专利检索 ap:("BRISTOL-MYERS SQUIBB COMPANY") AND inv:"Sergei Kolotuchin" 第 1 页

1.

发明申请
SYNTHETIC PROCESSES FOR THE PRODUCTION OF 1-((3S,4R)-4-(2,6-DIFLUORO-4-METHOXYPHENYL)-2-OXOPYRROLIDIN-3-YL)-3-PHENYLUREA 有权

公开(公告)号：US20210395200A1

公开(公告)日：2021-12-23

申请号：US17292123

申请日：2019-11-15

申请人： BRISTOL-MYERS SQUIBB COMPANY

发明人： Adrian Ortiz , Alina Borovika , Sergei Kolotuchin , Michael R. Luzung , Jeffrey A. Nye , Yichen Tan , Serge Zaretsky , Jason J. Zhu , Martin D. Eastgate

IPC分类号： C07D207/273

摘要： Highly efficient processes are provided for preparing key intermediates in the synthesis of compounds (I). The process are broadly applicable and can provide selected components having a variety of substituents. Some intermediates are claimed.

2.

发明授权
Substituted quinolinylcyclohexylpropanamide compounds and improved methods for their preparation 有权

公开(公告)号：US11919863B2

公开(公告)日：2024-03-05

申请号：US17552929

申请日：2021-12-16

申请人： BRISTOL-MYERS SQUIBB COMPANY

发明人： Albert J. Delmonte , Benjamin M. Cohen , Kenneth Joseph Fraunhoffer , Sergei Kolotuchin , Francisco Gonzalez-Bobes , Gregory Louis Beutner , Adam Joseph Freitag , Michael Scott Bultman , Yu Fan , Prantik Maity , Ian Scott Young , Hilary Plake Beck , Maksim Osipov , Jay Patrick Powers , Maureen Kay Reilly , Hunter Paul Shunatona , James Ross Walker , Mikhail Zibinsky

IPC分类号： C07D215/18 , C07C51/09 , C07C67/333 , C07C67/343

CPC分类号： C07D215/18 , C07C51/09 , C07C67/333 , C07C67/343

摘要： The disclosure is directed to improved methods for preparing substituted quinolinylcyclohexylpropanamide compounds.

3.

发明公开
PROCESS FOR THE PREPARATION OF 6-(CYCLOPROPANEAMIDO)-4-((2-METHOXY-3-(1-METHYL-1H-1,2,4-TRIAZOL-3-YL)PHENYL)AMINO)-N-(METHYL-D3)PYRIDAZINE-3-CARBOXAMIDE 审中-公开

公开(公告)号：US20230271946A1

公开(公告)日：2023-08-31

申请号：US18134564

申请日：2023-04-13

申请人： Bristol-Myers Squibb Company

发明人： Ke Chen , Joerg Deerberg , Dong Lin , Michael Dummeldinger , Bahar Inankur , Sergei Kolotuchin , Jun Li , Amanda J. Rogers , Victor W. Rosso , Eric M. Simmons , Maxime C.D. Soumeillant , Daniel S. Treitler , Jianji Wang , Bin Zheng , Michael J. Smith , Neil A. Strotman , Steven Tymonko , Tamas Benkovics

IPC分类号： C07D403/12 , C07C211/09 , C07D237/24 , C07D249/08

CPC分类号： C07D403/12 , C07C211/09 , C07D237/24 , C07D249/08 , C07B2200/13

摘要： The invention relates to an improved process for synthesizing 6-(cyclopropaneamido)-4-((2-methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)phenyl)amino)-5N-(methyl-d3)pyridazine-3-carboxamide of the formula:

Compound I is currently in clinical trials for the treatment of auto-immune and auto-inflammatory diseases such as psoriasis.

4.

