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公开(公告)号：US20200281905A1
公开(公告)日：2020-09-10
申请号：US16879810
申请日：2020-05-21
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Huji Turdi , Jon J. Hangeland , R. Michael Lawrence , Saleem Ahmad , Wei Meng , Robert Paul Brigance , Pratik Devasthale , Guohua Zhao
IPC: A61K31/438 , A61K31/675 , C07D211/90 , A61K31/4418 , C07D401/04 , A61K31/4439 , C07D413/04 , C07D221/20 , C07D413/14 , A61K31/5377 , C07D401/14 , A61K45/06 , C07F9/59 , C07F9/40 , C07D401/10 , C07D401/12 , C07D407/14 , C07D413/12 , C07D417/04 , C07D417/14 , C07D211/86 , C07F9/535 , C07D405/14
Abstract: The present invention provides compounds of Formula (I): or a stereoisomer, or a pharmaceutically acceptable salt thereof, wherein all of the variables are as defined herein. These compounds are monoacylglycerol acyltransferase type 2 (MGAT2) inhibitors which may be used as medicaments.
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公开(公告)号：US10695328B2
公开(公告)日：2020-06-30
申请号：US16445913
申请日：2019-06-19
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Huji Turdi , Jon J. Hangeland , R. Michael Lawrence , Saleem Ahmad , Wei Meng , Robert Paul Brigance , Pratik Devasthale , Guohua Zhao
IPC: A61K31/438 , A61K31/675 , C07D211/90 , A61K31/4418 , C07D401/04 , A61K31/4439 , C07D413/04 , C07D221/20 , C07D413/14 , A61K31/5377 , C07D401/14 , A61K45/06 , C07F9/59 , C07F9/40 , C07D401/10 , C07D401/12 , C07D407/14 , C07D413/12 , C07D417/04 , C07D417/14 , C07D211/86 , C07F9/535 , C07D405/14
Abstract: The present invention provides compounds of Formula (I): or a stereoisomer, or a pharmaceutically acceptable salt thereof, wherein all of the variables are as defined herein. These compounds are monoacylglycerol acyltransferase type 2 (MGAT2) inhibitors which may be used as medicaments.
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公开(公告)号：US20200123160A1
公开(公告)日：2020-04-23
申请号：US16538917
申请日：2019-08-13
Applicant: BRISTOL-MYERS SQUIBB COMPANY , UNIVERSITÉ DE MONTRÉAL
Inventor： Jacques Banville , Roger Remillard , Edward H. Ruediger , Daniel H. Deon , Marc Gagnon , Laurence Dube , Julia Guy , Eldon Scott Priestley , Shoshana L. Posy , Brad D. Maxwell , Pancras C. Wong , R. Michael Lawrence , Michael M. Miller
IPC: C07D487/04 , C07B59/00 , A61K51/04 , A61K31/55 , A61K31/5386 , A61K31/435 , A61K31/553 , A61K31/541 , A61K31/5377 , A61K31/5025 , A61K31/497 , A61K31/496 , A61K31/454 , A61K31/4439 , A61K31/433 , C07D513/04 , C07D519/00 , A61K45/06
Abstract: The present invention provides thiazole compounds of Formula I wherein W, Y, R0, R2, R4, R5, R6, R7, X1, X2, X3 and X4 are as defined herein, or a stereoisomer, tautomer, pharmaceutically acceptable salt, prodrug ester or solvate form thereof, wherein all of the variables are as defined herein. These compounds are inhibitors of platelet aggregation and thus can be used as medicaments for treating or preventing thromboembolic disorders.
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公开(公告)号：US10369140B2
公开(公告)日：2019-08-06
申请号：US15867825
申请日：2018-01-11
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Huji Turdi , Jon J. Hangeland , R. Michael Lawrence , Saleem Ahmad , Wei Meng , Robert Paul Brigance , Pratik Devasthale , Guohua Zhao
IPC: C07F9/40 , C07F9/59 , A61K45/06 , C07F9/535 , A61K31/438 , A61K31/675 , C07D211/86 , C07D211/90 , C07D221/20 , C07D401/04 , C07D401/10 , C07D401/12 , C07D401/14 , C07D405/14 , C07D407/14 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/14 , A61K31/4418 , A61K31/4439 , A61K31/5377
Abstract: The present invention provides compounds of Formula (I): or a stereoisomer, or a pharmaceutically acceptable salt thereof, wherein all of the variables are as defined herein. These compounds are monoacylglycerol acyltransferase type 2 (MGAT2) inhibitors which may be used as medicaments.
