  C07D211/28 ,  C07F7/08

Abstract: An improved process for making a compound B of the structure wherein n, R1, R2, and R3 are as defined in the specification. Compound B can be used to make tubulysin analogs that are, in turn, useful as anti-cancer agents, particularly when deployed in an antibody-drug conjugate.