发明授权
Substituted quinolinylcyclohexylpropanamide compounds and improved methods for their preparation 有权

公开(公告)号：US11236048B2

公开(公告)日：2022-02-01

申请号：US16624448

申请日：2018-06-29

申请人： BRISTOL-MYERS SQUIBB COMPANY

发明人： Albert J. Delmonte , Benjamin M. Cohen , Kenneth Joseph Fraunhoffer , Sergei Kolotuchin , Francisco Gonzalez-Bobes , Gregory Louis Beutner , Adam Joseph Freitag , Michael Scott Bultman , Yu Fan , Prantik Maity , Ian Scott Young , Hilary Plake Beck , Maksim Osipov , Jay Patrick Powers , Maureen Kay Reilly , Hunter Paul Shunatona , James Ross Walker , Mikhail Zibinsky

IPC分类号： C07D215/18 , C07C67/343 , C07C67/333 , C07C51/09

摘要： The disclosure is directed to improved methods for preparing substituted quinolinylcyclohexylpropanamide compounds.

5.

发明授权
Process for the preparation of 6-(cyclopropaneamido)-4-((2-methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)phenyl)amino)-n-(methyl- D3)pyridazine-3-carboxamide 有权

公开(公告)号：US11649226B2

公开(公告)日：2023-05-16

申请号：US17131718

申请日：2020-12-22

申请人： Bristol-Myers Squibb Company

发明人： Bahar Inankur , Sergei Kolotuchin , Maxime C. D. Soumeillant , Daniel S. Treitler

IPC分类号： C07D249/08 , C07D403/12 , C07C211/09 , C07D237/24

CPC分类号： C07D403/12 , C07C211/09 , C07D237/24 , C07D249/08 , C07B2200/13

摘要： The invention relates to an improved process for synthesizing 6-(cyclopropaneamido)-4-((2-methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)phenyl)amino)-N-(methyl-d3)pyridazine-3-carboxamide of the formula:

Compound I is currently in clinical trials for the treatment of auto-immune and auto-inflammatory diseases such as psoriasis.

6.

发明申请
PROCESS FOR THE PREPARATION OF 6-(CYCLOPROPANEAMIDO)-4-((2-METHOXY-3-(1-METHYL-1H-1,2,4-TRIAZOL-3-YL)PHENYL)AMINO)-N-(METHYL-D3)PYRIDAZINE-3-CARBOXAMIDE 有权

公开(公告)号：US20210107897A1

公开(公告)日：2021-04-15

申请号：US17131718

申请日：2020-12-22

申请人： Bristol-Myers Squibb Company

发明人： Ke Chen , Joerg Deerberg , Dong Lin , Michael Dummeldinger , Bahar Inankur , Sergei Kolotuchin , Jun Li , Amanda J. Rogers , Victor W. Rosso , Eric M. Simmons , Maxime C.D. Soumeillant , Daniel S. Treitler , Jianji Wang , Bin Zheng , Michael J. Smith , Neil A. Strotman , Steven Tymonko , Tamas Benkovics

IPC分类号： C07D403/12 , C07C211/09 , C07D237/24 , C07D249/08

摘要： The invention relates to an improved process for synthesizing 6-(cyclopropaneamido)-4-((2-methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)phenyl)amino)-N-(methyl-d3)pyridazine-3-carboxamide of the formula: Compound I is currently in clinical trials for the treatment of auto-immune and auto-inflammatory diseases such as psoriasis.

7.

发明授权
Process for the preparation of 6-(cyclopropaneamido)-4-((2-methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)phenyl)amino)-N-(methyl-d3)pyridazine-3-carboxamide 有权

公开(公告)号：US10899745B2

公开(公告)日：2021-01-26

申请号：US16498442

申请日：2018-03-29

申请人： BRISTOL-MYERS SQUIBB COMPANY

发明人： Ke Chen , Joerg Deerberg , Dong Lin , Michael Dummeldinger , Bahar Inankur , Sergei Kolotuchin , Jun Li , Amanda J. Rogers , Victor W. Rosso , Eric M. Simmons , Daniel S. Treitler , Jianji Wang , Michael J. Smith , Tamas Benkovics

IPC分类号： C07D403/12 , C07C211/09 , C07D237/24 , C07D249/08

摘要： The invention relates to an improved process for synthesizing 6-(cyclopropaneamido)-4-((2-methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)phenyl)amino)-N-(methyl-d3)pyridazine-3-carboxamide of the formula: [INSERT CHEMICAL STRUCTURE HERE] Compound I is currently in clinical trials for the treatment of auto-immune and auto-inflammatory diseases such as psoriasis.