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公开(公告)号：US20180362508A1
公开(公告)日：2018-12-20
申请号：US16061365
申请日：2016-12-15
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Michael C. Myers , R. Michael Lawrence , Donna M. Bilder , Wei Meng , Zulan Pi , Robert Paul Brigance , Heather Finlay
IPC: C07D403/04 , C07D413/14 , C07D413/04 , C07D417/14
Abstract: The present invention provides compounds of Formula (I): wherein all variables are as defined in the specification, and compositions comprising any of such novel compounds. These compounds are APJ agonists which may be used as medicaments, in particular for treating cardiovascular disorders.
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Patent Agency Ranking
公开(公告)号：US20170216263A1
公开(公告)日：2017-08-03
申请号：US15488642
申请日：2017-04-17
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Huji Turdi , Jon J. Hangeland , R. Michael Lawrence , Dong Cheng , Saleem Ahmad , Wei Meng , Robert Paul Brigance , Pratik Devasthale , Guohua Zhao
IPC: A61K31/438 , A61K31/5377 , A61K31/4439 , A61K31/4418 , A61K45/06 , C07D401/14 , C07D417/14 , C07D407/14 , C07D417/04 , C07D413/12 , C07D405/14 , C07D401/12 , C07D211/86 , C07D211/90 , C07D401/10 , A61K31/675
CPC classification number: A61K31/438 , A61K31/4418 , A61K31/4439 , A61K31/5377 , A61K31/675 , A61K45/06 , C07D211/86 , C07D211/90 , C07D221/20 , C07D401/04 , C07D401/10 , C07D401/12 , C07D401/14 , C07D405/14 , C07D407/14 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/14 , C07F9/4006 , C07F9/5352 , C07F9/59
Abstract: The present invention provides compounds of Formula (I): or a stereoisomer, or a pharmaceutically acceptable salt thereof, wherein all of the variables are as defined herein. These compounds are monoacylglycerol acyltransferase type 2 (MGAT2) inhibitors which may be used as medicaments.
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公开(公告)号：US09663466B2
公开(公告)日：2017-05-30
申请号：US14883067
申请日：2015-10-14
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Huji Turdi , Jon J. Hangeland , R. Michael Lawrence , Saleem Ahmad , Wei Meng , Robert Paul Brigance , Pratik Devasthale , Guohua Zhao
IPC: C07D211/90 , C07D401/04 , A61K31/675 , A61K31/4418 , A61K31/4439 , C07D413/04 , C07D221/20 , A61K31/438 , C07D413/14 , A61K31/5377 , C07F9/59 , C07D401/14 , A61K45/06 , C07D401/10 , C07D401/12 , C07D407/14 , C07D413/12 , C07D417/04 , C07D417/14 , C07D211/86 , C07F9/535 , C07F9/40 , C07D405/14
CPC classification number: A61K31/438 , A61K31/4418 , A61K31/4439 , A61K31/5377 , A61K31/675 , A61K45/06 , C07D211/86 , C07D211/90 , C07D221/20 , C07D401/04 , C07D401/10 , C07D401/12 , C07D401/14 , C07D405/14 , C07D407/14 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/14 , C07F9/4006 , C07F9/5352 , C07F9/59
Abstract: The present invention provides compounds of Formula (I): or a stereoisomer, or a pharmaceutically acceptable salt thereof, wherein all of the variables are as defined herein. These compounds are monoacylglycerol acyltransferase type 2 (MGAT2) inhibitors which may be used as medicaments.
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8.发明授权公开(公告)号：US09249096B2
公开(公告)日：2016-02-02
申请号：US14346747
申请日：2012-09-26
Applicant: Bristol-Myers Squibb Company
Inventor： Lynn Abell , Leonard Adam , Cullen L. Cavallaro , Heather Finlay , Todd J. Friends , Jon J. Hangeland , Ji Jiang , R. Michael Lawrence , Jennifer X. Qiao , Carol Hui Hu , Tammy C. Wang
IPC: C07D207/38 , C07D403/12 , C07D401/12 , C07D207/277 , C07D401/06 , C07D405/04 , C07D405/06 , C07D409/04 , C07D417/04 , C07D417/06 , C07D207/28 , C07D233/61 , C07D413/06
CPC classification number: C07D207/277 , C07D207/28 , C07D207/38 , C07D233/61 , C07D401/06 , C07D401/12 , C07D403/12 , C07D405/04 , C07D405/06 , C07D409/04 , C07D413/06 , C07D417/04 , C07D417/06
Abstract: The present invention provides compounds of Formula (I): as defined in the specification and compositions comprising any of such novel compounds. These compounds are endothelial lipase inhibitors which may be used as medicaments. The disclosure also provides a novel method of treating diseases or conditions related to the activity of endothelial lipase by use of compounds according to Formula (II): as defined in the specification and compositions comprising any of the compounds.
Abstract translation: 本发明提供式（I）化合物：如说明书中所定义和包含任何这些新化合物的组合物。 这些化合物是可用作药物的内皮脂肪酶抑制剂。 本公开还提供了一种通过使用根据式（II）的化合物来治疗与内皮脂肪酶活性相关的疾病或病症的新方法：如说明书中所定义和包含任何化合物的组合物。
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公开(公告)号：US09187424B1
公开(公告)日：2015-11-17
申请号：US14305098
申请日：2014-06-16
Applicant: Bristol-Myers Squibb Company
Inventor： Huji Turdi , Jon J. Hangeland , R. Michael Lawrence , Dong Cheng , Saleem Ahmad , Wei Meng , Robert Paul Brigance , Pratik Devasthale , Guohua Zhao
IPC: C07D211/90 , C07D401/04 , A61K31/4418 , A61K31/5377 , C07D401/10 , C07D413/04 , C07D401/14 , C07D221/20 , C07D413/14 , A61K45/06 , A61K31/4439 , A61K31/438
CPC classification number: A61K31/438 , A61K31/4418 , A61K31/4439 , A61K31/5377 , A61K31/675 , A61K45/06 , C07D211/86 , C07D211/90 , C07D221/20 , C07D401/04 , C07D401/10 , C07D401/12 , C07D401/14 , C07D405/14 , C07D407/14 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/14 , C07F9/4006 , C07F9/5352 , C07F9/59
Abstract: The present invention provides compounds of Formula (I): or a stereoisomer, or a pharmaceutically acceptable salt thereof, wherein all of the variables are as defined herein. These compounds are monoacylglycerol acyltransferase type 2 (MGAT2) inhibitors which may be used as medicaments.
Abstract translation: 本发明提供式（I）化合物或其立体异构体或其药学上可接受的盐，其中所有变量如本文所定义。 这些化合物是可用作药物的单酰基甘油酰基转移酶2型（MGAT2）抑制剂。
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10.发明申请ARYL DIHYDROPYRIDINONES AND PIPERIDINONE MGAT2 INHIBITORS 有权ARYL DIHYDROPYRIDINONES和PIPERIDINONE MGAT2抑制剂公开(公告)号：US20150315144A1
公开(公告)日：2015-11-05
申请号：US14305098
申请日：2014-06-16
Applicant: Bristol-Myers Squibb Company
Inventor： Huji Turdi , Jon J. Hangeland , R. Michael Lawrence , Dong Cheng , Saleem Ahmad , Wei Meng , Robert Paul Brigance , Pratik Devasthale , Guohua Zhao
IPC: C07D211/90 , C07D401/10 , C07D413/04 , C07D401/14 , A61K31/5377 , C07D413/14 , A61K45/06 , A61K31/4418 , A61K31/4439 , A61K31/438 , C07D401/04 , C07D221/20
CPC classification number: A61K31/438 , A61K31/4418 , A61K31/4439 , A61K31/5377 , A61K31/675 , A61K45/06 , C07D211/86 , C07D211/90 , C07D221/20 , C07D401/04 , C07D401/10 , C07D401/12 , C07D401/14 , C07D405/14 , C07D407/14 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/14 , C07F9/4006 , C07F9/5352 , C07F9/59
Abstract: The present invention provides compounds of Formula (I): or a stereoisomer, or a pharmaceutically acceptable salt thereof, wherein all of the variables are as defined herein. These compounds are monoacylglycerol acyltransferase type 2 (MGAT2) inhibitors which may be used as medicaments.
Abstract translation: 本发明提供式（I）化合物或其立体异构体或其药学上可接受的盐，其中所有变量如本文所定义。 这些化合物是可用作药物的单酰基甘油酰基转移酶2型（MGAT2）抑制剂。
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